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Journal of Genetics

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https://read.qxmd.com/read/30555100/genetics-of-ulcerative-colitis-putting-into-perspective-the-incremental-gains-from-indian-studies
#1
Garima Juyal, Ajit Sood, Vandana Midha, B K Thelma
Ulcerative colitis (UC), one of the two clinical subtypes of inflammatory bowel disease is perceived as a potential 'sleeping giant' in the Indian subcontinent. Clinical manifestation is overall believed to be the same across ethnic groups but overwhelming genetics from large European and fewer non-European studies have revealed shared as well as unique disease susceptibly signaturesbetween them, pointing to population specific differences at genomic and environmental levels. A systematic recount of the four major eras in UC genetics spanning earliest linkage analysis, cherry picked candidate gene association studies, unbiased genomewide association studies, their logical extension in trans-ethnic setting (Immunochip study), lastly whole exome sequencing efforts forrare variant burden; and lessons learnt thereof in context of genetically distinct Indian population was attempted in this review...
December 2018: Journal of Genetics
https://read.qxmd.com/read/30555099/genetics-of-language-and-its-implications-on-language-interventions
#2
Radhakrishnan Sriganesh, R Joseph Ponniah
Genetic variation of language genes affect neurophysiology of brain and can thus influence the way people respond to environmental language input, leading to differences in terms of their response to environmental language learning. Conversely, language learning environment too can affect gene expressions through neuroepigenetic mechanisms, leading to increasedinterindividual differences. Further, language-related cognitive processes such as learning, working memory and perception; and language-related affective factors such as stress and positive emotion involve neuroplasticity, which is also epigenetically regulated...
December 2018: Journal of Genetics
https://read.qxmd.com/read/30555098/identification-of-a-novel-gpr143-mutation-in-x-linked-ocular-albinism-with-marked-intrafamilial-phenotypic-variability
#3
Jae-Ho Jung, Eun Hye Oh, Jin-Hong Shin, Hyang-Sook Kim, Seo Young Choi, Kwang-Dong Choi, Changwook Lee, Jae-Hwan Choi
Ocular albinism type 1 (OA1) is an X-linked inherited disease characterized by impaired visual acuity, congenital nystagmus, foveal hypoplasia, hypopigmentation of iris and fundus. It is caused by mutations in the G protein-coupled receptor143 ( GPR143 ) gene. The genetic characteristics of OA1 have not been well defined in Asians. In this study, six members from three consecutive generations of a Korean family with OA1 were enrolled. We performed whole-exome sequencing followed by validation and segregation analysis...
December 2018: Journal of Genetics
https://read.qxmd.com/read/30555097/gene-fusion-of-heterophyletic-gamma-globin-genes-in-platyrrhine-primates
#4
José Ignacio Arroyo, Mariana F Nery
We performed phylogenetic analyses of HBG genes to assess its origin and interspecific variation among primates. Our analyses showed variation in HBG genes copy number ranging from one to three, some of them pseudogenes. For platyrrhines HBG genes, phylogenetic reconstructions of flanking regions recovered orthologous clades with distinct topologies for 5' and 3' flanking regions. The 5' region originated in the common ancestor of platyrrhines but the 3' region had an anthropoid origin. We hypothesize that the platyrrhine HBG genes of 5' and 3' heterophyletic origins arose from subsequent fusions of the (earlier) platyrrhine 5' portion and the (later) anthropoid 3' portion...
December 2018: Journal of Genetics
https://read.qxmd.com/read/30555096/novel-c-c2254t-p-q752-mutation-in-zfyve26-spg15-gene-in-a-patient-with-hereditary-spastic-paraparesis
#5
Mirella Vinci, Marco Fchera, Sebastiano Antonino Musumeci, Francesco Cali, Girolamo Aurelio Vitello
Hereditary spastic paraplegias are clinically and genetically heterogeneous degenerative disorders, and pathological variants in the autosomal recessive ZFYVE26 gene are considered as very rare causes. We describe a novel mutation in ZFYVE26 gene found in a patient with autosomal recessive spastic paraplegias. The use of a 'target-gene' approach allowed us to expand the clinical spectrum associated with hereditary spastic paraplegias.
December 2018: Journal of Genetics
https://read.qxmd.com/read/30555095/cloning-and-characterization-of-a-novel-low-molecular-weight-glutenin-subunit-gene-with-an-unusual-molecular-structure-of-aegilops-uniaristata
#6
Heng Tang, Xuye Du, Hongwei Wang, Xin Ma, Cunyao Bo, Anfei Li, Lingrang Kong
Low-molecular-weight glutenin subunits (LMW-GSs) are one of the important factors for the dough processing quality. In this study, a novel LMW-GS, designated LMW-N13, from the wheat relative species Aegilops uniaristata PI 554421 was cloned and characterized. Unlike previously published LMW-GSs, LMW-N13 has a large molecular weight and is the largest LMW-GS published thus far. Sequence alignments demonstrated that LMW-N13 is a LMW-i-type subunit but contains nine cysteine residues which is one more than typical LMW-i-type subunits...
December 2018: Journal of Genetics
https://read.qxmd.com/read/30555094/noninvasive-dna-based-species-and-sex-identification-of-asiatic-wild-dog-cuon-alpinus
#7
Shrushti Modi, Samrat Mondol, Pallavi Ghaskadbi, Zehidul Hussain, Parag Nigam, Bilal Habib
Asiatic wild dog ( Cuon alpinus ) or dhole is an endangered canid with fragmented distribution in South, East and Southeast Asia. The remaining populations of this species face severe conservation challenges from anthropogenic interventions, but only limited information is available at population and demography levels. Here, we describe the novel molecular approaches for unambiguous species and sex identification from noninvasively collected dhole samples. We successfully tested these assays on 130 field-collected dhole faecal samples from the Vidarbha part of central Indian tiger landscape that resulted in 97 and 77% successrates in species and sex identification, respectively...
December 2018: Journal of Genetics
https://read.qxmd.com/read/30555093/genetics-of-resistance-to-cercospora-leaf-spot-disease-caused-by-cercospora-canescens-and-psuedocercospora-cruenta-in-yardlong-bean-vigna-unguiculata-ssp-sesquipedalis-%C3%A3-grain-cowpea-v-unguiculata-ssp-unguiculata-populations
#8
Usa Duangsong, Kularb Laosatit, Prakit Somta, Peerasak Srinives
Yardlong bean ( Vigna unguiculata ssp. sesquipedalis ), a type of cowpea, is an important vegetable legume of Asia. Cercospora leaf spot (CLS) caused by Cercospora canescens and Psuedocercospora cruenta is an important phytopathological problem of the yardlong bean grown in tropical regions. The objectives of this study were to (i) determine mode of inheritance of resistance to CLS caused by C. canescens and P. cruenta , (ii) estimate the heritability of the resistance, (iii) estimate genetic effects on the resistance using six basic populations generated from the cross between the susceptible yardlong bean 'CSR12906' and the resistant grain cowpea ( V...
December 2018: Journal of Genetics
https://read.qxmd.com/read/30555092/identification-of-a-novel-glb1-mutation-in-a-consanguineous-pakistani-family-affected-by-rare-infantile-gm1-gangliosidosis
#9
Bibi Zubaida, Muhammad Almas Hashmi, Huma Arshad Cheema, Muhammad Naeem
Monosialotetrahexosylganglioside (GM1) is a rare lysosomal storage disorder caused by the deficiency of beta-galactosidase (β-Gal) encoded by galactose beta 1 ( GLB1 ). It is clinically characterized by developmental delay attributed to multifold accumulation of GM1 gangliosides in nerve cells. In this study, we present a case of infantile GM1 gangliosidosis in a consanguineous Pakistani family. The child was presented with developmental delay, hepatosplenomegaly and recurrent chest infections at 7.5 months of age...
December 2018: Journal of Genetics
https://read.qxmd.com/read/30555091/selection-and-validation-of-reference-genes-for-normalization-of-qrt-pcr-gene-expression-in-wheat-triticum-durum-l-under-drought-and-salt-stresses
#10
Jamshidi Goharrizi Kiarash, Henry Dayton Wilde, Farzane Amirmahani, Mohammad Mehdi Moemeni, Maryam Zaboli, Maryam Nazari, Sayyed Saeed Moosavi, Mina Jamalvandi
Eight candidate housekeeping genes were examined as internal controls for normalizing expression analysis of durum wheat ( Triticum durum L. ) under drought and salinity stress conditions. Quantitative real-time PCR was used to analyse gene expression of multiple stress levels, plant ages (24 and 50 days old), and plant tissues (leaf and root). The algorithms BestKeeper, NormFinder, GeNorm, the delta Ct method and the RefFinder were applied to determine the stability of candidate genes. Under drought stress, the most stable reference genes were glyceraldehyde-3 phosphate , ubiquitin and β- tubulin2 , whereas under salinity stress conditions, eukaryotic elongation factor 1-α , glyceraldehyde-3 phosphate and actin were identified as the most stable reference genes...
December 2018: Journal of Genetics
https://read.qxmd.com/read/30555090/a-genetic-system-on-chromosome-arm-1bl-of-wild-emmer-causes-distorted-segregation-in-common-wheat
#11
Yunzheng Miao, Siqing Yang, Yurong Jiang, Junkang Rong, Jinsheng Yu
Nonrandom segregation ratios of alleles 'segregation distortion' can have a striking impact on transmission genetics, and with widespread availability of genetic markers has been shown to be a frequent phenomenon. To investigate the possible effect of genetic interaction on segregation distortion and genetic map construction, the segregation and mapping of genetic markers locatedon wheat chromosomes 1A and 1B were followed in four recombinant substitution line (RSL) populations, produced using four chromosome-arm substitution lines (CASLs 1AS, 1AL, 1BS and 1BL) of wild emmer ( Triticum turgidum var...
December 2018: Journal of Genetics
https://read.qxmd.com/read/30555089/quantitative-trait-loci-that-determine-plasma-insulin-levels-in-f-2-intercross-populations-produced-from-crosses-between-ddd-sgn-and-c57bl-6j-inbred-mice
#12
Jun-Ichi Suto, Misaki Kojima
When compared to C57BL/6J (B6) mice, DDD/Sgn (DDD) mice has substantially higher plasma insulin levels in both sexes. In this study, we performed quantitative trait loci (QTL) mapping of plasma insulin levels in F2 male mice produced by crosses between DDD and B6 mice. By single-QTL scans, we identified one significant QTL on chromosome 9. When body weight was included as an additive covariate, we identified two significant QTL on chromosomes 9 and 12; the latter coincided with a QTL that was previously identified in F2 female mice produced by the same two strains...
December 2018: Journal of Genetics
https://read.qxmd.com/read/30555088/the-genetic-variants-of-solute-carrier-family-11-member-2-gene-and-risk-of-developing-type-2-diabetes
#13
Cansu Ozbayer, Hulyam Kurt, Medine Nur Kebapci, Hasan Veysi Gunes, Ertugrul Colak, Irfan Degirmenci
Type-2 diabetes (T2DM) is a metabolic disorder characterized by long-terminsulin resistance, impaired insulin secretion from β-cells, and loss of beta cell mass and function. Inflammation and oxidative stress play a key role in the development of diabetes and are associated with insulin resistance. Notably, recent studies have demonstrated an association between body iron stores, insulin resistance and T2DM. Free iron, a powerful pro-oxidant molecule, is involved in oxidative stress, lipid peroxidation and endothelial dysfunction via its ability to generate free radicals...
December 2018: Journal of Genetics
https://read.qxmd.com/read/30555087/mapping-qtl-controlling-agronomic-traits-in-a-doubled-haploid-population-of-winter-oilseed-rape-brassica-napus-l
#14
Farshad Fattahi, Barat Ali Fakheri, Mahmood Solouki, Christian Möllers, Abbas Rezaizad
Identification of superior alleles for agronomic traits in genetic resources of oilseed rape ( Brassica napus L.) would be useful for improving the performance of locally adapted cultivars in Iran. The objective of the present work was to analyse the genetic variation and inheritance of important agronomic traits in a doubled haploid population derived from a cross between two German oilseed rape cultivars, Sansibar and Oase. Field experiments were performed in 2016-2017 with 200 doubled haploid lines and the parental genotypes applying an alpha-lattice design with two replicates...
December 2018: Journal of Genetics
https://read.qxmd.com/read/30555086/the-jasmonate-responsive-transcription-factor-cbwrky24-regulates-terpenoid-biosynthetic-genes-to-promote-saponin-biosynthesis-in-conyza-blinii-h-l%C3%A3-v
#15
Wen-Jun Sun, Jun-Yi Zhan, Tian-Run Zheng, Rong Sun, Tao Wang, Zi-Zhong Tang, Tong-Liang Bu, Cheng-Lei Li, Qi Wu, Hui Chen
Conyza blinii H. Lév., the most effective component is saponin, is a biennial medicinal material that needs to be overwintered. WRKY transcription factors family is a large protein superfamily that plays a predominant role in plant secondary metabolism, but their characteristics and functions have not been identified in C. blinii . The CbWRKY24 sequence was selectedfrom the transcriptome database of the C. blinii leaves constructed in our laboratory. Phylogenetic tree analysis revealed that it was associated with AaWRKY1 which can regulate artemisinin synthesis in Artemisia annua ...
December 2018: Journal of Genetics
https://read.qxmd.com/read/30555085/a-novel-study-to-examine-the-association-of-pcsk9-rs505151-polymorphism-and-coronary-artery-disease-in-north-indian-population
#16
S Reddy, Naindeep Kaur, Jagtar Singh
There is a drastic increase in the number of people suffering from coronary artery disease (CAD) worldwide with Indians being no exception. Being a developing country and experiencing a dramatic shift in lifestyle and eating habits, urbanization and industrialization, all these factors have collectively predisposed the Indian population towards CAD and the prevalence data arequite alarming. Genetic studies have disclosed the role of genes in CAD susceptibility and severity. One such gene is proprotein convertase subtilisin/kexin type 9 ( PCSK9 ) which is sought to modulate the cholesterol levels and hence, has implications in CAD...
December 2018: Journal of Genetics
https://read.qxmd.com/read/30555084/identification-and-characterization-of-microsatellite-loci-in-west-atlantic-sea-cucumber-holothuria-grisea-selenka-1867
#17
Vanessa Alves Pereira, Jamille Martins Forte, José Pedro Vieira Arruda-Júnior, Fábio Mendonça Diniz, Rodrigo Maggioni, Carminda Sandra Brito Salmitovanderley
The sea cucumber Holothuria grisea has become the subject of intense and unregulated fishing in northeastern Brazil due to their growing demand in Asian market. However, there is little knowledge about the dynamics and genetics of H. grisea wild populations on the South American coast. In this study, we present the first set of H. grisea microsatellite markers, identified and characterized using Illumina paired-end reads of whole genome shotgun sequencing. From 50 strictly selected candidates, eight novel microsatellite markers were successfully developed...
December 2018: Journal of Genetics
https://read.qxmd.com/read/30555083/characterization-of-a-splice-variant-of-soybean-erecta-devoid-of-an-intracellular-kinase-domain-in-response-to-shade-stress
#18
Junbo Du, Yan Li, Xin Sun, Liang Yu, Hengke Jiang, Qiulin Cao, Jing Shang, Mengyuan Sun, Yi Liu, Kai Shu, Jiang Liu, Taiwen Yong, Weiguo Liu, Feng Yang, Xiaochun Wang, Chunyan Liu, Wenyu Yang
The receptor-like kinase ERECTA (ER) plays vital roles in plant adaptation under environmental stress including shade avoidance in Arabidopsis . In our previous study, we identified four ER paralogues in soybean (GmERs) that showed high similarities to Arabidopsis ER. Each GmER was predicted to generate diverse alternative splicing variants. However, whether soybean GmERs contribute to shade avoidance is unknown. Here we report our characterization of GmERs in response to shading. Promoter::GUS staining analysis shows that expression of GmER paralogous genes was differentially induced under shade stress...
December 2018: Journal of Genetics
https://read.qxmd.com/read/30555082/genetic-diversity-and-cultivar-variants-in-the-ncgr-cranberry-vaccinium-macrocarpon-aiton-collection
#19
B Schlautman, G Covarrubias-Pazaran, L Rodriguez-Bonilla, K Hummer, N Bassil, T Smith, J Zalapa
The American cranberry ( Vaccinium macrocarpon ) is an endemic domesticated species that has become an economically important commercial fruit crop. The USDA-ARS National Clonal Germplasm Repository (NCGR) houses the national Vaccinium collection, which includes representatives of historical cranberry cultivars and wild-selected germplasm. The objective of this study wasto examine the genotypes of 271 cranberry plants from 77 accessions representing 66 named cultivars using 12 simple-sequence repeats to assess clonal purity and cultivar relatedness...
December 2018: Journal of Genetics
https://read.qxmd.com/read/30555081/establishment-of-base-population-for-selective-breeding-of-catla-catla-catla-depending-on-phenotypic-and-microsatellite-marker-information
#20
Kanta Das Mahapatra, Lakshman Sahoo, Jatindra Nath Saha, Khuntia Murmu, Avinash Rasal, Priyanka Nandanpawar, Paramananda Das, Madhulita Patnaik
The phenotypic and microsatellite marker information of nine strains of catla ( Catla catla ) for growth trait was used to infer relationship within and between strains. This information helped in optimizing the proportion of individuals to be used from each strain while creating a base population for selective breeding. For this purpose, nine strains were collected from different sources and places of India namely West Bengal, Bihar, Odisha, Andhra Pradesh and Uttar Pradesh. Two riverine sources i.e. Ganga and Subarnarekha were also represented among the nine strains collected for base population...
December 2018: Journal of Genetics
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