journal
https://read.qxmd.com/read/37975667/distinct-functional-humoral-immune-responses-are-induced-after-live-attenuated-and-inactivated-seasonal-influenza-vaccination
#1
JOURNAL ARTICLE
Xin Tong, Yixiang Deng, Deniz Cizmeci, Laura Fontana, Michael A Carlock, Hannah B Hanley, Ryan P McNamara, Daniel Lingwood, Ted M Ross, Galit Alter
Influenza viruses infect 5-30% of the world's population annually, resulting in millions of incidents of hospitalization and thousands of mortalities worldwide every year. Although annual vaccination has significantly reduced hospitalization rates in vulnerable populations, the current vaccines are estimated to offer a wide range of protection from 10 to 60% annually. Such incomplete immunity may be related to both poor antigenic coverage of circulating strains, as well as to the insufficient induction of protective immunity...
November 17, 2024: Journal of Immunology
https://read.qxmd.com/read/38607279/disruption-of-ifn%C3%AE-gzmb-prf1-or-lyst-results-in-reduced-suppressive-function-in-human-cd8-t-cells
#2
JOURNAL ARTICLE
Chakrapani Vemulawada, Pranav S Renavikar, Michael P Crawford, Scott Steward-Tharp, Nitin J Karandikar
An imbalance between proinflammatory and regulatory processes underlies autoimmune disease pathogenesis. We have shown that acute relapses of multiple sclerosis are characterized by a deficit in the immune suppressive ability of CD8+ T cells. These cells play an important immune regulatory role, mediated in part through cytotoxicity (perforin [PRF]/granzyme [GZM]) and IFNγ secretion. In this study, we further investigated the importance of IFNγ-, GZMB-, PRF1-, and LYST-associated pathways in CD8+ T cell-mediated suppression...
April 12, 2024: Journal of Immunology
https://read.qxmd.com/read/38607278/integrin-%C3%AE-v%C3%AE-3-limits-cytokine-production-by-plasmacytoid-dendritic-cells-and-restricts-tlr-driven-autoimmunity
#3
JOURNAL ARTICLE
Alina K Lorant, Anna E Yoshida, Emily A Gilbertson, Talyn Chu, Caroline Stefani, Mridu Acharya, Jessica A Hamerman, Adam Lacy-Hulbert
Plasmacytoid dendritic cells (pDCs) are strongly implicated as a major source of IFN-I in systemic lupus erythematosus (SLE), triggered through TLR-mediated recognition of nucleic acids released from dying cells. However, relatively little is known about how TLR signaling and IFN-I production are regulated in pDCs. In this article, we describe a role for integrin αvβ3 in regulating TLR responses and IFN-I production by pDCs in mouse models. We show that αv and β3-knockout pDCs produce more IFN-I and inflammatory cytokines than controls when stimulated through TLR7 and TLR9 in vitro and in vivo...
April 12, 2024: Journal of Immunology
https://read.qxmd.com/read/38598411/the-transcription-factor-zfp335-promotes-differentiation-and-survival-of-effector-th1-cells-by-directly-regulating-lmna-expression
#4
JOURNAL ARTICLE
Haiyan Liu, Zhao Feng, Anjun Jiao, Linbo Lan, Renyi Ding, Wenhua Li, Huiqiang Zheng, Yanhong Su, Xiaoxuan Jia, Dan Zhang, Xiaofeng Yang, Lianjun Zhang, Lina Sun, Baojun Zhang
Ag-specific effector CD4+ T cells play a crucial role in defending against exogenous pathogens. However, the mechanisms governing the differentiation and function of IFN-γ-producing effector CD4+ Th1 cells in immune responses remain largely unknown. In this study, we elucidated the pivotal role of zinc finger protein 335 (Zfp335) in regulating effector Th1 cell differentiation and survival during acute bacterial infection. Mice with Zfp335 knockout in OT-II cells exhibited impaired Ag-specific CD4+ T cell expansion accompanied by a significant reduction in resistance to Listeria infection...
April 10, 2024: Journal of Immunology
https://read.qxmd.com/read/38587315/altering-%C3%AE-cell-antigen-exposure-to-exhausted-cd8-t-cells-prevents-autoimmune-diabetes-in-mice
#5
JOURNAL ARTICLE
David J De George, Gaurang Jhala, Claudia Selck, Prerak Trivedi, Thomas C Brodnicki, Leanne Mackin, Thomas W Kay, Helen E Thomas, Balasubramanian Krishnamurthy
Chronic destruction of insulin-producing pancreatic β cells by T cells results in autoimmune diabetes. Similar to other chronic T cell-mediated pathologies, a role for T cell exhaustion has been identified in diabetes in humans and NOD mice. The development and differentiation of exhausted T cells depends on exposure to Ag. In this study, we manipulated β cell Ag presentation to target exhausted autoreactive T cells by inhibiting IFN-γ-mediated MHC class I upregulation or by ectopically expressing the β cell Ag IGRP under the MHC class II promotor in the NOD8...
April 8, 2024: Journal of Immunology
https://read.qxmd.com/read/38578283/nk-cell-monocyte-cross-talk-underlies-nk-cell-activation-in-severe-covid-19
#6
JOURNAL ARTICLE
Madeline J Lee, Izumi de Los Rios Kobara, Trisha R Barnard, Xariana Vales Torres, Nicole H Tobin, Kathie G Ferbas, Anne W Rimoin, Otto O Yang, Grace M Aldrovandi, Aaron J Wilk, Jennifer A Fulcher, Catherine A Blish
NK cells in the peripheral blood of severe COVID-19 patients exhibit a unique profile characterized by activation and dysfunction. Previous studies have identified soluble factors, including type I IFN and TGF-β, that underlie this dysregulation. However, the role of cell-cell interactions in modulating NK cell function during COVID-19 remains unclear. To address this question, we combined cell-cell communication analysis on existing single-cell RNA sequencing data with in vitro primary cell coculture experiments to dissect the mechanisms underlying NK cell dysfunction in COVID-19...
April 5, 2024: Journal of Immunology
https://read.qxmd.com/read/38578274/antibody-mediated-depletion-of-autoreactive-t-lymphocytes-through-pd-1-improves-disease-outcomes-and-visualizes-t-cell-activation-in-experimental-autoimmune-encephalomyelitis
#7
JOURNAL ARTICLE
Connor Frank, Hannah E Salapa, Kevin J H Allen, Michael C Levin, Wojciech Dawicki, Ekaterina Dadachova
Long-term therapeutic outcomes of multiple sclerosis (MS) remain hindered by the chronic nature of immune cell stimulation toward self-antigens. Development of novel methods to target and deplete autoreactive T lymphocytes remains an attractive target for therapeutics for MS. We developed a programmed cell death 1 (PD-1)-targeted radiolabeled mAb and assessed its ability to deplete activated PD-1+ T lymphocytes in vitro and its ability to reduce disease burden of the myelin oligodendrocyte glycoprotein 35-55 experimental autoimmune encephalomyelitis (EAE) model in C57BL/6 mice...
April 5, 2024: Journal of Immunology
https://read.qxmd.com/read/38568091/myeloid-cells-and-sphingosine-1-phosphate-are-required-for-tcr%C3%AE-%C3%AE-intraepithelial-lymphocyte-recruitment-to-the-colon-epithelium
#8
JOURNAL ARTICLE
Sarah Mann Danielson, Adam R Lefferts, Eric Norman, Emilie H Regner, Hanna M Schulz, Danielle Sansone-Poe, David J Orlicky, Kristine A Kuhn
Intraepithelial lymphocytes (IELs) are T cells important for the maintenance of barrier integrity in the intestine. Colon IELs are significantly reduced in both MyD88-deficient mice and those lacking an intact microbiota, suggesting that MyD88-mediated detection of bacterial products is important for the recruitment and/or retention of these cells. Here, using conditionally deficient MyD88 mice, we show that myeloid cells are the key mediators of TCRαβ+ IEL recruitment to the colon. Upon exposure to luminal bacteria, myeloid cells produce sphingosine-1-phosphate (S1P) in a MyD88-dependent fashion...
April 3, 2024: Journal of Immunology
https://read.qxmd.com/read/38558245/adaptive-nk-cells-rapidly-expand-during-acute-hiv-infection-and-persist-despite-early-initiation-of-antiretroviral-therapy
#9
JOURNAL ARTICLE
Anna C Hearps, Jingling Zhou, Paul A Agius, Phuongnhi Ha, Silvia Lee, Patricia Price, Hans Kek, Eugene Kroon, Siriwat Akapirat, Suteeraporn Pinyakorn, Nittaya Phanuphak, Carlo Sacdalan, Denise Hsu, Jintanat Ananworanich, Sandhya Vasan, Alexandra Schuetz, Anthony Jaworowski
HIV is associated with NK cell dysfunction and expansion of adaptive-like NK cells that persist despite antiretroviral therapy (ART). We investigated the timing of NK cell perturbations during acute HIV infection and the impact of early ART initiation. PBMCs and plasma were obtained from people with HIV (PWH; all men who have sex with men; median age, 26.0 y) diagnosed during Fiebig stages I, II, III, or IV/V. Participants initiated ART a median of 3 d after diagnosis, and immunophenotyping was performed at diagnosis and longitudinally after ART...
April 1, 2024: Journal of Immunology
https://read.qxmd.com/read/38558134/promotion-of-an-antitumor-immune-program-by-a-tumor-specific-complement-activating-antibody
#10
JOURNAL ARTICLE
Ruchi Saxena, Ryan T Bushey, Michael J Campa, Elizabeth B Gottlin, Jian Guo, Edward F Patz, You-Wen He
Tumor-targeting Abs can be used to initiate an antitumor immune program, which appears essential to achieve a long-term durable clinical response to cancer. We previously identified an anti-complement factor H (CFH) autoantibody associated with patients with early-stage non-small cell lung cancer. We cloned from their peripheral B cells an mAb, GT103, that specifically recognizes CFH on tumor cells. Although the underlying mechanisms are not well defined, GT103 targets a conformationally distinct CFH epitope that is created when CFH is associated with tumor cells, kills tumor cells in vitro, and has potent antitumor activity in vivo...
April 1, 2024: Journal of Immunology
https://read.qxmd.com/read/38557795/inferring-b-cell-phylogenies-from-paired-h-and-l-chain-bcr-sequences-with-dowser
#11
JOURNAL ARTICLE
Cole G Jensen, Jacob A Sumner, Steven H Kleinstein, Kenneth B Hoehn
Abs are vital to human immune responses and are composed of genetically variable H and L chains. These structures are initially expressed as BCRs. BCR diversity is shaped through somatic hypermutation and selection during immune responses. This evolutionary process produces B cell clones, cells that descend from a common ancestor but differ by mutations. Phylogenetic trees inferred from BCR sequences can reconstruct the history of mutations within a clone. Until recently, BCR sequencing technologies separated H and L chains, but advancements in single-cell sequencing now pair H and L chains from individual cells...
April 1, 2024: Journal of Immunology
https://read.qxmd.com/read/38551350/persistence-of-a-skewed-repertoire-of-nk-cells-in-people-with-hiv-1-on-long-term-antiretroviral-therapy
#12
JOURNAL ARTICLE
Renee R Anderko, Allison E DePuyt, Rhianna Bronson, Arlene C Bullotta, Evgenia Aga, Ronald J Bosch, R Brad Jones, Joseph J Eron, John W Mellors, Rajesh T Gandhi, Deborah K McMahon, Bernard J Macatangay, Charles R Rinaldo, Robbie B Mailliard
HIV-1 infection greatly alters the NK cell phenotypic and functional repertoire. This is highlighted by the expansion of a rare population of FcRγ- NK cells exhibiting characteristics of traditional immunologic memory in people with HIV (PWH). Although current antiretroviral therapy (ART) effectively controls HIV-1 viremia and disease progression, its impact on HIV-1-associated NK cell abnormalities remains unclear. To address this, we performed a longitudinal analysis detailing conventional and memory-like NK cell characteristics in n = 60 PWH during the first 4 y of ART...
March 29, 2024: Journal of Immunology
https://read.qxmd.com/read/38536099/correction-selective-inhibition-of-the-interaction-between-sars-cov-2-spike-s1-and-ace2-by-spidar-peptide-induces-anti-inflammatory-therapeutic-responses
#13
Ramesh K Paidi, Malabendu Jana, Rama K Mishra, Debashis Dutta, Kalipada Pahan
Paidi, R. K., M. Jana, R. K. Mishra, D. Dutta, and K. Pahan. 2021. Selective inhibition of the interaction between SARS-CoV-2 spike S1 and ACE2 by SPIDAR peptide induces anti-inflammatory therapeutic responses. J. Immunol. 207: 2521-2533.In the original Supplemental Fig. 2C, the "Control" image was duplicated from the "Spike S1 (heat inactivated)" image due to an error during figure preparation. The supplemental figure has been corrected in the online version of the article.
March 27, 2024: Journal of Immunology
https://read.qxmd.com/read/38536025/correction-dx5-cd49b-positive-t-cells-are-not-synonymous-with-cd1d-dependent-nkt-cells
#14
Daniel G Pellicci, Kirsten J L Hammond, Jonathan Coquet, Konstantinos Kyparissoudis, Andrew G Brooks, Katherine Kedzierska, Rachael Keating, Stephen Turner, Stuart Berzins, Mark J Smyth, Dale I Godfrey
Pellicci, D. G., K. J. L. Hammond, J. Coquet, K. Kyparissoudis, A. G. Brooks, K. Kedzierska, R. Keating, S. Turner, S. Berzins, M. J. Smyth, and D. I. Godfrey. 2005. DX5/CD49b-positive T cells are not synonymous with CD1d-dependent NKT cells. J. Immunol. 175: 4416-4425. Fig. 2A of this article contains flow cytometry comparing C57BL/6 WT mice and CD1d-/- mice for αβTCR versus DX5 or αβTCR versus CD49b staining in mouse thymus, spleen, liver, bone marrow, and peripheral lymph nodes (PLNs)...
March 27, 2024: Journal of Immunology
https://read.qxmd.com/read/38517295/the-role-of-coinhibitory-receptors-in-b-cell-dysregulation-in-sars-cov-2-infected-individuals-with-severe-disease
#15
JOURNAL ARTICLE
Suguru Saito, Najmeh Bozorgmehr, Wendy Sligl, Mohammed Osman, Shokrollah Elahi
Severe SARS-CoV-2 infection is associated with significant immune dysregulation involving different immune cell subsets. In this study, when analyzing critically ill COVID-19 patients versus those with mild disease, we observed a significant reduction in total and memory B cell subsets but an increase in naive B cells. Moreover, B cells from COVID-19 patients displayed impaired effector functions, evidenced by diminished proliferative capacity, reduced cytokine, and Ab production. This functional impairment was accompanied by an increased apoptotic potential upon stimulation in B cells from severely ill COVID-19 patients...
March 22, 2024: Journal of Immunology
https://read.qxmd.com/read/38517294/antibody-suppressor-cxcr5-cd8-t-cells-are-more-potent-regulators-of-humoral-alloimmunity-after-kidney-transplant-in-mice-compared-to-cd4-regulatory-t-cells
#16
JOURNAL ARTICLE
Jing L Han, Jason M Zimmerer, Qiang Zeng, Sachi Chaudhari, Anjali Satoskar, Mahmoud Abdel-Rasoul, Hope Uwase, Christopher K Breuer, Ginny L Bumgardner
Adoptive cell therapy (ACT), especially with CD4+ regulatory T cells (CD4+ Tregs), is an emerging therapeutic strategy to minimize immunosuppression and promote long-term allograft acceptance, although much research remains to realize its potential. In this study, we investigated the potency of novel Ab-suppressor CXCR5+CD8+ T cells (CD8+ TAb-supp) in comparison with conventional CD25highFoxp3+CD4+ Tregs for suppression of humoral alloimmunity in a murine kidney transplant (KTx) model of Ab-mediated rejection (AMR)...
March 22, 2024: Journal of Immunology
https://read.qxmd.com/read/38506555/antagonism-of-the-platelet-activating-factor-pathway-mitigates-inflammatory-adverse-events-driven-by-anti-erythrocyte-antibody-therapy-in-mice
#17
JOURNAL ARTICLE
Kevin Doyoon Won, Lazaro Gil Gonzalez, Yoelys Cruz-Leal, Alequis Pavon Oro, Alan H Lazarus
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by low platelet counts primarily due to antiplatelet autoantibodies. Anti-D is a donor-derived polyclonal Ab against the rhesus D Ag on erythrocytes used to treat ITP. Unfortunately, adverse inflammatory/hypersensitivity reactions and a Food and Drug Administration-issued black box warning have limited its clinical use. This underscores the imperative to understand the inflammatory pathway associated with anti-erythrocyte Ab-based therapies...
March 20, 2024: Journal of Immunology
https://read.qxmd.com/read/38497670/il-10-differentially-promotes-mast-cell-responsiveness-to-il-33-resulting-in-enhancement-of-type-2-inflammation-and-suppression-of-neutrophilia
#18
JOURNAL ARTICLE
Saurav Ranjitkar, Dylan Krajewski, Chelsea Garcia, Caitlin Tedeschi, Stephanie H Polukort, Jeffrey Rovatti, Mohamed Mire, Christopher N Blesso, Evan Jellison, Sallie S Schneider, John J Ryan, Clinton B Mathias
Mast cells (MCs) play critical roles in the establishment of allergic diseases. We recently demonstrated an unexpected, proinflammatory role for IL-10 in regulating MC responses. IL-10 enhanced MC activation and promoted IgE-dependent responses during food allergy. However, whether these effects extend to IgE-independent stimuli is not clear. In this article, we demonstrate that IL-10 plays a critical role in driving IL-33-mediated MC responses. IL-10 stimulation enhanced MC expansion and degranulation, ST2 expression, IL-13 production, and phospho-relA upregulation in IL-33-treated cells while suppressing TNF-α...
March 18, 2024: Journal of Immunology
https://read.qxmd.com/read/38497668/high-affinity-mediated-viral-entry-triggers-innate-affinity-escape-resulting-in-type-i-ifn-resistance-and-impaired-t-cell-immunity
#19
JOURNAL ARTICLE
Haifeng C Xu, Piyush Pandey, Harry Ward, Michal Gorzkiewicz, Džiuljeta Abromavičiūtė, Constanze Tinz, Lisa Müller, Caroline Meyer, Aleksandra A Pandyra, Aslihan Yavas, Arndt Borkhardt, Irene Esposito, Karl S Lang, Philipp A Lang
Increased receptor binding affinity may allow viruses to escape from Ab-mediated inhibition. However, how high-affinity receptor binding affects innate immune escape and T cell function is poorly understood. In this study, we used the lymphocytic choriomeningitis virus (LCMV) murine infection model system to create a mutated LCMV exhibiting higher affinity for the entry receptor α-dystroglycan (LCMV-GPH155Y). We show that high-affinity receptor binding results in increased viral entry, which is associated with type I IFN (IFN-I) resistance, whereas initial innate immune activation was not impaired during high-affinity virus infection in mice...
March 18, 2024: Journal of Immunology
https://read.qxmd.com/read/38488511/potent-hpiv3-neutralizing-ighv5-51-antibodies-identified-from-multiple-individuals-show-l-chain-and-cdrh3-promiscuity
#20
JOURNAL ARTICLE
Alexandra A Abu-Shmais, Rose J Miller, Alexis K Janke, Rachael M Wolters, Clinton M Holt, Nagarajan Raju, Robert H Carnahan, James E Crowe, Jarrod J Mousa, Ivelin S Georgiev
Human parainfluenza virus 3 (HPIV3) is a widespread pathogen causing severe and lethal respiratory illness in at-risk populations. Effective countermeasures are in various stages of development; however, licensed therapeutic and prophylactic options are not available. The fusion glycoprotein (HPIV3 F), responsible for facilitating viral entry into host cells, is a major target of neutralizing Abs that inhibit infection. Although several neutralizing Abs against a small number of HPIV3 F epitopes have been identified to date, relatively little is known about the Ab response to HPIV3 compared with other pathogens, such as influenza virus and SARS-CoV-2...
March 15, 2024: Journal of Immunology
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