Martin K Madsen, Anja Sofie Petersen, Dea S Stenbaek, Inger Marie Sørensen, Harald Schiønning, Tobias Fjeld, Charlotte H Nykjaer, Sara Marie Ulv Larsen, Maria Grzywacz, Tobias Mathiesen, Ida L Klausen, Oliver Overgaard-Hansen, Kristoffer Brendstrup-Brix, Kristian Linnet, Sys S Johansen, Patrick M Fisher, Rigmor H Jensen, Gitte M Knudsen
OBJECTIVE: To evaluate the feasibility and prophylactic effect of psilocybin as well as its effects on hypothalamic functional connectivity (FC) in patients with chronic cluster headache (CCH). BACKGROUND: CCH is an excruciating and difficult-to-treat disorder with incompletely understood pathophysiology, although hypothalamic dysfunction has been implicated. Psilocybin may have beneficial prophylactic effects, but clinical evidence is limited. METHODS: In this small open-label clinical trial, 10 patients with CCH were included and maintained headache diaries for 10 weeks...
January 2024: Headache