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Seminars in Arthritis and Rheumatism

N Ferdowsi, W Stevens, M Baron, M Nikpour
OBJECTIVE: To review the current literature, and evaluate the psychometric properties of disease damage indices in rheumatic diseases. METHODS: A search of Medline, EMBASE, and Cochrane Library databases was performed to June 2018 to identify damage indices in all systemic rheumatic diseases. Articles were included in a systematic review if indices were composite (multi-organ) in nature and if adequate detail on methodology was described. Articles pertaining to the validation of these indices were also reviewed in order to assess the psychometric properties of the indices using the Outcome Measures in Rheumatology Arthritis Clinical Trials (OMERACT) filter as a guide...
January 17, 2019: Seminars in Arthritis and Rheumatism
Nicola Veronese, Cyrus Cooper, Jean-Yves Reginster, Marc Hochberg, Jaime Branco, Olivier Bruyère, Roland Chapurlat, Nasser Al-Daghri, Elaine Dennison, Gabriel Herrero-Beaumont, Jean-François Kaux, Emmanuel Maheu, René Rizzoli, Roland Roth, Lucio C Rovati, Daniel Uebelhart, Mila Vlaskovska, André Scheen
OBJECTIVES: Type 2 diabetes mellitus (T2DM) and osteoarthritis (OA) are common diseases that frequently co-exist, along with overweight/obesity. While the mechanical impact of excess body weight on joints may explain lower limb OA, we sought to explore whether T2DM is linked to OA outside of excess weight and whether T2DM may play a role in OA pathophysiology. The consequence of T2DM on OA outcomes is a question of research interest. METHODS: We conducted a critical review of the literature to explore the association between T2DM and OA, whether any association is site-specific for OA, and whether the presence of T2DM impacts on OA outcomes...
January 11, 2019: Seminars in Arthritis and Rheumatism
Sarah Stewart, Hannah Maxwell, Nicola Dalbeth
OBJECTIVES: Ultrasound lesions of gout have been described in people with asymptomatic hyperuricemia. However, the anatomical sites and ultrasound lesions most frequently involved in asymptomatic hyperuricemia have not yet been established. This systematic review and meta-analysis aimed to determine the prevalence of the Outcome Measures in Rheumatology (OMERACT) elementary ultrasound lesions of gout (double contour, aggregates, tophus, erosion) at various sites in people with asymptomatic hyperuricemia and to determine which sites and lesions discriminate from people with normouricemia...
January 11, 2019: Seminars in Arthritis and Rheumatism
Mickael Hiligsmann, Setareh A Williams, Lorraine A Fitzpatrick, Stuart S Silverman, Richard Weiss, Jean-Yves Reginster
OBJECTIVES: There is emerging evidence supporting sequential therapy with an osteoanabolic followed by an antiresorptive in patients at high-risk of fragility fractures. This study assessed the cost-effectiveness of sequential treatment with abaloparatide (ABL) followed by alendronate (ALN) [(ABL/ALN)] compared with teriparatide (TPTD) followed by ALN (TPTD/ALN). METHODS: A previously validated Markov microsimulation model was adapted to estimate the cost-effectiveness of sequential ABL/ALN compared with sequential TPTD/ALN and no treatment with a lifetime horizon from the US payer perspective...
January 10, 2019: Seminars in Arthritis and Rheumatism
Jiacai Cho, Manjari Lahiri, Lay Kheng Teoh, Preeti Dhanasekaran, Peter P Cheung, Aisha Lateef
OBJECTIVES: Data on flares in Asian patients with systemic lupus erythematosus (SLE) are scarce. Here, we aim to identify the baseline predictors of flares in a cohort of Southeast Asian patients with SLE. METHODS: Consecutive adult patients with prevalent SLE according to the 1997 ACR or 2012 SLICC criteria were enrolled and followed three-monthly. Clinical and laboratory data were collected at every visit using a standardised protocol. Flares were defined using the SELENA-SLEDAI Flare Index (SFI)...
January 5, 2019: Seminars in Arthritis and Rheumatism
Mónica Calderón-Goercke, Javier Loricera, Vicente Aldasoro, Santos Castañeda, Ignacio Villa, Alicia Humbría, Clara Moriano, Susana Romero-Yuste, Javier Narváez, Catalina Gómez-Arango, Eva Pérez-Pampín, Rafael Melero, Elena Becerra-Fernández, Marcelino Revenga, Noelia Álvarez-Rivas, Carles Galisteo, Francisca Sivera, Alejandro Olivé-Marqués, María Álvarez Del Buergo, Luisa Marena-Rojas, Carlos Fernández-López, Francisco Navarro, Enrique Raya, Eva Galindez-Agirregoikoa, Beatriz Arca, Roser Solans-Laqué, Arantxa Conesa, Cristina Hidalgo, Carlos Vázquez, José Andrés Román-Ivorra, Pau Lluch, Sara Manrique-Arija, Paloma Vela, Eugenio De Miguel, Carmen Torres-Martín, Juan Carlos Nieto, Carmen Ordas-Calvo, Eva Salgado-Pérez, Cristina Luna-Gomez, F Javier Toyos-Sáenz de Miera, Nagore Fernández-Llanio, Antonio García, Carmen Larena, Natalia Palmou-Fontana, Vanesa Calvo-Río, Diana Prieto-Peña, Carmen González-Vela, Alfonso Corrales, María Varela-García, Elena Aurrecoechea, Raquel Dos Santos, Ángel García-Manzanares, Norberto Ortego, Sabela Fernández, Francisco Ortiz-Sanjuán, Montserrat Corteguera, José L Hernández, Miguel Á González-Gay, Ricardo Blanco
OBJECTIVE: Tocilizumab (TCZ) has shown efficacy in clinical trials on giant cell arteritis (GCA). Real-world data are scarce. Our objective was to assess efficacy and safety of TCZ in unselected patients with GCA in clinical practice Methods: Observational, open-label multicenter study from 40 national referral centers of GCA patients treated with TCZ due to inefficacy or adverse events of previous therapy. Outcomes variables were improvement of clinical features, acute phase reactants, glucocorticoid-sparing effect, prolonged remission and relapses...
January 5, 2019: Seminars in Arthritis and Rheumatism
April Jorge, Victor M Castro, April Barnado, Vivian Gainer, Chuan Hong, Tianxi Cai, Tianrun Cai, Robert Carroll, Joshua C Denny, Leslie Crofford, Karen H Costenbader, Katherine P Liao, Elizabeth W Karlson, Candace H Feldman
OBJECTIVE: To utilize electronic health records (EHRs) to study SLE, algorithms are needed to accurately identify these patients. We used machine learning to generate data-driven SLE EHR algorithms and assessed performance of existing rule-based algorithms. METHODS: We randomly selected subjects with ≥ 1 SLE ICD-9/10 codes from our EHR and identified gold standard definite and probable SLE cases by chart review, based on 1997 ACR or 2012 SLICC Classification Criteria...
January 4, 2019: Seminars in Arthritis and Rheumatism
I C Scott, F Ibrahim, G Panayi, A P Cope, T Garrood, A Vincent, D L Scott, B Kirkham
OBJECTIVE: Treat-to-target in rheumatoid arthritis (RA) recommends targeting remission, with low disease activity (LDA) being an alternative goal. When deciding to target remission or LDA, important considerations are the likelihood of attaining them, and their impacts on function and health-related quality of life (HRQoL). We have addressed this by studying: (a) the frequency of remission and LDA/remission; (b) DAS28-ESR trends after remission; (c) ability of remission vs. LDA to identify patients with normal function (HAQ ≤ 0...
December 28, 2018: Seminars in Arthritis and Rheumatism
Elke O Kreps, Charlotte Carton, Maurizio Cutolo, Carlo Alberto Cutolo, Amber Vanhaecke, Bart P Leroy, Vanessa Smith
OBJECTIVES: Systemic sclerosis (SSc) is a rare and complex autoimmune disorder characterized by microvascular damage and progressive fibrosis which affects the skin and multiple other organs. Much of the published data concerning SSc and the eye consists of single case reports or small case studies. This systematic review aims to provide an overview of the current level of evidence for SSc-related ocular changes. MATERIALS AND METHODS: A systematic literature review was conducted using 3 electronic databases, according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines...
December 28, 2018: Seminars in Arthritis and Rheumatism
Allan Gibofsky, Ralf Thiele
No abstract text is available yet for this article.
December 21, 2018: Seminars in Arthritis and Rheumatism
Gonçalo Boleto, Lukshe Kanagaratnam, Moustapha Dramé, Jean-Hugues Salmon
OBJECTIVES: We performed a systematic review and meta-analysis of the current literature to assess the safety of combining two biologic disease-modifying antirheumatic drugs (bDMARDs) in the treatment of rheumatoid arthritis (RA). METHODS: We systematically searched for controlled studies evaluating safety in patients with RA treated with two bDMARDs independently of dose-regimen. Databases used were MEDLINE (via Pubmed), EMBase, Cochrane Library, Scopus, ClinicalTrials...
December 18, 2018: Seminars in Arthritis and Rheumatism
Elizabeth Smith, John D Pauling
BACKGROUND: Gastrointestinal involvement in systemic sclerosis is common and a major cause of disease-related morbidity. Patients increasingly enquire about dietary modifications that may help with gastrointestinal symptoms. Many clinical practice reviews and treatment guidelines make specific reference to dietary modifications in the management of gastrointestinal involvement in systemic sclerosis. We report the findings of a systematic literature review designed to evaluate the evidence to support dietary modification in the management of gastrointestinal symptoms of systemic sclerosis...
December 6, 2018: Seminars in Arthritis and Rheumatism
Klaus Flechsenhar, Janina S Ried, Jeffrey B Driban, Lori Lyn Price, Timothy McAlindon
OBJECTIVE: We previously published data representing calculations for sample sizes assuming that the reduction of the incidence of knee joint replacement (KJR) would be an endpoint to prove efficacy of a disease-modifying drug in osteoarthritis (DMOAD). The sample sizes required for such hypothetical studies appeared to be high, rendering those studies unrealistic in the clinical research setting for practical reasons. The purpose of this work is to calculate sample sizes for hypothetical trials for DMOAD efficacy using a proxy for reaching end-stage knee osteoarthritis (esKOA) as an endpoint...
December 6, 2018: Seminars in Arthritis and Rheumatism
Carlos Antonio Moura, Carlos Geraldo Moura, Thiara Moura
No abstract text is available yet for this article.
December 5, 2018: Seminars in Arthritis and Rheumatism
Lin Chu Yang, Adalberto Loyola-Sanchez, Kelle Hurd, Elizabeth D Ferucci, Louise Crane, Bonnie Healy, Cheryl Barnabe
BACKGROUND: Research adhering to community engagement processes leads to improved outcomes. The level of Indigenous communities' engagement in rheumatology research is unknown. OBJECTIVE: To characterize the frequency and level of community engagement reporting in arthritis studies conducted in Australia (AUS), Canada (CAN), New Zealand (NZ) and the United States of America (USA). METHODS: Studies identified through systematic reviews on topics of arthritis epidemiology, disease phenotypes and outcomes, health service utilization and mortality in Indigenous populations of AUS, CAN, NZ and USA, were evaluated for their descriptions of community engagement...
December 4, 2018: Seminars in Arthritis and Rheumatism
Nina Kello, Lara El Khoury, Galina Marder, Richard Furie, Ekaterini Zapantis, Diane Lewis Horowitz
INTRODUCTION: Thrombotic microangiopathy (TMA) is a life-threatening, albeit infrequent, complication of systemic lupus erythematosus (SLE) and anti-phospholipid syndrome (APS). Recommendations for the treatment of SLE- and APS-related secondary TMA are currently based solely on case reports and expert opinion. Unfortunately, interventions may not yield timely results or effectively halt the progression of TMA. Since complement activation plays a key role in the pathogenesis of secondary TMA due to SLE, APS, a therapy that targets the complement pathway is an attractive intervention...
December 4, 2018: Seminars in Arthritis and Rheumatism
A Heiligenhaus, K Minden, C Tappeiner, H Baus, B Bertram, C Deuter, I Foeldvari, D Föll, M Frosch, G Ganser, M Gaubitz, A Günther, C Heinz, G Horneff, C Huemer, I Kopp, C Lommatzsch, T Lutz, H Michels, T Neß, U Neudorf, U Pleyer, M Schneider, H Schulze-Koops, S Thurau, M Zierhut, H W Lehmann
BACKGROUND: Uveitis in juvenile idiopathic arthritis (JIAU) is frequently associated with the development of complications and visual loss. Topical corticosteroids are the first line therapy, and disease modifying anti-rheumatic drugs (DMARDs) are commonly used. However, treatment has not been standardized. METHODS: Interdisciplinary guideline were developed with representatives from the German Ophthalmological Society, Society for Paediatric Rheumatology, Professional Association of Ophthalmologists, German Society for Rheumatology, parents' group, moderated by the Association of the Scientific Medical Societies in Germany...
December 4, 2018: Seminars in Arthritis and Rheumatism
Sarah Y Bessen, Michael Y Bessen, Christianne M Yung
INTRODUCTION: Pegloticase is a PEGylated uric acid specific enzyme indicated for the treatment of refractory gout. Anti-pegloticase antibodies contribute to high discontinuation rates, increased risk of infusion reactions, and early loss of drug efficacy. OBJECTIVE: To describe the use of methotrexate to recapture function of pegloticase after development of anti-drug antibodies while treating gout. METHODS: We report two cases of using methotrexate as an adjunct to treatment with pegloticase for refractory tophaceous gout...
December 4, 2018: Seminars in Arthritis and Rheumatism
Javier Narváez, Maribel Mora-Limiñana, Inmaculada Ros, Mónica Ibañez, Joan Valldeperas, David Crémer, Joan M Nolla, Antonio Juan-Mas
OBJECTIVE: To investigate the prevalence, clinical characteristics and prognosis of pulmonary arterial hypertension (PAH) in adult onset Still's disease (AOSD). METHODS: We retrospectively reviewed all patients with AOSD diagnosed during a 33-year period in 2 referral tertiary care hospitals, selecting for analysis those who presented PAH confirmed as by right heart catheterization. A systematic review of the literature (PubMed 1990 to July 2018) was also performed, in order to determine the prognosis and the most appropriate treatment strategy for this complication...
December 4, 2018: Seminars in Arthritis and Rheumatism
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