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Journals Toxicon : Official Journal of ...

Toxicon : Official Journal of the International Society on Toxinology

https://read.qxmd.com/read/38642905/deciphering-the-interactions-of-scopoletin-and-scopolin-from-catunaregam-nilotica-roots-against-naja-nigricollis-phospholipase-a-2-enzyme
#1
JOURNAL ARTICLE
M Salihu, L G Hassan, U Z Faruq, A J Yusuf
Catuneragam nilotica has been used in ethnomedicine to treat snakebite, inflammation, and diarrhea among others. The aim of this research is to isolate, and characterize potential potential phospholipase A2 (PLA2 ) inhibitors from the roots of C. nilotica. The plant material was collected, authenticated, and sequentially extracted using solvents of increasing polarity starting from n-hexane, ethyl acetate, and methanol. The extracts as reported in our previous work, were screened in vitro for their inhibitory activity against PLA2 enzyme from N...
April 18, 2024: Toxicon: Official Journal of the International Society on Toxinology
https://read.qxmd.com/read/38642904/evaluation-on-the-traditional-safe-use-of-kochiae-fructus-oriented-by-antioxidant-properties-and-oral-safety-of-its-ethanolic-extract
#2
JOURNAL ARTICLE
Xuelin Chen, Kun Zhang, Hanlei Wang, Xia Zhao, Yumei Zhang
Kochiae Fructus (KF) is a traditional Chinese medicine, which has been used to delay aging and treat inflammation, such as rubella, eczema, cutaneous pruritus, etc. In order to fully understand the traditional medicinal value of KF, we evaluated the antioxidant properties and oral safety of its ethanolic extract. Considering flavonoids and phenolics in medicinal plants generally have strong antioxidant activity, we firstly detected the total flavonoids and phenolics contents of KFEE and its fractions. Secondly, we evaluated the antioxidant activities of KFEE and its fractions...
April 18, 2024: Toxicon: Official Journal of the International Society on Toxinology
https://read.qxmd.com/read/38636613/alleviation-of-microcystin-leucine-arginine-induced-hepatotoxicity-an-updated-overview
#3
REVIEW
Habibeh Mashayekhi-Sardoo, Ramin Rezaee, Bamdad Riahi-Zanjani, Gholamreza Karimi
OBJECTIVES: Contamination of surface waters is a major health threat for all living creatures. Some types of blue-green algae that naturally occur in fresh water, are able to produce various toxins, like Microcystins (MCs). Microcystin-leucine arginine (MC-LR) produced by Microcystis aeruginosa is the most toxic and abundant isoforms of MCs, and it causes hepatotoxicity. The present article reviews preclinical experiments examined different treatments, including herbal derivatives, dietary supplements and drugs against MC-LR hepatotoxicity...
April 16, 2024: Toxicon: Official Journal of the International Society on Toxinology
https://read.qxmd.com/read/38636612/sudden-peak-in-tetrodotoxin-in-french-oysters-during-the-summer-of-2021-source-investigation-using-microscopy-metabarcoding-and-droplet-digital-pcr
#4
JOURNAL ARTICLE
Laura Biessy, John K Pearman, Kenneth Neil Mertens, Damien Réveillon, Véronique Savar, Philipp Hess, Hannah Hampton, Lucy Thompson, Luc Lebrun, Aouregan Terre-Terrillon, Kirsty F Smith
Tetrodotoxin (TTX) is a potent neurotoxin causing human intoxications from contaminated seafood worldwide and is of emerging concern in Europe. Shellfish have been shown to contain varying TTX concentrations globally, with concentrations typically higher in Pacific oysters Crassostrea gigas in Europe. Despite many decades of research, the source of TTX remains unknown, with bacterial or algal origins having been suggested. The aim of this study was to identify potential source organisms causing TTX contamination in Pacific oysters in French coastal waters, using three different techniques...
April 16, 2024: Toxicon: Official Journal of the International Society on Toxinology
https://read.qxmd.com/read/38631492/naja-nigricincta-nigricincta-venom-a-murine-model-evaluation-of-skeletal-and-cardio-myonecrosis-kidney-injury-and-inflammatory-response-along-with-neutralisation-efficacy-by-the-saimr-savp-and-echitab-plus-icp-polyvalent-antivenoms
#5
JOURNAL ARTICLE
Esta L Saaiman Engelbrecht, Vinny Naidoo, Christo J Botha
African spitting cobra, Naja nigricincta nigricincta (Zebra snake), envenomation is an important cause of snakebite morbidity and mortality in Namibia. The snake is endemic to central and northern Namibia as well as southern Angola. The venom is mainly cytotoxic, resulting in aggressive dermo-necrosis and often accompanied by severe systemic complications. No specific antivenom exists. Rhabdomyolysis, systemic inflammatory response, haemostatic abnormalities, infective necrotising fasciitis as well as acute kidney failure have been documented...
April 15, 2024: Toxicon: Official Journal of the International Society on Toxinology
https://read.qxmd.com/read/38626820/efficacy-of-maturase-k-and-rpl20-protein-extracted-from-c-procera-leaves-on-anopheles-stephensi
#6
JOURNAL ARTICLE
Manisha Kirar, S P Singh, Hitesh Singh, Neelam Sehrawat
The present work is carried out to protein isolation, purification, and characterization from leaves, stem, and seed of C. procera and to evaluate the larvicidal potential on Anopheles stephensi. The whole protein was isolated using protein extraction buffer and precipitated by ammonium sulphate and larvicidal active protein was purified by the column chromatography. The homogeneity of larvicidal protein was confirmed by the SDS-PAGE. The identification of protein was done by the HPLC and LC-MS/ESI-MS. The crude protein from leaves showed 100% mortality of 3rd instar larvae of An...
April 14, 2024: Toxicon: Official Journal of the International Society on Toxinology
https://read.qxmd.com/read/38615997/interaction-of-beauvericin-in-combination-with-antibiotics-against-methicillin-resistant-staphylococcus-aureus-and-salmonella-typhimurium
#7
JOURNAL ARTICLE
Vásquez Bonilla J Norberto, Barranco Florido J Esteban, A Hamdan Partida, Ponce Alquicira Edith, Octavio Loera
Multidrug resistance in bacteria is a major challenge worldwide, increasing both mortality by infections and costs for the health systems. Therefore, it is of utmost importance to find new drugs against resistant bacteria. Beauvericin (BEA) is a mycotoxin produced by entomopathogenic and other fungi of the genus Fusarium. Our work determines the effect of BEA combined with antibiotics, which has not been previously explored. The combination analysis included different antibiotics against non-methicillin-resistant Staphylococcus aureus (NT-MRSA), methicillin-resistant Staphylococcus aureus (MRSA), and Salmonella typhimurium...
April 12, 2024: Toxicon: Official Journal of the International Society on Toxinology
https://read.qxmd.com/read/38615996/using-network-pharmacology-and-molecular-docking-to-uncover-the-mechanism-by-which-quercetin-alleviates-deoxynivalenol-induced-porcine-intestinal-injury
#8
JOURNAL ARTICLE
Pu Guo, Xuemin Li, Yunda Xue, Qirong Lu, Yu Liu, Jianglin Xiong, Zhongyuan Wu, Shulin Fu, Chun Ye, Xu Wang, Yinsheng Qiu
Deoxynivalenol is a widespread feed contaminant that leads to vomit, which results in serious symptom such as increased intestinal permeability and even intestinal mucosal necrosis. Recent studies have reported the role of quercetin in alleviating deoxynivalenol-induced intestinal injury; however, the mechanisms and targets remain unclear. Thus, we aimed to identify the mechanisms of action by using a combination of network pharmacology and molecular docking. We identified 151 quercetin targets, 235 deoxynivalenol targets and 47 porcine intestinal injury targets by searching compound database and PubMed database, among which there were two common targets...
April 12, 2024: Toxicon: Official Journal of the International Society on Toxinology
https://read.qxmd.com/read/38614247/role-of-nitric-oxide-and-signaling-pathways-modulating-the-stimulatory-effect-of-snake-venom-secretory-pla-2-s-on-non-opsonized-zymosan-phagocytosis-by-macrophages
#9
JOURNAL ARTICLE
Juliana Pavan Zuliani, José María Gutiérrez, Catarina Teixeira
The phagocytic activity of macrophages activated with MT-II, a Lys-49 PLA2 homolog, and MT-III, an Asp-49 PLA2 , from Bothrops asper snake venom, was investigated in this study using a pharmacological approach. Stimulating thioglycollate-elicited macrophages with both venom components enhanced their ability to phagocytose non-opsonized zymosan particles. MT-II and MT-III-induced phagocytosis was drastically inhibited by pretreating cells with L-NAME, aminoguanidine or L-NIL, cNOS or iNOS inhibitors, or with ODQ (sGC inhibitor) or Rp-cGMPS (PKG inhibitor)...
April 11, 2024: Toxicon: Official Journal of the International Society on Toxinology
https://read.qxmd.com/read/38614246/individual-cytotoxicity-of-three-major-type-a-trichothene-t-2-ht-2-and-diacetoxyscirpenol-in-human-jurkat-t-cells
#10
JOURNAL ARTICLE
Phattarawadee Wattanasuntorn, Patchara Phuktes, Saranya Poapolathep, Sontana Mimapan, Muncharee Tattiyapong, Johanna Fink-Gremmels, Isabelle P Oswald, Amnart Poapolathep
Mycotoxins are toxic, fungal secondary metabolites that contaminate agricultural commodities, food, and feed. Among them, T-2, HT-2, and diacetoxyscirpenol (DAS; the major type A trichothecene) are primarily produced from Fusarium species. These mycotoxins exert numerous toxicological effects in animals and humans, such as dermatotoxicity, haematotoxicity, hepatotoxicity, nephrotoxicity, neurotoxicity, and immunotoxicity. In the present study, human Jurkat T cells were used as a model to investigate apoptotic cell death induced by T-2, HT-2, and DAS...
April 11, 2024: Toxicon: Official Journal of the International Society on Toxinology
https://read.qxmd.com/read/38614245/intravenous-administration-of-recombinant-ph%C3%AE-1%C3%AE-antinociceptive-properties-and-morphine-tolerance-reversal-in-a-cancer-associated-pain-model
#11
JOURNAL ARTICLE
Mariana de Melo Cardoso, Rahisa Scussel, Jessica da Silva Abel, Fernando Oriques Pereira, Lidiane Anastácio Cruz, Franciane da Costa Constante, Ellen De Pieri, Helena Mendes Abelaira, Juliano Ferreira, Marcus Vinícius Gomez, Flávia K Rigo, Ricardo Andrez Machado-de-Ávila
Cancer-related pain is considered one of the most prevalent symptoms for those affected by cancer, significantly influencing quality of life and treatment outcomes. Morphine is currently employed for analgesic treatment in this case, however, chronic use of this opioid is limited by the development of analgesic tolerance and adverse effects, such as digestive and neurological disorders. Alternative therapies, such as ion channel blockade, are explored. The toxin Phα1β has demonstrated efficacy in blocking calcium channels, making it a potential candidate for alleviating cancer-related pain...
April 11, 2024: Toxicon: Official Journal of the International Society on Toxinology
https://read.qxmd.com/read/38614244/synergistic-effects-of-metformin-and-forskolin-on-oxidative-stress-induced-by-diabetes-and-hepatocellular-cancer-an-animal-study
#12
JOURNAL ARTICLE
Qian Yang, Mohammed Abed Jawad, Abdullah Ali Alzahrani, Zahraa F Hassan, Ahmed Elawady, Ahmed Hjazi, Mehran Naghibi
AIM: This study proposed to assess the synergistic effects of Forskolin and Metformin (alone and in combination) on glucose, hematological, liver serum, and oxidative stress parameters in diabetic, healthy, and hepatocellular carcinoma (HCC) induced rats. MATERIALS AND METHODS: Eighty male Wistar rats were divided into 10 experimental groups (8 rats for each group), including 1) healthy group, 2) diabetic group, 3) HCC group, 4) diabet+Metformin (300 mg/kg), 5) diabet+Forskolin (100 mg/kg), 6) diabet+Metformin (300 mg/kg) & Forskolin (100 mg/kg), 7) HCC+Metformin (300 mg/kg), 8) HCC+Forskolin (100 mg/kg), 9) HCC+Metformin (300 mg/kg) & Forskolin (100 mg/kg), and 10) healthy group+Metformin (300 mg/kg) & Forskolin (100 mg/kg)...
April 11, 2024: Toxicon: Official Journal of the International Society on Toxinology
https://read.qxmd.com/read/38614243/pine-needle-abortions-in-cattle-due-to-consumption-of-pinus-ponderosa-in-argentina-case-reports
#13
A Martinez, R Apostolo, R Herrera, D Gardner, L Borrelli, G Zabaleta, C Robles, J Ferrería
Two outbreaks of pine needle abortions in cattle are here reported for the first time in Argentina. The cases occurred in Chubut and Neuquén provinces in the Patagonia region, causing 29.6% and 9% of abortions in each herd respectively. In both outbreaks, the dams were in the last third of gestation, and, due to a period of cold, snow and lack of available forage, they gained access to Pinus ponderosa and Pinus contorta forests. No pathological lesions, serological, molecular, or microbiological evidence of infectious causes were observed in any of the six fetuses analyzed...
April 11, 2024: Toxicon: Official Journal of the International Society on Toxinology
https://read.qxmd.com/read/38583578/the-pla-2-inhibitor-from-crotalus-durissus-terrificus-blood-plasma-cnf-inhibits-group-iii-pla-2-from-honeybee-venom
#14
JOURNAL ARTICLE
Paula Ladeira Ortolani, Patrícia Cota Campos, Consuelo Latorre Fortes-Dias
Crotalus neutralizing factor (CNF) is an endogenous glycoprotein from Crotalus durissus terrificus snake blood that inhibits secretory phospholipases A2 (sPLA2 ) from the Viperid but not from Elapid venoms (subgroups IA and IIA, respectively). In the present study, we demonstrated that CNF can inhibit group III-PLA2 from bee venom by forming a stable enzyme-inhibitor complex. This finding opens up new possibilities for the potential use of CNF and/or CNF-based derivatives in the therapeutics of bee stings.
April 5, 2024: Toxicon: Official Journal of the International Society on Toxinology
https://read.qxmd.com/read/38579983/cu-doped-fe-3-o-4-nanoparticles-for-efficient-detoxification-of-epsilon-toxin-toward-substituting-magnetically-recyclable-detoxifying-agent-for-formaldehyde
#15
JOURNAL ARTICLE
Parvaneh Esmaeilnejad-Ahranjani, Marzieh Lotfi, Azadeh Zahmatkesh, Abbass Ali Esskandary
This research presents the synthesis and characterization of Cu-doped Fe3 O4 (Cu-Fe3 O4 ) nanoparticles as a magnetically recoverable and reusable detoxifying agent for the efficient and long-lasting neutralization of bacterial toxins. The nanoparticles were synthesized using the combustion synthesis method and characterized through SEM, XRD, BET, TGA, and VSM techniques. The detoxification potential of Cu-Fe3 O4 was compared with traditional formaldehyde (FA) in detoxifying epsilon toxin (ETx) from Clostridium perfringens Type D, the causative agent of enterotoxemia in ruminants...
April 3, 2024: Toxicon: Official Journal of the International Society on Toxinology
https://read.qxmd.com/read/38579982/temporal-variation-in-the-concentrations-and-profiles-of-paralytic-shellfish-toxins-and-tetrodotoxin-in-scallop-mizuhopecten-yessoensis-and-bloody-clam-anadara-broughtonii-collected-from-the-coast-of-miyagi-prefecture-japan
#16
JOURNAL ARTICLE
Tatsunari Shingai, Yoshiko Chiba, Mitsue Kondo, Mari Yotsu-Yamashita
For food safety, the concentrations and profiles of paralytic shellfish toxins (PSTs) and tetrodotoxin were examined in economically important scallops and bloody clams collected from the coast of the Miyagi Prefecture, Japan. PSTs were the major toxins in both species. The tetrodotoxin concentration in scallops increased in summer, although the highest value (18.7 μg/kg) was lower than the European Food Safety Authority guideline threshold (44 μg/kg). This confirmed the safety for tetrodotoxin in this area...
April 3, 2024: Toxicon: Official Journal of the International Society on Toxinology
https://read.qxmd.com/read/38574827/exploration-of-antimicrobial-and-anticancer-activities-of-l-amino-acid-oxidase-from-egyptian-naja-haje-venom
#17
JOURNAL ARTICLE
Walaa H Salama, Ahmed A Abd-Rabou, Roqaya I Bassuiny, Amr E ElHakim, Yasser E Shahein
Hepatocellular carcinoma and bacterial resistance are major health burdens nowadays. Thus, providing new therapies that overcome that resistance is of great interest, particularly those derived from nature rather than chemotherapeutics to avoid cytotoxicity on normal cells. Venomous animals are among the natural sources that assisted in the discovery of novel therapeutic regimens. L-amino acid oxidase Nh-LAAO (140 kDa), purified from Egyptian Naja haje venom by a successive two-step chromatography protocol, has an optimal pH and temperature of 8 and 37 °C...
April 2, 2024: Toxicon: Official Journal of the International Society on Toxinology
https://read.qxmd.com/read/38570167/acute-death-as-a-result-of-poisoning-tropical-bos-taurus-indicus-but-not-temperate-bos-taurus-taurus-cattle-after-oral-dosing-with-lupinus-leucophyllus-velvet-lupine
#18
JOURNAL ARTICLE
Benedict T Green, Kevin D Welch, Stephen T Lee, T Zane Davis, Clinton A Stonecipher, Bryan L Stegelmeier, Daniel Cook
Due to climate change and increasing summer temperatures, tropical cattle may graze where temperate cattle have grazed, exposing tropical cattle to toxic plants they may be unfamiliar with. This work compared the toxicity of Lupinus leucophyllus (velvet lupine) in temperate and tropical cattle. Orally dosed velvet lupine in tropical cattle caused death. If producers opt to graze tropical cattle, additional care must be taken on rangelands where toxic lupines like velvet lupine grow.
April 1, 2024: Toxicon: Official Journal of the International Society on Toxinology
https://read.qxmd.com/read/38565396/protobothrops-jerdonii-jerdon-s-pit-viper-and-protobothrops-himalayanus-bites-clinical-report-on-envenomings-from-north-east-india-managed-through-remote-consultation-by-a-national-level-poison-control-center
#19
Ravikar Ralph, Deepak Sharma, Rohit Jain, Amith Balachandran, Yu-Wei Chiang, Ganesh S R
Members of the genus Protobothrops are amongst the more than twenty-eight range-restricted Indian pit-viper species. Their bites and envenomings are rarely documented from India. Pit-viper envenomings can be challenging to treat in the Indian setting, since available antivenoms do not satisfactorily neutralize their venoms. Herein, we present the first Indian reports on bites and envenoming by Protobothrops jerdonii and Protobothrops himalayanus resulting in local effects, coagulopathy and acute kidney injury in the case of the former and possible mild, isolated coagulopathy in the case of the latter; and discuss management-related challenges in the context of absent specific antivenoms...
March 31, 2024: Toxicon: Official Journal of the International Society on Toxinology
https://read.qxmd.com/read/38556062/knockdown-of-lncrna-neat1-suppresses-streptococcus-pneumoniae-induced-ferroptosis-in-alveolar-epithelial-cells-by-regulating-the-nrf2-gpx4-pathway
#20
JOURNAL ARTICLE
Lin Xu, Lu Zhang, Yang Xiang, Xiangyan Zhang
OBJECTIVES: Streptococcus pneumoniae (SP) is a major cause of community-acquired pneumonia. Ferroptosis pitches in pneumonia. Long noncoding RNA nuclear paraspeckle assembly transcript 1 (lncRNA NEAT1) regulates ferroptosis in various cells. Therefore, this study probed the mechanism of lncRNA NEAT1 on SP-induced ferroptosis in AECs. METHODS: Serum lncRNA NEAT1 level in 36 streptococcus pneumonia patients were retrospectively detected, with its correlations with inflammatory factor (TNF-α/IL-1β/IL-6) levels analyzed...
March 29, 2024: Toxicon: Official Journal of the International Society on Toxinology
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