Karim I Mersal, Mohammed S Abdel-Maksoud, Eslam M H Ali, Usama M Ammar, Seyed-Omar Zaraei, Md Mamunul Haque, Tanuza Das, Noha F Hassan, Eunice EunKyeong Kim, Jun-Seok Lee, HaJeung Park, Kwan Hyi Lee, Mohammed I El-Gamal, Hee-Kwon Kim, Tamer M Ibrahim, Chang-Hyun Oh
A series of 36 pyrazol-4-yl pyridine derivatives (8a-i, 9a-i, 10a-i, and 11a-i) was designed, synthesized, and evaluated for its antiproliferative activity over NCI-60 cancer cell line panel and inhibitory effect against JNK isoforms (JNK1, JNK2, and JNK3). All the synthesized compounds were tested against the NCI-60 cancer cell line panel. Compounds 11b, 11c, 11g, and 11i were selected to determine their GI50s and exerted a superior potency over the reference standard SP600125 against the tested cell lines...
September 15, 2023: European Journal of Medicinal Chemistry