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Kurume Medical Journal

Aritomo Ao, Osamu Tokunaga, Chie Aita, Tomoya Samura, Yuji Sasaki, Reiko Miyashita, Takeshi Miyanomae
Children with severe motor and intellectual disabilities (SMID) are continually exposed to stress due to their need to receive daily care. In particular, chronic physical and acute mental stress derived from daily medical care due to unstable health status are issues specific to SMID children. Therefore, it is important to approach these issues for the maintenance of their lives and quality of life. Seventeen children with a SMIDmedical care dependent group (SMID-MCDG) score of 25 or more will be enrolled in this study...
November 27, 2018: Kurume Medical Journal
Joe Iwanaga, Charlotte Wilson, Emily Simonds, Marc Vetter, Jingo Kusukawa, Koh-Ichi Yamaki, Rod J Oskouian, R Shane Tubbs
The bifid mandibular canal (BMC) is an anatomical variant of the mandible that is often observed on cone-beam computed tomographic images. We identified a BMC during routine cadaveric dissection. The upper mandibular canal contained the inferior alveolar nerve and artery, and the lower mandibular canal contained a large inferior alveolar vein. This latter vein left the mandible through a lateral lingual foramen and joined the anterior jugular vein. Additionally, this vein gave rise to small tributaries to the mental foramen and anterior surface of the mandible from the second mandibular canal...
December 21, 2018: Kurume Medical Journal
Mamatha Hosapatna, Anne D Souza, Vrinda Hari Ankolekar
INTRODUCTION: The gall bladder (GB) is a storage reservoir that allows bile acids to be delivered in a high concentration. The quadrate (QL) and caudate lobes (CL) are functional parts of the liver. The knowledge of the gross and developmental anatomy of GB and CL and QL of liver is important for surgeons who operate in this region. The present study was conducted to examine the developmental sequence and morphometry of the GB, and CL and QL of liver. MATERIALS AND METHODS: In the present cross sectional study the parameters measured were length of GB from the neck to the lowest point on the fundus, and the length and width of QL and CL measured at the midpoint...
November 19, 2018: Kurume Medical Journal
Chiyoe Kitagawa, Akiko Kada, Akiko M Saito, Yukito Ichinose, Hideo Saka
Combination chemotherapy with platinum preparations is the standard first-line treatment for stage IIIB/IV non-small-cell lung cancer. However, the median survival in patients receiving this therapy is 8 to 10 months, and it is essential to improve the results of chemotherapy in non-small-cell lung cancer. Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors hinder EGFR signal transmission by binding to the adenosine triphosphate binding site of intracellular tyrosine kinase and inhibiting the autophospholylation of EGFR...
November 15, 2018: Kurume Medical Journal
Daihei Kida, Hiroya Hashimoto, Noriko Ito, Yukari Kito, Kouichi Mori, Nobunori Takahashi, Yasushi Tomita
In total hip arthroplasty (THA), it is generally accepted that the bones of the acetabular cup and femur of hip joint must be accurately cut and components (artificial joint parts) be implanted in exact positions at exact angles to achieve improvement of daily living (ADL) and quality of life (QOL). However, with the conventional surgical method, it is difficult to grasp and measure the acetabular cup and femoral stem precisely during surgery, making some kind of reliable guide necessary. Although it was reported that an accurate angle was achieved in acetabular cup implantation by support instruments for surgical planning, an effective support instrument is now being developed for stem implantation on the out-of-reach femur side...
September 10, 2018: Kurume Medical Journal
Tomoko Kugiyama, Masamichi Koganemaru, Asako Kuhara, Masakazu Nabeta, Yusuke Uchiyama, Norimitsu Tanaka, Masahiro Kawabata, Toshi Abe
Cerebral air embolism following central venous catheter (CVC) removal is extremely rare. We report a case of cerebral air embolism with loss of consciousness after removal of CVC caused by pulmonary arteriovenous malformation (PAVM). Computed tomography revealed air bubbles in the internal carotid arteries along the sulci in the cerebral hemispheres, as well as a PAVM. The cerebral air embolism was treated with hyperbaric oxygen and intravenous thrombolytic therapy, and transcatheter embolization of the PAVM was performed...
August 30, 2018: Kurume Medical Journal
Hiroko Kimura, Teruyuki Hiraki, Sayo Arata, Kazuo Ushijima
A 64-year-old male (a building demolition worker) was diagnosed with malignant left-sided pleural mesothelioma, and left-sided pleurectomy/decortication was scheduled. Differential lung ventilation (DLV) was performed during the removal of the visceral pleura by connecting the affected lung to a ventilator and the healthy lung to an anesthesia machine, and then separately ventilating the left and right lungs. Anesthetic management using DLV was successfully established without causing significant changes in oxygenation or circulatory dynamics...
August 30, 2018: Kurume Medical Journal
Hiromitsu Ohmori, Mashio Nakamura, Akiko Kada, Akiko M Saito, Yoshitami Sanayama, Tomoe Shinagawa, Hiroshi Fujita, Akiko Wakisaka, Keiko Maruhashi, Akiko Okumura, Noboru Takizawa, Hiroaki Murata, Michiko Inoue, Hideo Kaneko, Hidekazu Taniguchi, Masayuki Kawasaki, Nozomi Sano, Shinjiro Akaboshi, Naoyuki Tanuma, Sui Sone, Masao Kumode, Tomoki Takechi, Yukihiro Koretsune, Ryo Sumimoto, Takeshi Miyanomae
Sudden death in patients with severe motor and intellectual disabilities (SMID) is sometimes caused in part by pulmonary thromboembolism (PTE), and deep venous thrombosis (DVT) has drawn attention as a possible embolic source. Warfarin, which is a conventional therapeutic agent, is not easy to control appropriately, and daily management can be especially difficult in SMID patients. On the other hand, edoxaban tosilate hydrate, which has been newly approved for insurance coverage for the treatment of DVT, is not listed in the Guidelines for the Diagnosis, Treatment and Prevention of Pulmonary Thromboembolism and Deep Vein Thrombosis (DVT-PTE guidelines)...
August 30, 2018: Kurume Medical Journal
Joe Iwanaga, Charlotte Wilson, Emily Simonds, Marc Vetter, Cameron Schmidt, Emre Yilmaz, Paul J Choi, Rod J Oskouian, R Shane Tubbs
Pterygopalatine ganglion block (sphenopalatine ganglion block) is a well-known procedure for treating cluster headache and for relieving cancer pain. In this review, the history and anatomy of the pterygopalatine ganglion are discussed, and images, including computed tomography and endoscopy, are presented to improve understanding of the clinical anatomy of the ganglion regarding the block procedure.
August 30, 2018: Kurume Medical Journal
Charlotte Wilson, Joe I Wanaga, Emily Simonds, Emre Yilmaz, Rod J Oskouian, R Shane Tubbs
The posterior auricular artery (PAA), a branch of the external carotid artery, gives rise to a conchal network formed by PAA perforators through the conchal floor of the auricle. However, this branch and its entrance (foramen) to the anterior concha, is rarely illustrated in the literature and has not been studied in detail. Therefore, we aimed to investigate the morphology of the perforating artery (PA) and its vascular foramen (VF). Ten sides from five formalin-fixed frozen Caucasian cadaveric heads were used...
August 30, 2018: Kurume Medical Journal
Misa Nakamura, Seiji Tanaka, Tadashi Inoue, Yasuto Maeda, Kiyohito Okumiya, Takuya Esaki, G O Shimomura, Kenji Masunaga, Shinichiro Nagamitsu, Yushiro Yamashita
Conversion disorder (CD) is sometimes accompanied by motor and sensory impairments, such as muscle weakness, paralysis, sensory hypersensitivity, and sensory loss. Sjögren's syndrome (SS) complicates 5-10% of cases of systemic lupus erythematosus (SLE). Patients with SS or SLE present with various neurological symptoms and psychiatric manifestations. When neurological symptoms are present, it is important to distinguish whether the symptoms are caused by a neurological or a mental disorder because the former requires early intensive intervention, such as methylprednisolone pulse therapy (MPT), whereas psychotherapy or antidepressant drugs are recommended for mental disorders...
July 10, 2018: Kurume Medical Journal
Hidetomo Himuro
Due to its strong oxidation activity, ozone has been well known to kill bacteria and exert toxic effects on human tissues. At the same time, ozone is being used for the treatment of diseases such as inflammatory bowel disease in some European countries. However, the use of ozone for therapeutic purposes, despite its strong toxic effects, remains largely unexplored. Interestingly, we found that intrarectal administration of ozone gas induced transient colonic epithelial cell damage characterized by the impairment of cell survival pathways involved in DNA replication, cell cycle, and mismatch repair...
July 10, 2018: Kurume Medical Journal
Hirotaka Okada, Noriko Yoshida, Tatsuyuki Kakuma, Kouji Toyomasu
OBJECTIVE: We examined the effects of dietary chlorella ingestion on oxidative stress and fatigue symptoms in healthy men under resting and fatigue conditions. METHOD: We conducted a double-blind, parallel-arm controlled study. Twenty-seven healthy male volunteers (mean age, 35.4±10.4 years) were randomly divided into the chlorella and placebo groups, and received chlorella (6 g/day) and lactose as placebo (7.2 g/day), respectively, for 4 weeks. To simulate mild fatigue, subjects underwent exercise (40% of the heart rate reserve) for 30 minutes...
July 10, 2018: Kurume Medical Journal
Yoshiko Fujishima, Koichi Watanabe, Yoko Tabira, Joe Iwanaga, Yui Odo, Tsuyoshi Saga, R Shane Tubbs, Koh-Ichi Yamaki
We encountered a case of retroaortic left renal vein (RLRV) during an anatomical dissection course at our medical school in 2017. The case was a female cadaver who was 88 years old at death. Six roots of the left renal vein (RV) arose from the hilus of the kidney and joined to form one left renal vein, crossed dorsal to the abdominal aorta (AA) at the level of the second lumbar vertebra, and then drained into the inferior vena cava (IVC). Two roots joined at the right renal hilus to become the right RV to then drain into the IVC at the level of the first lumbar vertebral body...
July 10, 2018: Kurume Medical Journal
Koichi Tsunoda, Rika Kobayashi, Akiko Kada, Akiko M Saito, Y U Hanada, Hayato Misawa, Keizo Horibe, Tonghyo Chong, Miwako Honda, Yoko Morita, Osamu Komiyama
The oropharynx is examined by focusing an electric light, penlight, or forehead mirror on a desired visual field using a tongue depressor. However, it is extremely difficult to obtain objective recorded evidence for display with these methods, and the tools for examination have remained virtually unchanged for the past century. Treatment of the pharynx/oral cavity is exceedingly difficult, particularly in elderly patients and children. Therefore, there is an increasing need to develop a method for displaying the visual field during oropharyngeal examinations which is acceptable to patients, which can easily be applied at all medical institutions, which can be displayed to third parties, and which can be used by doctors for recording data and determining treatment...
July 10, 2018: Kurume Medical Journal
Mayuko Motomura, Koichi Watanabe, Yoko Tabira, Joe Iwanaga, Wakako Matsuuchi, Daichi Yoshida, Tsuyoshi Saga, Koh-Ichi Yamaki
We encountered a case of duplicated right vertebral artery during an anatomical dissection course for medical students in 2015. Two vertebral arteries were found in the right neck of a 91-year-old female cadaver. The proximal leg of the arteries arose from the area between the right subclavian artery and the right common carotid artery that diverged from the brachiocephalic artery. The distal leg arose from the right subclavian artery as expected. The proximal leg entered the transverse foramen of the fourth cervical vertebra and the distal leg entered the transverse foramen of the sixth cervical vertebra...
April 27, 2018: Kurume Medical Journal
Sakura Okamoto, Hideo Saka, Masahide Oki, Namie Somiya, Sachiyo Yokoyama, Yoshihiro Mizutani, Akiko Kada, Akira Tomita
Airway stenting is a procedure in which a stent is inserted into a stenotic site in the airway. However, the optimal ventilation for airway stenting remains controversial. We have planned a randomized, unblinded controlled study to compare intraoperative respiratory status by dividing patients, who underwent airway stenting, into spontaneous respiration (SP) and controlled ventilation with muscle relaxants (MR) groups. This study started in April 2016. The subjects, patients aged ≥20 years with airway stenosis caused by malignant neoplasms for which airway stenting was scheduled, are randomly allocated to SP and MR groups...
April 27, 2018: Kurume Medical Journal
Akihiro Koba, Ryuichiro Tanoue, Shogo Kikuta, Shingo Hirashima, Yoshihiro Miyazono, Jingo Kusukawa
Mandibular osteotomy carries with it a risk of damaging blood vessels and nerves when using traditional surgical techniques. Piezosurgery® , is a new technique that uses ultrasonic vibration to enable bone-selective sectioning without damage to the surrounding soft tissues. However, paralysis may not be completely eliminated using Piezosurgery® for osteotomy. We investigated how piezoelectric surgery in bilateral sagittal splitting ramus osteotomy (BSSRO) affected the surrounding soft tissue. Forty-four patients with skeletal mandibular prognathism underwent mandibular setback with BSSRO...
April 27, 2018: Kurume Medical Journal
Tomotaka Kawayama, Takashi Kinoshita, Kazuko Matsunaga, Yoshiko Naito, Jun Sasaki, Yoshikazu Tominaga, Tomoaki Hoshino
Asthma is an allergic disease characterized by chronic airway inflammation, airway hyperresponsiveness (AHR), reversibility and remodeling. Inhaled corticosteroids (ICS) are effective in many patients with asthma. However, ICS are a controlling, but not but curative treatment, and there are still many patients with refractory and difficult-to-treat asthma. The evaluation of airway inflammation by induced sputum, non-specific AHR by methacholine, and asthmatic reactions by specific allergen challenge techniques are useful not only to investigate the pathogenesis of asthma but also to help develop new drugs for asthma management...
April 27, 2018: Kurume Medical Journal
Gen Suzuki, Hideya Yamazaki, Norihiro Aibe, Koji Masui, Naomi Sasaki, Kotoha Tatekawa, Daisuke Shimizu, Takuya Kimoto, Takeshi Nishimura, Akihiro Nakashima, Kei Yamada
Reirradiation to previously irradiated peripheral bone metastases for pain has been shown to be safe and effective, but no specific trial has been completed to define the indications for reirradiation of patients with recurrent symptoms of metastatic bone disease. Thus, we aimed to assess the effectiveness and prognostic factors of reirradiation for painful bone metastases. To do so, we reviewed the cases of 14 patients with painful bone metastases who had undergone reirradiation at our hospital. A favorable pain response after reirradiation was achieved in 50% (7/14) of the patients...
February 26, 2018: Kurume Medical Journal
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