journal
https://read.qxmd.com/read/38536107/benchmarking-machine-learning-based-real-time-respiratory-signal-predictors-in-4d-sbrt
#1
JOURNAL ARTICLE
Lukas Wimmert, Maximilian Nielsen, Frederic Madesta, Tobias Gauer, Christian Hofmann, Rene Werner
BACKGROUND: Stereotactic body radiotherapy of thoracic and abdominal tumors has to account for respiratory intrafractional tumor motion. Commonly, an external breathing signal is continuously acquired that serves as a surrogate of the tumor motion and forms the basis of strategies like breathing-guided imaging and gated dose delivery. However, due to inherent system latencies, there exists a temporal lag between the acquired respiratory signal and the system response. Respiratory signal prediction models aim to compensate for the time delays and to improve imaging and dose delivery...
March 27, 2024: Medical Physics
https://read.qxmd.com/read/38530135/lung-ct-harmonization-of-paired-reconstruction-kernel-images-using-generative-adversarial-networks
#2
JOURNAL ARTICLE
Aravind R Krishnan, Kaiwen Xu, Thomas Z Li, Lucas W Remedios, Kim L Sandler, Fabien Maldonado, Bennett A Landman
BACKGROUND: The kernel used in CT image reconstruction is an important factor that determines the texture of the CT image. Consistency of reconstruction kernel choice is important for quantitative CT-based assessment as kernel differences can lead to substantial shifts in measurements unrelated to underlying anatomical structures. PURPOSE: In this study, we investigate kernel harmonization in a multi-vendor low-dose CT lung cancer screening cohort and evaluate our approach's validity in quantitative CT-based assessments...
March 26, 2024: Medical Physics
https://read.qxmd.com/read/38517433/physical-dose-validation-of-dynamic-treatment-for-gamma-knife-radiosurgery
#3
JOURNAL ARTICLE
Benjamin Z Tham, Dionne M Aleman, Robert K Heaton, Håkan Nordström, Catherine Coolens
BACKGROUND: Dynamic treatment in Gamma Knife (GK) radiosurgery systems delivers radiation continuously with couch movement, as opposed to stationary step-and-shoot treatment where radiation is paused when moving between isocenters. Previous studies have shown the potential for dynamic GK treatment to give faster treatment times and improved dose conformity and homogeneity. However, these studies focused only on computational simulations and lack physical validation. PURPOSE: This study aims conduct dynamic treatment dosimetric validation with physical experimental measurements...
March 22, 2024: Medical Physics
https://read.qxmd.com/read/38517359/pet-spect-spectral-ct-cbct-imaging-in-a-small-animal-radiation-therapy-platform-a-monte-carlo-study-part-ii-biologically-guided-radiotherapy
#4
JOURNAL ARTICLE
Xiadong Li, Hui Wang, Lixia Xu, Yu Kuang
BACKGROUND: This study addresses the technical gap between clinical radiation therapy (RT) and preclinical small-animal RT, hindering the comprehensive validation of innovative clinical RT approaches in small-animal models of cancer and the translation of preclinical RT studies into clinical practices. PURPOSE: The main aim was to explore the feasibility of biologically guided RT implemented within a small-animal radiation therapy (SART) platform, with integrated quad-modal on-board positron emission tomography (PET), single-photon emission computed tomography, photon-counting spectral CT, and cone-beam CT (CBCT) imaging, in a Monte Carlo model as a proof-of-concept...
March 22, 2024: Medical Physics
https://read.qxmd.com/read/38513254/superparamagnetic-iron-oxide-nanoparticle-enhanced-percutaneous-microwave-ablation-ex-vivo-characterization-using-magnetic-resonance-thermometry
#5
JOURNAL ARTICLE
Sharath K Bhagavatula, Sajanlal R Panikkanvalappil, Junichi Tokuda, Vincent Levesque, Zuzana Tatarova, Guigen Liu, John E Markert, Oliver Jonas
BACKGROUND: Percutaneous microwave ablation (pMWA) is a minimally invasive procedure that uses a microwave antenna placed at the tip of a needle to induce lethal tissue heating. It can treat cancer and other diseases with lower morbidity than conventional surgery, but one major limitation is the lack of control over the heating region around the ablation needle. Superparamagnetic iron oxide nanoparticles have the potential to enhance and control pMWA heating due to their ability to absorb microwave energy and their ease of local delivery...
March 21, 2024: Medical Physics
https://read.qxmd.com/read/38507783/ct-based-radiomics-for-differentiating-peripherally-located-pulmonary-sclerosing-pneumocytoma-from-carcinoid
#6
JOURNAL ARTICLE
Yi Zhang, Xiaohuang Yang, Feng Bi, Lu Wen, Yue Niu, Yanhui Yang, Huashan Lin, Xiaoping Yu
BACKGROUND: Pulmonary sclerosing pneumocytoma (PSP) and pulmonary carcinoid (PC) are difficult to distinguish based on conventional imaging examinations. In recent years, radiomics has been used to discriminate benign from malignant pulmonary lesions. However, the value of radiomics based on computed tomography (CT) images to differentiate PSP from PC has not been well explored. PURPOSE: We aimed to investigate the feasibility of radiomics in the differentiation between PSP and PC...
March 20, 2024: Medical Physics
https://read.qxmd.com/read/38507277/technical-note-a-universal-worksheet-for-failure-mode-and-effects-analysis-a-project-of-the-japanese-college-of-medical-physics
#7
JOURNAL ARTICLE
Shie Nishioka, Hiroyuki Okamoto, Takahito Chiba, Satoshi Kito, Yoshitomo Ishihara, Masaru Isono, Tomohiro Ono, Asumi Mizoguchi, Norifumi Mizuno, Naoki Tohyama, Masahiko Kurooka, Seiichi Ota, Daisuke Shimizu
BACKGROUND: Failure mode and effects analysis (FMEA), which is an effective tool for error prevention, has garnered considerable attention in radiotherapy. FMEA can be performed individually, by a group or committee, and online. PURPOSE: To meet the needs of FMEA for various purposes and improve its accessibility, we developed a simple, self-contained, and versatile web-based FMEA risk analysis worksheet. METHODS: We developed an FMEA worksheet using Google products, such as Google Sheets, Google Forms, and Google Apps Script...
March 20, 2024: Medical Physics
https://read.qxmd.com/read/38507259/deep-learning-based-target-decomposition-for-markerless-lung-tumor-tracking-in-radiotherapy
#8
JOURNAL ARTICLE
Yabo Fu, Pengpeng Zhang, Qiyong Fan, Weixing Cai, Hai Pham, Andreas Rimner, John Cuaron, Laura Cervino, Jean M Moran, Tianfang Li, Xiang Li
BACKGROUND: In radiotherapy, real-time tumor tracking can verify tumor position during beam delivery, guide the radiation beam to target the tumor, and reduce the chance of a geometric miss. Markerless kV x-ray image-based tumor tracking is challenging due to the low tumor visibility caused by tumor-obscuring structures. Developing a new method to enhance tumor visibility for real-time tumor tracking is essential. PURPOSE: To introduce a novel method for markerless kV image-based tracking of lung tumors via deep learning-based target decomposition...
March 20, 2024: Medical Physics
https://read.qxmd.com/read/38507254/first-measurements-of-radon-220-diffusion-in-mice-tumors-towards-treatment-planning-in-diffusing-alpha-emitters-radiation-therapy
#9
JOURNAL ARTICLE
Guy Heger, Mirta Dumančić, Ishai Luz, Maayan Vatarescu, Noam Weizman, Brian W Miller, Tomer Cooks, Lior Arazi
BACKGROUND: Diffusing alpha-emitters radiation therapy ("Alpha-DaRT") is a new method for treating solid tumors with alpha particles, relying on the release of the short-lived alpha-emitting daughter atoms of radium-224 from interstitial sources inserted into the tumor. Alpha-DaRT tumor dosimetry is governed by the spread of radium's progeny around the source, as described by an approximate framework called the "diffusion-leakage model". The most important model parameters are the diffusion lengths of radon-220 and lead-212, and their estimation is therefore essential for treatment planning...
March 20, 2024: Medical Physics
https://read.qxmd.com/read/38507253/a-comprehensive-investigation-of-the-performance-of-a-commercial-scintillator-system-for-applications-in-electron-flash-radiotherapy
#10
JOURNAL ARTICLE
Kevin Liu, Shannon Holmes, Emil Schüler, Sam Beddar
BACKGROUND: Dosimetry in ultra-high dose rate (UHDR) beamlines is significantly challenged by limitations in real-time monitoring and accurate measurement of beam output, beam parameters, and delivered doses using conventional radiation detectors, which exhibit dependencies in ultra-high dose-rate (UHDR) and high dose-per-pulse (DPP) beamline conditions. PURPOSE: In this study, we characterized the response of the Exradin W2 plastic scintillator (Standard Imaging, Inc...
March 20, 2024: Medical Physics
https://read.qxmd.com/read/38507246/dosimetry-of-large-field-valencia-applicators-for-cobalt-60-based-brachytherapy
#11
JOURNAL ARTICLE
Gustavo H Píriz, Gabriel A Gonzalez-Sprinberg, Facundo Ballester, Javier Vijande
BACKGROUND: Non-melanoma skin cancer is one of the most common types of cancer and one of the main approaches is brachytherapy. For small lesions, the treatment of this cancer with brachytherapy can be done with two commercial applicators, one of these is the Large Field Valencia Applicators (LFVA). PURPOSE: The aim of this study is to test the capabilities of the LFVA to use clinically 60 Co sources instead of the 192 Ir ones. This study was designed for the same dwell positions and weights for both sources...
March 20, 2024: Medical Physics
https://read.qxmd.com/read/38497549/nonunion-scaphoid-bone-shape-prediction-using-iterative-kernel-principal-polynomial-shape-analysis
#12
JOURNAL ARTICLE
Junjun Zhu, Junhao Zhao, Xianggeng Luo, Zikai Hua
BACKGROUND: The scaphoid is an important mechanical stabilizer for both the proximal and distal carpal columns. The precise estimation of the complete scaphoid bone based on partial bone geometric information is a crucial factor in the effective management of scaphoid nonunion. Statistical shape model (SSM) could be utilized to predict the complete scaphoid shape based on the defective scaphoid. However, traditional principal component analysis (PCA) based SSM is limited by its linearity and the inability to adjust the number of modes used for prediction...
March 18, 2024: Medical Physics
https://read.qxmd.com/read/38493501/first-monte-carlo-beam-model-for-ultra-high-dose-rate-radiotherapy-with-a-compact-electron-linac
#13
JOURNAL ARTICLE
Tianyuan Dai, Austin M Sloop, Mahbubur R Rahman, Jacob P Sunnerberg, Megan A Clark, Ralph Young, Sebastian Adamczyk, Philip Von Voigts-Rhetz, Chris Patane, Michael Turk, Lesley Jarvis, Brian W Pogue, David J Gladstone, Petr Bruza, Rongxiao Zhang
BACKGROUND: FLASH radiotherapy based on ultra-high dose rate (UHDR) is actively being studied by the radiotherapy community. Dedicated UHDR electron devices are currently a mainstay for FLASH studies. PURPOSE: To present the first Monte Carlo (MC) electron beam model for the UHDR capable Mobetron (FLASH-IQ) as a dose calculation and treatment planning platform for preclinical research and FLASH-radiotherapy (RT) clinical trials. METHODS: The initial beamline geometry of the Mobetron was provided by the manufacturer, with the first-principal implementation realized in the Geant4-based GAMOS MC toolkit...
March 17, 2024: Medical Physics
https://read.qxmd.com/read/38478966/a-comprehensive-lung-ct-landmark-pair-dataset-for-evaluating-deformable-image-registration-algorithms
#14
JOURNAL ARTICLE
Edward R Criscuolo, Yabo Fu, Yao Hao, Zhendong Zhang, Deshan Yang
PURPOSE: Deformable image registration (DIR) is a key enabling technology in many diagnostic and therapeutic tasks, but often does not meet the required robustness and accuracy for supporting clinical tasks. This is in large part due to a lack of high-quality benchmark datasets by which new DIR algorithms can be evaluated. Our team was supported by the National Institute of Biomedical Imaging and Bioengineering to develop DIR benchmark dataset libraries for multiple anatomical sites, comprising of large numbers of highly accurate landmark pairs on matching blood vessel bifurcations...
March 13, 2024: Medical Physics
https://read.qxmd.com/read/38478305/adapting-low-dose-ct-denoisers-for-texture-preservation-using-zero-shot-local-noise-level-matching
#15
JOURNAL ARTICLE
Youngjun Ko, Seongjong Song, Jongduk Baek, Hyunjung Shim
BACKGROUND: On enhancing the image quality of low-dose computed tomography (LDCT), various denoising methods have achieved meaningful improvements. However, they commonly produce over-smoothed results; the denoised images tend to be more blurred than the normal-dose targets (NDCTs). Furthermore, many recent denoising methods employ deep learning(DL)-based models, which require a vast amount of CT images (or image pairs). PURPOSE: Our goal is to address the problem of over-smoothed results and design an algorithm that works regardless of the need for a large amount of training dataset to achieve plausible denoising results...
March 13, 2024: Medical Physics
https://read.qxmd.com/read/38478014/physics-and-small-scale-dosimetry-of-%C3%AE-alpha-emitters-for-targeted-radionuclide-therapy-the-case-of-211-at-211-rm-at
#16
JOURNAL ARTICLE
Mario Enrique Alcocer-Ávila, Alexandre Larouze, Jean-Emmanuel Groetz, Elif Hindié, Christophe Champion
BACKGROUND: Monte Carlo simulations have been considered for a long time the gold standard for dose calculations in conventional radiotherapy and are currently being applied for the same purpose in innovative radiotherapy techniques such as targeted radionuclide therapy (TRT). PURPOSE: We present in this work a benchmarking study of the latest version of the Transport d'Ions Lourds Dans l'Aqua & Vivo (TILDA-V ) Monte Carlo track structure code, highlighting its capabilities for describing the full slowing down of <mml:math xmlns:mml="https://www...
March 13, 2024: Medical Physics
https://read.qxmd.com/read/38477841/experimental-demonstration-of-real-time-cardiac-physiology-based-radiotherapy-gating-for-improved-cardiac-radioablation-on-an-mr-linac
#17
JOURNAL ARTICLE
Osman Akdag, Pim T S Borman, Stefano Mandija, Peter L Woodhead, Prescilla Uijtewaal, Bas W Raaymakers, Martin F Fast
BACKGROUND: Cardiac radioablation is a noninvasive stereotactic body radiation therapy (SBRT) technique to treat patients with refractory ventricular tachycardia (VT) by delivering a single high-dose fraction to the VT isthmus. Cardiorespiratory motion induces position uncertainties resulting in decreased dose conformality. Electocardiograms (ECG) are typically used during cardiac MRI (CMR) to acquire images in a predefined cardiac phase, thus mitigating cardiac motion during image acquisition...
March 13, 2024: Medical Physics
https://read.qxmd.com/read/38477717/multi-energy-blended-cbct-spectral-imaging-and-scatter-decoupled-material-decomposition-using-a-spectral-modulator-with-flying-focal-spot-smffs
#18
JOURNAL ARTICLE
Yifan Deng, Hao Zhou, Zhilei Wang, Adam S Wang, Hewei Gao
BACKGROUND: Cone-beam CT (CBCT) has been extensively employed in industrial and medical applications, such as image-guided radiotherapy and diagnostic imaging, with a growing demand for quantitative imaging using CBCT. However, conventional CBCT can be easily compromised by scatter and beam hardening artifacts, and the entanglement of scatter and spectral effects introduces additional complexity. PURPOSE: The intertwined scatter and spectral effects within CBCT pose significant challenges to the quantitative performance of spectral imaging...
March 13, 2024: Medical Physics
https://read.qxmd.com/read/38477634/quantitative-measurement-of-the-ureter-on-three-dimensional-magnetic-resonance-urography-images-using-deep-learning
#19
JOURNAL ARTICLE
Rile Nai, Kexin Wang, Xiaoqing Li, Shangsong Du, Tuya E, He Xiao, Shuo Quan, Yaofeng Zhang, Junhua Yu, Jialun Li, Xiaodong Zhang, Xiaoying Wang
BACKGROUND: Accurate measurement of ureteral diameters plays a pivotal role in diagnosing and monitoring urinary tract obstruction (UTO). While three-dimensional magnetic resonance urography (3D MRU) represents a significant advancement in imaging, the traditional manual methods for assessing ureteral diameters are characterized by labor-intensive procedures and inherent variability. In the realm of medical image analysis, deep learning has led to a paradigm shift, yet the development of a comprehensive automated tool for the precise segmentation and measurement of ureters in MR images is an unaddressed challenge...
March 13, 2024: Medical Physics
https://read.qxmd.com/read/38465398/technical-note-cryostat-transmission-characterization-for-mr-linac-temporal-stability-clinical-impact-and-change-implementation
#20
JOURNAL ARTICLE
Urszula Jelen, Claire Pagulayan, Zoë Moutrie, Jason Arts, Armia George, Michael G Jameson
BACKGROUND: In the Unity MR linac (Elekta AB, Stockholm, Sweden), the radiation beam traverses the cryostat and the coil support structure. The resulting beam attenuation must be considered for output calibration and its variation with gantry angle must be characterized in the treatment planning system (TPS). PURPOSE: The aim of this work was to investigate the impact of a change of the cryostat transmission characterization (CTC) curve, due to the helium level modification, on clinical treatment plan dosimetry and to report on the experience with the CTC curve update...
March 11, 2024: Medical Physics
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