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Folia Medica

Diogo Telles-Correia, Sérgio Saraiva, João Gama Marques
Karl Jaspers published the first edition of 'General Psychopathology' in 1913. Now, coinciding with its 100th anniversary whose importance was consecrated through multiple congresses, we see a parallelism and a return to the dilemma of the 'Methodenstreit', which led Karl Jaspers to introduce the phenomenological method for psychopathology to understand the subjective manifestations of the mind. Phenomenology is part of the research and clinical methods in psychiatry and psychology as a way to capture the subjective in psychopathology...
September 1, 2018: Folia Medica
Ivo S Petrov, Arman Sh Postadzhiyan, Mariya P Tokmakova, Lyudmila G Kitova, Svetlin N Tsonev, Janet Addison, Reneta T Petkova, Vasil I Lachev
BACKGROUND: Familial hypercholesterolaemia (FH) is a genetic disorder causing accelerated atherosclerosis and premature cardiovascular disease (CVD). This retrospective observational study examined the clinical characteristics and management of FH subjects in Bulgaria over a 12-month period. MATERIALS AND METHODS: Twelve cardiology sites participated in this study from May 2015 to May 2016. Eligible subjects had at least two routine low-density lipo-protein cholesterol (LDL C) measurements and a prescription for lipid-lowering therapy (LLT) at the start of the observation period...
September 1, 2018: Folia Medica
Özlem Çakın, Gokhan Tazegul, Ayça Gümüş, Melike Cengiz, Atilla Ramazanoğlu
Aluminum phosphide (AlP) is a commonly used cheap rodenticide, insecticide, and fumigant. Most intoxications in the literature are suicidal ingestions, however, AlP may cause incidental inhalational toxicities as well. After ingestion or inhalation, nausea, vomiting, dyspnea and abdominal pain develops within minutes. Hallmark of toxicity is refractory hypotension, cardiac failure and severe metabolic acidosis developing within a matter of hours are the major cause of mortality. In Turkey, AlP tablets are widely accessible and are sold without any restrictions...
September 1, 2018: Folia Medica
Ermira Krasniqi, Mynyr Koni, Idriz Berisha, Arben Boshnjaku
AIM: The present study analyzes the adherence phenomenon and possible correlations between active individuals and their educational status on the prevalence of medicine use in the population of a young and developing country such as Kosova. MATERIALS AND METHODS: This is an observational, cross-sectional, research study including a total number of 162 subjects aged 40-65 years residents of Kosova. Gender distribution was: 32.7% males and 67.3% females. Assessments of medication adherence and compliance, the level of physical activity (PA), and education were made by reliable and validated questionnaires...
September 1, 2018: Folia Medica
Farzad Khademi, Arshid Yousefi-Avarvand, Amirhossein Sahebkar, Fahimeh Ghanbari, Hamid Vaez
BACKGROUND: Bacterial infections are the most common complications in people with HIV/AIDS. There has been no previous report on the prevalence of bacterial co-infections in Iranian HIV/AIDS-positive subjects. AIM: To evaluate the frequency of bacterial infections in hospitalized HIV/AIDS-infected patients in Iran. MATERIALS AND METHODS: Based on PRISMA guidelines, a computerized search in related data banks using relevant keywords was performed in both Persian and English languages for articles that were published until March 10, 2017...
September 1, 2018: Folia Medica
Radostina V Cherneva, Dimitar T Kostadinov
Biomarker research in COPD is becoming the most rapidly progressing sphere in respiratory medicine. Although "omics" generate a huge amount of biomarkers, fibrinogen is the only one validated by the European Medicines Agency. Thousands of studies analyzing different biological samples from the respiratory tract, collected in different ways, using various kits and techniques are generating more and more data, rendering biomarkers very confusing rather than having practical value. It seems that in order to be applicable and validated, biomarkers should be analysed in an accurately described cohort of patients, homogeneous in disease severity and activity...
September 1, 2018: Folia Medica
Slaveyko N Djambazov, Toni Y Vekov, Evgeni V Mekov, Georgi S Slavchev, Rosen E Petkov, Dimitar T Kostadinov, Ljubliana T Konteva
BACKGROUND: Patients with non-small-cell lung cancer (NSCLC) with anaplastic lymphoma kinase (ALK) rearrangement mutation are found to be 3-13%. AIM: To evaluate the prevalence of ALK mutations in EGFR-negative NSCLC patients in Bulgaria. MATERIALS AND METHODS: One hundred and thirty-two patients with EGFR-negative NSCLC were examined for ALK mutation analysis between January and June 2016. Data were obtained from patients' register of four major oncological hospitals in Bulgaria...
September 1, 2018: Folia Medica
Valeri Y Andreev, Nikolay A Yanev, Stefan K Stanimirov, Ivan N Ivanov, Savelina L Popovska, Petkana A Hristova, Yavor Y Ivanov
BACKGROUND: Autofluorescence bronchoscopy (AFB) allows a more sensitive approach to the diagnosis of premalignant and malignant endobronchial lesions than white light bronchoscopy (WLB) can do. AIM: To assess the autofluorescence bronchoscopy and white light bronchoscopy in diagnosing malignant endobronchial lesions. MATERIALS AND METHODS: The design of the study is a retrospective case-control study. Thirty-two parameters were entered into an Excel file and analysed with SPSS v...
September 1, 2018: Folia Medica
Konstantinos Dinas, Georgios C Pratilas, Maria Nasioutziki, Eleftherios Vavoulidis, Vasileios Makris, Panagiotis D Loufopoulos, Matthias Kalder
BACKGROUND: Fine needle aspiration cytology (FNAC) has been and still is challenged about its role in the management of breast lesions. Guidelines today mandate that breast lesions should be managed with a triple assessment system consisting of clinical, radiological, and pathological evaluation. AIM: This article will try and clarify whether FNAC stands as a tool in this assessment. MATERIALS AND METHODS: PubMed was searched for articles concerning prospective, retrospective and review studies about clinical applications of FNAC...
September 1, 2018: Folia Medica
Mariela P Tsanova, Neshka A Manchorova-Veleva, Nonka G Mateva, Snejana Ts Tsanova
BACKGROUND: Dental applications of CAD/CAM concept have been available for almost 30 years. They have allowed dentists to work with novel materials with better properties. One of these materials is zirconia ceramic. AIM: To evaluate prospectively the longevity of CAD/CAM indirect zirconia restorations of severely destroyed vital molars and to study the risk factors associated with restoration failures. MATERIALS AND METHODS: Thirty-two indirect zirconia restorations were made in 19 patients...
September 1, 2018: Folia Medica
Atanas G Baltadjiev, Stefka V Vladeva, Dimitar B Bahariev
BACKGROUND: The complex study of adipose tissue in women with type 2 diabetes mellitus (T2DM) is of importance for the clinical course and prognosis of the disease. AIM: To study the distribution of adipose tissue in Bulgarian females with T2DM. PATIENTS AND METHODS: The study included 92 women with T2DM (age range 40-60 years). The control group consisted of 40 age-matched women. Measurement parameters: height, weight, 9 skinfolds (sf) - sfTriceps, sfBiceps brachii, sfForearm, sfSubscapular, sfXrib, sfAbdomen, sfSuprailiaca, sfThigh, and sfCalf; bioelectrical impedance analysis - % body fat tissue and visceral fat tissue...
September 1, 2018: Folia Medica
Violeta I Getova, Stanislav R Georgiev, Assena H Stoimenova, Elina S Petkova-Georgieva
BACKGROUND: Since 2012, in compliance with the changes in the European legislation, the Bulgarian Drug Agency (BDA) has been receiving adverse drug reaction (ADR) reports directly from patients as well as from healthcare professionals and marketing authorization holders (MAH). Adverse reaction reports from patients and consumers have different characteristics from those sent by healthcare professionals. Moreover, they may require specific algorithm and assessment methods in order to be informative and beneficial to the pharmacovigilance system...
September 1, 2018: Folia Medica
Maria Z Mutafchieva, Milena N Draganova-Filipova, Plamen I Zagorchev, Georgi T Tomov
BACKGROUND: The erosive-atrophic form of oral lichen planus (OLP) is associated with severe pain and burning sensation and is often unresponsive to treatment. Topical corticosteroids are considered as a medication of first choice but they can produce adverse effects. Therefore, new therapeutic approaches are required. AIM: The aim of this study was to investigate the effectiveness of biomodulation with diode laser in patients presenting with long-standing erosive-atrophic OLP...
September 1, 2018: Folia Medica
Domenico Fenga, Michele A Rosa
Management of bone tumors of the limbs is still a field to be explored. The problems to be faced are diff erent, especially when the lower limbs are the point of interest, due to the diff erent leg length residual. A possible solution, provided by new technologies, is the use of electromagnetic expandable prosthesis. This device is successfully used in the management of paediatric malignant bone tumors. The strength of this prosthesis is the possibility to assist the musculoskeletal growth in children. To our acknowledge review of literature points out only few cases in which this mechanism is used in adult population...
September 1, 2018: Folia Medica
Antonio Ortin-Barcelo, David J Ortolà Morales, Michele Attilio Rosa, Domenico Fenga, Miguel A Bañuls-Pattarelli, Fernando A Lopez-Prats
We present a series of cases of type A3.1.2 unstable fractures of the thoracolumbar hinge treated percutaneously with third-generation kyphoplasty and only one next level percutaneous screws. Four women aged 75 to 85 years with thoracolumbar vertebral fractures, classified as type A.3.1.2, were treated with Precept® monosegmental percutaneous fixation and the third-generation SpineJack® augmentation system. The traditional treatment of type A3 unstable vertebral wedging fractures is performed with transpedicular fixation of two or more levels adjacent to the fracture causing great rigidity...
September 1, 2018: Folia Medica
Ali Noorafshan, Reza Asadi-Golshan, Mahboobeh Erfanizadeh, Saied Karbalay-Doust
BACKGROUND: Olive oil is a food additive and used in many biological studies as a solvent for other chemicals, including drugs. AIM: The present study aimed to investigate the effects of olive oil on rats' cerebellum structure and motor function. MATERIALS AND METHODS: Male rats were randomly divided into two groups orally receiving distilled water and olive oil (1 ml/kg/day). At the end of week 4, motor function was assessed in the rotarod test...
September 1, 2018: Folia Medica
Hristina I Zlatanova, Ilin K Kandilarov, Ilia D Kostadinov, Delian P Delev, Maria T Georgieva-Kotetarova
BACKGROUND: Antidepressants have been found to possess antinociceptive and analgesic properties and are prescribed in the treatment of chronic pain. AIM: To evaluate the antinociceptive properties of escitalopram after a single administration. MATERIALS AND METHODS: Forty Wistar rats were used in the study. They were divided into 5 groups (n=8) treated with saline solution (control group), metamizole (150 mg/kg b.w.), escitalopram (5, 10 and 20 mg/kg b...
September 1, 2018: Folia Medica
Elena V Elefterova-Florova, Dora N Popova, Rositsa V Andreeva
Food-dependent exercise-induced anaphylaxis (FDEIA) is an unusual and under-recognized form of exercise induced anaphylaxis, which usually occurs if exercise takes place within a few hours after ingestion of sensitizing food, but in some cases may also arise if food follows the exercise. We report a case of a 31-year-old woman who presented to our Department with a history of repeated episodes of acute allergic reactions, triggered by physical activity, after consumption of various vegetables and legumes. This is the first described case of FDEIA in Bulgaria...
September 1, 2018: Folia Medica
Saime G Sagiroglu, Sezen Koçaslan, Selman Sarica, Nagihan Bilal, Israfil Orhan
Chordomas are rare malignant tumors that develop from the residual of embryonic notochord. These tumors may be seen along the spine and have a local aggressive progression. Skull base chordomas often originate from the clivus as localization. These tumors are usually found to be overgrown when they are diagnosed. They are locally invasive and rarely develop distant metastasis. These chordomas cannot usually be completely removed due to their localization. Because these tumors are advanced at the time of diagnosis and are adjacent to important structures, they are among the tumors with high rates of mortality and morbidity...
September 1, 2018: Folia Medica
Mustafa Sungur, Selahattin Çalışkan
BACKGROUND: Prostate cancer (PCa) is the second most common cancer and sixth most common cause of cancer associated death among men in the world. Multiple studies demonstrated the relationship between obesity and PCa in the recent years. AIM: The present study aimed to investigate the impact of obesity on postoperative oncological results after radical prostatectomy. MATERIALS AND METHODS: A total of 110 patients who were treated radical prostatectomy between January 2011 and April 2016 were analyzed retrospectively...
June 1, 2018: Folia Medica
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