Xiangyang Wang, Xiangyu Chen, Jierong Chen, Chunhui Liao, Xiaofan Yang, Jiasheng Zhou, Shanshan Liu, Shusen Ye, Yuhao Zheng, Linzi Huang, Jiacong Zhao, Lilin Ye, Bihui Huang, Yingjiao Cao
Ever-growing evidence has revealed that group 2 innate lymphoid cells (ILC2s) exhibit pleiotropic effects in antihelminth immunity, allergy, tissue protection, and cancer. Currently, the role of ILC2s in cancer is highly controversial regarding the intricate tumor microenvironment (TME), and the tumor-promoting or antitumor immunological mechanisms of ILC2s remain largely unknown. In this study, we report that dopamine receptor 1 (DRD1) restrains ILC2 activity in the TME. DRD1 deficiency promotes ILC2 activation, which irritates eosinophil recruitment and cytotoxic CD8+ T cell expansion during ongoing malignancy...
September 20, 2023: Journal of Immunology