journal
https://read.qxmd.com/read/38797545/supar-in-cardiovascular-disease
#1
REVIEW
Jaya Montecillo, Thomas Pirker, Christopher Pemberton, Janice Chew-Harris
Soluble urokinase plasminogen activator receptor (suPAR), the soluble counterpart of urokinase plasminogen activator receptor, is found in the circulation at various levels. suPAR and its parent molecule, cell surface uPAR, exhibit similar structure and extracellular functional roles facilitating fibrinolysis, cellular adhesion, and migration. Studies have assessed the correlation between suPAR in cardiovascular disease (CVD). It is postulated that suPAR may serve as an indicator of inflammatory activation and burden during CVD progression...
2024: Advances in Clinical Chemistry
https://read.qxmd.com/read/38797544/mitochondria-a-source-of-potential-biomarkers-for-non-communicable-diseases
#2
REVIEW
Amulya Ichegiri, Kshitij Kodolikar, Vaibhavi Bagade, Mrunal Selukar, Tuli Dey
Mitochondria, as an endosymbiont of eukaryotic cells, controls multiple cellular activities, including respiration, reactive oxygen species production, fatty acid synthesis, and death. Though the majority of functional mitochondrial proteins are translated through a nucleus-controlled process, very few of them (∼10%) are translated within mitochondria through their own machinery. Germline and somatic mutations in mitochondrial and nuclear DNA significantly impact mitochondrial homeostasis and function...
2024: Advances in Clinical Chemistry
https://read.qxmd.com/read/38797543/proteostasis-in-neurodegenerative-diseases
#3
REVIEW
Sumit Kinger, Yuvraj Anandrao Jagtap, Prashant Kumar, Akash Choudhary, Amit Prasad, Vijay Kumar Prajapati, Amit Kumar, Gunjan Mehta, Amit Mishra
Proteostasis is essential for normal function of proteins and vital for cellular health and survival. Proteostasis encompasses all stages in the "life" of a protein, that is, from translation to functional performance and, ultimately, to degradation. Proteins need native conformations for function and in the presence of multiple types of stress, their misfolding and aggregation can occur. A coordinated network of proteins is at the core of proteostasis in cells. Among these, chaperones are required for maintaining the integrity of protein conformations by preventing misfolding and aggregation and guide those with abnormal conformation to degradation...
2024: Advances in Clinical Chemistry
https://read.qxmd.com/read/38797542/adipokines-in-pregnancy
#4
REVIEW
Monika Dawid, Karolina Pich, Ewa Mlyczyńska, Natalia Respekta-Długosz, Dominka Wachowska, Aleksandra Greggio, Oliwia Szkraba, Patrycja Kurowska, Agnieszka Rak
Reproductive success consists of a sequential events chronology, starting with the ovum fertilization, implantation of the embryo, placentation, and cellular processes like proliferation, apoptosis, angiogenesis, endocrinology, or metabolic changes, which taken together finally conduct the birth of healthy offspring. Currently, many factors are known that affect the regulation and proper maintenance of pregnancy in humans, domestic animals, or rodents. Among the determinants of reproductive success should be distinguished: the maternal microenvironment, genes, and proteins as well as numerous pregnancy hormones that regulate the most important processes and ensure organism homeostasis...
2024: Advances in Clinical Chemistry
https://read.qxmd.com/read/38797541/pleiotropic-functions-and-clinical-importance-of-circulating-hdl-pon1-complex
#5
REVIEW
Abdolkarim Mahrooz
High density lipoprotein (HDL) functions are mostly mediated through a complex proteome, particularly its enzymes. HDL can provide a scaffold for the assembly of several proteins that affect each other's function. HDL particles, particularly small, dense HDL3, are rich in paraoxonase 1 (PON1), which is an important enzyme in the functionality of HDL, so the antioxidant and antiatherogenic properties of HDL are largely attributed to this enzyme. There is an increasing need to represent a valid, reproducible, and reliable method to assay HDL function in routine clinical laboratories...
2024: Advances in Clinical Chemistry
https://read.qxmd.com/read/38797540/blood-brain-barrier-biomarkers
#6
REVIEW
Juan F Zapata-Acevedo, Alejandra Mantilla-Galindo, Karina Vargas-Sánchez, Rodrigo E González-Reyes
The blood-brain barrier (BBB) is a dynamic interface that regulates the exchange of molecules and cells between the brain parenchyma and the peripheral blood. The BBB is mainly composed of endothelial cells, astrocytes and pericytes. The integrity of this structure is essential for maintaining brain and spinal cord homeostasis and protection from injury or disease. However, in various neurological disorders, such as traumatic brain injury, Alzheimer's disease, and multiple sclerosis, the BBB can become compromised thus allowing passage of molecules and cells in and out of the central nervous system parenchyma...
2024: Advances in Clinical Chemistry
https://read.qxmd.com/read/38762244/preface
#7
EDITORIAL
Gregory S Makowski
No abstract text is available yet for this article.
2024: Advances in Clinical Chemistry
https://read.qxmd.com/read/38762243/tear-biomarkers
#8
REVIEW
Erika Ponzini
An extensive exploration of lacrimal fluid molecular biomarkers in understanding and diagnosing a spectrum of ocular and systemic diseases is presented. The chapter provides an overview of lacrimal fluid composition, elucidating the roles of proteins, lipids, metabolites, and nucleic acids within the tear film. Pooled versus single-tear analysis is discussed to underline the benefits and challenges associated with both approaches, offering insights into optimal strategies for tear sample analysis. Subsequently, an in-depth analysis of tear collection methods is presented, with a focus on Schirmer's test strips and microcapillary tubes methods...
2024: Advances in Clinical Chemistry
https://read.qxmd.com/read/38762242/autoantibody-evaluation-in-idiopathic-inflammatory-myopathies
#9
REVIEW
Anne E Tebo
Idiopathic inflammatory myopathies (IIM), generally referred to as myositis is a heterogeneous group of diseases characterized by muscle inflammation and/or skin involvement, diverse extramuscular manifestations with variable risk for malignancy and response to treatment. Contemporary clinico-serologic categorization identifies 5 main clinical groups which can be further stratified based on age, specific clinical manifestations and/or risk for cancer. The serological biomarkers for this classification are generally known as myositis-specific (MSAs) and myositis-associated antibodies...
2024: Advances in Clinical Chemistry
https://read.qxmd.com/read/38762241/molecular-tools-to-regulate-gene-expression-in-trypanosoma-cruzi
#10
REVIEW
Lays Adrianne M Trajano-Silva, Simon Ngao Mule, Giuseppe Palmisano
Developing molecular strategies to manipulate gene expression in trypanosomatids is challenging, particularly with respect to the unique gene expression mechanisms adopted by these unicellular parasites, such as polycistronic mRNA transcription and multi-gene families. In the case of Trypanosoma cruzi (T. cruzi), the causative agent of Chagas Disease, the lack of RNA interference machinery further complicated functional genetic studies important for understanding parasitic biology and developing biomarkers and potential therapeutic targets...
2024: Advances in Clinical Chemistry
https://read.qxmd.com/read/38762240/advances-in-periodontal-biomarkers
#11
REVIEW
Ulvi Kahraman Gürsoy, Meltem Özdemir Kabalak, Mervi Gürsoy
Due to technologic advancements, periodontology has witnessed a boost in biomarker research over the past three decades. Indeed, with the aid of omics, our understanding of the healthy periodontium, pathogenesis of periodontal diseases, and healing after periodontal treatment has improved significantly. Yet, the traditional methods, periodontal probing and radiographies, remain the most common methods to diagnose periodontal disease and monitor treatment. Although these approaches can produce reliable diagnostic outcomes, they generally detect disease only after significant tissue degradation thus making treatment outcome highly uncertain...
2024: Advances in Clinical Chemistry
https://read.qxmd.com/read/38762239/fibrinogen-structure-abnormalities-and-laboratory-assays
#12
REVIEW
Berrak Güven, Murat Can
Fibrinogen is the primary precursor protein for the fibrin clot, which is the final target of blood clotting. It is also an acute phase reactant that can vary under physiologic and inflammatory conditions. Disorders in fibrinogen concentration and/or function have been variably linked to the risk of bleeding and/or thrombosis. Fibrinogen assays are commonly used in the management of bleeding as well as the treatment of thrombosis. This chapter examines the structure of fibrinogen, its role in hemostasis as well as in bleeding abnormalities and measurement thereof with respect to clinical management...
2024: Advances in Clinical Chemistry
https://read.qxmd.com/read/38762238/biochemical-diagnosis-of-congenital-disorders-of-glycosylation
#13
REVIEW
Alexandre Raynor, Walid Haouari, Elodie Lebredonchel, François Foulquier, François Fenaille, Arnaud Bruneel
Congenital disorders of glycosylation (CDG) are one of the fastest growing groups of inborn errors of metabolism, comprising over 160 described diseases to this day. CDG are characterized by a dysfunctional glycosylation process, with molecular defects localized in the cytosol, the endoplasmic reticulum, or the Golgi apparatus. Depending on the CDG, N-glycosylation, O-glycosylation and/or glycosaminoglycan synthesis can be affected. Various proteins, lipids, and glycosylphosphatidylinositol anchors bear glycan chains, with potential impacts on their folding, targeting, secretion, stability, and thus, functionality...
2024: Advances in Clinical Chemistry
https://read.qxmd.com/read/38514212/myocardial-fibrosis-in-right-heart-dysfunction
#14
JOURNAL ARTICLE
Lucia Agoston-Coldea, Andra Negru
Cardiac fibrosis, associated with right heart dysfunction, results in significant morbidity and mortality. Stimulated by various cellular and humoral stimuli, cardiac fibroblasts, macrophages, CD4+ and CD8+ T cells, mast and endothelial cells promote fibrogenesis directly and indirectly by synthesizing numerous profibrotic factors. Several systems, including the transforming growth factor-beta and the renin-angiotensin system, produce type I and III collagen, fibronectin and α-smooth muscle actin, thus modifying the extracellular matrix...
2024: Advances in Clinical Chemistry
https://read.qxmd.com/read/38514211/biomarkers-of-minimal-residual-disease-and-treatment
#15
JOURNAL ARTICLE
Nigel P Murray
Minimal residual disease (MRD) has been defined as a very small numbers of cancer cells that remain in the body after curative treatment. Its presence or absence will ultimately determine prognosis. With the introduction of new technologies the presence of MRD in patients with solid tumours can be detected and characterized. As MRD predicts future relapse, be it early or late treatment failure, in an otherwise asymptomatic patient its treatment and when to start treatment remains to be determined. Thus the concepts of personalized medicine using different biomarkers to classify the biological properties of MRD maybe come possible...
2024: Advances in Clinical Chemistry
https://read.qxmd.com/read/38514210/advances-in-familial-hypercholesterolemia
#16
JOURNAL ARTICLE
Martine Paquette, Alexis Baass
Familial hypercholesterolemia (FH), a semi-dominant genetic disease affecting more than 25 million people worldwide, is associated with severe hypercholesterolemia and premature atherosclerotic cardiovascular disease. Over the last decade, advances in data analysis, screening, diagnosis and cardiovascular risk stratification has significantly improved our ability to deliver precision medicine for these patients. Furthermore, recent updates on guideline recommendations and new therapeutic approaches have also proven to be highly beneficial...
2024: Advances in Clinical Chemistry
https://read.qxmd.com/read/38514209/advances-in-sepsis-biomarkers
#17
JOURNAL ARTICLE
Maximo J Marin, Xander M R van Wijk, Allison B Chambliss
Sepsis, a dysregulated host immune response to an infectious agent, significantly increases morbidity and mortality for hospitalized patients worldwide. This chapter reviews (1) the basic principles of infectious diseases, pathophysiology and current definition of sepsis, (2) established sepsis biomarkers such lactate, procalcitonin and C-reactive protein, (3) novel, newly regulatory-cleared/approved biomarkers, such as assays that evaluate white blood cell properties and immune response molecules, and (4) emerging biomarkers and biomarker panels to highlight future directions and opportunities in the diagnosis and management of sepsis...
2024: Advances in Clinical Chemistry
https://read.qxmd.com/read/38514208/extracellular-vesicles-in-heart-failure
#18
JOURNAL ARTICLE
Alexander E Berezin, Alexander A Berezin
Physiologically, extracellular vesicles (EVs) have been implicated as crucial mediators of immune response, cell homeostasis, angiogenesis, cell differentiation and growth, and tissue repair. In heart failure (HF) they may act as regulators of cardiac remodeling, microvascular inflammation, micro environmental changes, tissue fibrosis, atherosclerosis, neovascularization of plaques, endothelial dysfunction, thrombosis, and reciprocal heart-remote organ interaction. The chapter summaries the nomenclature, isolation, detection of EVs, their biologic role and function physiologically as well as in the pathogenesis of HF...
2024: Advances in Clinical Chemistry
https://read.qxmd.com/read/38280808/osteopontin-in-cancer
#19
JOURNAL ARTICLE
Alpana Kumari, Dharambir Kashyap, Vivek Kumar Garg
Osteopontin (OPN) is a heavily post-translationally modified protein with a molecular weight of 44-70 kDa, depending on the degree of glycosylation. OPN is involved in various biological processes, including bone remodeling, immune response, cell adhesion, migration, and survival. It is essential for controlling osteoclast and osteoblast activity for maintaining bone mass and bone strength. Additionally, OPN has been linked to cardiovascular, inflammatory illnesses, as well as the onset and progression of cancer...
2024: Advances in Clinical Chemistry
https://read.qxmd.com/read/38280807/molecular-biology-of-sars-cov-2-and-techniques-of-diagnosis-and-surveillance
#20
JOURNAL ARTICLE
Takayuki Ishige
The World Health Organization (WHO) declared coronavirus disease 2019 (COVID-19), a disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a global pandemic in March 2020. Reverse transcription-polymerase chain reaction (RT-PCR) is the reference technique for molecular diagnosis of SARS-CoV-2 infection. The SARS-CoV-2 virus is constantly mutating, and more transmissible variants have emerged, making genomic surveillance a crucial tool for investigating virus transmission dynamics, detecting novel genetic variants, and assessing mutation impact...
2024: Advances in Clinical Chemistry
journal
journal
25561
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.