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Seminars in Thrombosis and Hemostasis

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https://read.qxmd.com/read/30887486/comprehensive-coagulation-profiling-at-the-point-of-care-using-a-novel-laser-based-approach
#1
Seemantini K Nadkarni
Delays in identifying internal bleeding are life-threatening, thus underscoring the need for rapid and comprehensive coagulation profiling at the bedside. The authors review a novel optical coagulation profiler that measures several coagulation metrics including prothrombin time, activated clotting time, clot polymerization rate (α-angle), clot stiffness (maximum amplitude), fibrinolysis (LY), and platelet function, using a single multifunctional instrument. The optical profiler is based on the principles of Laser Speckle Rheology that quantifies tissue viscoelasticity from light scattering patterns called laser speckle...
March 18, 2019: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/30887485/novel-coagulation-analyzers-in-development-a-glimpse-toward-the-future-of-microfluidics
#2
Sitaram M Emani
Coagulation diagnostic testing in pediatric patients currently requires large volume blood sampling and is performed on analyzers that are not well-suited for multiplexed assays on a given sample. For patients who require serial testing at regular intervals, repetitive phlebotomy leads to iatrogenic anemia and need for blood transfusions. Over the past decade, novel microfluidic platforms have been developed that allow for complex multiplexed assays to be performed on small sample volumes, near patient, with high fidelity...
March 18, 2019: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/30743280/management-of-patients-taking-oral-anticoagulants-who-need-urgent-surgery-for-hip-fracture
#3
Elvira Grandone, Angelo Ostuni, Giovanni L Tiscia, Francesco Marongiu, Doris Barcellona
The number of hip fractures in anticoagulated patients is predicted to increase, due to people living longer. However, evidence regarding urgent perioperative management of elderly patients with hip fracture who take oral anticoagulants (vitamin K antagonists or direct oral anticoagulants) is scarce. In this article, the authors present a narrative review of the evidence to date supporting the urgent management of hip fracture in anticoagulated elderly patients. They discuss the complexity of managing the high risk of procedure-related bleeding and, at the same time, the high risk of thromboembolism...
February 11, 2019: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/30743279/to-maintain-or-cease-non-vitamin-k-antagonist-oral-anticoagulants-prior-to-minimal-bleeding-risk-procedures-a-review-of-evidence-and-recommendations
#4
Yvonne Brennan, Emmanuel J Favaloro, Jennifer Curnow
For procedures associated with minimal bleeding risk, there are data and experience to support the practice of continuing vitamin K antagonists rather than interrupting therapy, to prevent exposing patients to the undue risk of developing thromboembolism during anticoagulation cessation. Despite the increasing use of non-vitamin K oral anticoagulants (NOACs), there is little evidence to guide the management of these drugs around minimal bleeding risk procedures. This review examines and discusses the major society guidelines and recommendations addressing the management of NOACs around minimal bleeding risk procedures...
February 11, 2019: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/30699441/analytical-assessment-of-the-new-roche-cobas-t-711-fully-automated-coagulation-analyzer
#5
Giuseppe Lippi, Gian Luca Salvagno, Matteo Gelati, Giovanni Poli, Davide Giavarina, Emmanuel J Favaloro
This study aimed to provide a preliminary evaluation of the analytical performance of the new Roche COBAS T 711: fully automated coagulation analyzer, which uses both liquid and lyophilized reagent cassettes. The analytical assessment included analysis of imprecision and linearity of prothrombin time (PT), activated partial thromboplastin time (APTT), and fibrinogen on COBAS T 711: analyzer. Test results of 120 routine plasma samples were also compared with those obtained using two other coagulation analyzers (Instrumentation Laboratory ACL TOP 700 and Stago STA-R MAX)...
January 30, 2019: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/30943570/innovations-in-thrombosis-and-hemostasis-a-glimpse-towards-the-future-of-diagnostic-analyzers
#6
Elizabeth M Van Cott, Kristi J Smock, Giuseppe Lippi
No abstract text is available yet for this article.
April 2019: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/30943569/2019-eberhard-f-mammen-award-announcements-part-i-most-popular-articles
#7
Emmanuel J Favaloro
No abstract text is available yet for this article.
April 2019: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/30912102/flow-devices-to-assess-platelet-function-historical-evolution-and-current-choices
#8
Raisa Cintra Lomanto Santos Silva, Eric Franklin Grabowski
Platelet function testing, which began more than a hundred years ago, is a time-consuming and uncertain process. Simulating hemostasis and the blood vessel microenvironment in vitro is challenging, which poses a difficulty for diagnosing platelet dysfunction and mild von Willebrand disease (VWD). In an effort to simulate the rheological microenvironment within blood vessels, several blood flow devices have been introduced since the 1980s. These devices are capable of reproducing the shear rates found in arterioles and venules, and of incorporating endothelial cell monolayers and surfaces with adsorbed platelet-adhesive proteins...
April 2019: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/30912101/recent-advances-in-mainstream-hemostasis-diagnostics-and-coagulation-testing
#9
Emmanuel J Favaloro, Giuseppe Lippi
The authors provide a narrative review of mainstream hemostasis analyzers. The review is presented in two parts. In the first part, the authors give voice to several internationally representative manufacturers of mainstream hemostasis analyzers. They ask these manufacturers to (1) answer a series of survey questions that may otherwise reflect common questions asked by users or potential users of their equipment, (2) provide a bullet list of their main focus areas, and (3) provide other information in regard to their instrumentation...
April 2019: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/30822795/recent-advances-in-thrombosis-and-hemostasis-part-iv
#10
Sam Schulman
No abstract text is available yet for this article.
March 2019: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/30822794/2018-eberhard-f-mammen-award-announcements-part-ii-young-investigator-awards
#11
Emmanuel J Favaloro
No abstract text is available yet for this article.
March 2019: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/30743281/thromboprophylaxis-in-patients-with-acute-spinal-cord-injury-a-narrative-review
#12
REVIEW
Siavash Piran, Sam Schulman
Patients with acute spinal cord injury (SCI) have the highest risk of venous thromboembolism (VTE) among hospitalized patients. The incidence of total deep vein thrombosis ranges from 50 to 100% in untreated patients and pulmonary embolism is the third most common cause of mortality in these patients. The pathophysiology of the increased risk of VTE is explained by venous stasis after injury, endothelial vessel wall injury from surgery, and a hypercoagulable state associated with trauma. The current thromboprophylaxis options are limited, with low-molecular-weight heparin (LMWH) being the current standard of care...
March 2019: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/30347414/harms-and-benefits-of-using-aspirin-for-primary-prevention-of-cardiovascular-disease-a-narrative-overview
#13
REVIEW
Giuseppe Lippi, Elisa Danese, Emmanuel J Favaloro
Aspirin is one of the most often used drugs for prevention and treatment of a variety of thrombotic disorders. This narrative review aims to provide an overview of evidence highlighting potential benefits and relative harms of aspirin in primary prevention of cardiovascular disease. The authors summarize key findings of the ASPirin in Reducing Events in the Elderly (ASPREE) Investigator Group randomized trial and also provide a comparative overview of recent meta-analyses. Overall, all-cause mortality was largely heterogeneous, with some meta-analyses showing a modestly decreased risk in patients taking aspirin, with others reporting no effects, but the ASPREE Investigator Group trial evidencing 14% higher risk...
March 2019: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/30119139/atrial-fibrillation-and-malignancy-the-clinical-performance-of-non-vitamin-k-oral-anticoagulants-a-systematic-review
#14
Vincenzo Russo, Roberta Bottino, Anna Rago, Pierpaolo Di Micco, Antonio D' Onofrio, Biagio Liccardo, Paolo Golino, Gerardo Nigro
Atrial fibrillation (AF) is commonly diagnosed in the setting of active cancer. Because of an increased risk of either thromboembolic events or bleeding, the decision to initiate therapeutic anticoagulation in patients with active cancer can be challenging. Moreover, little is still known about the optimal anticoagulation therapy in the setting of AF and cancer, and no guidelines are as yet available. Considering that nonvitamin K antagonist oral anticoagulants (NOACs) are recommended as alternatives to vitamin K antagonists for stroke prevention in AF patients with CHA2 DS2- VASc score ≥2, the authors performed a systematic review of the current literature to describe the efficacy and safety of NOACs in AF patients with malignancy...
March 2019: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/30699461/editorial-compilation-vi
#15
Emmanuel J Favaloro, Giuseppe Lippi
No abstract text is available yet for this article.
February 2019: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/30699460/welcome-to-seminars-in-thrombosis-and-hemostasis-2019-new-2017-impact-factor-and-most-highly-cited-papers
#16
Emmanuel J Favaloro
No abstract text is available yet for this article.
February 2019: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/30641578/erratum-quebec-platelet-disorder-update-on-pathogenesis-diagnosis-and-treatment
#17
Catherine P M Hayward, Georges E Rivard
No abstract text is available yet for this article.
February 2019: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/30634199/the-elusive-diagnosis-of-disseminated-intravascular-coagulation-does-a-diagnosis-of-dic-exist-anymore
#18
REVIEW
Jecko Thachil
Disseminated intravascular coagulation (DIC) is an intermediary mechanism of disease known to develop as a complication in other conditions like sepsis, trauma, cancer, or obstetrical disorders. Patients with DIC may present to different specialists depending on symptomology and as such a good understanding of the pathophysiological process is necessary to ensure best management. However, more recently, controversy has risen where experts doubt whether DIC really exists in many of the historically well-established diagnoses...
February 2019: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/30634198/neutrophil-extracellular-traps-in-arterial-and-venous-thrombosis
#19
REVIEW
Elodie Laridan, Kimberly Martinod, Simon F De Meyer
Thrombotic complications are still a major health risk worldwide. Our view on the pathophysiology of thrombosis has significantly changed since the discovery of neutrophil extracellular traps (NETs) and their prothrombotic characteristics. Generated by neutrophils that release their decondensed chromatin as a network of extracellular fibers, NETs promote thrombus formation by serving as a scaffold that activates platelets and coagulation. The thrombogenic involvement of NETs has been described in various settings of thrombosis, including stroke, myocardial infarction, and deep vein thrombosis...
February 2019: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/30630207/sticky-platelet-syndrome-35-years-of-growing-evidence
#20
REVIEW
Peter Kubisz, Pavol Holly, Jan Stasko
Since the identification of antithrombin deficiency by Egeberg in 1956, ongoing research in prothrombotic defects continues to progress. Interestingly, past research has predominantly focused on coagulation factors and not on other components of the hemostatic system. The possible role of platelet function defects in the development of thrombotic events was suggested for the first time in the late 1970s, when an increased platelet adhesiveness and aggregation after epinephrine (EPI) and adenosine diphosphate (ADP) was found in a group of patients with unexplained transient ischemic attack...
February 2019: Seminars in Thrombosis and Hemostasis
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