Reza Dabbaghipour, Elham Ahmadi, Mona Entezam, Omid Rahbar Farzam, Sepideh Sohrabi, Sajjad Jamali, Ali Saber Sichani, Hadi Paydar, Behzad Baradaran
The transcription factor, known as basic leucine zipper ATF-like 3 (BATF3), is a crucial contributor to the development of conventional type 1 dendritic cells (cDC1), which is definitely required for priming CD8 + T cell-mediated immunity against intracellular pathogens and malignancies. In this respect, BATF3-dependent cDC1 can bring about immunological tolerance, an autoimmune response, graft immunity, and defense against infectious agents such as viruses, microbes, parasites, and fungi. Moreover, the important function of cDC1 in stimulating CD8 + T cells creates an excellent opportunity to develop a highly effective target for vaccination against intracellular pathogens and diseases...
February 15, 2024: Immunogenetics