Sitian Zhang, Lianghu Gu, Yongtong Lin, Hanxiao Zeng, Nanjin Ding, Jiangchun Wei, Xiaoxia Gu, Chang Liu, Weiguang Sun, Yuan Zhou, Yonghui Zhang, Zhengxi Hu
By co-culturing two endophytic fungi (Chaetomium virescens and Xylaria grammica) collected from the medicinal and edible plant Smilax glabra Roxb. and analyzing them with MolNetEnhancer module on GNPS platform, seven undescribed chromone-derived polyketides (chaetoxylariones A-G), including three pairs of enantiomer ones (2a/2b, 4a/4b and 6a/6b) and four optical pure ones (1, 3, 5 and 7), as well as five known structural analogues (8-12), were obtained. The structures of these new compounds were characterized by NMR spectroscopy, single-crystal X-ray diffraction, 13 C NMR calculation and DP4+ probability analyses, as well as the comparison of the experimental electronic circular dichroism (ECD) data...
April 3, 2024: Bioorganic Chemistry