journal
Journals Seminars in Thrombosis and Hem...

Seminars in Thrombosis and Hemostasis

https://read.qxmd.com/read/36940717/pediatric-presentation-of-antiphospholipid-syndrome-a-review-of-recent-literature-with-estimation-of-local-prevalence
#1
JOURNAL ARTICLE
Massimo Radin, Irene Cecchi, Marta Arbrile, Davide Montin, Loredana Farinasso, Michele Cioffi, Silvia Grazietta Foddai, Alice Barinotti, Elisa Menegatti, Simone Baldovino, Savino Sciascia, Dario Roccatello
We aimed to investigate the epidemiology, the clinical and laboratory characteristics of the pediatric involvement of antiphospholipid syndrome (APS), by performing a review of the current evidence and reviewing local experience in the Northwest Italy. To achieve this, we performed a detailed literature search to identify articles describing clinical and laboratory characteristics of pediatric APS. In concomitance, we conducted a registry-based study collecting data from the Piedmont and Aosta Valley Rare Disease Registry including pediatric patients diagnosed with APS in the last 11 years...
March 20, 2023: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/36940716/laboratory-evaluation-of-antithrombin-protein-c-and-protein-s
#2
JOURNAL ARTICLE
Richard A Marlar
Thrombophilia is a complex disease process, clinically manifesting in various forms of venous thromboembolism. Although both genetic and acquired (or environmental) risks factors have been reported, the presence of a genetic defect (antithrombin [AT], protein C [PC], protein S [PS]) is considered three of the major contributing factors of thrombophilia. The presence of each of these risk factors can be established by clinical laboratory analysis; however, the clinical provider and laboratory personnel must understand the testing limitations and shortcomings associated with the assays for these factors to be able to ensure an accurate diagnosis...
March 20, 2023: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/36940715/substrates-cofactors-and-cellular-targets-of-coagulation-factor-xia
#3
JOURNAL ARTICLE
André L Lira, Tia C L Kohs, Samantha A Moellmer, Joseph J Shatzel, Owen J T McCarty, Cristina Puy
Coagulation factor XI (FXI) has increasingly been shown to play an integral role in several physiologic and pathological processes. FXI is among several zymogens within the blood coagulation cascade that are activated by proteolytic cleavage, with FXI converting to the active serine protease form (FXIa). The evolutionary origins of FXI trace back to duplication of the gene that transcribes plasma prekallikrein, a key factor in the plasma kallikrein-kinin system, before further genetic divergence led to FXI playing a unique role in blood coagulation...
March 20, 2023: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/36940714/novel-insights-into-heterozygous-factor-xiii-deficiency
#4
JOURNAL ARTICLE
Akbar Dorgalaleh
The prevalence and clinical significance of heterozygous factor XIII (FXIII) deficiency has long been debated, with controversial reports emerging since 1988. In the absence of large epidemiologic studies, but based on a few studies, a prevalence of 1 per 1,000 to 5,000 is estimated. In southeastern Iran, a hotspot area for the disorder, a study of more than 3,500 individuals found an incidence of 3.5%. Between 1988 and 2023, a total of 308 individuals were found with heterozygous FXIII deficiency, of which molecular, laboratory, and clinical presentations were available for 207 individuals...
March 20, 2023: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/36940713/the-post-venous-thromboembolism-functional-status-scale-from-call-to-action-to-application-in-research-extension-to-covid-19-patients-and-its-use-in-clinical-practice
#5
JOURNAL ARTICLE
Cindy M M de Jong, Gudula J A M Boon, Y N Jenny Le, Stefano Barco, Bob Siegerink, Frederikus A Klok
A broad spectrum of long-term sequelae may be present in venous thromboembolism (VTE) survivors, affecting their quality of life and functioning. To monitor recovery and improve the prognosis of patients with persistent functional limitations, the development of a new outcome measure that could better capture the consequences of VTE was an unmet need. Starting as a call to action, the Post-VTE Functional Status (PVFS) scale was developed to meet this need. The PVFS scale is an easy-to-use clinical tool to measure and quantify functional outcomes after VTE by focusing on key aspects of daily life...
March 20, 2023: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/36940712/a-brief-history-of-hemostasis-and-thrombosis-at-the-mayo-clinic
#6
JOURNAL ARTICLE
Dong Chen, Rajiv Pruthi
Coagulation is a crucial biological mechanism in human bodies to prevent blood loss. Abnormal coagulation can cause bleeding diathesis or thrombosis, common pathologic conditions in our clinical practice. Many individuals and organizations have dedicated their efforts in the past decades to understanding the biological and pathological mechanisms of coagulation and developing laboratory testing tools and treatment options to help patients with bleeding or thrombotic conditions. Since 1926, the Mayo Clinic coagulation group has made significant contributions to the clinical and laboratory practice, basic and translational research on various hemostatic and thrombotic disorders, and the education and collaboration to share and advance our knowledge in coagulation through a highly integrated team and practice model...
March 20, 2023: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/36940711/2023-eberhard-f-mammen-award-announcements-part-i-most-popular-articles
#7
JOURNAL ARTICLE
Emmanuel J Favaloro
No abstract text is available yet for this article.
March 20, 2023: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/36921613/platelet-parameters-as-biomarkers-for-thrombosis-risk-in-cancer-a-systematic-review-and-meta-analysis
#8
JOURNAL ARTICLE
Anne Lind Malte, Johanne Andersen Højbjerg, Julie Brogaard Larsen
Cancer-associated thrombosis (CAT) is a major cause of both morbidity and mortality in cancer patients. Platelet count has been investigated as a predictor of CAT in various settings while knowledge on platelet activation parameters is sparse. This report provides a systematic review and meta-analysis on available literature on associations between platelet count and/or function and arterial and venous thrombosis in adult cancer patients. The review was performed according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement...
March 15, 2023: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/36913971/contraceptives-and-thrombosis-an-intertwined-revolutionary-road
#9
JOURNAL ARTICLE
Doris Barcellona, Francesco Marongiu, Elvira Grandone
The development of oral contraceptives (OCs) began in 1921 and continued in the following years until the first regulatory approval from the Food and Drug Administration was granted in 1960. However, it took several years to realize that OCs presented an important but not frequent risk of venous thrombosis. Several reports ignored this dangerous effect and only in 1967 the Medical Research Council clearly stated this as an important risk. Later, research led to the formulation of second-generation OCs containing progestins, which nevertheless presented an increased thrombotic risk...
March 13, 2023: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/36868268/sex-related-differences-in-patients-characteristics-risk-factors-and-symptomatology-in-older-adults-with-pulmonary-embolism-findings-from-the-serious-pe-study
#10
JOURNAL ARTICLE
Behnood Bikdeli, Alfonso Muriel, Yun Wang, Gregory Piazza, Candrika D Khairani, Rachel P Rosovsky, Ghazaleh Mehdipoor, Michelle L O'Donoghue, Olga Madridano, Juan Bosco Lopez-Saez, Meritxell Mellado, Ana Maria Diaz Brasero, Elvira Grandone, Primavera A Spagnolo, Yuan Lu, Laurent Bertoletti, Luciano López-Jiménez, Manuel Jesús Núñez, Ángeles Blanco-Molina, Marie Gerhard-Herman, Samuel Z Goldhaber, Shannon M Bates, David Jimenez, Harlan M Krumholz, Manuel Monreal
Sex-specific factors are implicated in pulmonary embolism (PE) presentation in young patients, as indicated by increased risk in pregnancy. Whether sex differences exist in PE presentation, comorbidities, and symptomatology in older adults, the age group in which most PEs occur, remains unknown. We identified older adults (aged ≥65 years) with PE in a large international PE registry replete with information about relevant clinical characteristics (RIETE registry, 2001-2021). To provide national data from the United States, we assessed sex differences in clinical characteristics and risk factors of Medicare beneficiaries with PE (2001-2019)...
March 3, 2023: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/36828005/changes-in-coagulation-in-cancer-patients-undergoing-cytoreductive-surgery-with-hyperthermic-intraperitoneal-chemotherapy-treatment-hipec-a-systematic-review
#11
JOURNAL ARTICLE
Mikkel Lundbech, Matilde Damsbo, Andreas Engel Krag, Anne-Mette Hvas
Venous thromboembolism and postoperative bleeding are complications of cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC). The aim of this systematic review was to summarize current knowledge on the effect of cytoreductive surgery with HIPEC on coagulation and fibrinolysis within 10 days after surgery. Studies were identified in PubMed, Embase, and Web of Science on December 12, 2022. Data on biomarkers of coagulation and fibrinolysis measured preoperatively up to the 10th postoperative day were extracted...
February 24, 2023: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/36807283/the-role-of-the-von-willebrand-factor-collagen-binding-assay-vwf-cb-in-the-diagnosis-and-treatment-of-von-willebrand-disease-vwd-and-way-beyond-a-comprehensive-36-year-history
#12
JOURNAL ARTICLE
Emmanuel J Favaloro
The von Willebrand factor (VWF) collagen binding (VWF:CB) assay was first reported for use in von Willebrand diagnostics in 1986, by Brown and Bosak. Since then, the VWF:CB has continued to be used to help diagnose von Willebrand disease (VWD) ( correctly ) and also to help assign the correct subtype, as well as to assist in the monitoring of VWD therapy, especially desmopressin (DDAVP). However, it is important to recognize that the specific value of any VWF:CB is predicated on the use of an optimized VWF:CB, and that not all VWF:CB assays are so optimized...
February 20, 2023: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/36807282/association-between-severe-acute-respiratory-syndrome-coronavirus-2infection-coronavirus-disease-2019-and-lupus-anticoagulant-hypoprothrombinemia-syndrome-a-case-report-and-literature-assessment
#13
JOURNAL ARTICLE
Marta Monti, Tiziano Martini, Vittorio Pengo, Giovanni Poletti, Paola Pedrazzi, Chiara Biasoli, Maddalena Giovacchini, Tommaso Fasano
No abstract text is available yet for this article.
February 20, 2023: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/36807290/assessment-of-hemostatic-profile-in-neonates-with-intrauterine-growth-restriction-a-systematic-review-of-literature
#14
JOURNAL ARTICLE
Eleni Karapati, Rozeta Sokou, Zoi Iliodromiti, Marina Tsaousi, Alma Sulaj, Andreas G Tsantes, Chrysa Petropoulou, Abraham Pouliakis, Argirios E Tsantes, Theodora Boutsikou, Nicoletta Iacovidou
Intrauterine growth restriction (IUGR) affects nearly 10 to 15% of pregnancies and is responsible for many short- and long-term adverse consequences, including hemostatic derangement. Both thrombotic and hemorrhagic events are described in the perinatal period in these neonates. The aim of this study was to systematically review the literature on the laboratory studies used to evaluate the hemostatic system of the IUGR small for gestational age neonate. We reviewed the current literature via PubMed and Scopus until September 2022...
February 17, 2023: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/36781153/increased-platelet-activation-demonstrated-by-elevated-cd36-and-p-selectin-expression-in-1-year-post-recovered-covid-19-patients
#15
JOURNAL ARTICLE
Samuel Sherng Young Wang, Keefe Chee, Shiun Woei Wong, Guat Bee Tan, Hong Ang, Bernard PuiLam Leung, Chuen Wen Tan, Kollengode Ramanathan, Rinkoo Dalan, Christine Cheung, David Chien Lye, Barnaby Edward Young, Eng Soo Yap, Yew Woon Chia, Bingwen Eugene Fan
No abstract text is available yet for this article.
February 13, 2023: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/36781152/editorial-compilation-xiii
#16
JOURNAL ARTICLE
Emmanuel J Favaloro, Leonardo Pasalic, Giuseppe Lippi
No abstract text is available yet for this article.
February 13, 2023: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/36750218/hemostasis-in-the-pregnant-woman-the-placenta-the-fetus-and-the-newborn-infant
#17
JOURNAL ARTICLE
Beth Boulden Warren, Genevieve C Moyer, Marilyn J Manco-Johnson
The hemostasis system is composed of procoagulant, anticoagulant, and fibrinolytic proteins that interact with endothelial and blood cells and with each other in a complex system of checks and balances to maintain blood flow while preventing both hemorrhage and thrombosis. Pregnancy is a unique physiological state in which biological alterations predispose both mother and fetus to both bleeding and clotting. The placenta is a vascular interface for maternal and fetal blood exchange which predisposes the mother to hemorrhage...
February 7, 2023: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/36750217/the-history-of-extracorporeal-membrane-oxygenation-and-the-development-of-extracorporeal-membrane-oxygenation-anticoagulation
#18
JOURNAL ARTICLE
Robert Bartlett, Deepa J Arachichilage, Meera Chitlur, Shiu-Ki Rocky Hui, Cindy Neunert, Andrew Doyle, Andrew Retter, Beverley J Hunt, Hoong Sern Lim, Arun Saini, Thomas Renné, Vadim Kostousov, Jun Teruya
Extracorporeal membrane oxygenation (ECMO) was first started for humans in early 1970s by Robert Bartlett. Since its inception, there have been numerous challenges with extracorporeal circulation, such as coagulation and platelet activation, followed by consumption of coagulation factors and platelets, and biocompatibility of tubing, pump, and oxygenator. Unfractionated heparin (heparin hereafter) has historically been the defacto anticoagulant until recently. Also, coagulation monitoring was mainly based on bedside activated clotting time and activated partial thromboplastin time...
February 7, 2023: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/36731488/drug-drug-interactions-in-the-treatment-of-cancer-associated-venous-thromboembolism-with-direct-oral-anticoagulants
#19
JOURNAL ARTICLE
Maja Hellfritzsch, Jakob Nørgaard Henriksen, Marianne Ingerslev Holt, Erik Lerkevang Grove
Venous thromboembolism (VTE) is a frequent complication of cancer, and management of cancer-associated thrombosis (CAT) is challenging due to increased risks of bleeding and recurrent VTE. Recent trials have shown an acceptable efficacy and safety of direct oral anticoagulants (DOACs) in the treatment of CAT compared to low-molecular weight heparin. Although DOACs provide an effective and convenient treatment option in CAT, the need to assess the risk of drug-drug interactions (DDI) with antineoplastic therapies poses a barrier to their use in clinical practice...
February 2, 2023: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/36731487/prognostic-impact-of-the-international-society-on-thrombosis-and-hemostasis-disseminated-intravascular-coagulation-score-in-sepsis-a-systematic-review
#20
JOURNAL ARTICLE
Christian Sandberg Frank, Julie Brogaard Larsen
The International Society on Thrombosis and Haemostasis (ISTH) diagnostic criteria for disseminated intravascular coagulation (DIC) are widely used for DIC diagnosis. However, the prognostic value of the score may vary between different patient populations and settings. This systematic review investigated the association between the ISTH DIC score and mortality in sepsis patients. A literature search was conducted in PubMed and Embase. Inclusion criteria were studies including adult and pediatric patients hospitalized with sepsis, using any sepsis definition, and investigating the association between mortality and the ISTH DIC score...
February 2, 2023: Seminars in Thrombosis and Hemostasis
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