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Medicine (Baltimore)

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May 2019: Medicine (Baltimore)
Jin Li, Jing Hu, Dingcheng Xiang, Bo Ji, Suowen Xu, Lei Shi, Shujin Zhao
Hypertension, including secondary and essential hypertension (EH) variants, is a multifactorial disease, affecting more than one billion people worldwide. Secondary hypertension results from mutations in the putative gene KLHL3 (Kelch-like protein 3); however, it has not been reported whether the KLHL3 gene polymorphisms are associated with EH. Here, we investigated the association between KLHL3 (rs2301708 and rs7444370) polymorphisms and EH in the Chinese Han population.This case-control study included 522 subjects-260 patients with EH and 262 normotensive controls matched for age, gender, body mass index (BMI), hemoglobin A1c (HbA1c), total cholesterol (TC), triglyceride (TG), and levels of Na, K, and Cl...
May 2019: Medicine (Baltimore)
Hong Zhu, Xi Yang, Yaqin Zhao, Cheng Yi
RATIONALE: Hepatocellular carcinoma (HCC), one of the most common cancers worldwide, is an aggressive tumor with very poor prognosis. Regorafenib was the first agent to show a survival benefit over placebo in patients who showed progression while being treated with sorafenib, but it remains an unsatisfactory agent owing to its serious side effects. Therefore, more efficient and milder therapies are needed. PATIENT CONCERNS: Herein, we report a patient with advanced HCC with many lung metastases who showed progression during sorafenib treatment...
May 2019: Medicine (Baltimore)
Xiang Yu, Rong-Hua Zhou
RATIONALE: Patients of critical pulmonary artery stenosis would face severe hypoxemia, cardiac failure as well as massive hemorrhage during percutaneous balloon dilation and pulmonary arterial stent implantation. Here, we present a case in which the elective use of extracorporeal membrane oxygenation (ECMO) support successfully facilitated safe percutaneous balloon dilation of pulmonary artery and stent implantation on a patient with severe pulmonary artery stenosis caused by aorto-arteritis...
May 2019: Medicine (Baltimore)
Ping-Rong Shen, Jin Cen, Xue-Qian Qian, Yuan-Ming Shen, Xiao-Dong Cheng, Xiao-Yun Wan
INTRODUCTION: Synchronous occurrence of benign cystic mesothelioma and adenomatoid tumor of uterus (UAT) are very rare and few cases have been published in the English literature. They are easily misdiagnosed as malignant by clinicians, due to the lack of reports. PATIENT CONCERNS: A case of benign mesothelial combined with uterus adenomatoid tumor (UAT) in a 48-year-old Chinese woman was reported. Our patient presented with abdominal pain and surgery showed a large subserous mass (12...
May 2019: Medicine (Baltimore)
Jian-Han Lai, Chien-Yuan Hung, Cheng-Hsin Chu, Chih-Jen Chen, Hsiang-Hung Lin, Han-Jung Lin, Ching-Chung Lin
BACKGROUND AND AIMS: The before-procedure or after-procedure rectal indomethacin administration was shown to be useful in preventing post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. We designed this prospective randomized study to compare the efficacy of single-dose and double-dose rectal indomethacin administration in preventing post-ERCP pancreatitis (PEP). METHODS: We enrolled patients who underwent the ERCP in Taipei Mackay Memorial Hospital from 2016 June to 2017 November...
May 2019: Medicine (Baltimore)
Eugene Lee, Leigh Anne Shafer, John R Walker, Celeste Waldman, Valerie Michaud, Chengyue Yang, Charles N Bernstein, Linda Hathout, Jason Park, Jeff Sisler, Kristy Wittmeier, Gayle Restall, Harminder Singh
Better pre-colonoscopy education may lead to improved bowel preparation, decreased anxiety, and a willingness to go direct-to-colonoscopy. We assessed information experiences, needs, and preferences of patients undergoing colonoscopy.A self-administered survey was distributed between 08/2015 and 06/2016 to patients in Winnipeg, Canada when they attended an outpatient colonoscopy. The amount, type, helpfulness, and satisfaction with information provided were analyzed. Linear and logistic regression analyses were used to assess predictors of satisfaction with various aspects of the information received, as well as overall satisfaction with the provided information...
May 2019: Medicine (Baltimore)
Kangsheng Liu, Qin Zhang, Feng Pan, Xiang Dong Wang, Hu Wenjing, Hua Tong
BACKGROUND: The rapid development of bioinformatic technology is boosting the discovery of components hiding in the darkness. As a type of universal, conservative, tissue-specific and stable molecules, circular RNA (circRNA) is a class of endogenous non-coding RNA that has no 5' cap and 3' poly(A) tail and forms a covalently closed continuous loop. At present, 3 types of circRNAs including exonic circRNA (ecRNA), intronic circRNA (ciRNA), and axon-intronic circRNA have been reported. Nowadays informatic technology and high-throughput sequencing have verified the abundance of endogenous circRNAs in eukaryocytes, with predominantly expressed in the cell cytoplasm...
May 2019: Medicine (Baltimore)
Xu Liang, Yue Zhang, Jia-Xing Wang, Li-Fei Wang, Wan-Rong Huang, Xin Tang
To evaluate the outcomes and complications of intravitreal injections of ranibizumab in patients during pars plana vitrectomy for treatment of diabetic vitreous hemorrhage. This retrospective, observational, comparative study included 103 patients (103 eyes) who underwent pars plana vitrectomy for treatment of diabetic vitreous hemorrhage. Sixty-six patients received an intravitreal injection of 0.05 mg (0.05 cc) of ranibizumab at the end of surgery. Main outcome measures were the occurrence of recurrent early vitreous hemorrhage, reoperation, intraocular pressure, best corrected visual acuity...
May 2019: Medicine (Baltimore)
Yu-Jun Chang, Chih-Ming Lin, Yang-Hao Ou, Chi-Kuang Liu, Wei-Liang Chen, Shih-Liang Chang
Early treatment of acute ischemic stroke with intravenous thrombolysis therapy (ITT) followed by intra-arterial thrombectomy (IAT) is a promising new treatment option for improving functional outcomes. Identifying patients who will benefit from this treatment combination is important.A total of 92 acute ischemic stroke patients who received ITT and IAT with a minimum of 1-year follow-up were included in the study. All parameters of clinical and imaging examinations at baseline were examined which parameters were significantly correlated with the 1-year functional outcomes (modified Rankin scale [mRS], National Institute of Health Stroke Scale [NIHSS], and Barthel Index) after stroke...
May 2019: Medicine (Baltimore)
Liping Liu, Dan Sun
BACKGROUND: Antiphospholipid syndrome (APS) is a rare heterogenous autoimmune disorder with severe life-threatening complications shown during pregnancy. In this analysis, we aimed to systematically compare the pregnancy outcomes (both maternal and fetal) in patients with APS. METHODS: Web of Science, Google Scholar, Medicus, Cochrane Central, Embase, and Medline were searched for relevant English publications. The main inclusion criteria were based on studies that compared pregnancy outcomes in patients with APS vs a control group...
May 2019: Medicine (Baltimore)
Wenwei Yang, Shuquan Li, Qingrui Yang
BACKGROUND: Programmed death 1 protein (PD-1) and programmed death-ligand 1 (PD-L1) inhibitors are promising cancer immunotherapy. Their dermatologic safety profiles are still poorly understood. The purpose of this article is to evaluate the incidence of selected dermatologic and mucosal adverse effects (AEs) and determine the risk of developing these adverse events associated with PD-1/PD-L1 inhibitors, compared with chemotherapy or ipilimumab. METHODS: PubMed was searched for eligible studies (up to February 21, 2019)...
May 2019: Medicine (Baltimore)
Jianzhong Zhang, Zhonglin Cai, Bin Yang, Hongjun Li
BACKGROUND: Various studies have explored the association between outdoor air pollution and semen quality. However, the results were still controversial. The object of the current meta-analysis is to evaluate the role of outdoor air pollution in semen quality. METHODS: Databases including PubMed, Web of Science, and Embase will be searched to identify qualified studies. All qualified cross-sectional studies researching the association between outdoor air pollution and sperm parameters will be included...
May 2019: Medicine (Baltimore)
Michele Vitacca, Mauro Vitacca
Health information systems are the core support to decision-making in health organizations. Economic and clinical managements often function separately, while a governance system for quality and safety functions with quality checks and performance accountability, could improve efficiency. The aims of this study were, within a respiratory rehabilitation unit (RRU), to: develop a management-strategy dashboard based on key performance areas (KPAs), identify key performance indicators (KPIs) for each KPA which allow multidimensional assessment; estimate the expected results from the implementation of this dashboard using the balanced score card (BSC) method...
May 2019: Medicine (Baltimore)
Guan Shi, Qingshan Liu, Hao Chen, Fei Feng, Pu Jia, Li Bao, Hai Tang
RATIONALE: Percutaneous osteoplasty (POP) has been proved effective to relieve pain in metastases of vertebral, pelvis, and femur. Nevertheless, there are few reports about the effectiveness of POP in the humeral head metastases. In this study, we described 2 patients with humeral head metastases treated with POP in our hospital. PATIENT CONCERNS: Case 1 was a 79-year-old man with vertebral and right humeral head metastasis after radical surgery or and periods of chemotherapy for bladder cancer...
May 2019: Medicine (Baltimore)
Ruolin Hou, Jing Wu, Dake He, Yumei Yan, Ling Li
RATIONALE: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is the most frequent autoimmune encephalitis in children, and its presentation is various. The disease can be triggered by various infections. PATIENT CONCERNS: Case 1 was a 7-year-old female with the presentation of seizure, repeated fever, language disorder, and decreased muscle strength of the right limbs; Case 2 was a 7-year-old male with the manifestation of repeated emesis, headache, involuntary movement, altered personality, seizures, and cognitive impairment; Case 3 was a 2-year-old female with repeated fever, emesis, seizures, coma, and decreased muscle strength of limbs...
May 2019: Medicine (Baltimore)
Yen-Jung Chen, Fu-Lun Chen, Jin-Hua Chen, Man-Tzu Marcie Wu, Yen-Ling Chen, Du-Shieng Chien, Yu Ko
To investigate the epidemiology trend and characteristics of sepsis-related hospitalizations in Taiwan, and to compare the differences among different severity levels of sepsis.This study is a retrospective national claim database analysis. Hospitalized adult patients with sepsis between 2010 and 2014 were identified from the Two-Million-Sample Longitudinal Health and Welfare Database (LHWD) by the International Classification of Diseases 9th Edition Clinical Modification (ICD-9-CM). The patients were divided into 3 severity groups based on their medical records during hospitalization...
May 2019: Medicine (Baltimore)
Jae Suk Kim, Min Ji Kang, Kyeong Do Jeong, Je Hyung Hwang
RATIONALE: We report a case of haptic fracture of polyimide intraocular lens (IOL) and its dislocation after neodymium:YAG (Nd:YAG) laser capsulotomy. To the best of our knowledge, this is the first report of both the fracture and dislocation of the IOL after laser posterior capsulotomy. PATIENT CONCERNS: A 78-year-old male was referred to our clinic with a history of decreased visual acuity after Nd:YAG laser posterior capsulotomy in the right eye. A dislocated IOL was observed on slit lamp examination...
May 2019: Medicine (Baltimore)
Xinrong Chen, Kun Yang, Yujie Xu, Ka Li
OBJECTIVES: The use of citation analysis to identify the first 100 papers in inflammatory bowel disease (IBD) provides unique insights into advances in disease understanding and subsequent follow-up treatment innovations over time. METHODS: The Thomson Reuters Web of Science database with the search terms "inflammatory bowel disease" or "Crohn disease" or "ulcerative colitis" or "colitis" was used to identify all English language full manuscripts for the study...
May 2019: Medicine (Baltimore)
Jianwu Zhao, Xin Zhao, Lili Yang, Yang Qu, Rongpeng Dong, Mingyang Kang, Xiwen Zhang, Changjun Zheng, Tong Yu
RATIONALE: The aim of this study was to assess the accuracy of percutaneous puncture needle with screw view model of navigation (SVMN) and the effect of periacetabular vertebroplasty (PVP) with granulated allogeneic bone grafting in thoracolumbar compressive fracture (TCF). PATIENT CONCERNS: A 46-year-old female patient associated with high fall injury showed symptoms characterized by back pain and restricted movement of the right lower extremity. DIAGNOSES: The patient was diagnosed with a TCF, right femoral neck fracture, and lumbar vertebrae hyperosteogeny...
May 2019: Medicine (Baltimore)
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