journal
https://read.qxmd.com/read/37975667/distinct-functional-humoral-immune-responses-are-induced-after-live-attenuated-and-inactivated-seasonal-influenza-vaccination
#1
JOURNAL ARTICLE
Xin Tong, Yixiang Deng, Deniz Cizmeci, Laura Fontana, Michael A Carlock, Hannah B Hanley, Ryan P McNamara, Daniel Lingwood, Ted M Ross, Galit Alter
Influenza viruses infect 5-30% of the world's population annually, resulting in millions of incidents of hospitalization and thousands of mortalities worldwide every year. Although annual vaccination has significantly reduced hospitalization rates in vulnerable populations, the current vaccines are estimated to offer a wide range of protection from 10 to 60% annually. Such incomplete immunity may be related to both poor antigenic coverage of circulating strains, as well as to the insufficient induction of protective immunity...
November 17, 2024: Journal of Immunology
https://read.qxmd.com/read/38536099/correction-selective-inhibition-of-the-interaction-between-sars-cov-2-spike-s1-and-ace2-by-spidar-peptide-induces-anti-inflammatory-therapeutic-responses
#2
Ramesh K Paidi, Malabendu Jana, Rama K Mishra, Debashis Dutta, Kalipada Pahan
Paidi, R. K., M. Jana, R. K. Mishra, D. Dutta, and K. Pahan. 2021. Selective inhibition of the interaction between SARS-CoV-2 spike S1 and ACE2 by SPIDAR peptide induces anti-inflammatory therapeutic responses. J. Immunol. 207: 2521-2533.In the original Supplemental Fig. 2C, the "Control" image was duplicated from the "Spike S1 (heat inactivated)" image due to an error during figure preparation. The supplemental figure has been corrected in the online version of the article.
March 27, 2024: Journal of Immunology
https://read.qxmd.com/read/38536025/correction-dx5-cd49b-positive-t-cells-are-not-synonymous-with-cd1d-dependent-nkt-cells
#3
Daniel G Pellicci, Kirsten J L Hammond, Jonathan Coquet, Konstantinos Kyparissoudis, Andrew G Brooks, Katherine Kedzierska, Rachael Keating, Stephen Turner, Stuart Berzins, Mark J Smyth, Dale I Godfrey
Pellicci, D. G., K. J. L. Hammond, J. Coquet, K. Kyparissoudis, A. G. Brooks, K. Kedzierska, R. Keating, S. Turner, S. Berzins, M. J. Smyth, and D. I. Godfrey. 2005. DX5/CD49b-positive T cells are not synonymous with CD1d-dependent NKT cells. J. Immunol. 175: 4416-4425. Fig. 2A of this article contains flow cytometry comparing C57BL/6 WT mice and CD1d-/- mice for αβTCR versus DX5 or αβTCR versus CD49b staining in mouse thymus, spleen, liver, bone marrow, and peripheral lymph nodes (PLNs)...
March 27, 2024: Journal of Immunology
https://read.qxmd.com/read/38517295/the-role-of-coinhibitory-receptors-in-b-cell-dysregulation-in-sars-cov-2-infected-individuals-with-severe-disease
#4
JOURNAL ARTICLE
Suguru Saito, Najmeh Bozorgmehr, Wendy Sligl, Mohammed Osman, Shokrollah Elahi
Severe SARS-CoV-2 infection is associated with significant immune dysregulation involving different immune cell subsets. In this study, when analyzing critically ill COVID-19 patients versus those with mild disease, we observed a significant reduction in total and memory B cell subsets but an increase in naive B cells. Moreover, B cells from COVID-19 patients displayed impaired effector functions, evidenced by diminished proliferative capacity, reduced cytokine, and Ab production. This functional impairment was accompanied by an increased apoptotic potential upon stimulation in B cells from severely ill COVID-19 patients...
March 22, 2024: Journal of Immunology
https://read.qxmd.com/read/38517294/antibody-suppressor-cxcr5-cd8-t-cells-are-more-potent-regulators-of-humoral-alloimmunity-after-kidney-transplant-in-mice-compared-to-cd4-regulatory-t-cells
#5
JOURNAL ARTICLE
Jing L Han, Jason M Zimmerer, Qiang Zeng, Sachi Chaudhari, Anjali Satoskar, Mahmoud Abdel-Rasoul, Hope Uwase, Christopher K Breuer, Ginny L Bumgardner
Adoptive cell therapy (ACT), especially with CD4+ regulatory T cells (CD4+ Tregs), is an emerging therapeutic strategy to minimize immunosuppression and promote long-term allograft acceptance, although much research remains to realize its potential. In this study, we investigated the potency of novel Ab-suppressor CXCR5+CD8+ T cells (CD8+ TAb-supp) in comparison with conventional CD25highFoxp3+CD4+ Tregs for suppression of humoral alloimmunity in a murine kidney transplant (KTx) model of Ab-mediated rejection (AMR)...
March 22, 2024: Journal of Immunology
https://read.qxmd.com/read/38506555/antagonism-of-the-platelet-activating-factor-pathway-mitigates-inflammatory-adverse-events-driven-by-anti-erythrocyte-antibody-therapy-in-mice
#6
JOURNAL ARTICLE
Kevin Doyoon Won, Lazaro Gil Gonzalez, Yoelys Cruz-Leal, Alequis Pavon Oro, Alan H Lazarus
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by low platelet counts primarily due to antiplatelet autoantibodies. Anti-D is a donor-derived polyclonal Ab against the rhesus D Ag on erythrocytes used to treat ITP. Unfortunately, adverse inflammatory/hypersensitivity reactions and a Food and Drug Administration-issued black box warning have limited its clinical use. This underscores the imperative to understand the inflammatory pathway associated with anti-erythrocyte Ab-based therapies...
March 20, 2024: Journal of Immunology
https://read.qxmd.com/read/38497670/il-10-differentially-promotes-mast-cell-responsiveness-to-il-33-resulting-in-enhancement-of-type-2-inflammation-and-suppression-of-neutrophilia
#7
JOURNAL ARTICLE
Saurav Ranjitkar, Dylan Krajewski, Chelsea Garcia, Caitlin Tedeschi, Stephanie H Polukort, Jeffrey Rovatti, Mohamed Mire, Christopher N Blesso, Evan Jellison, Sallie S Schneider, John J Ryan, Clinton B Mathias
Mast cells (MCs) play critical roles in the establishment of allergic diseases. We recently demonstrated an unexpected, proinflammatory role for IL-10 in regulating MC responses. IL-10 enhanced MC activation and promoted IgE-dependent responses during food allergy. However, whether these effects extend to IgE-independent stimuli is not clear. In this article, we demonstrate that IL-10 plays a critical role in driving IL-33-mediated MC responses. IL-10 stimulation enhanced MC expansion and degranulation, ST2 expression, IL-13 production, and phospho-relA upregulation in IL-33-treated cells while suppressing TNF-α...
March 18, 2024: Journal of Immunology
https://read.qxmd.com/read/38497668/high-affinity-mediated-viral-entry-triggers-innate-affinity-escape-resulting-in-type-i-ifn-resistance-and-impaired-t-cell-immunity
#8
JOURNAL ARTICLE
Haifeng C Xu, Piyush Pandey, Harry Ward, Michal Gorzkiewicz, Džiuljeta Abromavičiūtė, Constanze Tinz, Lisa Müller, Caroline Meyer, Aleksandra A Pandyra, Aslihan Yavas, Arndt Borkhardt, Irene Esposito, Karl S Lang, Philipp A Lang
Increased receptor binding affinity may allow viruses to escape from Ab-mediated inhibition. However, how high-affinity receptor binding affects innate immune escape and T cell function is poorly understood. In this study, we used the lymphocytic choriomeningitis virus (LCMV) murine infection model system to create a mutated LCMV exhibiting higher affinity for the entry receptor α-dystroglycan (LCMV-GPH155Y). We show that high-affinity receptor binding results in increased viral entry, which is associated with type I IFN (IFN-I) resistance, whereas initial innate immune activation was not impaired during high-affinity virus infection in mice...
March 18, 2024: Journal of Immunology
https://read.qxmd.com/read/38488511/potent-hpiv3-neutralizing-ighv5-51-antibodies-identified-from-multiple-individuals-show-l-chain-and-cdrh3-promiscuity
#9
JOURNAL ARTICLE
Alexandra A Abu-Shmais, Rose J Miller, Alexis K Janke, Rachael M Wolters, Clinton M Holt, Nagarajan Raju, Robert H Carnahan, James E Crowe, Jarrod J Mousa, Ivelin S Georgiev
Human parainfluenza virus 3 (HPIV3) is a widespread pathogen causing severe and lethal respiratory illness in at-risk populations. Effective countermeasures are in various stages of development; however, licensed therapeutic and prophylactic options are not available. The fusion glycoprotein (HPIV3 F), responsible for facilitating viral entry into host cells, is a major target of neutralizing Abs that inhibit infection. Although several neutralizing Abs against a small number of HPIV3 F epitopes have been identified to date, relatively little is known about the Ab response to HPIV3 compared with other pathogens, such as influenza virus and SARS-CoV-2...
March 15, 2024: Journal of Immunology
https://read.qxmd.com/read/38488502/transient-binding-dynamics-of-complement-system-pattern-recognition-molecules-on-pathogens
#10
JOURNAL ARTICLE
Maximilian Peter Götz, Mario Alejandro Duque Villegas, Beatrice Fageräng, Aileen Kerfin, Mikkel-Ole Skjoedt, Peter Garred, Anne Rosbjerg
Previous studies of pattern recognition molecules (PRMs) of the complement system have revealed difficulties in observing binding on pathogens such as Aspergillus fumigatus and Escherichia coli, despite complement deposition indicative of classical and lectin pathway activation. Thus, we investigated the binding dynamics of PRMs of the complement system, specifically C1q of the classical pathway and mannose-binding lectin (MBL) of the lectin pathway. We observed consistently increasing deposition of essential complement components such as C4b, C3b, and the terminal complement complex on A...
March 15, 2024: Journal of Immunology
https://read.qxmd.com/read/38488501/sensitization-with-fungal-protease-allergen-establishes-long-lived-allergenic-th-cell-memory-in-the-lung
#11
JOURNAL ARTICLE
Abigail Shapiro, Nicolas W S Caballes, Rebecca N Vera, Bruce S Klein, Paul J Brennan, Yen-Fei Wu, Darin L Wiesner
Allergic asthma is a chronic inflammatory disease that affects millions of individuals worldwide. Exposure to allergens produced by a variety of otherwise harmless microbes, including fungi, predisposes individuals to immunopathologic disease upon subsequent encounters with allergen. We developed a mouse model that employs a purified protease produced by Aspergillus (Asp f 13) to investigate the contributions of CD4+ Th cells to recurrent lung inflammation. Notably, memory CD4+ T cells enhanced the eosinophil response of sensitized/rechallenged animals...
March 15, 2024: Journal of Immunology
https://read.qxmd.com/read/38477617/chicken-ufl1-restricts-avian-influenza-virus-replication-by-disrupting-the-viral-polymerase-complex-and-facilitating-type-i-ifn-production
#12
JOURNAL ARTICLE
Weiqiang Li, Yu Lin, Xiyi Wang, Huixing Yang, Yangbao Ding, Zuxian Chen, Zhuoliang He, Junsheng Zhang, Luxiang Zhao, Peirong Jiao
During avian influenza virus (AIV) infection, host defensive proteins promote antiviral innate immunity or antagonize viral components to limit viral replication. UFM1-specific ligase 1 (UFL1) is involved in regulating innate immunity and DNA virus replication in mammals, but the molecular mechanism by which chicken (ch)UFL1 regulates AIV replication is unclear. In this study, we first identified chUFL1 as a negative regulator of AIV replication by enhancing innate immunity and disrupting the assembly of the viral polymerase complex...
March 13, 2024: Journal of Immunology
https://read.qxmd.com/read/38477614/cd4-t-cell-derived-il-21-is-critical-for-sustaining-plasmodium-infection-induced-germinal-center-responses-and-promoting-the-selection-of-memory-b-cells-with-recall-potential
#13
JOURNAL ARTICLE
Jordan T Johnson, Fionna A Surette, Graham R Ausdal, Manan Shah, Allen M Minns, Scott E Lindner, Ryan A Zander, Noah S Butler
Development of Plasmodium-specific humoral immunity is critically dependent on CD4 Th cell responses and germinal center (GC) reactions during blood-stage Plasmodium infection. IL-21, a cytokine primarily produced by CD4 T cells, is an essential regulator of affinity maturation, isotype class-switching, B cell differentiation, and maintenance of GC reactions in response to many infection and immunization models. In models of experimental malaria, mice deficient in IL-21 or its receptor IL-21R fail to develop memory B cell populations and are not protected against secondary infection...
March 13, 2024: Journal of Immunology
https://read.qxmd.com/read/38466035/the-dysregulated-il-23-th17-axis-in-endometriosis-pathophysiology
#14
JOURNAL ARTICLE
Danielle J Sisnett, Katherine B Zutautas, Jessica E Miller, Harshavardhan Lingegowda, Soo Hyun Ahn, Alison McCallion, Olga Bougie, Bruce A Lessey, Chandrakant Tayade
Endometriosis is a chronic inflammatory disease in which endometrial-like tissue grows ectopically, resulting in pelvic pain and infertility. IL-23 is a key contributor in the development and differentiation of TH17 cells, driving TH17 cells toward a pathogenic profile. In a variety of inflammatory and autoimmune disorders, TH17 cells secrete proinflammatory cytokines, including IL-17, contributing to disease pathophysiology. Our studies and others have implicated IL-17 and TH17 cell dysregulation in endometriosis, which is associated with disease severity...
March 11, 2024: Journal of Immunology
https://read.qxmd.com/read/38456672/experimental-structures-of-antibody-mhc-i-complexes-reveal-details-of-epitopes-overlooked-by-computational-prediction
#15
JOURNAL ARTICLE
Lisa F Boyd, Jiansheng Jiang, Javeed Ahmad, Kannan Natarajan, David H Margulies
mAbs to MHC class I (MHC-I) molecules have proved to be crucial reagents for tissue typing and fundamental studies of immune recognition. To augment our understanding of epitopic sites seen by a set of anti-MHC-I mAb, we determined X-ray crystal structures of four complexes of anti-MHC-I Fabs bound to peptide/MHC-I/β2-microglobulin (pMHC-I). An anti-H2-Dd mAb, two anti-MHC-I α3 domain mAbs, and an anti-β2-microglobulin mAb bind pMHC-I at sites consistent with earlier mutational and functional experiments, and the structures explain allelomorph specificity...
March 8, 2024: Journal of Immunology
https://read.qxmd.com/read/38436421/prmt5-promotes-t-follicular-helper-cell-differentiation-and-germinal-center-responses-during-influenza-virus-infection
#16
JOURNAL ARTICLE
Kaitlin A Read, Stephanie A Amici, Sadaf Farsi, Madeline Cutcliffe, Bella Lee, Chan-Wang Jerry Lio, Hsin-Jung Joyce Wu, Mireia Guerau-de-Arellano, Kenneth J Oestreich
Protein arginine methyltransferases (PRMTs) modify diverse protein targets and regulate numerous cellular processes; yet, their contributions to individual effector T cell responses during infections are incompletely understood. In this study, we identify PRMT5 as a critical regulator of CD4+ T follicular helper cell (Tfh) responses during influenza virus infection in mice. Conditional PRMT5 deletion in murine T cells results in an almost complete ablation of both Tfh and T follicular regulatory populations and, consequently, reduced B cell activation and influenza-specific Ab production...
March 4, 2024: Journal of Immunology
https://read.qxmd.com/read/38426910/murine-mhc-deficient-nonobese-diabetic-mice-carrying-human-hla-dq8-develop-severe-myocarditis-and-myositis-in-response-to-anti-pd-1-immune-checkpoint-inhibitor-cancer-therapy
#17
JOURNAL ARTICLE
Jeremy J Racine, John F Bachman, Ji-Gang Zhang, Adel Misherghi, Raheem Khadour, Sana Kaisar, Olivia Bedard, Catherine Jenkins, Annie Abbott, Elvira Forte, Peter Rainer, Nadia Rosenthal, Susanne Sattler, David V Serreze
Myocarditis has emerged as an immune-related adverse event of immune checkpoint inhibitor (ICI) cancer therapy associated with significant mortality. To ensure patients continue to safely benefit from life-saving cancer therapy, an understanding of fundamental immunological phenomena underlying ICI myocarditis is essential. We recently developed the NOD-cMHCI/II-/-.DQ8 mouse model that spontaneously develops myocarditis with lower mortality than observed in previous HLA-DQ8 NOD mouse strains. Our strain was rendered murine MHC class I and II deficient using CRISPR/Cas9 technology, making it a genetically clean platform for dissecting CD4+ T cell-mediated myocarditis in the absence of classically selected CD8+ T cells...
March 1, 2024: Journal of Immunology
https://read.qxmd.com/read/38426898/ythdc1-crm1-facilitates-m6a-modified-circrna388-nuclear-export-to-induce-coelomocyte-autophagy-via-the-mir-2008-ulk-axis-in-apostichopus-japonicus
#18
JOURNAL ARTICLE
Jiqing Liu, Yina Shao, Chenghua Li
N 6-methyladenosine (m6A), the most prevalent internal modification in eukaryotic RNA, was able to mediate circular RNA (circRNA) function in many immune processes. Nevertheless, the functional role of m6A-modified circRNAs in innate immunity of invertebrates remained unclear. In this study, we identified m6A-modified circRNA388 from cultured sea cucumber (Apostichopus japonicus) coelomocytes, which was mainly detected in cytoplasm after Vibrio splendidus infection. A knockdown assay indicated that cytoplasm circRNA388 promoted coelomocyte autophagy and decreased the number of intracellular V...
March 1, 2024: Journal of Immunology
https://read.qxmd.com/read/38426888/repositioning-the-early-pathology-of-type-1-diabetes-to-the-extraislet-vasculature
#19
JOURNAL ARTICLE
Anne Costanzo, Don Clarke, Marie Holt, Siddhartha Sharma, Kenna Nagy, Xuqian Tan, Lisa Kain, Brian Abe, Sandrine Luce, Christian Boitard, Tine Wyseure, Laurent O Mosnier, Andrew I Su, Catherine Grimes, M G Finn, Paul B Savage, Michael Gottschalk, Jeremy Pettus, Luc Teyton
Type 1 diabetes (T1D) is a prototypic T cell-mediated autoimmune disease. Because the islets of Langerhans are insulated from blood vessels by a double basement membrane and lack detectable lymphatic drainage, interactions between endocrine and circulating T cells are not permitted. Thus, we hypothesized that initiation and progression of anti-islet immunity required islet neolymphangiogenesis to allow T cell access to the islet. Combining microscopy and single cell approaches, the timing of this phenomenon in mice was situated between 5 and 8 wk of age when activated anti-insulin CD4 T cells became detectable in peripheral blood while peri-islet pathology developed...
March 1, 2024: Journal of Immunology
https://read.qxmd.com/read/38416039/single-cell-analysis-reveals-a-subset-of-high-il-12p40-secreting-dendritic-cells-within-mouse-bone-marrow-derived-macrophages-differentiated-with-m-csf
#20
JOURNAL ARTICLE
Kate Bridges, Gabriela A Pizzurro, Mihir Khunte, Meibin Chen, Erick Salvador Rocha, Amanda F Alexander, Victor Bass, Laura N Kellman, Janani Baskaran, Kathryn Miller-Jensen
Macrophages and dendritic cells (DCs), although ontogenetically distinct, have overlapping functions and exhibit substantial cell-to-cell heterogeneity that can complicate their identification and obscure innate immune function. In this study, we report that M-CSF-differentiated murine bone marrow-derived macrophages (BMDMs) exhibit extreme heterogeneity in the production of IL-12, a key proinflammatory cytokine linking innate and adaptive immunity. A microwell secretion assay revealed that a small fraction of BMDMs stimulated with LPS secrete most IL-12p40, and we confirmed that this is due to extremely high expression of Il12b, the gene encoding IL-12p40, in a subset of cells...
February 28, 2024: Journal of Immunology
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