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Journals Clinical and Experimental Phar...

Clinical and Experimental Pharmacology & Physiology

https://read.qxmd.com/read/38636943/correction-to-gsk3%C3%AE-inhibitor-tdzd8-ameliorates-brain-damage-through-both-ros-scavenging-and-inhibition-of-apoptosis-in-hyperglycemic-subarachnoid-haemorrhage-rats
#1
(no author information available yet)
No abstract text is available yet for this article.
June 2024: Clinical and Experimental Pharmacology & Physiology
https://read.qxmd.com/read/38636942/salvianic-acid-a-sodium-facilitates-cardiac-microvascular-endothelial-cell-proliferation-by-enhancing-the-hypoxia-inducible-factor-1-alpha-vascular-endothelial-growth-factor-signalling-pathway-post-myocardial-infarction
#2
JOURNAL ARTICLE
Jichun Liu, Fei Wu, Zhenhan Li, Shengwei Zheng, Yanqiang Huang, Hao Chen
Cardiac microvascular endothelial cells (CMECs) are important cells surrounding the cardiomyocytes in the heart that maintain microenvironment homeostasis. Salvianic acid A sodium (SAAS) has been reported to prevent myocardial infarction (MI) injury. However, the role of SAAS on CMEC proliferation remains unclear. CEMCs exposed to oxygen glucose deprivation (OGD) were used to explore the angiogenic abilities of SAAS. In vivo, C57BL/6 mice were divided into three groups: sham, MI and SAAS + MI groups...
June 2024: Clinical and Experimental Pharmacology & Physiology
https://read.qxmd.com/read/38636940/loganin-exerts-neuroprotective-effect-by-inhibiting-neuronal-pyroptosis-in-rat-with-cerebral-haemorrhage
#3
JOURNAL ARTICLE
Yu Wang, Min Zhao, Jing Li, Yue Liu
Intracerebral haemorrhage (ICH) presents significant challenges in clinical management because of the high morbidity and mortality, necessitating novel therapeutic approaches. This study aimed to assess the neuroprotective effects of loganin in a rat ICH model. Sprague-Dawley rats were used, subjected to a collagenase-induced ICH model, followed by loganin treatment at doses of 2.5, 5 and 10 mg/kg. Neurological functions were evaluated using the modified neurological severity score (mNSS) and a rotarod test...
June 2024: Clinical and Experimental Pharmacology & Physiology
https://read.qxmd.com/read/38621772/colorectal-cancer-cells-with-stably-expressed-sirt3-demonstrate-proliferating-retardation-by-wnt-%C3%AE-catenin-cascade-inactivation
#4
JOURNAL ARTICLE
Tianyu Li, Leqi Fan, Yijiang Jia, Chen Xu, Wei Guo, Yuji Wang, Ye Li
Colorectal cancer (CRC) is a typical and lethal digestive system malignancy. In this study, we investigated the effect of sirtuin 3 (SIRT3) expression, a fidelity mitochondrial protein, on the proliferation of CRC cells and the mechanisms involved. Using the University of Alabama at Birmingham Cancer Data Analysis Portal database and the Clinical Proteomic Tumour Analysis Consortium database, we discovered that low expression of SIRT3 in CRC was a negative factor for survival prognosis (P < ...
June 2024: Clinical and Experimental Pharmacology & Physiology
https://read.qxmd.com/read/38621769/metformin-ameliorates-endometrial-thickness-in-a-rat-model-of-thin-endometrium
#5
JOURNAL ARTICLE
M Imran, Aditya Khandvilkar, Siddhanath Metkari, Geetanjali Sachdeva, Uddhav Chaudhari
Metformin, a well-established anti-diabetic drug, is also used in managing various other metabolic disorders including polycystic ovarian syndrome (PCOS). There are evidences to show that metformin improves endometrial functions in PCOS women. However, fewer studies have explored the direct effects of metformin on endometrium. Previous in vitro studies have shown that therapeutic serum concentrations of metformin enhance endometrial epithelial cell proliferation. The present study was undertaken to investigate in vivo effects of metformin on endometrial proliferation in a rat model of thin endometrium...
June 2024: Clinical and Experimental Pharmacology & Physiology
https://read.qxmd.com/read/38584327/npas2-transcriptionally-activated-by-arrb1-promotes-the-malignant-behaviours-of-lung-adenocarcinoma-cells-and-regulates-the-reprogramming-of-glucose-metabolism
#6
JOURNAL ARTICLE
Shenglan Wang, Chunhong Huang, Yanbin Zheng, Xinjie Wu, Yutong Zhong
Lung adenocarcinoma (LUAD) is a serious threat to public health and is accompanied by increased morbidity and mortality worldwide. Neuronal PAS domain protein2 (NPAS2) has been confirmed as an oncogene in LUAD; however, little is known about its molecular mechanism. Here, the expression level of NPAS2 was detected in LUAD cell lines and 16HBE cells. Gain- and loss-of-function experiments were performed. Cell Counting Kit-8, colony formation, flow cytometry, wound-healing and Transwell assays were conducted to assess cell proliferation, apoptosis, migration and invasion, respectively...
May 2024: Clinical and Experimental Pharmacology & Physiology
https://read.qxmd.com/read/38566371/overexpression-of-hsp27-accelerates-stress-induced-gastric-ulcer-healing-via-the-cxcl12-cxcr4-axis
#7
JOURNAL ARTICLE
Qiaoyan Lu, Hua Tang
Chronic stress often triggers gastrointestinal complications, including gastric injury and ulcers. Understanding the role of heat shock protein 27 (HSP27) in stress-induced gastric ulcers could unveil novel therapeutic targets. Here, we established a stress-induced gastric ulcer rat model using water immersion restraint stress and administered adenovirus-packaged HSP27 overexpression vector. Gastric ulcer severity was scored, and mucosal changes were assessed. Gastric epithelial and endothelial cells were treated with lipopolysaccharide and transfected with HSP27 overexpression vectors to evaluate cell viability, migration and angiogenesis...
May 2024: Clinical and Experimental Pharmacology & Physiology
https://read.qxmd.com/read/38527859/exploring-the-modulatory-effects-of-sotagliflozin-on-dyslipidemia-in-mice-the-role-of-glucagon-fibroblast-growth-factor-21-and-glucagon-like-peptide-1
#8
JOURNAL ARTICLE
Nitin J Deshmukh, M S Kalshetti, Mohan Patil, Pankaj Autade, Ganesh V Sangle
Sotagliflozin is the first dual SGLT1/2 inhibitor antidiabetic drug approved by the US Food and Drug Administration for the management of heart failure. SGLT1/2 inhibition is observed to potentiate the secretion of the incretin hormone, glucagon-like peptide-1 (GLP-1). The current preclinical research sought to investigate the effect of sotagliflozin on the secretion of fat-regulating peptides such as GLP-1, glucagon and fibroblast growth factor 21 (FGF21) and their prospective association with sotagliflozin's potential beneficial effects on dyslipidaemia...
May 2024: Clinical and Experimental Pharmacology & Physiology
https://read.qxmd.com/read/38452757/a-2-week-treatment-with-5-azacytidine-improved-the-hypercontractility-state-in-prostate-from-obese-mice-role-of-the-nitric-oxide-cyclic-guanosine-monophosphate-signalling-pathway
#9
JOURNAL ARTICLE
Ana Carolina Ghezzi, Gabriela Reolon Passos, Mariana Gonçalves de Oliveira, Akila Lara Oliveira, Guilherme Rossi Assis-Mendonça, Glaucia Coelho de Mello, Edson Antunes, Fabiola Zakia Monica
Benign prostatic hyperplasia (BPH) is characterised by increases in prostate volume and contraction. Downregulation of the nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signalling pathway contributes to prostate dysfunctions. Previous studies in cancer cells or vessels have shown that the epigenetic mechanisms control the gene and protein expression of the enzymes involved in the production of NO and cGMP. This study is aimed to evaluate the effect of a 2-week treatment of 5-azacytidine (5-AZA), a DNA-methyltransferase inhibitor, in the prostate function of mice fed with a high-fat diet...
April 2024: Clinical and Experimental Pharmacology & Physiology
https://read.qxmd.com/read/38452756/differential-responses-of-cerebral-and-renal-oxygenation-to-altered-perfusion-conditions-during-experimental-cardiopulmonary-bypass-in-sheep
#10
JOURNAL ARTICLE
Roger G Evans, Andrew D Cochrane, Sally G Hood, Bruno Marino, Naoya Iguchi, Rinaldo Bellomo, Peter R McCall, Nobuki Okazaki, Alemayehu H Jufar, Lachlan F Miles, Taku Furukawa, Connie P C Ow, Jaishankar Raman, Clive N May, Yugeesh R Lankadeva
We tested whether the brain and kidney respond differently to cardiopulmonary bypass (CPB) and to changes in perfusion conditions during CPB. Therefore, in ovine CPB, we assessed regional cerebral oxygen saturation (rSO2 ) by near-infrared spectroscopy and renal cortical and medullary tissue oxygen tension (PO2 ), and, in some protocols, brain tissue PO2 , by phosphorescence lifetime oximetry. During CPB, rSO2 correlated with mixed venous SO2 (r = 0.78) and brain tissue PO2 (r = 0...
April 2024: Clinical and Experimental Pharmacology & Physiology
https://read.qxmd.com/read/38452755/epidemiology-and-risk-factors-of-bloodstream-infections-among-adolescents-and-young-adults-with-acute-lymphoblastic-leukaemia-an-11-year-retrospective-cohort-study
#11
JOURNAL ARTICLE
Longlong Xue, Yishu Tang, Liwen Wang, Cong Xu, Qian Cheng, Xin Li
Adolescent and young adults (AYAs) belong to a unique category of patients diagnosed with acute lymphoblastic leukaemia (ALL). Bloodstream infection (BSI) is a leading cause of treatment-related mortality in ALL patients. However, the epidemiology and risk factors for mortality from BSIs in AYA patients remain unclear. In this study, we analysed these aspects in AYAs patients and compared similarities and differences with children (<15 years old) and older adults (>39 years old). We analysed the pathogenic epidemiology, antibiotic resistance and BSI risk factors of 73 children, 180 AYAs, and 110 older adults with ALL in three comprehensive hospitals from January 2010 to August 2021...
April 2024: Clinical and Experimental Pharmacology & Physiology
https://read.qxmd.com/read/38423007/study-on-the-mechanism-underlying-trichosanthis-peel-injection-induced-improvements-in-myocardial-fibrosis-markers-in-patients-with-chronic-heart-failure
#12
JOURNAL ARTICLE
Yue He, Xinsheng Gu, Zhou Yang, Hao Wang, Ping Liu
In this research, we aimed to observe the changes in myocardial fibrosis indices in patients with chronic heart failure before and after treatment and to evaluate the anti-chronic heart failure and ventricular remodelling effects of Trichosanthis peel (TP) injection. This study was a single-center, open, single-blind, randomized controlled study with an optimal efficacy design. Patients were consecutively and randomly divided into two groups, with 36 patients in the TP injection group and 36 patients in the conventional treatment group...
April 2024: Clinical and Experimental Pharmacology & Physiology
https://read.qxmd.com/read/38408759/phosphatidylserine-accelerates-wound-healing-and-reduces-necrosis-in-the-rats-growth-factor-activation
#13
JOURNAL ARTICLE
Partow Mirzaee Saffari, Pooria Asili, Sadaf Eshraghi, Ahad Muhammadnejad, Ahmad Reza Dehpour, Ramin Goudarzi, Alireza Partoazar
To examine the effect of topical phosphatidylserine (PS) on wound healing factors and tissue necrosis in in vivo models. Topical PS was applied to evaluate aspects of the wound healing process and growth factors production of vascular endothelial growth factors (VEGF) as well a necrosis reduction in the skin flap of rat models. Moreover, phenytoin (PHT) and cyclosporine A (CsA) were used topically as positive control treatments in wound and necrosis models, respectively. Immunohistochemistry (IHC) VEGF, transforming growth factor-β (TGF-β), fibroblast growth factor (FGF) and histopathology were analysed on the wounds of rats...
April 2024: Clinical and Experimental Pharmacology & Physiology
https://read.qxmd.com/read/38382550/scutellarin-inhibits-oleic-acid-induced-vascular-smooth-muscle-foam-cell-formation-via-activating-autophagy-and-inhibiting-nlrp3-inflammasome-activation
#14
JOURNAL ARTICLE
Wen-Cong Gao, Tie-Hua Yang, Bin-Bao Wang, Qian Liu, Qing Li, Xiao-Huan Zhou, Chang-Bo Zheng, Peng Chen
Abnormalities in vascular smooth muscle cells (VSMCs) are pivotal in the pathogenesis of cardiovascular pathologies such as atherosclerosis and hypertension. Scutellarin (Scu), a flavonoid derived from marigold flowers, exhibits a spectrum of biological activities including anti-inflammatory, antioxidant, antitumor, immunomodulatory and antimicrobial effects. Notably, Scu has demonstrated the capacity to mitigate vascular endothelial damage and prevent atherosclerosis via its antioxidative properties. Nevertheless, the influence of Scu on the formation of VSMC-derived foam cells remains underexplored...
April 2024: Clinical and Experimental Pharmacology & Physiology
https://read.qxmd.com/read/38382536/dapagliflozin-alleviates-high-glucose-induced-injury-of-endothelial-cells-via-inducing-autophagy
#15
JOURNAL ARTICLE
Gen Li, Ningxin Hou, Huagang Liu, Jun Li, Hongping Deng, Hongwen Lan, Sizheng Xiong
Hyperglycaemia is a key factor in the progression of diabetes complications. Dapagliflozin (DAPA), a new type of hypoglycaemic agent, has been shown to play an important role in anti-apoptotic, anti-inflammatory and antioxidant activities. Previous studies have demonstrated an endothelial protective effect of DAPA, but the underlying mechanism was still unclear. Autophagy is a homeostatic cellular mechanism that circulates unfolded proteins and damaged organelles through lysosomal dependent degradation...
April 2024: Clinical and Experimental Pharmacology & Physiology
https://read.qxmd.com/read/38382534/gaillardin-exerts-potent-antileukemic-effects-on-hl-60-cells-and-intensifies-arsenic-trioxide-cytotoxicity-providing-new-insight-into-sesquiterpene-lactones-in-leukaemia-treatment
#16
JOURNAL ARTICLE
Hanieh Noormohamadi, Maryam Hamzeloo-Moghadam, Davood Bashash, Maryam Kargar, Mehrdad Izadirad, Seyedeh Zahra Hasanpour, Ahmad Gharehbaghian
The use of all-trans retinoic acid and arsenic trioxide resulted in favourable therapeutic responses in standard-risk acute promyelocytic leukaemia (APL) patients. However, resistance to these agents has made treating the high-risk subgroup more problematic, and possible side effects limit their clinical dosages. Numerous studies have proven the cytotoxic properties of Gaillardin, one of the Inula oculus-christi-derived sesquiterpene lactones. Due to the adverse effects of arsenic trioxide on the high-risk subgroup of APL patients, we aimed to assess the cytotoxic effect of Gaillardin on HL-60 cells as a single or combined-form approach...
April 2024: Clinical and Experimental Pharmacology & Physiology
https://read.qxmd.com/read/38350599/synergic-actions-of-botulinum-neurotoxin-a-and-oxaliplatin-on-colorectal-tumour-cell-death-through-the-upregulation-of-trpm2-channel-mediated-oxidative-stress
#17
JOURNAL ARTICLE
Sıdıka Demir, İpek Duman, Mustafa Nazıroğlu
Botulinum neurotoxin A (BoNT) is being shown to have anticancer action as a potential adjuvant treatment. The transient receptor potential (TRP) melastatin 2 (TRPM2) stimulator action of BoNT was reported in glioblastoma cells, but not in colorectal cancer (HT29) cells. By activating TRPM2, we evaluated the impacts of BoNT and oxaliplatin (OXA) incubations on oxidant and apoptotic values within the HT29 cells. Control, BoNT (5 IU for 24 h), OXA (50 μM for 24 h) and their combinations were induced...
April 2024: Clinical and Experimental Pharmacology & Physiology
https://read.qxmd.com/read/38302082/correction-to-exosomal-mir-21-5p-derived-from-multiple-myeloma-cells-promote-renal-epithelial-mesenchymal-transition-through-targeting-tgf-%C3%AE-smad7-signalling-pathway
#18
(no author information available yet)
No abstract text is available yet for this article.
March 2024: Clinical and Experimental Pharmacology & Physiology
https://read.qxmd.com/read/38302081/adrenalectomy-attenuates-hyperalgesia-but-does-not-regulate-muscle-wasting-in-a-female-rat-model-of-fibromyalgia
#19
JOURNAL ARTICLE
Daniely Messias Costa, Raquel Prado da Silva, João da Cruz-Filho, Tatiane de Oliveira Santos, Hevely Catharine Dos Anjos-Santos, Waldecy de Lucca, Ísis do Carmo Kettelhut, Luiz Carlos Navegantes, Patrícia Rodrigues Marques de Souza, Enilton Aparecido Camargo, Sandra Lauton-Santos, Daniel Badauê-Passos, André Souza Mecawi, Josimari Melo DeSantana, Danilo Lustrino
Although it is well established that fibromyalgia (FM) syndrome is characterized by chronic diffuse musculoskeletal hyperalgesia, very little is known about the effect of this pathology on muscle tissue plasticity. Therefore, the present study aimed to characterize the putative alterations in skeletal muscle mass in female rats subjected to a FM model by inducing chronic diffuse hyperalgesia (CDH) through double injections of acidic saline (pH 4.0) into the left gastrocnemius muscle at 5-day intervals...
March 2024: Clinical and Experimental Pharmacology & Physiology
https://read.qxmd.com/read/38302080/sew2871-reduces-seizures-via-the-sphingosine-1-phosphate-receptor-1-pathway-in-the-pentylenetetrazol-and-phenobarbitone-kindling-model-of-drug-refractory-epilepsy
#20
JOURNAL ARTICLE
Ashish Jain, Arti Ralta, Gitika Batra, Rupa Joshi, Nitika Garg, Alka Bhatia, Bikash Medhi, Amitava Chakrabarti, Ajay Prakash
Epilepsy is a prevalent neurological disorder characterized by neuronal hypersynchronous discharge in the brain, leading to central nervous system (CNS) dysfunction. Despite the availability of anti-epileptic drugs (AEDs), resistance to AEDs is the greatest challenge in treating epilepsy. The role of sphingosine-1-phosphate-receptor 1 (S1PR1) in drug-resistant epilepsy is unexplored. This study investigated the effects of SEW2871, a potent S1PR1 agonist, on a phenobarbitone (PHB)-resistant pentylenetetrazol (PTZ)-kindled Wistar rat model...
March 2024: Clinical and Experimental Pharmacology & Physiology
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