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Acta Reumatológica Portuguesa

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https://read.qxmd.com/read/30641543/haemophagocytic-syndrome-in-systemic-lupus-erythematosus-clues-to-an-early-diagnosis
#1
Raquel Miriam Ferreira, Sara Ganhão, Eva Mariz, Sofia Pimenta, Lúcia Costa
Macrophage activation syndrome (MAS) is a rare life-threatening condition that involves excessive activation of inflammatory cells and overproduction of different cytokines. It is characterized by persistent fever, hepatosplenomegaly, cytopenias and coagulopathy. Other prominent features are hyperferritinemia and findings of activated macrophages in haemopoietic organs, often associated with multi-organ impairment. Its occurrence has been linked to numerous triggers such as viral agents, malignancy and rheumatic diseases...
October 2018: Acta Reumatológica Portuguesa
https://read.qxmd.com/read/30641542/systemic-sclerosis-and-myositis-as-a-paraneoplastic-syndrome-secondary-to-multiple-myeloma
#2
Daniela Santos-Faria, Joana Leite Silva, Joana Sousa-Neves, Joana Ramos Rodrigues, Carmo Afonso, Daniela Peixoto
We present a case of paraneoplastic systemic sclerosis (SSc) and myositis associated to a multiple myeloma (MM) in a 52-year-old Caucasian man. After MM treatment, skin and muscle changes improved, with no further relapses. Although rare, "scleroderma-like" or myositis lesions may be associated with MM. However, to the best of our knowledge, this is the first case reporting these two clinical conditions simultaneously associated with MM.
October 2018: Acta Reumatológica Portuguesa
https://read.qxmd.com/read/30641541/mickey-mouse-sign-a-rare-and-specific-finding-of-paget-s-disease-of-bone
#3
Miguel Guerra, Diogo Fonseca, Taciana Videira, Romana Vieira, Joana Abelha Aleixo, Patrícia Pinto
No abstract text is available yet for this article.
October 2018: Acta Reumatológica Portuguesa
https://read.qxmd.com/read/30641540/silent-acute-myocarditis-in-eosinophilic-granulomatosis-with-polyangiitis
#4
Raquel Miriam Ferreira, Pedro Madureira, Teresa Pinho, Elisabete Martins, Sofia Pimenta, Lúcia Costa
Eosinophilic granulomatosis with polyangiitis is a rare multisystemic disorder, characterized by necrotizing vasculitis affecting small to medium-sized vessels, associated with asthma and eosinophilia. Cardiac involvement is the most important predictor of mortality and it seems to be more frequent in anti-neutrophil cytoplasmic antibodies-negative patients. Cardiomyopathy and congestive heart failure can occur but a significant proportion of patients are asymptomatic. We present a case of this condition in a 65-year-old woman with a past medical history of rhinosinusitis and recent episodes of asthma, that developed palpable purpura, sensory deficiency and excruciating pain mainly in the lower limbs...
October 2018: Acta Reumatológica Portuguesa
https://read.qxmd.com/read/30641539/neuromuscular-manifestations-of-primary-biliary-cholangitis-two-case-reports-and-literature-review
#5
Luisa Brites, Joana Ribeiro, Mariana Luis, Mariana Santiago, Luis Negrão, Catia Duarte
Primary biliary cholangitis (PBC) is a rare chronic disease, characterized by progressive cholestasis that could end in end-stage liver disease. Its diagnosis is based in the presence of a cholestatic pattern and antimitochondrial antibodies. Neurological complications of PBC are unusual, but there are descriptions of association with myopathies and neuropathies, being polymyositis the most frequent. We report two cases of patients with the diagnosis of PBC with neurologic complications: one case with asymptomatic PBC and myopathy and another one with demyelinating neuropathy...
October 2018: Acta Reumatológica Portuguesa
https://read.qxmd.com/read/30641538/determinants-of-non-nociceptive-pain-in-rheumatoid-arthritis
#6
Teresa Martins Rocha, Sofia Pimenta, Alexandra Bernardo, Miguel Bernardes, Margarida Barbosa, Raquel Lucas, Jan Vollert, Lúcia Costa, Christoph Maier
INTRODUCTION: Features suggestive of neuropathic pain (NP) have been described in RA in addition to nociceptive pain. We aimed to determine the clinical predictors of NP in RA patients and study its association with radiographic structural damage. METHODS: Cross-sectional study was performed with RA patients followed at our Rheumatology department. Patients with diagnosed neuropathy of other origin, non-RA related risk factors for NP (e.g. diabetes mellitus) or fibromyalgia according to expert opinion were excluded...
October 2018: Acta Reumatológica Portuguesa
https://read.qxmd.com/read/30641537/the-association-between-clinically-suspect-arthralgia-and-adipokines-in-obese-patients
#7
Reyhan Kose, Gokhan Sargin, Taskin Senturk, Songul Cildag, Mustafa Unubol, Burçin İrem Abas, Cigdem Yenisey
OBJECTIVE: Obesity is a moderate low-grade chronic inflammatory condition. The cause of low-grade inflammation in obese patients who have clinically suspect arthralgia (CSA) may be the subject of debate in clinical practice. Our aim is to determine whether inflammation is associated with obesity or rheumatic disease, and the association between leptin, chemerin, visfatin and inflammatory markers in obese patients with/without musculoskeletal symptoms. METHODS: Seventy-four obese patients who admitted to our rheumatology clinic with CSA were enrolled...
October 2018: Acta Reumatológica Portuguesa
https://read.qxmd.com/read/30641536/slicc-classification-criteria-for-juvenile-systemic-lupus-erythematosus-a-cross-sectional-study
#8
Fabiane Mitie Osaku, Melissa Mariti Fraga, Patricia Pontes Aires, Ana Amorim Caparroz, Claudio Arnaldo Len, Maria Teresa Terreri
OBJECTIVES: to verify the sensitivity and specificity of the criteria for systemic lupus erythematosus, proposed by the Systemic Lupus International Collaborating Clinics (SLICC) and compare it to the ACR lupus criteria, in a pediatric population. PATIENTS AND METHODS: this is an observational cohort study, with a descriptive analysis of data from a Pediatric Rheumatology center, including 23 patients with Juvenile Systemic Lupus Erythematosus (jSLE) and a control group of 24 patients with Juvenile Idiopathic Arthritis (JIA), both groups recently diagnosed and virgin of treatment...
October 2018: Acta Reumatológica Portuguesa
https://read.qxmd.com/read/30641535/th17-pathway-genes-polymorphisms-in-algerian-patients-with-systemic-sclerosis
#9
Yasmine Mellal, Ines Allam, Azzedine Tahiat, Amina Abessemed, Rachid Nebbab, Aicha Ladjouze, Reda Djidjik
OBJECTIVE: TH17 cells have involved in the pathogenesis of several autoimmune diseases including systemic sclerosis (SSc). The aim of our study was to investigate an association of IL-17A, IL-17F, IL-21, IL-23R and STAT3 genes with SSc susceptibility, and clinical and immunological phenotypes. PATIENTS AND METHODS: The case-control study included 136 patients suffering from SSc and 317 healthy controls of the Algerian population. Eight single nucleotide polymorphisms (SNP) of genes encoding TH17 pathway were genotyped using TaqMan allelic discrimination assays...
October 2018: Acta Reumatológica Portuguesa
https://read.qxmd.com/read/30641534/articular-cartilage-of-knee-and-first-mtp-joint-are-the-preferred-sites-to-find-double-contour-sign-as-an-evidence-of-urate-crystal-deposition-in-asymptomatic-hyperuricemic-individuals
#10
Danveer Bhadu, Siddharth Kumar Das, Archana Wakhlu, Urmila Dhakad
BACKGROUND/OBJECTIVE: A cross-sectional study to determine the preferred sites of urate crystal deposition in asymptomatic hyperuricemic individuals by ultrasound. METHODS: In two years period twenty four asymptomatic hyperuricemic individuals (serum uric acid ≥7mg/dl) and fifty controls (serum uric acid <7mg/dl) with age more than 18 years were included in this study. Double contour sign was looked for at three articular cartilage sites (first metatarsophalangeal, tibiotalar and femoral condyle) whereas hyperechoic aggregates were looked for at one joint site (radiocarpal joint) and two tendon sites (patellar tendon and triceps tendon)...
October 2018: Acta Reumatológica Portuguesa
https://read.qxmd.com/read/30641533/predictors-of-walking-capacity-in-obese-adults-with-knee-osteoarthritis
#11
Flávia Yázigi, Margarida Espanha, Adilson Marques, Julia Teles, Pedro Teixeira
INTRODUCTION: Knee osteoarthritis(KOA) has a considerable prevalence in obese individuals and recommendations of weight loss for KOA management are gaining greater importance. Exercise is recommended to interrupt the cycle obesity-KOA-pain-inactivity, where walking is the most common exercise pattern recommended for obese individuals who initiate a weight loss exercise program. Thus this study aimed to analyse the factors which can affect the walking capacity in obese adults with symptomatic KOA...
October 2018: Acta Reumatológica Portuguesa
https://read.qxmd.com/read/30641532/telerheumatology-breaking-barriers-to-access-care-in-rheumatology
#12
Vítor Teixeira, Inês Cordeiro, Maria João Gonçalves, João Eurico Fonseca, Carla Macieira
Telehealth applied to rheumatology, known as telerheumatology, is an emerging trend in healthcare in many countries. It constitutes a promising approach with the potential to anticipate the contact of patients from remote areas with Rheumatologists, leading to earlier diagnosis and treatment, and thus probably to better long-term outcomes. Telerheumatology under the scope of International collaborations may also improve the access of the PALOP population to Rheumatology care, resulting in proper shared decisions for patient's evacuation, preventing family separation and reducing the costs associated to intercontinental dislocations...
October 2018: Acta Reumatológica Portuguesa
https://read.qxmd.com/read/30095802/seronegative-cat-scratch-disease-in-a-patient-with-systemic-lupus-erythematosus
#13
Francisca Aguiar, Teresa Martins-Rocha, Mariana Rodrigues, Iva Brito
No abstract text is available yet for this article.
August 10, 2018: Acta Reumatológica Portuguesa
https://read.qxmd.com/read/30414376/seronegative-cat-scratch-disease-in-a-patient-with-systemic-lupus-erythematosus
#14
Francisca Aguiar, Teresa Martins-Rocha, Mariana Rodrigues, Iva Brito
No abstract text is available yet for this article.
July 2018: Acta Reumatológica Portuguesa
https://read.qxmd.com/read/30414375/presence-of-anti-porphyromonas-gingivalis-peptidylarginine-deiminase-antibodies-in-serum-from-juvenile-systemic-lupus-erythematosus-patients
#15
Carlos Marcelo Figueredo, Manuela R Sete, Juliana C Carlos, Ronaldo Lira, Elisabeth Boström, Flavio Sztajnbok
The presence of a biofilm-associated gingival inflammation in patients having juvenile systemic lupus erythematosus (jSLE) might function as a reservoir of anaerobic Gram-negative bacteria such as Porphyromonas gingivalis. Porphyromonas gingivalis also express functional endogenous peptidylarginine deiminase (PAD) enzymes, which catalyzes a citrullination reaction that can lead to formation of citrullinated peptides. We analyzed 30 patients with jSLE (16.2±1.5 years-old) and 29 healthy controls (15.4±2.3 years old jSLE was diagnosed according to the criteria of the American College of Rheumatology...
July 2018: Acta Reumatológica Portuguesa
https://read.qxmd.com/read/30414374/iloprost-infusion-through-elastomeric-pump-for-the-outpatient-treatment-of-severe-raynaud-s-phenomenon-and-digital-ulcers-a-single-centre-experience
#16
Ana Catarina Duarte, Lurdes Barbosa, Maria José Santos, Ana Cordeiro
Raynaud's phenomenon (RP) and digital ulcers (DU) are the main clinical features of vasculopathy that occurs in several systemic rheumatic diseases. Intravenous iloprost is recommended for the treatment of severe RP and DU in patients with systemic sclerosis and portable devices for iloprost infusion have been recently designed, allowing outpatient treatment. This new alternative for drug administration not only avoids absenteeism, with the patient having the opportunity to continue his own family and work life, but also reduces the costs associated with hospitalization...
July 2018: Acta Reumatológica Portuguesa
https://read.qxmd.com/read/30414373/neonatal-lupus-erythematosus-in-a-newborn-with-citrullinemia
#17
Rita Pimenta, Filipa Urbano, Luís Soares-de-Almeida, Sónia Fernandes
A 24-day-old female newborn presented with multiple annular erythematous plaques with a targetoid shape, on the forehead, neck and upper trunk, that had begun ten days earlier. She had been diagnosed with citrullinemia type 1 in the first week of life and arginine supplementation was initiated. Her personal and family history was otherwise unremarkable. Laboratory tests showed high levels of anti-La/SSB and anti-Ro/SSA in both mother and baby. The patient was diagnosed with Neonatal lupus erythematosus on the basis of the clinical, histopathological and laboratorial findings...
July 2018: Acta Reumatológica Portuguesa
https://read.qxmd.com/read/30414372/pulmonary-involvement-in-neonatal-lupus-a-challenging-diagnosis-case-report-and-literature-review
#18
Sandra Pereira, Filipa Flor-de-Lima, Henrique Soares, Ana Vilan, Catarina Ferraz, Mariana Rodrigues, Cláudia Moura, Gustavo Rocha, Hercília Guimarães, Iva Brito
INTRODUCTION: Pulmonary involvement is relatively frequent in adult and juvenile patients with Systemic Lupus Erythematosus (SLE), but its occurrence in newborns with Neonatal Lupus Erythematosus (NLE) is exceedingly rare. CASE REPORT: A mother with SLE and positive anti-SSA/Ro and anti-SSB/La delivered a preterm newborn with third-degree heart block and positive anti-SSA/Ro confirmed postnatally. A temporary pacemaker was placed at D3 and a definitive pacemaker only at D15 due to sepsis with concurrent mild respiratory failure...
July 2018: Acta Reumatológica Portuguesa
https://read.qxmd.com/read/30414371/immunoglobulin-g4-related-disease-with-recurrent-uveitis-and-kidney-tumor-mimicking-childhood-polyarteritis-nodosa-a-rare-case-report
#19
Mariana Machado Forti Nastri, Glaucia Vanessa Novak, Adriana Elias Maluf Sallum, Lucia Maria Arruda Campos, Roberto Augusto Plaza Teixeira, Clovis Artur Silva
INTRODUCTION: Immunoglobulin G4-related disease (IgG4-RD) is an condition rarely reported in children. Additionally, IgG4-RD may rarely mimic vasculitis in adults and may infrequently present with uveitis. In our service, 6,198 patients were followed-up and only one (0.0001%) of them had IgG4-RD. To our knowledge, the present IgG4-RD case was the first mimicking childhood polyarteritis nodosa (c-PAN) with recurrent uveitis and kidney tumor. CASE REPORT: We describe herein a 7-year-old boy that presented intermittent fever...
July 2018: Acta Reumatológica Portuguesa
https://read.qxmd.com/read/30414370/whole-peripheral-blood-mir-146a-and-mir-155-expression-levels-in-systemic-lupus-erythematosus-patients
#20
Russka Shumnalieva, Darina Kachakova, Viara Shoumnalieva-Ivanova, Polina Miteva, Radka Kaneva, Simeon Monov
Objective: To evaluate the diagnostic value of peripheral blood microribonucleic acid (miRNA, miR)-146a and miR-155 expression in systemic lupus erythematosus (SLE). Methods: Expression levels of miR-155 and miR-146a in whole peripheral blood samples from 40 SLE patients and 32 healthy controls (HCs) were determined by quantitative reverse transcription-polymerase chain reaction qRT-PCR (SYBR Green technology) and 2-∆∆Ct method was used for analysis. SPSS v20 was used for receiver operating characteristic (ROC) curve and Spearman correlation analysis...
July 2018: Acta Reumatológica Portuguesa
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