journal
https://read.qxmd.com/read/38437627/do-ionic-liquids-exhibit-the-required-characteristics-to-dissolve-extract-stabilize-and-purify-proteins-past-present-future-assessment
#21
REVIEW
Pankaj Bharmoria, Alesia A Tietze, Dibyendu Mondal, Tejwant Singh Kang, Arvind Kumar, Mara G Freire
Proteins are highly labile molecules, thus requiring the presence of appropriate solvents and excipients in their liquid milieu to keep their stability and biological activity. In this field, ionic liquids (ILs) have gained momentum in the past years, with a relevant number of works reporting their successful use to dissolve, stabilize, extract, and purify proteins. Different approaches in protein-IL systems have been reported, namely, proteins dissolved in ( i ) neat ILs, ( ii ) ILs as co-solvents, ( iii ) ILs as adjuvants, ( iv ) ILs as surfactants, ( v ) ILs as phase-forming components of aqueous biphasic systems, and ( vi ) IL-polymer-protein/peptide conjugates...
March 4, 2024: Chemical Reviews
https://read.qxmd.com/read/38408451/the-promise-and-potential-of-metal-organic-frameworks-and-covalent-organic-frameworks-in-vaccine-nanotechnology
#22
REVIEW
Yalini H Wijesundara, Thomas S Howlett, Sneha Kumari, Jeremiah J Gassensmith
The immune system's complexity and ongoing evolutionary struggle against deleterious pathogens underscore the value of vaccination technologies, which have been bolstering human immunity for over two centuries. Despite noteworthy advancements over these 200 years, three areas remain recalcitrant to improvement owing to the environmental instability of the biomolecules used in vaccines─the challenges of formulating them into controlled release systems, their need for constant refrigeration to avoid loss of efficacy, and the requirement that they be delivered via needle owing to gastrointestinal incompatibility...
February 26, 2024: Chemical Reviews
https://read.qxmd.com/read/38382032/the-rise-of-boron-containing-compounds-advancements-in-synthesis-medicinal-chemistry-and-emerging-pharmacology
#23
REVIEW
R Justin Grams, Webster L Santos, Ion Romulus Scorei, Antonio Abad-García, Carol Ann Rosenblum, Andrei Bita, Hugo Cerecetto, Clara Viñas, Marvin A Soriano-Ursúa
Boron-containing compounds (BCC) have emerged as important pharmacophores. To date, five BCC drugs (including boronic acids and boroles) have been approved by the FDA for the treatment of cancer, infections, and atopic dermatitis, while some natural BCC are included in dietary supplements. Boron's Lewis acidity facilitates a mechanism of action via formation of reversible covalent bonds within the active site of target proteins. Boron has also been employed in the development of fluorophores, such as BODIPY for imaging, and in carboranes that are potential neutron capture therapy agents as well as novel agents in diagnostics and therapy...
February 21, 2024: Chemical Reviews
https://read.qxmd.com/read/38382030/wireless-battery-free-and-fully-implantable-organ-interfaces
#24
REVIEW
Aman Bhatia, Jessica Hanna, Tucker Stuart, Kevin Albert Kasper, David Marshall Clausen, Philipp Gutruf
Advances in soft materials, miniaturized electronics, sensors, stimulators, radios, and battery-free power supplies are resulting in a new generation of fully implantable organ interfaces that leverage volumetric reduction and soft mechanics by eliminating electrochemical power storage. This device class offers the ability to provide high-fidelity readouts of physiological processes, enables stimulation, and allows control over organs to realize new therapeutic and diagnostic paradigms. Driven by seamless integration with connected infrastructure, these devices enable personalized digital medicine...
February 21, 2024: Chemical Reviews
https://read.qxmd.com/read/38373737/orthogonal-translation-for-site-specific-installation-of-post-translational-modifications
#25
REVIEW
Qinglei Gan, Chenguang Fan
Post-translational modifications (PTMs) endow proteins with new properties to respond to environmental changes or growth needs. With the development of advanced proteomics techniques, hundreds of distinct types of PTMs have been observed in a wide range of proteins from bacteria, archaea, and eukarya. To identify the roles of these PTMs, scientists have applied various approaches. However, high dynamics, low stoichiometry, and crosstalk between PTMs make it almost impossible to obtain homogeneously modified proteins for characterization of the site-specific effect of individual PTM on target proteins...
February 19, 2024: Chemical Reviews
https://read.qxmd.com/read/38373392/porous-conductive-textiles-for-wearable-electronics
#26
REVIEW
Yichun Ding, Jinxing Jiang, Yingsi Wu, Yaokang Zhang, Junhua Zhou, Yufei Zhang, Qiyao Huang, Zijian Zheng
Over the years, researchers have made significant strides in the development of novel flexible/stretchable and conductive materials, enabling the creation of cutting-edge electronic devices for wearable applications. Among these, porous conductive textiles (PCTs) have emerged as an ideal material platform for wearable electronics, owing to their light weight, flexibility, permeability, and wearing comfort. This Review aims to present a comprehensive overview of the progress and state of the art of utilizing PCTs for the design and fabrication of a wide variety of wearable electronic devices and their integrated wearable systems...
February 19, 2024: Chemical Reviews
https://read.qxmd.com/read/38364021/chiral-induced-spin-selectivity
#27
REVIEW
Brian P Bloom, Yossi Paltiel, Ron Naaman, David H Waldeck
Since the initial landmark study on the chiral induced spin selectivity (CISS) effect in 1999, considerable experimental and theoretical efforts have been made to understand the physical underpinnings and mechanistic features of this interesting phenomenon. As first formulated, the CISS effect refers to the innate ability of chiral materials to act as spin filters for electron transport; however, more recent experiments demonstrate that displacement currents arising from charge polarization of chiral molecules lead to spin polarization without the need for net charge flow...
February 16, 2024: Chemical Reviews
https://read.qxmd.com/read/38354693/correction-to-fluorinated-materials-as-positive-electrodes-for-li-and-na-ion-batteries
#28
Kévin Lemoine, Annie Hémon-Ribaud, Marc Leblanc, Jérôme Lhoste, Jean-Marie Tarascon, Vincent Maisonneuve
No abstract text is available yet for this article.
February 14, 2024: Chemical Reviews
https://read.qxmd.com/read/38354371/low-valent-transition-metalate-anions-in-synthesis-small-molecule-activation-and-catalysis
#29
REVIEW
Vanessa R Landaeta, Thomas M Horsley Downie, Robert Wolf
This review surveys the synthesis and reactivity of low-oxidation state metalate anions of the d-block elements, with an emphasis on contributions reported between 2006 and 2022. Although the field has a long and rich history, the chemistry of transition metalate anions has been greatly enhanced in the last 15 years by the application of advanced concepts in complex synthesis and ligand design. In recent years, the potential of highly reactive metalate complexes in the fields of small molecule activation and homogeneous catalysis has become increasingly evident...
February 14, 2024: Chemical Reviews
https://read.qxmd.com/read/38354333/design-and-application-of-fluorescent-probes-to-detect-cellular-physical-microenvironments
#30
REVIEW
Junbao Ma, Rui Sun, Kaifu Xia, Qiuxuan Xia, Yu Liu, Xin Zhang
The microenvironment is indispensable for functionality of various biomacromolecules, subcellular compartments, living cells, and organisms. In particular, physical properties within the biological microenvironment could exert profound effects on both the cellular physiology and pathology, with parameters including the polarity, viscosity, pH, and other relevant factors. There is a significant demand to directly visualize and quantitatively measure the fluctuation in the cellular microenvironment with spatiotemporal resolution...
February 14, 2024: Chemical Reviews
https://read.qxmd.com/read/38335114/twisted-van-der-waals-quantum-materials-fundamentals-tunability-and-applications
#31
REVIEW
Xueqian Sun, Manuka Suriyage, Ahmed Raza Khan, Mingyuan Gao, Jie Zhao, Boqing Liu, Md Mehedi Hasan, Sharidya Rahman, Ruo-Si Chen, Ping Koy Lam, Yuerui Lu
Twisted van der Waals (vdW) quantum materials have emerged as a rapidly developing field of two-dimensional (2D) semiconductors. These materials establish a new central research area and provide a promising platform for studying quantum phenomena and investigating the engineering of novel optoelectronic properties such as single photon emission, nonlinear optical response, magnon physics, and topological superconductivity. These captivating electronic and optical properties result from, and can be tailored by, the interlayer coupling using moiré patterns formed by vertically stacking atomic layers with controlled angle misorientation or lattice mismatch...
February 9, 2024: Chemical Reviews
https://read.qxmd.com/read/38331392/macromolecular-crowding-phase-separation-and-homeostasis-in-the-orchestration-of-bacterial-cellular-functions
#32
REVIEW
Begoña Monterroso, William Margolin, Arnold J Boersma, Germán Rivas, Bert Poolman, Silvia Zorrilla
Macromolecular crowding affects the activity of proteins and functional macromolecular complexes in all cells, including bacteria. Crowding, together with physicochemical parameters such as pH, ionic strength, and the energy status, influences the structure of the cytoplasm and thereby indirectly macromolecular function. Notably, crowding also promotes the formation of biomolecular condensates by phase separation, initially identified in eukaryotic cells but more recently discovered to play key functions in bacteria...
February 8, 2024: Chemical Reviews
https://read.qxmd.com/read/38320111/process-simulation-and-optimization-on-ionic-liquids
#33
REVIEW
Jose Palomar, Jesús Lemus, Pablo Navarro, Cristian Moya, Rubén Santiago, Daniel Hospital-Benito, Elisa Hernández
Ionic liquids (ILs) are promising alternative compounds that enable the development of technologies based on their unique properties as solvents or catalysts. These technologies require integrated product and process designs to select ILs with optimal process performances at an industrial scale to promote cost-effective and sustainable technologies. The digital era and multiscale research methodologies have changed the paradigm from experiment-oriented to hybrid experimental-computational developments guided by process engineering...
February 6, 2024: Chemical Reviews
https://read.qxmd.com/read/38314694/soft-sensors-and-actuators-for-wearable-human-machine-interfaces
#34
REVIEW
Jonghwa Park, Youngoh Lee, Seungse Cho, Ayoung Choe, Jeonghee Yeom, Yun Goo Ro, Jinyoung Kim, Dong-Hee Kang, Seungjae Lee, Hyunhyub Ko
Haptic human-machine interfaces (HHMIs) combine tactile sensation and haptic feedback to allow humans to interact closely with machines and robots, providing immersive experiences and convenient lifestyles. Significant progress has been made in developing wearable sensors that accurately detect physical and electrophysiological stimuli with improved softness, functionality, reliability, and selectivity. In addition, soft actuating systems have been developed to provide high-quality haptic feedback by precisely controlling force, displacement, frequency, and spatial resolution...
February 5, 2024: Chemical Reviews
https://read.qxmd.com/read/38305159/direct-methane-oxidation-by-copper-and-iron-dependent-methane-monooxygenases
#35
REVIEW
Frank J Tucci, Amy C Rosenzweig
Methane is a potent greenhouse gas that contributes significantly to climate change and is primarily regulated in Nature by methanotrophic bacteria, which consume methane gas as their source of energy and carbon, first by oxidizing it to methanol. The direct oxidation of methane to methanol is a chemically difficult transformation, accomplished in methanotrophs by complex methane monooxygenase (MMO) enzyme systems. These enzymes use iron or copper metallocofactors and have been the subject of detailed investigation...
February 2, 2024: Chemical Reviews
https://read.qxmd.com/read/38291556/a-guide-to-printed-stretchable-conductors
#36
REVIEW
Tushar Sakorikar, Nikolas Mihaliak, Febby Krisnadi, Jinwoo Ma, Tae-Il Kim, Minsik Kong, Omar Awartani, Michael D Dickey
Printing of stretchable conductors enables the fabrication and rapid prototyping of stretchable electronic devices. For such applications, there are often specific process and material requirements such as print resolution, maximum strain, and electrical/ionic conductivity. This review highlights common printing methods and compatible inks that produce stretchable conductors. The review compares the capabilities, benefits, and limitations of each approach to help guide the selection of a suitable process and ink for an intended application...
January 30, 2024: Chemical Reviews
https://read.qxmd.com/read/38284616/chemically-modified-platforms-for-better-rna-therapeutics
#37
REVIEW
Yesi Shi, Xueyan Zhen, Yiming Zhang, Yongjiang Li, Seyoung Koo, Qimanguli Saiding, Na Kong, Gang Liu, Wei Chen, Wei Tao
RNA-based therapies have catalyzed a revolutionary transformation in the biomedical landscape, offering unprecedented potential in disease prevention and treatment. However, despite their remarkable achievements, these therapies encounter substantial challenges including low stability, susceptibility to degradation by nucleases, and a prominent negative charge, thereby hindering further development. Chemically modified platforms have emerged as a strategic innovation, focusing on precise alterations either on the RNA moieties or their associated delivery vectors...
January 29, 2024: Chemical Reviews
https://read.qxmd.com/read/38259248/phase-engineering-of-nanostructural-metallic-materials-classification-structures-and-applications
#38
REVIEW
Jialun Gu, Fenghui Duan, Sida Liu, Wenhao Cha, Jian Lu
Metallic materials are usually composed of single phase or multiple phases, which refers to homogeneous regions with distinct types of the atom arrangement. The recent studies on nanostructured metallic materials provide a variety of promising approaches to engineer the phases at the nanoscale. Tailoring phase size, phase distribution, and introducing new structures via phase transformation contribute to the precise modification in deformation behaviors and electronic structures of nanostructural metallic materials...
January 23, 2024: Chemical Reviews
https://read.qxmd.com/read/38253355/-in-situ-and-operando-x-ray-scattering-methods-in-electrochemistry-and-electrocatalysis
#39
REVIEW
Olaf M Magnussen, Jakub Drnec, Canrong Qiu, Isaac Martens, Jason J Huang, Raphaël Chattot, Andrej Singer
Electrochemical and electrocatalytic processes are of key importance for the transition to a sustainable energy supply as well as for a wide variety of other technologically relevant fields. Further development of these processes requires in-depth understanding of the atomic, nano, and micro scale structure of the materials and interfaces in electrochemical devices under reaction conditions. We here provide a comprehensive review of in situ and operando studies by X-ray scattering methods, which are powerful and highly versatile tools to provide such understanding...
January 22, 2024: Chemical Reviews
https://read.qxmd.com/read/38241488/flexible-and-stretchable-light-emitting-diodes-and-photodetectors-for-human-centric-optoelectronics
#40
REVIEW
Sehui Chang, Ja Hoon Koo, Jisu Yoo, Min Seok Kim, Moon Kee Choi, Dae-Hyeong Kim, Young Min Song
Optoelectronic devices with unconventional form factors, such as flexible and stretchable light-emitting or photoresponsive devices, are core elements for the next-generation human-centric optoelectronics. For instance, these deformable devices can be utilized as closely fitted wearable sensors to acquire precise biosignals that are subsequently uploaded to the cloud for immediate examination and diagnosis, and also can be used for vision systems for human-interactive robotics. Their inception was propelled by breakthroughs in novel optoelectronic material technologies and device blueprinting methodologies, endowing flexibility and mechanical resilience to conventional rigid optoelectronic devices...
January 19, 2024: Chemical Reviews
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