Journals Molecular and Cellular Endocri...

Molecular and Cellular Endocrinology
Ana Carolina Barros Silva, Ingrid Iara Damas, Camila Aparecida Moma, Icleia Siqueira Barreto, Denise Engelbrecht Zantut-Wittmann
UNLABELLED: Graves' disease (GD), an autoimmune thyroid disease, is one of the main autoimmune diseases in the general population. It is known that the pathophysiology of this disease may be related to immunological mechanisms dysregulation. These mechanisms can be influenced by GD therapies, such as iodide or antithyroid drugs (ATD). OBJECTIVE: Verify relation between clinical, biochemical and treatment modalities used prior to surgery and histopathological characteristics observed in total thyroidectomy products from patients previously diagnosed with Graves' disease...
July 17, 2024: Molecular and Cellular Endocrinology
Cristiane Dias Lisboa, José Luciano Maciel de Souza, Custódio José Gaspar, Patrick Turck, Vanessa Duarte Ortiz, Isabel Cristina Teixeira Proença, Tânia Regina G Fernandes, Elissa Fernandes, Silvio Tasca, Cristina Campos Carraro, Adriane Belló-Klein, Alex Sander da Rosa Araujo, Alexandre Luz de Castro
Pulmonary arterial hypertension (PAH) is characterised by an increase in mean pulmonary arterial pressure and a compromised the right ventricle (RV), together with progression to heart failure and premature death. Studies have evaluated the role of melatonin as a promising therapeutic strategy for PAH. The objective of this study was to evaluate melatonin's effects on oxidative stress and on the TLR4/NF-kβ inflammatory pathway in the RV of rats with PAH. Male Wistar rats were divided into the following groups: control, monocrotaline (MCT), and monocrotaline plus melatonin groups...
July 11, 2024: Molecular and Cellular Endocrinology
Manas Kubal, Magdalena Lech, Fannie Lajeunesse-Trempe, Eftychia E Drakou, Ashley B Grossman, Georgios K Dimitriadis
Parathyroid carcinoma (PCA) is a rare malignancy accounting for approximately 1% of all patients with primary hyperparathyroidism. It is characterised by excessive parathyroid hormone (PTH) production. This manuscript reviews recent advances in the management of parathyroid carcinoma, focusing on molecular insights, diagnostic modalities, surgical innovations, adjuvant therapies, and emerging targeted treatments. Recently published manuscripts (between 2022 and 2023) were obtained from Medical Literature Analysis and Retrieval System Online (Medline), Excerpta Medica (Embase), Cochrane Central Register of Controlled Trials (CENTRAL), and European Union Drug Regulating Authorities Clinical Trials (EudraCT)...
July 10, 2024: Molecular and Cellular Endocrinology
Nahuel E Wanionok, Germán A Colareda, Juan M Fernandez
Osteoporosis is the most common metabolic bone disorder and is associated with a high incidence of fractures. Angiogenesis and adequate blood flow are important during bone repair and maintenance. Estrogens play a key role in bone formation, in the prevention of bone resorption and vasculature maintenance. Hormone replacement therapy (HRT) has been used with great benefits for bone fracture prevention but has been linked to the development of serious important side effects, including cancer and stroke. Phytoestrogens are an attractive alternative to HRT because their chemical structure is similar to estradiol but, they could behave as selective modulators: acting as antagonists of estrogen receptors in the breast and endometrium and as agonists in the vascular endothelium and bone...
July 10, 2024: Molecular and Cellular Endocrinology
Thiago Henrique Caldeira de Oliveira, Gleisy Kelly Neves Gonçalves
This study addresses the increasing prevalence of obesity, especially among postmenopausal. Estrogen plays a crucial role in regulating adipose tissue in women, with its absence after menopause associated with metabolic complications. The study aimed to determine the lipolytic activity in different adipose tissue depots of ovariectomized rats submitted to a high-fat diet. Also, to analyze the expression of estrogen receptors in adipose tissues and perform histological and morphometric analyzes of these deposits...
July 10, 2024: Molecular and Cellular Endocrinology
Maho Sakaki, Yuji Kamatari, Akira Kurisaki, Masayuki Funaba, Osamu Hashimoto
Activin E activates brown and beige adipocytes and has been controversially implicated as a factor that induces obesity and fatty liver. Here, we sought to address this controversial issue by producing recombinant human activin E to evaluate its effects on HB2 brown adipocytes in vitro. Activin E increased uncoupling protein 1 (Ucp1) and fibroblast growth factor 21 (Fgf21) mRNA expression in the adipocytes. This upregulation was suppressed by SB431542, an inhibitor of activin receptor-like kinase (Alk) TGF-β type I receptors...
July 5, 2024: Molecular and Cellular Endocrinology
Zoran Gluvic, Milan Obradovic, Mia Manojlovic, Rosaria Vincenza Giglio, Angelo Maria Patti, Marcello Ciaccio, Jasjit S Suri, Manfredi Rizzo, Esma R Isenovic
Polymetabolic syndrome achieved pandemic proportions and dramatically influenced public health systems functioning worldwide. Chronic vascular complications are the major contributors to increased morbidity, disability, and mortality rates in diabetes patients. Nitric oxide (NO) is among the most important vascular bed function regulators. However, NO homeostasis is significantly deranged in pathological conditions. Additionally, different hormones directly or indirectly affect NO production and activity and subsequently act on vascular physiology...
July 3, 2024: Molecular and Cellular Endocrinology
Jingru Qu, Lei Tian, Man Zhang, Bei Sun, Liming Chen
Obesity is characterized by excessive accumulation of adipose tissue (mainly visceral). The morphology and function of mitochondria are crucial for regulating adipose browning and weight loss. Research suggests that the SGLT2 inhibitor canagliflozin may induce weight loss through an unknown mechanism, particularly targeting visceral adipose tissue. While Krueppel-Like Factor 4 (KLF4) is known to be essential for energy metabolism and mitochondrial function, its specific impact on visceral adipose tissue remains unclear...
July 2, 2024: Molecular and Cellular Endocrinology
Liuru Su, Guang Li, Billy K C Chow, João C R Cardoso
Genomes and transcriptomes from diverse organisms are providing a wealth of data to explore the evolution and origin of neuropeptides and their receptors in metazoans. While most neuropeptide-receptor systems have been extensively studied in vertebrates, there is still a considerable lack of understanding regarding their functions in invertebrates, an extraordinarily diverse group that account for the majority of animal species on Earth. Cephalochordates, commonly known as amphioxus or lancelets, serve as the evolutionary proxy of the chordate ancestor...
June 27, 2024: Molecular and Cellular Endocrinology
Tongwei Zhang, Junnan Fang, Jingyi Hu, Yue Kong, Ran Jiang, Huihui Wang, Guang Yang, Guidong Yao
Polycystic ovary syndrome (PCOS) is a type of follicular dysplasia with an unclear pathogenesis, posing certain challenges in its diagnosis and treatment. Cancer susceptibility candidate 15 (CASC15), a long non-coding RNA closely associated with tumour development, has been implicated in PCOS onset and development. Therefore, this study aimed to investigate the molecular mechanisms underlying PCOS by downregulating CASC15 expression in both in vitro and in vivo models. We explored the potential regulatory relationship between CASC15 expression and PCOS by examining cell proliferation, cell cycle dynamics, cell autophagy, steroid hormone secretion capacity, and overall ovarian function in mice...
June 26, 2024: Molecular and Cellular Endocrinology
Ahmet Kuralay, Miriam C McDonough, Jon M Resch
Mineralocorticoids play a key role in hydromineral balance by regulating sodium retention and potassium wasting. Through favoring sodium, mineralocorticoids can cause hypertension from fluid overload under conditions of hyperaldosteronism, such as aldosterone-secreting tumors. An often-overlooked mechanism by which aldosterone functions to increase sodium is through stimulation of salt appetite. To drive sodium intake, aldosterone targets neurons in the hindbrain which uniquely express 11β-hydroxysteroid dehydrogenase type 2 (HSD2)...
June 26, 2024: Molecular and Cellular Endocrinology
Xuewei Zheng, ShunShun Zhang, HaoDi Ma, Yirui Dong, Jiayu Zheng, Li Zeng, Jiangbo Liu, Yanzhenzi Dai, Qinan Yin
The tricarboxylic acid (TCA) cycle is an essential interface that coordinates cellular metabolism and is as a primary route determining the fate of a variety of fuel sources, including glucose, fatty acid and glutamate. The crosstalk of nutrients replenished TCA cycle regulates breast cancer (BC) progression by changing substrate levels-induced epigenetic alterations, especially the methylation, acetylation, succinylation and lactylation. Long non-coding RNAs (lncRNA) have dual roles in inhibiting or promoting energy reprogramming, and so altering the metabolic flux of fuel sources to the TCA cycle, which may regulate epigenetic modifications at the cellular level of BC...
June 25, 2024: Molecular and Cellular Endocrinology
Lillian R Jackson, Beau Alward
Innate social behaviors like aggression are modulated by sex steroid hormones such as androgens and estrogens. However, we know little about how the same hormone regulates similar behaviors in both sexes. We investigated the role of androgenic signaling in the regulation of aggression in Astatotilapia burtoni, a social fish in which males and females perform similar aggressive behaviors. We used androgen receptor (AR) α knockout (KO) animals for this study, which was recently shown to be required for male-typical aggression and mating...
June 24, 2024: Molecular and Cellular Endocrinology
Mariana Ferreira Bizzi, Juliana Beaudette Drummond, Sergio Veloso Brant Pinheiro, Eduardo Paulino, Stanley Almeida Araújo, Beatriz Santana Soares Rocha, Alexandre V Giannetti, Júnia Ribeiro de Oliveira Longo Schweizer, Sayka Barry, Márta Korbonits, Antonio Ribeiro-Oliveira
INTRODUCTION: AMPK (AMP-activated protein kinase) is an enzyme that acts as a metabolic sensor and regulates multiple pathways via phosphorylating proteins in metabolic and proliferative pathways. The aim of this work was to study the activated cellular AMPK (phosphorylated-AMPK at Thr172, pAMPK) levels in pituitary tumor samples from patients with sporadic and familial acromegaly, as well as in samples from normal human pituitary gland. METHODS: We studied pituitary adenoma tissue from patients with sporadic somatotroph adenomas, familial acromegaly with heterozygote germline variants in the aryl hydrocarbon receptor interacting protein (AIP) gene (p...
June 20, 2024: Molecular and Cellular Endocrinology
Shabnam Fayezi, Sophie Oehms, Helena Wolff von Gudenberg, Maharajah Ponnaiah, Marie Lhomme, Thomas Strowitzki, Ariane Germeyer
BACKGROUND: Ovarian somatic cells support the maturation and fertility of oocytes. Metabolic desaturation of fatty acids in these cells has a positive paracrine impact on the maturation of oocytes. We hypothesized that the enzyme stearoyl-CoA desaturase 1 (SCD1) in granulosa cells regulates the lipid cargo of exosomes secreted from these cells by maintaining the balance between saturated and unsaturated lipids. We investigated the effect of SCD1 on exosome lipid content in a cumulus-granulosa cell model under physiologically relevant in vitro conditions...
June 18, 2024: Molecular and Cellular Endocrinology
Isabelle Tenori Ribeiro, Matheus Naia Fioretto, Sérgio Alexandre Alcantara Dos Santos, Ketlin Thassiani Colombelli, Luiz Marcos Frediani Portela, Marcus Vinicius Niz Alvarez, Pedro de Magalhães Padilha, Aislan Quintiliano Delgado, Marcus Vinicius Lage Silva Giaculi Marques, José Roberto Bosqueiro, Fábio Rodrigues Ferreira Seiva, Luís Fernando Barbisan, Antonio Marcus de Andrade Paes, Elena Zambrano, Luis Antonio Justulin
This study investigated the impact of maternal protein restriction (MPR) and early postnatal sugar consumption (SUG) on the liver health of adult male descendant rats. Male offspring of mothers fed a normal protein diet (NPD) or a low protein diet (LPD) were divided into four groups: Control (CTR), Sugar Control (CTR+SUG), LPD during gestation and lactation (GLLP), and LPD with sugar (GLLP+SUG). Sugar consumption (10% glucose diluted in water) began after weaning on day 21 (PND 21), and at 90 days (PND 90), rats were sacrificed for analysis...
June 14, 2024: Molecular and Cellular Endocrinology
Caijie Shen, Yang Shuwen, Nan Wu, Wang Jian, Shating Du, Huimin Chu, Weiping Du
Diabetic cardiomyopathy (DCM) is characterized by oxidative damage and inflammatory responses. Myeloid differentiation protein 1 (MD1) exhibits antioxidant and anti-inflammatory properties. However, the specific role of MD1 in DCM has yet to be elucidated. This study aims to investigate the role of MD1 in DCM and to elucidate the underlying mechanisms. We utilized a gain-of-function approach to explore the involvement of MD1 in DCM. Diabetes was induced in MD1-transgenic (MD1-TG) mice and their wild-type (WT) counterparts via streptozotocin (STZ) injection...
June 13, 2024: Molecular and Cellular Endocrinology
Benjamin J Gigliotti, Jennifer A Brooks, Lori J Wirth
Medullary thyroid carcinoma (MTC) is a rare primary neuroendocrine thyroid carcinoma that is distinct from other thyroid or neuroendocrine cancers. Most cases of MTC are sporadic, although MTC exhibits a high degree of heritability as part of the multiple endocrine neoplasia syndromes. REarranged during Transfection (RET) mutations are the primary oncogenic drivers and advances in molecular profiling have revealed that MTC is enriched in druggable alterations. Surgery at an early stage is the only chance for cure, but many patients present with or develop metastases...
June 12, 2024: Molecular and Cellular Endocrinology
Pratikshya Sahoo, Debarshi Sarkar, Shubhangi Sharma, Arpit Verma, Suraj Kumar Naik, Vikash Prashar, Jyoti Parkash, Shio Kumar Singh
Orexins (OXs) are neuropeptides which regulate various physiological processes. OXs exist in two different forms, mainly orexin A (OXA) and orexin B (OXB) and their effects are mediated via OX1R and OX2R. Presence of OXB and OX2R in mouse testis is also reported. However, the role of OXB/OX2R in the male gonad remains unexplored. Herein we investigated the role of OXB/OX2R system in testicular physiology under in vivo and ex vivo conditions. Adult mice were given a single dose of bilateral intratesticular injection of siRNA targeting OX2R and were sacrificed 96 h post-injection...
June 10, 2024: Molecular and Cellular Endocrinology
Amir Ajoolabady, Domenico Pratico, Jun Ren
Angiotensin II (Ang II) is a protein hormone capable of physiologically regulating blood pressure through diverse mechanisms. Ang II is mainly produced by the liver at homeostatic levels. However, excessive production of Ang II is closely associated with a series of pathological events in the body. The endothelial dysfunction is one of these pathological events that can drive vascular anomalies. The excessive exposure of endothelial cells (ECs) to Ang II may induce endothelial dysfunction via diverse mechanisms...
June 7, 2024: Molecular and Cellular Endocrinology
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