William Mouton, Guy Oriol, Christelle Compagnon, Carla Saade, Kahina Saker, Priscille Franc, Bouchra Mokdad, Aurore Fleurie, Xavier Lacoux, Soizic Daniel, Franck Berthier, Cécile Barnel, Bruno Pozzetto, Jean-Baptiste Fassier, Valérie Dubois, Sophia Djebali, Maxence Dubois, Thierry Walzer, Jacqueline Marvel, Karen Brengel-Pesce, Sophie Trouillet-Assant
OBJECTIVES: In the post-SARS-CoV-2 pandemic era, "breakthrough infections" are still documented, due to variants of concerns (VoCs) emergence and waning humoral immunity. Despite widespread utilization, the definition of the anti-Spike (S) immunoglobulin-G (IgG) threshold to define protection has unveiled several limitations. Here, we explore the advantages of incorporating T-cell response assessment to enhance the definition of immune memory profile. METHODS: SARS-CoV-2 interferon-gamma release assay test (IGRA) was performed on samples collected longitudinally from immunocompetent healthcare workers throughout their immunization by infection and/or vaccination, anti-receptor-binding domain IgG levels were assessed in parallel...
April 16, 2024: European Journal of Immunology