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JOURNAL ARTICLE
Rashmi Dhital, Neha Chiruvolu Singh, Andrea M Spiker, Dilli Ram Poudel, Brian Pedersen, Christie M Bartels
OBJECTIVE: Avascular necrosis (AVN) is a devastating complication often necessitating arthroplasty, particularly common in systemic lupus erythematosus (SLE). Limited research exists on arthroplasty trends since new steroid-sparing agents. We analyzed trends and characteristics associated with AVN and AVN-related arthroplasties among SLE and RA hospitalizations using two decades of data from the U.S. National Inpatient Sample (NIS). METHODS: This cross-sectional study used NIS (2000-2019) to identify hospitalized adults with SLE and RA, with or without AVN, using ICD codes...
April 10, 2024: Seminars in Arthritis and Rheumatism
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JOURNAL ARTICLE
Jessica L Fairley, Dylan Hansen, Susanna Proudman, Joanne Sahhar, Gene-Siew Ngian, Jenny Walker, Lauren V Host, André La Gerche, David Prior, Andrew Burns, Kathleen Morrisroe, Wendy Stevens, Mandana Nikpour, Laura Ross
OBJECTIVES: To quantify the frequency and clinical implications of systemic sclerosis (SSc)-associated left ventricular function (LV) impairment. METHODS: Australian Scleroderma Cohort Study participants meeting ACR/EULAR criteria for SSc with ≥1 echocardiographic LVEF measurement were included. Overt LV dysfunction was indicated by reduced LV ejection fraction (LVEF) and subclinical LV dysfunction was measured using impaired LV global longitudinal strain (LV-GLS>-16 %)...
April 6, 2024: Seminars in Arthritis and Rheumatism
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JOURNAL ARTICLE
Calvo-Paramo Enrique, Santos Ana María, Rodríguez-Salas Gustavo, Rueda Igor, Chamorro-Melo Magali, Padilla-Ortiz Diana, Arias-Correal Sofia, Mantilla Marta Juliana, Santacruz Juan Camilo, Rueda Juan Camilo, Cristian Mesa, Porras Marlon, Segura Charry Juan Sebastián, Giraldo-Cadavid Luis F, Pacheco-Tena Cesar, Cardiel Mario Humberto, Santos-Moreno Pedro, Londono John
INTRODUCTION/OBJECTIVES: Enthesitis is a cardinal feature of spondylarthritis (SpA), and the pelvis is a common site of enthesitis. This study aimed to establish the association between pelvic enthesis involvement on pelvic X-ray and SpA diagnosis through a radiographic enthesis index (REI) and to assess the reliability and accuracy of this REI. MATERIALS AND METHODS: The participants were SpA patients and a control group composed of patients with chronic lumbar pain without SpA...
April 4, 2024: Seminars in Arthritis and Rheumatism
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JOURNAL ARTICLE
Wei Liu, Lihong Ye, Baojie Hua, Yudan Yang, Ziwei Dong, Yuqing Jiang, Jiayu Li, Xiaohui Sun, Ding Ye, Chengping Wen, Yingying Mao, Zhixing He
BACKGROUND: Limited research has been conducted on the association between long-term exposure to air pollutants and the incidence of gout. OBJECTIVES: This study aims to assess the individual and combined effects of prolonged exposure to five air pollutants (NO2 , NOx , PM10 , PMcoarse and PM2.5 2 ) on the incidence of gout among 458,884 initially gout-free participants enrolled in the UK Biobank. METHODS: Employing a land use regression model, we utilized an estimation method to ascertain the annual concentrations of the five air pollutants...
March 30, 2024: Seminars in Arthritis and Rheumatism
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JOURNAL ARTICLE
Chan-Mi Lee, Margaret Wang, Aarthi Rajkumar, Cassandra Calabrese, Leonard Calabrese
BACKGROUND/PURPOSE: Vasculitis as an immune-related adverse event (irAE) from checkpoint inhibitor therapy (ICI) to treat cancer is a rare clinical event, and little is known regarding its nosology, clinical manifestations, or response to treatment and outcomes. METHODS: To address these gaps, we used the Preferred Reporting Items for Systemic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) framework to further define this complication. Two independent PUBMED searches in September and November of 2022 revealed 127 publications with 37 excluded from title by relevance, 43 excluded by article type, and 23 excluded due to lack of biopsy results, or biopsy negative for vasculitis...
March 27, 2024: Seminars in Arthritis and Rheumatism
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JOURNAL ARTICLE
Jessica Polo Y la Borda, Santos Castañeda, Fernando Sánchez-Alonso, Zulema Plaza, Carmen García-Gómez, Iván Ferraz-Amaro, Celia Erausquin, Ramón Valls-García, María D Fábregas, Esmeralda Delgado-Frías, Antonio J Mas, Carlos González-Juanatey, Javier Llorca, Miguel A González-Gay
OBJECTIVE: To establish the predictive value of the QRESEARCH risk estimator version 3 (QRISK3) algorithm in identifying Spanish patients with ankylosing spondylitis (AS) at high risk of cardiovascular (CV) events and CV mortality. We also sought to determine whether to combine QRISK3 with another CV risk algorithm: the traditional SCORE, the modified SCORE (mSCORE) EULAR 2015/2016 or the SCORE2 may increase the identification of AS patients with high-risk CV disease. METHODS: Information of 684 patients with AS from the Spanish prospective CARdiovascular in ReuMAtology (CARMA) project who at the time of the initial visit had no history of CV events and were followed in rheumatology outpatient clinics of tertiary centers for 7...
March 27, 2024: Seminars in Arthritis and Rheumatism
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JOURNAL ARTICLE
Isaac Pons, Alba Jeréz, Gerard Espinosa, Ignasi Rodríguez-Pintó, Doruk Erkan, Yehuda Shoenfeld, Ricard Cervera
OBJECTIVE: To analyze the demographic, clinical, and laboratory characteristics of catastrophic antiphospholipid syndrome (CAPS) patients with cardiac involvement, and to identify the factors associated with this cardiac involvement. MATERIAL AND METHODS: Based on the analysis of the "CAPS Registry", the demographic, clinical, and serological characteristics of patients with cardiac involvement were analyzed. Cardiac involvement was defined as heart failure, valvular disease, acute myocardial infarction, pericardial effusion, pulmonary arterial hypertension, systolic dysfunction, intracardiac thrombosis, and microvascular disease...
March 26, 2024: Seminars in Arthritis and Rheumatism
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REVIEW
Heba A T Aref, Tarek Turk, Ruhee Dhanani, Andrew Xiao, Joanne Olson, Pauline Paul, Liz Dennett, Elaine Yacyshyn, Cheryl A Sadowski
INTRODUCTION: Shared decision-making (SDM) tools are facilitators of decision-making through a collaborative process between patients/caregivers and clinicians. These tools help clinicians understand patient's perspectives and help patients in making informed decisions based on their preferences. Despite their usefulness for both patients and clinicians, SDM tools are not widely implemented in everyday practice. One barrier is the lack of clarity on the development and evaluation processes of these tools...
March 19, 2024: Seminars in Arthritis and Rheumatism
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JOURNAL ARTICLE
Antonio Vitale, Valeria Caggiano, Eduardo Martin-Nares, Micol Frassi, Lorenzo Dagna, Pravin Hissaria, Paolo Sfriso, José Hernández-Rodríguez, Guillermo Ruiz-Irastorza, Sara Monti, Abdurrahman Tufan, Matteo Piga, Henrique A Mayrink Giardini, Giuseppe Lopalco, Ombretta Viapiana, Amato De Paulis, Paola Triggianese, Rosetta Vitetta, Alejandra de-la-Torre, Alex Fonollosa, Federico Caroni, Jurgen Sota, Edoardo Conticini, Jessica Sbalchiero, Alessandra Renieri, Giulia Casamassima, Ewa Wiesik-Szewczyk, Derya Yildirim, Andrea Hinojosa-Azaola, Francesca Crisafulli, Franco Franceschini, Corrado Campochiaro, Alessandro Tomelleri, Alicia Callisto, Mark Beecher, Sara Bindoli, Chiara Baggio, Verónica Gómez-Caverzaschi, Laura Pelegrín, Adriana Soto-Peleteiro, Alessandra Milanesi, Ibrahim Vasi, Alberto Cauli, Isabele Parente de Brito Antonelli, Florenzo Iannone, Riccardo Bixio, Francesca Della Casa, Ilaria Mormile, Carmelo Gurnari, Alessia Fiorenza, Germán Mejia-Salgado, Perla Ayumi Kawakami-Campos, Gaafar Ragab, Francesco Ciccia, Piero Ruscitti, Monica Bocchia, Alberto Balistreri, Gian Marco Tosi, Bruno Frediani, Luca Cantarini, Claudia Fabiani
VEXAS syndrome is a recently described monogenic autoinflammatory disease capable of manifesting itself with a wide array of organs and tissues involvement. Orbital/ocular inflammatory manifestations are frequently described in VEXAS patients. The objective of this study is to further describe orbital/ocular conditions in VEXAS syndrome while investigating potential associations with other disease manifestations. In the present study, twenty-seven out of 59 (45.8 %) VEXAS patients showed an inflammatory orbital/ocular involvement during their clinical history...
March 18, 2024: Seminars in Arthritis and Rheumatism
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JOURNAL ARTICLE
Jyoti Panwar, Mirkamal Tolend, Eva Kirkhus, Arthur B Meyers, Bernadette Redd, Iwona Sudol-Szopinska, Nisha Varma, Emilio J Inarejos Clemente, Robert A Colbert, Jonathan Akikusa, Simone Appenzeller, John A Carrino, Nele Herregods, Kerri Highmore, Lennart Jans, Jacob L Jaremko, Thekla von Kalle, Marion A van Rossum, Dax G Rumsey, Hemalatha Srinivasalu, Jennifer Stimec, Shirley M Tse, Marinka Twilt, Nikolay Tzaribachev, Andrea S Doria
Inter-reader reliability of a new scoring system for evaluating joint inflammation and enthesitis in whole body MRI (WBMRI) in juvenile idiopathic arthritis was tested. The scoring system grades 732 item-region combinations of bone marrow and soft tissue changes for commonly involved joints and entheseal sites. Five radiologists rated 17 WBMRI scans through an online rating platform. Item-wise reliability was calculated for 117 items with non-zero scores in >10 % of readings. Interquartile ranges of the five-reader Kappa reliability coefficients were 0...
March 16, 2024: Seminars in Arthritis and Rheumatism
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JOURNAL ARTICLE
Beverley Shea, Jordi Pardo Pardo, Shawna Grosskleg, Dorcas E Beaton, Philip Conaghan, Wim Goettsch, Catherine Hofstetter, Lara Maxwell, Joachim Musaus, Daniel Ollendorf, Grayson Schultz, Randall Stevens, Vibeke Strand, Peter Tugwell, Paula Williamson, Sean Tunis, Lee S Simon
OBJECTIVE: This manuscript highlights the importance of enhancing the uptake of Core Outcome Sets (COS) by building partnerships with Collaborators and addressing their needs in COS development. METHODS AND SETTING: This session was structured as a simulation, resembling a format akin to a classic television game show. The moderator posed a series of questions to eight different Collaborator groups who briefly described the importance of COS within their areas of interest...
March 16, 2024: Seminars in Arthritis and Rheumatism
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REVIEW
Aslihan Avanoglu-Guler, Corrado Campochiaro, Giacomo De Luca, Michael Hughes, Abdurrahman Tufan, Lorraine Green, Francesco Del Galdo, Marco Matucci-Cerinic, Lorenzo Dagna
In SSc, dystrophic calcinosis is one of the major clinical manifestations, characterized by the deposition of insoluble calcific substances in tissues, predominantly in the chemical form of calcium hydroxyapatite. Furthermore, calcinosis might lead to compressive neuropathies and severe pain. Current evidence suggests that tissue ischemia and repeated trauma are implicated in the development of calcinosis; however, there are still too many unknown areas that need to be investigated. Detection of calcinosis is commonly performed using X-ray or ultrasound...
March 16, 2024: Seminars in Arthritis and Rheumatism
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JOURNAL ARTICLE
Zubeyir Salis, Jeffrey B Driban, Timothy E McAlindon
OBJECTIVE: Identifying participants who will progress to advanced stage in knee osteoarthritis (KOA) trials remains a significant challenge. Current tools, relying on total knee replacements (TKR), fall short in reliability due to the extraneous factors influencing TKR decisions. Acknowledging these limitations, our study identifies a critical need for a more robust metric to assess severe KOA. The end-stage KOA (esKOA) measure, which combines symptomatic and radiographic criteria, serves as a solid indicator...
March 16, 2024: Seminars in Arthritis and Rheumatism
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JOURNAL ARTICLE
Eaman Alhassan, Belina Y Yi, Jack Rodman, Michael H Weisman, Ashley Crew, Leanna Wise
OBJECTIVES: There is little to no data about the presentation and clinical course of anti-melanoma differentiation-associated gene-5 antibody (anti-MDA-5) dermatomyositis in a primarily U.S. Hispanic population. We describe the clinical course of anti-MDA-5 dermatomyositis in our majority Hispanic population. METHODS: This is a multicenter, retrospective case series of anti-MDA-5 dermatomyositis. Patients diagnosed with anti-MDA-5 dermatomyositis from June 2015 to March 2023 at four medical centers in Los Angeles, California, were included...
March 15, 2024: Seminars in Arthritis and Rheumatism
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LETTER
Ferida Chehem Daoud Chehem, Olivier Espitia, Christian Agard
No abstract text is available yet for this article.
March 13, 2024: Seminars in Arthritis and Rheumatism
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JOURNAL ARTICLE
Alexandre Sepriano, Sofia Ramiro, Désirée van der Heijde, Anna Moltó, Cécile Gaujoux-Viala, Maxime Dougados, Robert Landewé
OBJECTIVES: To compare the long-term outcomes of three phenotypes of axial SpA (axSpA). METHODS: Patients with a clinical diagnosis of axSpA from the DESIR cohort were grouped into three phenotypes at baseline: 'Pure axSpA' ('Axial'), 'axSpA with peripheral signs' ('IBP+Peripheral') and 'axSpA at risk' ('At risk') by latent class analysis. Clinical and imaging data were collected up to 5 years. Clinical outcomes, measured in each visit, included disability (BASFI) and quality of life (QoL; SF36)...
March 2, 2024: Seminars in Arthritis and Rheumatism
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JOURNAL ARTICLE
Gregory C McDermott, Michael DiIorio, Yumeko Kawano, Mary Jeffway, Megan MacVicar, Kumar Dahal, Su-Jin Moon, Thany Seyok, Jonathan Coblyn, Elena Massarotti, Michael E Weinblatt, Dana Weisenfeld, Katherine P Liao
OBJECTIVE: Switching biologic and targeted synthetic DMARD (b/tsDMARD) medications occurs commonly in RA patients, however data are limited on the reasons for these changes. The objective of the study was to identify and categorize reasons for b/tsDMARD switching and investigate characteristics associated with treatment refractory RA. METHODS: In a multi-hospital RA electronic health record (EHR) cohort, we identified RA patients prescribed ≥1 b/tsDMARD between 2001 and 2017...
March 1, 2024: Seminars in Arthritis and Rheumatism
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REVIEW
Seher Sener, Veysel Cam, Seza Ozen, Ezgi Deniz Batu
BACKGROUND/OBJECTIVES: Janus kinase (JAK) inhibitors have been increasingly used in the treatment of juvenile dermatomyositis (JDM). This review aims to comprehensively analyze previous studies concerning the utilization of JAK inhibitors in JDM patients. METHODS: We conducted a thorough review of MEDLINE and Scopus databases, spanning from their inception to September 1st, 2023, to identify articles involving JDM patients treated with JAK inhibitors. RESULTS: Our literature search yielded 26 articles that encompassed 195 patients with JDM who received JAK inhibitors...
March 1, 2024: Seminars in Arthritis and Rheumatism
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JOURNAL ARTICLE
Lara J Maxwell, Grace C Wright, Grayson Schultz, Shawna Grosskleg, Jennifer L Barton, Willemina Campbell, Francis Guillemin, Catherine Hofstetter, Beverley J Shea, Lee S Simon, Adewale Adebajo, Cheryl Barnabe, Niti Goel, Patricia Hurley, Elena Nikiphorou, Jennifer Petkovic, Peter Tugwell
OBJECTIVE: To increase awareness and understanding of the principles of Equity, Diversity, and Inclusivity (EDI) within Outcome Measures in Rheumatology's (OMERACT) members. For this, we aimed to obtain ideas on how to promote and foster these principles within the organization and determine the diversity of the current membership in order to focus future efforts. METHODS: We held a plenary workshop session at OMERACT 2023 with roundtable discussions on barriers and solutions to increased diversity within OMERACT...
February 29, 2024: Seminars in Arthritis and Rheumatism
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JOURNAL ARTICLE
Lara J Maxwell, Caitlin Jones, Clifton O Bingham, Maarten Boers, Annelies Boonen, Ernest Choy, Robin Christensen, Philip G Conaghan, Maria Antonietta D'Agostino, Andrea S Doria, Shawna Grosskleg, Catherine L Hill, Catherine Hofstetter, Ben Horgan, Féline Kroon, Ying Ying Leung, Sarah Mackie, Alexa Meara, Beverley J Shea, Lee S Simon, Zahi Touma, Peter Tugwell, George A Wells, Dorcas E Beaton
OBJECTIVE: To develop a set of detailed definitions for foundational domains commonly used in OMERACT (Outcome Measures in Rheumatology) core domain sets. METHODS: We identified candidate domain definitions from prior OMERACT publications and websites and publications of major organizations involved in outcomes research for six domains commonly used in OMERACT Core Domain Sets: pain intensity, pain interference, physical function, fatigue, patient global assessment, and health-related quality of life...
February 29, 2024: Seminars in Arthritis and Rheumatism
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