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Journal of General Physiology

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https://read.qxmd.com/read/31010811/rapid-resensitization-of-asic2a-is-conferred-by-three-amino-acid-residues-in-the-n-terminus
#1
Jae Seung Lee, Hae-Jin Kweon, Hyosang Lee, Byung-Chang Suh
Acid-sensing ion channels (ASICs), sensory molecules that continuously monitor the concentration of extracellular protons and initiate diverse intracellular responses through an influx of cations, are assembled from six subtypes that can differentially combine to form various trimeric channel complexes and elicit unique electrophysiological responses. For instance, homomeric ASIC1a channels have been shown to exhibit prolonged desensitization, and acid-evoked currents become smaller when the channels are repeatedly activated by extracellular protons, whereas homomeric or heteromeric ASIC2a channels continue to respond to repetitive acidic stimuli without exhibiting such desensitization...
April 22, 2019: Journal of General Physiology
https://read.qxmd.com/read/31010810/microscopic-heat-pulses-activate-cardiac-thin-filaments
#2
Shuya Ishii, Kotaro Oyama, Tomomi Arai, Hideki Itoh, Seine A Shintani, Madoka Suzuki, Fuyu Kobirumaki-Shimozawa, Takako Terui, Norio Fukuda, Shin'ichi Ishiwata
During the excitation-contraction coupling of the heart, sarcomeres are activated via thin filament structural changes (i.e., from the "off" state to the "on" state) in response to a release of Ca2+ from the sarcoplasmic reticulum. This process involves chemical reactions that are highly dependent on ambient temperature; for example, catalytic activity of the actomyosin ATPase rises with increasing temperature. Here, we investigate the effects of rapid heating by focused infrared (IR) laser irradiation on the sliding of thin filaments reconstituted with human α-tropomyosin and bovine ventricular troponin in an in vitro motility assay...
April 22, 2019: Journal of General Physiology
https://read.qxmd.com/read/31010809/tracking-nitroxyl-derived-posttranslational-modifications-of-phospholamban-in-cardiac-myocytes
#3
COMMENT
Cecilia Beatriz Mundiña-Weilenmann, Alicia Mattiazzi
No abstract text is available yet for this article.
April 22, 2019: Journal of General Physiology
https://read.qxmd.com/read/31010808/isolating-a-reverse-mode-atp-synthase-dependent-mechanism-of-mitoflash-activation
#4
COMMENT
Lan Wei-LaPierre, Robert T Dirksen
No abstract text is available yet for this article.
April 22, 2019: Journal of General Physiology
https://read.qxmd.com/read/31004065/how-ca-2-influx-is-attenuated-in-the-heart-during-a-fight-or-flight-response
#5
COMMENT
Maedeh Bazmi, Ariel L Escobar
No abstract text is available yet for this article.
April 19, 2019: Journal of General Physiology
https://read.qxmd.com/read/31000581/phase-1-repolarization-rate-defines-ca-2-dynamics-and-contractility-on-intact-mouse-hearts
#6
María Micaela López Alarcón, Ainhoa Rodríguez de Yurre, Juan Ignacio Felice, Emiliano Medei, Ariel L Escobar
In the heart, Ca2+ influx through L-type Ca2+ channels triggers Ca2+ release from the sarcoplasmic reticulum. In most mammals, this influx occurs during the ventricular action potential (AP) plateau phase 2. However, in murine models, the influx through L-type Ca2+ channels happens in early repolarizing phase 1. The aim of this work is to assess if changes in the open probability of 4-aminopyridine (4-AP)-sensitive Kv channels defining the outward K+ current during phase 1 can modulate Ca2+ currents, Ca2+ transients, and systolic pressure during the cardiac cycle in intact perfused beating hearts...
April 18, 2019: Journal of General Physiology
https://read.qxmd.com/read/30992369/rejection-of-the-biophoton-hypothesis-on-the-origin-of-photoreceptor-dark-noise
#7
Victor I Govardovskii, Luba A Astakhova, Alexander Yu Rotov, Michael L Firsov
Rod photoreceptors of the vertebrate retina produce, in darkness, spontaneous discrete current waves virtually identical to responses to single photons. The waves comprise an irreducible source of noise (discrete dark noise) that may limit the threshold sensitivity of vision. The waves obviously originate from acts of random activation of single rhodopsin molecules. Until recently, it was generally accepted that the activation occurs due to the rhodopsin thermal motion. Yet, a few years ago it was proposed that rhodopsin molecules are activated not by heat but rather by real photons generated within the retina by chemiluminescence...
April 16, 2019: Journal of General Physiology
https://read.qxmd.com/read/30988062/bile-acids-inhibit-human-purinergic-receptor-p2x4-in-a-heterologous-expression-system
#8
Alexandr V Ilyaskin, Florian Sure, Viatcheslav Nesterov, Silke Haerteis, Christoph Korbmacher
We recently demonstrated that bile acids, especially tauro-deoxycholic acid (t-DCA), modify the function of the acid-sensing ion channel ASIC1a and other members of the epithelial sodium channel (ENaC)/degenerin (DEG) ion channel family. Surprisingly, ASIC1 shares a high degree of structural similarity with the purinergic receptor P2X4, a nonselective cation channel transiently activated by ATP. P2X4 is abundantly expressed in the apical membrane of bile duct epithelial cells and is therefore exposed to bile acids under physiological conditions...
April 15, 2019: Journal of General Physiology
https://read.qxmd.com/read/30988061/concatenated-%C3%AE-aminobutyric-acid-type-a-receptors-revisited-finding-order-in-chaos
#9
Vivian Wan Yu Liao, Han Chow Chua, Natalia Magdalena Kowal, Mary Chebib, Thomas Balle, Philip Kiær Ahring
γ-aminobutyric acid type A receptors (GABAA Rs), the major inhibitory neurotransmitter receptors in the mammalian central nervous system, are arguably the most challenging member of the pentameric Cys-loop receptors to study due to their heteromeric structure. When two or more subunits are expressed together in heterologous systems, receptors of variable subunit type, ratio, and orientation can form, precluding accurate interpretation of data from functional studies. Subunit concatenation is a technique that involves the linking of individual subunits and in theory allows the precise control of the uniformity of expressed receptors...
April 15, 2019: Journal of General Physiology
https://read.qxmd.com/read/30988060/progress-on-the-regulation-of-myofibrillar-function-part-2
#10
Henk L Granzier, Richard L Moss
No abstract text is available yet for this article.
April 15, 2019: Journal of General Physiology
https://read.qxmd.com/read/30979787/what-a-drag-skeletal-myosin-binding-protein-c-affects-sarcomeric-shortening
#11
COMMENT
Brett A Colson
No abstract text is available yet for this article.
April 12, 2019: Journal of General Physiology
https://read.qxmd.com/read/30975697/elastic-domains-of-giant-proteins-in-striated-muscle-modeling-compliance-with-rulers
#12
COMMENT
P Bryant Chase
No abstract text is available yet for this article.
April 11, 2019: Journal of General Physiology
https://read.qxmd.com/read/30948421/nebulin-and-titin-modulate-cross-bridge-cycling-and-length-dependent-calcium-sensitivity
#13
Srboljub M Mijailovich, Boban Stojanovic, Djordje Nedic, Marina Svicevic, Michael A Geeves, Thomas C Irving, Henk L Granzier
Various mutations in the structural proteins nebulin and titin that are present in human disease are known to affect the contractility of striated muscle. Loss of nebulin is associated with reduced actin filament length and impairment of myosin binding to actin, whereas titin is thought to regulate muscle passive elasticity and is likely involved in length-dependent activation. Here, we sought to assess the modulation of muscle function by these sarcomeric proteins by using the computational platform muscle simulation code (MUSICO) to quantitatively separate the effects of structural changes, kinetics of cross-bridge cycling, and calcium sensitivity of the thin filaments...
April 4, 2019: Journal of General Physiology
https://read.qxmd.com/read/30902836/inhale-exhale-probing-the-inside-out-mechanism-of-nicotine-addiction-using-novel-fluorescent-sensors
#14
Owen B McManus, Christopher A Werley, Graham T Dempsey
No abstract text is available yet for this article.
March 22, 2019: Journal of General Physiology
https://read.qxmd.com/read/30898841/mentors-doing-science-with-alan-hodgkin
#15
Denis A Baylor
No abstract text is available yet for this article.
March 21, 2019: Journal of General Physiology
https://read.qxmd.com/read/30890556/the-enduring-relationship-between-myosin-enzymatic-activity-and-the-speed-of-muscle-contraction
#16
REVIEW
Richard L Moss, R John Solaro
No abstract text is available yet for this article.
March 19, 2019: Journal of General Physiology
https://read.qxmd.com/read/30886053/under-pressure-ano1-mediates-pressure-sensing-in-the-lymphatic-system
#17
Maiwase Tembo, Anne E Carlson
No abstract text is available yet for this article.
March 18, 2019: Journal of General Physiology
https://read.qxmd.com/read/30877142/mitoflash-biogenesis-and-its-role-in-the-autoregulation-of-mitochondrial-proton-electrochemical-potential
#18
Gaomin Feng, Beibei Liu, Jinghang Li, Tianlei Cheng, Zhanglong Huang, Xianhua Wang, Heping Peace Cheng
Respiring mitochondria undergo an intermittent electrical and chemical excitation called mitochondrial flash (mitoflash), which transiently uncouples mitochondrial respiration from ATP production. How a mitoflash is generated and what specific role it plays in bioenergetics remain incompletely understood. Here, we investigate mitoflash biogenesis in isolated cardiac mitochondria by varying the respiratory states and substrate supply and by dissecting the involvement of different electron transfer chain (ETC) complexes...
March 15, 2019: Journal of General Physiology
https://read.qxmd.com/read/30872560/comparing-models-with-one-versus-multiple-myosin-binding-sites-per-actin-target-zone-the-power-of-simplicity
#19
Alf Månsson
Mechanokinetic statistical models describe the mechanisms of muscle contraction on the basis of the average behavior of a large ensemble of actin-myosin motors. Such models often assume that myosin II motor domains bind to regularly spaced, discrete target zones along the actin-based thin filaments and develop force in a series of strain-dependent transitions under the turnover of ATP. The simplest models assume that there is just one myosin-binding site per target zone and a uniform spatial distribution of the myosin motor domains in relation to each site...
March 14, 2019: Journal of General Physiology
https://read.qxmd.com/read/30872559/small-calcium-leaks-big-muscle-adaptations
#20
Caitlin Sedwick
JGP study finds that mild calcium leak is associated with improved resistance to muscle fatigue.
March 14, 2019: Journal of General Physiology
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