journal
https://read.qxmd.com/read/37986386/operative-timing-and-the-safety-of-emergency-laparoscopic-cholecystectomy-a-retrospective-analysis
#21
JOURNAL ARTICLE
Guo-Cai Li, Yong Xu, Hong-Gang Tian, Qin-Xian Huang, Ze-Yu Xu
The ideal operative timing for laparoscopic cholecystectomy (LC) remains controversial, particularly in emergency patients. This study aimed to evaluate the necessity of operative timing for emergency LC. One hundred ninety-four patients who had undergone operative timings were classified into groups of <72h and >72h from the onset of symptoms to the operation. Baseline data, basic disease, operative bleeding, complications, and conversion rates were analyzed by Variance analysis and logistic regression analysis...
November 17, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37986385/rez%C3%A5-m-water-vapor-thermal-therapy-in-patients-with-benign-prostatic-hyperplasia-initial-real-world-data-from-japan
#22
JOURNAL ARTICLE
Daisuke Obinata, Junichi Mochida, Rio Uehara, Miyu Osawa, Sho Hashimoto, Ken Nakahara, Tsuyoshi Yoshizawa, Kenya Yamaguchi, Satoru Takahashi
Benign prostatic hyperplasia (BPH) is prevalent in older men. As surgery can be high risk in this group, minimally invasive procedures are preferrable. This study aimed to assess the initial results of minimally invasive Rezūm water vapor thermal therapy (WVTT) in patients with BPH. This single-center retrospective study included 25 consecutive patients with BPH who underwent WVTT between September 2022 and July 2023. Parameters including age, Charlson Comorbidity Index and Geriatric 8 (G8) scores, operative time, and number of vapor injections were evaluated...
November 17, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37986384/trends-in-gender-disparity-in-the-field-of-helicobacter-pylori-research-from-2000-to-2020-a-cross-sectional-study
#23
JOURNAL ARTICLE
Huiqin Shi, Shu Huang, Zhenju Tan, Xinyue Ma, Han Zhang, Wei Zhang, Lei Shi, Xiaolin Zhong, Muhan Lü, Xia Chen, Xiaowei Tang
Many studies have investigated gender disparity in scientific publications, but this has been poorly studied in the field of digestive diseases. This study aimed to determine the gender difference of first and senior authors in publications related to Helicobacter pylori (H. pylori) during the past 20 years. Data were derived from original articles published in the main journals of digestive diseases (Journal of Hepatology, Gut, Gastroenterology, American Journal of Gastroenterology, Endoscopy, Gastrointestinal Endoscopy, Alimentary Pharmacology and Therapeutics, Digestive Endoscopy, Journal of Gastroenterology, Helicobacter, and Gastric Cancer) in 2000, 2005, 2010, 2015, and 2020...
November 17, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37986383/screening-and-identification-of-hub-genes-of-scar-physique-via-weighted-gene-co-expression-network-analysis
#24
JOURNAL ARTICLE
Shuxian Ma, Xuze Li, Wenhao Wu, Pei Zhang, Yanjie Yang, Lining Huang, Qian Wan
Scar physique refers to the abnormal repair of skin injury in some people, which may easily lead to keloid or hypertrophic scar. However, the mechanism of scar physique is still unclear. GSE108110 was obtained from the gene expression omnibus database. Differently expression genes (DEGs) between normal skin tissue of non-scar physique individuals and normal skin tissue of scar physique individuals were screened by R package "limma". Weighted gene co-expression network analysis was performed to find highly relevant gene modules...
November 17, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37986382/platelet-transfusion-for-spontaneous-intracerebral-hemorrhage-with-prior-antiplatelet-a-systematic-review-and-meta-analysis
#25
JOURNAL ARTICLE
Yan Lin, Yong Liu, Lei Liu, Lili Zhang, Yapeng Lin, Jianping Yu, Jie Yang
BACKGROUND: Recent studies have highlighted the unfavorable prognosis of patients with spontaneous intracerebral hemorrhage (ICH) who have received prior antiplatelet therapy (PAP). Platelet infusion therapy (PIT) is commonly administered to such patients at many medical institutions, but its efficacy remains a subject of debate. METHODS: To address this uncertainty, we conducted a comprehensive search of PubMed, EMBASE, and Cochrane Library databases for eligible studies published before June 30, 2023...
November 17, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37986381/multiple-microarray-analysis-for-identification-of-key-genes-involved-in-diabetic-nephropathy
#26
JOURNAL ARTICLE
Hui Bi, Liang Ma, Xu Zhong, Gang Long
The purpose of our study was to discover genes with significantly aberrant expression in diabetic nephropathy (DN) and to determine their potential mechanism. We acquired renal tubules, glomerulus and blood samples data from DN patients and controls from the GEO database. The differentially expressed genes (DEGs) in renal tubules, glomerulus and blood samples between DN patients and controls were studied. Based on these DEGs, we carried out the functional annotation and constructed protein-protein interaction (PPI) network...
November 17, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37986380/cervical-kyphosis-surgery-using-a-cervical-pedicle-screw-placed-with-a-u-shaped-wire-that-enables-observation-of-the-lateral-edge-of-the-cortical-bone-of-the-spinal-canal-a-case-report-and-literature-review
#27
REVIEW
Chikara Ushiku, Shoshi Akiyama, Tomoaki Kanai, Naomu Sawada, Mitsuru Saito
RATIONALE: A cervical pedicle screw (CPS) serves as an important anchor for cervical surgeries. Its placement requires the development of a highly safe and easy-to-handle method. Considering that the lateral end of the cortical bone of the spinal canal (LE point) is the most crucial for CPS placement, we devised a U-shaped wire capable of identifying LE points under direct vision and reliably confirming the site with C-arm lateral fluoroscopy. PATIENT CONCERNS: A 65-year-old male, who had been aware of numbness in both hands, mild finger dexterity disorder, and gait disturbance for half a year, visited our hospital due to the progression of his symptoms in the previous 2 months...
November 17, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37986379/global-research-hotspots-and-trends-in-exercise-interventions-for-rheumatoid-arthritis-over-the-past-two-decades-a-bibliometric-and-visualization-study
#28
JOURNAL ARTICLE
Jie Xu, Meng Chen, Yingli Yu, Liugang Tang, Xiaobing Luo, Yuandong Cheng
Rheumatoid arthritis (RA) is a prolonged multifactorial autoimmune disease of unknown etiology. With the global population aging, the incidence of RA is increasing, highlighting the need for more effective treatments. Exercise interventions have been recognized as safe and effective for managing pain, improving function, and reducing fatigue in RA patients. However, the existing literature in this field lacks a thorough, organized, and clear line of analysis. In this study, we conducted a comprehensive analysis of the 20-year literature on exercise interventions for RA, aiming to identify hotspots and cutting-edge trends...
November 17, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37986378/bioinformatics-strategies-to-identify-differences-in-molecular-biomarkers-for-ischemic-stroke-and-myocardial-infarction
#29
JOURNAL ARTICLE
Min Wang, Yuan Gao, Huaqiu Chen, Ying Shen, Jianjie Cheng, Guangming Wang
Ischemic strokes (ISs) are commonly treated by intravenous thrombolysis using a recombinant tissue plasminogen activator; however, successful treatment can only occur within 3 hours after the stroke. Therefore, it is crucial to determine the causes and underlying molecular mechanisms, identify molecular biomarkers for early diagnosis, and develop precise preventive treatments for strokes. We aimed to clarify the differences in gene expression, molecular mechanisms, and drug prediction approaches between IS and myocardial infarction (MI) using comprehensive bioinformatics analysis...
November 17, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37986377/clinical-impact-using-low-dose-mycophenolate-mofetil-with-tacrolimus-on-infectious-noninfectious-complications-and-acute-rejection-in-renal-transplant-a-single-hospital-experience-in-mexico
#30
JOURNAL ARTICLE
Jorge Andrade-Sierra, Hernesto Hernández-Reyes, Enrique Rojas-Campos, Ernesto Germán Cardona-Muñoz, José Ignacio Cerrillos-Gutiérrez, Eduardo González-Espinoza, Luis Alberto Evangelista-Carrillo, Miguel Medina-Pérez, Basilio Jalomo-Martínez, Alejandra Guillermina Miranda-Díaz, Víctor Manuel Martínez-Mejía, Benjamin Gómez-Navarro, Antonio de Jesús Andrade-Ortega, Juan José Nieves-Hernández, Claudia Alejandra Mendoza-Cerpa
Evidence supporting a starting dose of 2 g/day of mycophenolate mofetil (MMF) in combination with tacrolimus (TAC) for renal transplantation (RT) is still limited, but maintaining a dose of <2 g could result in worse clinical outcomes in terms of acute rejection (AR). This study aimed to determine the association between AR and infectious and noninfectious complications after RT with a dose of 1.5 g vs 2 g of MMF. A prospective cohort study was performed with a 12-month follow-up of recipients of RT from living donors with low (1...
November 17, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37986376/establishment-of-a-6-signature-risk-model-associated-with-cellular-senescence-for-predicting-the-prognosis-of-breast-cancer
#31
JOURNAL ARTICLE
Xiu-Xia Zhang, Xin Yu, Li Zhu, Jun-Hua Luo
This study focused on screening novel markers associated with cellular senescence for predicting the prognosis of breast cancer. The RNA-seq expression profile of BRCA and clinical data were obtained from TCGA. The pam algorithm was used to cluster patients based on senescence-related genes. The weighted gene co-expression network analysis was used to identify co-expressed genes, and LASSO-Cox analysis was performed to build a risk prognosis model. The performance of the model was also evaluated. We additionally explored the role of senescence in cancer development and possible regulatory mechanism...
November 17, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37986375/influence-of-minimum-segment-width-on-intensity-modulated-radiotherapy-plan-for-left-sided-breast-cancer-after-breast-conserving-surgery
#32
JOURNAL ARTICLE
Ning Wang, Lijuan Chen, Guosen Huang, Haitao Sun
To research the influence of the minimum segment width (MSW) on intensity-modulated radiotherapy (IMRT) plan for left breast cancer after breast conserving surgery and provide a reference for plan optimization. Ten patients with left-sided early-stage breast cancer after breast-conserving surgery (BCS) were selected for postoperative radiotherapy. The Monaco 5.11 treatment planning system (TPS) was used, and the optimization parameters of the plan were fixed, while MSW were set to 0.5, 1, 1.5, and 2 cm, and four 5 field-IMRT plans were designed for every patient...
November 17, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37986374/pregnancy-in-women-with-autosomal-recessive-alport-syndrome-caused-by-novel-compound-heterozygous-mutations-of-col4a3-gene-two-cases-reports
#33
JOURNAL ARTICLE
Xiaoli Gao, Meilu Li, Kan Wang, Zengyan Li, Cha Han
RATIONALE: Autosomal recessive Alport syndrome (ARAS) is an hereditary heterogeneous disease that poses a serious risk to pregnant women. PATIENT CONCERNS: We reported 2 cases of pregnancy with progressive proteinuria. The case 1 was a 21-year-old woman with 24-h proteinuria increased from 2.03 to 11.72 g at 13 to 35 weeks of gestation, and the case 2 was a 28-year-old woman with 24-h proteinuria increased from 2.10 to 9.32 g at 8 to 36 weeks of gestation...
November 17, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37986373/causal-relationship-between-dried-fruit-intake-and-frozen-shoulder-two-sample-mendelian-randomization
#34
JOURNAL ARTICLE
Guang-Hua Deng
To investigate the causal relationship between dried fruit intake and frozen shoulder using Mendelian randomization (MR). Genome wide association studies were conducted to pool data and select genetic loci independently associated with dried fruit intake and frozen shoulder in people of European ancestry as instrumental variables. Three MR analyses, inverse variance weighting, weighted median and MR-Egger, were used to investigate the causal relationship between dried fruit intake and frozen shoulder. Heterogeneity and multiplicity tests were used, and sensitivity analyses were conducted using the leave-one-out method to explore the robustness of the results...
November 17, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37986372/endogenous-endophthalmitis-caused-by-urinary-tract-infection-a-case-report
#35
JOURNAL ARTICLE
Cong Ren, Zhongen Li, Fan Meng, Yongle Du, Hao Sun, Bin Guo
RATIONALE: Endogenous endophthalmitis is a vision-threatening intraocular infection caused by hematogenous spread of infectious organisms from distant sites. PATIENT CONCERNS: A 71-year-old man with a history of fever and dysuria 5 days prior to presentation presented with sudden loss of vision in his left eye. The patient had no history of ocular surgery or trauma, and ocular examination revealed a large amount of exudative plaque covering the pupil. Therefore, fundus examination was not feasible...
November 17, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37986371/leptin-and-risk-factors-for-atherosclerosis-a-review
#36
REVIEW
Cheng Wang, Liping Chang, Jia Wang, Libo Xia, Liyuan Cao, Wei Wang, Jianwen Xu, Huize Gao
Leptin is a hormone secreted primarily by adipose tissue. It regulates an organism's metabolism, energy balance, and body weight through a negative feedback mechanism. When a person or animal has low body fat and little energy, the leptin level in the body decreases, and conversely, when there is an excess of nutrients, the leptin level increases, giving a feeling of satiety. However, when leptin levels are abnormal (too high or too low) for a number of reasons, it can negatively affect your health, inducing inflammatory responses, obesity, and other problems...
November 17, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37986370/expression-and-clinical-implications-of-hla-g-and-pd-l1-following-kidney-transplantation-a-cohort-study
#37
JOURNAL ARTICLE
Silvia M Botelho, Isabela J Wastowski, Renata T Simões, Maria A P C Cysneiros, Antonio da Silva Menezes, Aline L Rezende, Nílzio A da Silva
Kidney transplantation (KT) is the preferred treatment for end-stage renal diseases. Human leukocyte antigen G (HLA-G) and programmed death-ligand 1 (PD-L1) have notable clinical and therapeutic significance in transplantation because of their roles in promoting tolerance. This study aimed to assess HLA-G and PD-L1 levels at various stages following KT. A cohort of 12 patients was monitored from the pretransplant phase to 12 months post-surgery. Blood samples were taken at specific intervals: before kidney transplantation (T0), and then on the 7th (T7), 30th (T30), 90th (T90), 180th (T180), and 365th days post transplantation...
November 17, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37986369/published-trends-and-research-hotspots-of-central-venous-catheter-associated-thrombosis-from-1973-to-2022-a-scientometric-analysis
#38
JOURNAL ARTICLE
Zuoyan Liu, Xinxin Chen, Shiqi Tao, Jiuhong You, Hui Ma, Cheng Huang
This study aims to explore the intellectual landscape and research hotspots in the central venous catheter-related thrombosis (CVC-RT) research field. Studies discussing CVC-RT published from 1973 to 2022 in the Web of Science Core Collection database were retrieved on February 24th, 2022. Citespace was used to perform a scientometric analysis to identify the intellectual landscape and research hotspots in the research fields of CVC-RT. A total of 4358 studies were retrieved, with an ascending trend in publication numbers...
November 17, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37986368/effects-of-sham-acupuncture-for-chronic-musculoskeletal-pain-syndrome-a-systematic-review-and-network-meta-analysis-of-randomized-controlled-trials
#39
JOURNAL ARTICLE
Chuan Yu, Rui Zhang, Bin Shen, Xiang Li, Yiyi Fang, Yiyun Jiang, Guofan Jian
BACKGROUND: Acupuncture has been widely used for chronic musculoskeletal pain syndrome (MPS). Due to the strong influence of sham acupuncture (SA) in clinical trials, the treatment of MPS by acupuncture remains controversial. Different types of SA procedures might produce different responses. The purpose of this systematic review was to assess the effect of SA on MPS. METHODS: We searched 8 literature databases for randomized controlled trials (RCTs) on acupuncture for chronic MPS with SA as a control from database inception to November 29, 2022...
November 17, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37986367/construction-and-validation-of-a-transient-receptor-potential-related-long-noncoding-rna-signature-for-prognosis-prediction-in-breast-cancer-patients
#40
JOURNAL ARTICLE
Qiaonan Guo, Pengjun Qiu, Kelun Pan, Jianpeng Chen, Baiwei Wang, Jianqing Lin
Breast cancer (BC) is the most commonly diagnosed malignancy in women around the world. Accumulating evidence suggests that transient receptor potential (TRP) channels play a significant role in tumor progression and immune cell infiltration. Hence, we conducted the study to investigate the correlation between TRP-associated lncRNAs and the prognosis of breast carcinoma. In the current study, 33 TRP-associated genes were selected from a review published by Amrita Samanta et al, and the TRP-related lncRNAs were identified by Pearson analysis...
November 17, 2023: Medicine (Baltimore)
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