Karolina Aleksandrowicz, Dominika Hempel, Barbara Polityńska, Anna M Wojtukiewicz, Kenneth V Honn, Dean G Tang, Marek Z Wojtukiewicz
Thrombin, a pleiotropic enzyme involved in coagulation, plays a crucial role in both procoagulant and anticoagulant pathways. Thrombin converts fibrinogen into fibrin, initiates platelet activation, and promotes clot formation. Thrombin also activates anticoagulant pathways, indirectly inhibiting factors involved in coagulation. Tissue factor triggers thrombin generation, and the overexpression of thrombin in various cancers suggests that it is involved in tumor growth, angiogenesis, and metastasis. Increased thrombin generation has been observed in cancer patients, especially those with metastases...
November 20, 2023: Seminars in Thrombosis and Hemostasis