journal
Journals Seminars in Thrombosis and Hem...

Seminars in Thrombosis and Hemostasis

https://read.qxmd.com/read/38000903/the-molecular-structure-of-fibrinogen
#1
JOURNAL ARTICLE
Genesio Murano
Seminars in Thrombosis and Hemostasis (STH) celebrates 50 years of publishing in 2024. To celebrate this landmark event, STH is republishing some archival material. This manuscript represents the first full paper ever published in STH. The manuscript published without an abstract, and essentially covered in considerable detail the molecular structure of fibrinogen, as was known at that time. Fittingly, it covers some historical perspectives, the physicochemical properties and structure of fibrinogen across several species of animals (including humans) and its transformation into fibrin...
November 24, 2023: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/37984359/the-complex-role-of-thrombin-in-cancer-and-metastasis-focus-on-interactions-with-the-immune-system
#2
JOURNAL ARTICLE
Karolina Aleksandrowicz, Dominika Hempel, Barbara Polityńska, Anna M Wojtukiewicz, Kenneth V Honn, Dean G Tang, Marek Z Wojtukiewicz
Thrombin, a pleiotropic enzyme involved in coagulation, plays a crucial role in both procoagulant and anticoagulant pathways. Thrombin converts fibrinogen into fibrin, initiates platelet activation, and promotes clot formation. Thrombin also activates anticoagulant pathways, indirectly inhibiting factors involved in coagulation. Tissue factor triggers thrombin generation, and the overexpression of thrombin in various cancers suggests that it is involved in tumor growth, angiogenesis, and metastasis. Increased thrombin generation has been observed in cancer patients, especially those with metastases...
November 20, 2023: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/37984358/recommendations-on-the-use-of-covid-19-convalescent-plasma-to-treat-immunocompromised-patients
#3
JOURNAL ARTICLE
Massimo Franchini, Arturo Casadevall, Jonathon W Senefeld, Michael J Joyner, David J Sullivan, Daniele Focosi
No abstract text is available yet for this article.
November 20, 2023: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/37967836/international-council-for-standardization-in-haematology-guidance-for-new-lot-verification-of-coagulation-reagents-calibrators-and-controls
#4
JOURNAL ARTICLE
Robert C Gosselin, Donna Castellone, Akbar Dorgalaleh, Kieron Hickey, Giuseppe Lippi, Karen Moffat, Rebecca O'Toole, Joe Rigano
The clinical laboratory uses commercial products with limited shelf life or certain expiry dates requiring frequent lot changes. Prior to implementation for clinical use, laboratories should determine the performance of the new reagent lot to ensure that there is no significant shift in reagent performance or reporting of patient data. This guideline has been written on behalf of the International Council for Standardization in Haematology (ICSH) to provide the framework and provisional guidance for clinical laboratories for evaluating and verifying the performance of new lot reagents used for coagulation testing...
November 15, 2023: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/37967835/variable-performance-of-lupus-anticoagulant-testing-the-australasian-asia-pacific-experience
#5
JOURNAL ARTICLE
Emmanuel J Favaloro, Elysse Dean, Sandya Arunachalam
Lupus anticoagulant (LA) is one of three tests identified as laboratory criteria for definite antiphospholipid syndrome (APS). The other two tests are anticardiolipin antibody (aCL) and anti-β2-glycoprotein I (aβ2GPI) antibody. The presence of LA is assessed using clot-based tests, while the presence of aCL and aβ2GPI is assessed by immunological assays. Since no test can be considered 100% sensitive or specific for LA, current guidelines recommend using two different clot-based assays reflecting different principles, with the dilute Russell viper venom time (dRVVT) and activated partial thromboplastin time (aPTT) recommended...
November 15, 2023: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/37967834/the-bleeding-time-test-in-2024-a-glorious-past-and-current-challenges
#6
JOURNAL ARTICLE
Anetta Undas
No abstract text is available yet for this article.
November 15, 2023: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/37903565/description-of-an-in-vitro-platelet-function-analyzer-pfa-100-pfa-200-30-years-in-the-making
#7
JOURNAL ARTICLE
Emmanuel J Favaloro
No abstract text is available yet for this article.
October 30, 2023: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/37879345/erratum-laboratory-diagnosis-of-activated-protein-c-resistance-and-factor-v-leiden
#8
JOURNAL ARTICLE
Mehran Bahraini, Alieh Fazeli, Akbar Dorgalaleh
No abstract text is available yet for this article.
October 25, 2023: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/37863041/classification-criteria-for-the-antiphospholipid-syndrome-not-the-same-as-diagnostic-criteria-for-antiphospholipid-syndrome
#9
JOURNAL ARTICLE
Emmanuel J Favaloro, Leonardo Pasalic, Giuseppe Lippi
No abstract text is available yet for this article.
October 20, 2023: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/37852295/in-search-of-the-perfect-thrombosis-and-bleeding-associated-cancer-scale
#10
JOURNAL ARTICLE
Marek Z Wojtukiewicz, Petra Tesarova, Debora Karetová, Jerzy Windyga
Thrombosis and bleeding are commonly observed in cancer patients, and their management is crucial for positive patient outcomes. A comprehensive, prophylactic, and therapeutic management of venous thrombosis should focus on identifying the patients who would benefit most from treatment to reduce mortality and minimize the risk of thrombosis recurrence without significantly increasing the risk of bleeding. Existing cancer scales provide valuable information for assessing the overall burden of cancer and guiding treatment decisions, but their ability to predict thrombotic and bleeding events remains limited...
October 18, 2023: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/37832586/platelet-contributions-to-the-pre-metastatic-tumor-microenvironment
#11
JOURNAL ARTICLE
Harvey G Roweth
Alongside their conventional roles in thrombosis and hemostasis, platelets have long been associated with nonhemostatic pathologies, including tumor cell metastasis. Numerous mechanistic studies have since demonstrated that the direct binding of platelets to intravascular tumor cells promotes key hallmarks of metastasis, including survival in circulation and tumor cell arrest at secondary sites. However, platelets also interact with nonmalignant cells that make up the stromal and immune compartments within both primary and metastatic tumors...
October 13, 2023: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/37832585/trends-2020-2022-toward-reduced-prevalence-of-postcoronavirus-disease-syndrome-and-improved-quality-of-life-for-hospitalized-coronavirus-disease-2019-patients-with-severe-infection-and-venous-thromboembolism
#12
JOURNAL ARTICLE
Antonio Bozzani, Vittorio Arici, Guido Tavazzi, Franco Ragni, Francesco Mojoli, Elena Cavallini, Floris van Vugt, Sara Cutti, Silvia Figini, Alessandro Venturi, Antonio V Sterpetti, Eloisa Arbustini
The coronavirus disease 2019 (COVID-19) pandemic seems to be at its end. During the first outbreak, alfa was the dominant variant, and in the two following years, delta was the dominant variant. Questions remain about the prevalence and severity of post-COVID syndrome (PCS). We compared the medium-term outcomes of a selected group of patients considered at high risk for PCS: hospitalized patients with severe COVID-19 infection who presented clinical evidence of the acute onset of venous thromboembolism. Weighted Cox regression was used to estimate the adjusted hazard ratios for the risk of early and medium-term complications and quality of life (QoL) in COVID-19 patients developing acute venous thrombo-embolism according to the period of admission to the hospital...
October 13, 2023: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/37832584/the-diagnostic-role-of-lung-ultrasound-and-contrast-enhanced-ultrasound-in-pulmonary-embolism
#13
JOURNAL ARTICLE
Andrea Boccatonda, Lorenzo Andreetto, Susanna Vicari, Elena Campello, Paolo Simioni, Walter Ageno
The diagnosis of pulmonary embolism (PE) relies essentially on a probabilistic approach that requires careful clinical assessments, targeted laboratory tests, and the use of appropriate imaging tools. Nowadays, the diagnostic gold standard is computed tomographic pulmonary angiography. Lung ultrasound (LUS) can play a role in the diagnosis of PE mainly by allowing the visualization of peripheral lung infarctions. Hypoechoic, pleural-based parenchymal consolidation is the most typical and common finding of pulmonary infarction...
October 13, 2023: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/37832583/optimizing-and-extending-the-risk-adapted-management-of-acute-pulmonary-embolism-beyond-the-acute-phase-progress-in-pulmonary-embolism-research
#14
JOURNAL ARTICLE
Stefano Barco, Frederikus A Klok, Behnood Bikdeli
No abstract text is available yet for this article.
October 13, 2023: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/37813372/thrombin-generation-markers-as-predictors-of-cancer-associated-venous-thromboembolism-a-systematic-review
#15
JOURNAL ARTICLE
Tua Gyldenholm, Anne-Mette Hvas, Thomas Decker Christensen, Julie Brogaard Larsen
Venous thromboembolism (VTE) is a main contributor to morbidity and mortality in cancer patients. Biomarkers with the potential to predict cancer-associated VTE are continually sought. Of these, markers of thrombin generation present a likely option. The present systematic review examines the ability of three widely used biomarkers of thrombin generation: prothrombin fragment 1.2 (F1.2), thrombin-antithrombin complex (TAT), and ex vivo thrombin generation, to predict VTE in both solid and hematologic adult cancer patients...
October 9, 2023: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/37813371/whole-blood-viscosity-and-cerebral-blood-flow-in-acute-ischemic-stroke
#16
JOURNAL ARTICLE
Prajwal Gyawali, Thomas P Lillicrap, Carlos G Esperon, Aseem Bhattarai, Andrew Bivard, Neil Spratt
Existing effective treatments for ischemic stroke restore blood supply to the ischemic region using thrombolysis or mechanical removal of clot. However, it is increasingly recognized that successful removal of occlusive thrombus from the large artery-recanalization, may not always be accompanied by successful restoration of blood flow to the downstream tissues-reperfusion. Ultimately, brain tissue survival depends on cerebral perfusion, and a functioning microcirculation. Because capillary diameter is often equal to or smaller than an erythrocyte, microcirculation is largely dependent on erythrocyte rheological (hemorheological) factors such as whole blood viscosity (WBV)...
October 9, 2023: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/37813370/fifty-years-of-fibrinogen-structure-and-function
#17
JOURNAL ARTICLE
Marguerite Neerman-Arbez, Alessandro Casini
No abstract text is available yet for this article.
October 9, 2023: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/37758179/congenital-bleeding-disorders-and-covid-19-a-systematic-literature-review
#18
JOURNAL ARTICLE
Akbar Dorgalaleh, Seyed Mehrab Safdari, Shadi Tabibian, Mahmood Shams, Ali Dabbagh, Azadeh Rezazadeh
Hypercoagulability is a prominent feature of coronavirus disease 2019 (COVID-19) and can lead to fatal consequences. Although the impact of COVID-19 on several disorders is well-established, its effect on congenital bleeding disorders (CBDs) is not well-documented. To address this ambiguity, a systematic review was conducted on the available studies to determine the impact of COVID-19 and vaccination aimed to prevent COVID-19 on patients with CBDs. We performed a systematic literature review using relevant keywords and followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) protocol...
September 27, 2023: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/37758178/the-most-highly-cited-publications-from-seminars-in-thrombosis-and-hemostasis-a-data-analysis-50-years-in-the-making
#19
JOURNAL ARTICLE
Emmanuel J Favaloro
No abstract text is available yet for this article.
September 27, 2023: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/37751774/abo-blood-group-and-the-risk-of-thrombosis-in-cancer-patients-a-mini-review
#20
JOURNAL ARTICLE
Salah Elsherif, Ali Zidan, Olivia Saville, Maha Othman
Cancer-associated thrombosis (CT), especially venous thromboembolism (VTE), is a common occurrence with several factors contributing to a wide diversity in thrombosis risk. The association between ABO blood groups and the risk for CT has been examined in various studies, with non-O blood type associated with an increased thrombosis risk; however, these studies have reported varying results with recognized limitations. ABO blood groups are known to be implicated in hemostasis, in an association mediated through von Willebrand factor (VWF)...
September 26, 2023: Seminars in Thrombosis and Hemostasis
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