Jiarou Li, Yansong Liu, Jingjing Bai, Tiantian Liu, Xionghai Qin, Tianyou Hu, Sicong Wang, Yunlong Li, Shanpeng Cui, Zhen Quan, Yiming Luo, Junbo Zheng, Hongliang Wang
Sepsis-associated acute kidney injury (SA-AKI) has a high mortality rate and lacks effective targeted treatment. We applied lipopolysaccharides-induced injury models in human and mouse renal tubular epithelial cells, and at the same time, we selected a commonly used sedative drug, dexmedetomidine, to investigate its potential for renal protection. We found a significant increase in the expression level of HSP90, and the interaction with glutathione peroxidase 4 (GPX4) led to autophagic degradation of GPX4, triggering ferroptosis...
November 22, 2023: European Journal of Pharmacology