Haoting Hsu, Claudio Zanettini, Modupe Coker, Sarah Boudova, David Rach, Godfrey Mvula, Titus H Divala, Randy G Mungwira, Francesca Boldrin, Giulia Degiacomi, Laura Cioetto Mazzabò, Riccardo Manganelli, Miriam K Laufer, Yuji Zhang, Luigi Marchionni, Cristiana Cairo
Vγ9Vδ2 T lymphocytes are programmed for broad antimicrobial responses with rapid production of Th1 cytokines even before birth, and thus thought to play key roles against pathogens in infants. The process regulating Vδ2 cell acquisition of cytotoxic potential shortly after birth remains understudied. We observed that perforin production in cord blood Vδ2 cells correlates with phenotypes defined by the concomitant assessment of PD-1 and CD56. Bulk RNA sequencing of sorted Vδ2 cell fractions indicated that transcripts related to cytotoxic activity and NK function are enriched in the subset with the highest proportion of perforin+ cells...
December 23, 2023: Cellular Immunology