Cassandra Mariet, Jacques Grill, Yassine Ajlil, David Castel, Volodia Dangouloff-Ros, Nathalie Boddaert, Alexandra Meurgey, Daniel Pissaloux, Romain Appay, Raphaël Saffroy, Stéphanie Puget, Thomas Blauwblomme, Kévin Beccaria, Lauren Hasty, Valérie Rigau, Thomas Roujeau, Aude Aline-Fardin, Fabrice Chrétien, Alice Métais, Pascale Varlet, Arnault Tauziède-Espariat
Pilocytic astrocytomas (PA) typically exhibit distinct clinical, radiological, histopathological, and genetic features. DNA-methylation profiling distinguishes PA according to their location (infratentorial, midline, hemispheric, or spinal). In the hemispheric location, distinguishing PA from glioneuronal tumors remains a common diagnostic challenge for neuropathologists. Furthermore, the current version of the DKFZ classifier seems to have difficulty separating them from gangliogliomas. In this study, after central radiological review, we identified a histopathologically defined set of PA (histPA, n = 11) and a cohort of DNA-methylation defined PA (mcPA, n = 11)...
January 17, 2024: Journal of Neuropathology and Experimental Neurology