journal
https://read.qxmd.com/read/38438567/c-c%C3%A2-motif-chemokine-ligand-2-regulates-prostaglandin-synthesis-and-embryo-attachment-of-the-bovine-endometrium-during-implantation
#21
JOURNAL ARTICLE
Chi Sun Yun, Yuyu Saito, Al-Nur Md Iftekhar Rahman, Takahiro Suzuki, Hideyuki Takahashi, Keiichiro Kizaki, M A M Yahia Khandoker, Nobuhiko Yamauchi
C-C motif chemokine ligand 2 (CCL2) has been reported to be expressed in the bovine endometrium during pregnancy. However, the details of its functions involved in the implantation mechanism are still not clear. The purpose of this study is to analyze the functional properties of CCL2 in the bovine endometrium and embryos. The expression of CCR2 was not different between the luteal phase and implantation phase of their endometrial tissues, but was significantly high in IFNa treated bovine endometrial stromal (BES) cells in vitro...
March 5, 2024: Cell and Tissue Research
https://read.qxmd.com/read/38424269/dynamic-relationship-among-extracellular-matrix-and-body-wall-cells-in-hirudo-verbana-morphogenesis
#22
JOURNAL ARTICLE
Laura Pulze, Nicolò Baranzini, Francesco Acquati, Gaia Marcolli, Annalisa Grimaldi
A great bulk of recent experimental evidence suggests the key role of the complex crosstalk between the extracellular matrix (ECM) and the cellular component of tissues during morphogenesis and embryogenesis. In particular, remodeling of the ECM and of its physical interactions pattern with surrounding cells represent two crucial processes that might be involved in muscle development. However, little information is available on this topic, especially on invertebrate species. To obtain new insights on how tuning the ECM microenvironment might drive cellular fate during embryonic development, we used the invertebrate medicinal leech Hirudo verbana as a valuable experimental model, due to its simple anatomy and the recapitulation of many aspects of the basic biological processes of vertebrates...
March 1, 2024: Cell and Tissue Research
https://read.qxmd.com/read/38416172/the-application-and-development-of-electron-microscopy-for-three-dimensional-reconstruction-in-life-science-a-review
#23
REVIEW
Jingjing Zhao, Xiaoping Yu, Xuping Shentu, Danting Li
Imaging technologies have played a pivotal role in advancing biological research by enabling visualization of biological structures and processes. While traditional electron microscopy (EM) produces two-dimensional images, emerging techniques now allow high-resolution three-dimensional (3D) characterization of specimens in situ, meeting growing needs in molecular and cellular biology. Combining transmission electron microscopy (TEM) with serial sectioning inaugurated 3D imaging, attracting biologists seeking to explore cell ultrastructure and driving advancement of 3D EM reconstruction...
February 28, 2024: Cell and Tissue Research
https://read.qxmd.com/read/38411945/exosomes-from-adipose-derived-stem-cells-activate-sebocytes-through-the-pi3k-akt-srebp-1-pathway-to-accelerate-wound-healing
#24
JOURNAL ARTICLE
Yingbo Zhang, Christos C Zouboulis, Zhibo Xiao
Sebocyte regeneration after injury is considered a key element of functional skin repair. Exosomes from adipose-derived stem cells (ADSCs-EXO) accelerate wound healing by promoting the proliferation of fibroblasts. However, the effects of ADSCs-EXO on sebocytes are largely unknown. In this study, the effects of ADSCs-EXO on sebocyte proliferation and migration were evaluated. The levels of phosphorylated AKT (p-AKT), AKT, sterol regulatory-element binding protein (SREBP), and perilipin-1 (PLIN-1) were detected with immunofluorescence, quantitative PCR, and western blot analysis...
February 27, 2024: Cell and Tissue Research
https://read.qxmd.com/read/38409390/anatomical-changes-of-tenebrio-molitor-and-tribolium-castaneum-during-complete-metamorphosis
#25
JOURNAL ARTICLE
Maria Luigia Vommaro, Sandro Donato, Simone Caputo, Raffaele G Agostino, Aurora Montali, Gianluca Tettamanti, Anita Giglio
In holometabolous insects, extensive reorganisation of tissues and cells occurs at the pupal stage. The remodelling of the external exoskeleton and internal organs that intervenes during metamorphosis has been traditionally studied in many insect species based on histological or ultrastructural methods. This study demonstrates the use of synchrotron X-ray phase-contrast micro-computed tomography as a powerful, non-destructive tool for in situ morphological observation of anatomical structures at the pupal stage in two Tenebrionid beetles, i...
February 27, 2024: Cell and Tissue Research
https://read.qxmd.com/read/38403745/tissue-distribution-of-cysteine-string-protein-dnajc5-in-c-elegans-analysed-by-crispr-cas9-mediated-tagging-of-endogenous-dnj-14
#26
JOURNAL ARTICLE
Eleanor Barker, Alan Morgan, Jeff W Barclay
Cysteine string protein (CSP) is a member of the DnaJ/Hsp40 family of molecular chaperones. CSP is enriched in neurons, where it mainly localises to synaptic vesicles. Mutations in CSP-encoding genes in flies, worms, mice and humans result in neuronal dysfunction, neurodegeneration and reduced lifespan. Most attention has therefore focused on CSP's neuronal functions, although CSP is also expressed in non-neuronal cells. Here, we used genome editing to fluorescently tag the Caenorhabditis elegans CSP orthologue, dnj-14, to identify which tissues preferentially express CSP and hence may contribute to the observed mutant phenotypes...
February 26, 2024: Cell and Tissue Research
https://read.qxmd.com/read/38403744/bone-morphogenetic-protein-6-bmp6-antagonises-experimental-proliferative-vitreoretinopathy-established-by-tgf-%C3%AE-2-stimulation-in-retinal-pigment-epithelial-cells-through-modulation-of-the-p38-and-jnk-mapk-pathways
#27
JOURNAL ARTICLE
Xuan Liu, Ming Liu, Li Chen
The formation of the epiretinal fibrotic membrane by retinal pigment epithelial (RPE) cells is a primary pathological change for proliferative vitreoretinopathy (PVR). Bone morphogenetic protein 6 (BMP6) is an antifibrogenic factor in various cells. To date, it is still unknown whether BMP6 can interfere with the fibrogenesis of RPE cells during the progression of PVR. This work aimed to address the relationship between BMP6 and transforming growth factor-β2 (TGF-β2)-elicited fibrogenesis of RPE cells, an experimental model for studying PVR in vitro...
February 26, 2024: Cell and Tissue Research
https://read.qxmd.com/read/38388750/nescient-helix-loop-helix-1-nhlh1-is-a-novel-activating-transcription-factor-5-atf5-target-gene-in-olfactory-and-vomeronasal-sensory-neurons-in-mice
#28
JOURNAL ARTICLE
Chiharu Ishii, Haruo Nakano, Riko Higashiseto, Yusaku Ooki, Mariko Umemura, Shigeru Takahashi, Yuji Takahashi
Activating transcription factor 5 (ATF5) is a transcription factor that belongs to the cAMP-response element-binding protein/ATF family and is essential for the differentiation and survival of sensory neurons in mouse olfactory organs. However, transcriptional target genes for ATF5 have yet to be identified. In the present study, chromatin immunoprecipitation-quantitative polymerase chain reaction (ChIP-qPCR) experiments were performed to verify ATF5 target genes in the main olfactory epithelium and vomeronasal organ in the postnatal pups...
February 23, 2024: Cell and Tissue Research
https://read.qxmd.com/read/38383905/identification-of-vagal-afferent-nerve-endings-in-the-mouse-colon-and-their-spatial-relationship-with-enterochromaffin-cells
#29
JOURNAL ARTICLE
Nick J Spencer, Melinda A Kyloh, Lee Travis, Timothy J Hibberd
Understanding how the gut communicates with the brain, via sensory nerves, is of significant interest to medical science. Enteroendocrine cells (EEC) that line the mucosa of the gastrointestinal tract release neurochemicals, including the largest quantity of 5-hydroxytryptamine (5-HT). How the release of substances, like 5-HT, from enterochromaffin (EC) cells activates vagal afferent nerve endings is unresolved. We performed anterograde labelling from nodose ganglia in vivo and identified vagal afferent axons and nerve endings in the mucosa of whole-mount full-length preparations of mouse colon...
February 22, 2024: Cell and Tissue Research
https://read.qxmd.com/read/38369646/comparative-transcriptomic-and-phenotypic-analysis-of-induced-pluripotent-stem-cell-hepatocyte-like-cells-and-primary-human-hepatocytes
#30
JOURNAL ARTICLE
Neeti Gandhi, Lauren Wills, Kyle Akers, Yiqi Su, Parker Niccum, T M Murali, Padmavathy Rajagopalan
Primary human hepatocytes (PHHs) are used extensively for in vitro liver cultures to study hepatic functions. However, limited availability and invasive retrieval prevent their widespread use. Induced pluripotent stem cells exhibit significant potential since they can be obtained non-invasively and differentiated into hepatic lineages, such as hepatocyte-like cells (iHLCs). However, there are concerns about their fetal phenotypic characteristics and their hepatic functions compared to PHHs in culture. Therefore, we performed an RNA-sequencing (RNA-seq) analysis to understand pathways that are either up- or downregulated in each cell type...
February 19, 2024: Cell and Tissue Research
https://read.qxmd.com/read/38369645/paracrine-and-endocrine-pathways-of-natriuretic-peptides-assessed-by-ligand-receptor-mapping-in-the-japanese-eel-brain
#31
JOURNAL ARTICLE
Tomoki Izumi, Ami Saito, Takanori Ida, Takao Mukuda, Yukitoshi Katayama, Marty Kwok-Shing Wong, Takehiro Tsukada
The natriuretic peptide (NP) family consists of cardiac NPs (ANP, BNP, and VNP) and brain NPs (CNPs) in teleosts. In addition to CNP1-4, a paralogue of CNP4 (named CNP4b) was recently discovered in basal teleosts including Japanese eel. Mammals have lost most Cnps during the evolution, but teleost cnps were conserved and diversified, suggesting that CNPs are important hormones for maintaining brain functions in teleost. The present study evaluated the potency of each Japanese eel CNP to their NP receptors (NPR-A, NPR-B, NPR-C, and NPR-D) overexpressed in CHO cells...
February 19, 2024: Cell and Tissue Research
https://read.qxmd.com/read/38366086/entry-of-cannabidiol-into-the-fetal-postnatal-and-adult-rat-brain
#32
JOURNAL ARTICLE
Georgia Fitzpatrick, Yifan Huang, Fiona Qiu, Mark D Habgood, Robert L Medcalf, Heidi Ho, Katarzyna M Dziegielewska, Norman R Saunders
Cannabidiol is a major component of cannabis but without known psychoactive properties. A wide range of properties have been attributed to it, such as anti-inflammatory, analgesic, anti-cancer, anti-seizure and anxiolytic. However, being a fairly new compound in its purified form, little is known about cannabidiol brain entry, especially during development. Sprague Dawley rats at four developmental ages: embryonic day E19, postnatal day P4 and P12 and non-pregnant adult females were administered intraperitoneal cannabidiol at 10 mg/kg with [3 H] labelled cannabidiol...
February 17, 2024: Cell and Tissue Research
https://read.qxmd.com/read/38353742/long-noncoding-rna-xist-inhibition-promotes-leydig-cell-apoptosis-by-acting-as-a-competing-endogenous-rna-for-microrna-145a-5p-that-targets-sirt1-in-late-onset-hypogonadism
#33
JOURNAL ARTICLE
Jing Wang, Yiqiong Yang, Yang Xu, Zhipeng Xu, Xiaozhi Zhao, Ruipeng Jia, Yutian Dai
Leydig cell (LCs) apoptosis is responsible for decreased serum testosterone levels during late-onset hypogonadism (LOH). Our study was designed to illustrate the regulatory effect of lncRNA XIST on LCs and to clarify its molecular mechanism of action in LOH. The Leydig cells (TM3) was treated by 300 μM H2 O2 for 8 h to establish Leydig cell oxidative stress model in vitro. The expression levels of lncRNA XIST in the testicular tissues of patients with LOH were measured using fluorescence in situ hybridization (FISH)...
February 14, 2024: Cell and Tissue Research
https://read.qxmd.com/read/38347202/calcium-imaging-of-adult-olfactory-epithelium-reveals-amines-as-important-odor-class-in-fish
#34
JOURNAL ARTICLE
M Dieris, D Kowatschew, T Hassenklöver, I Manzini, S I Korsching
The odor space of aquatic organisms is by necessity quite different from that of air-breathing animals. The recognized odor classes in teleost fish include amino acids, bile acids, reproductive hormones, nucleotides, and a limited number of polyamines. Conversely, a significant portion of the fish olfactory receptor repertoire is composed of trace amine-associated receptors, generally assumed to be responsible for detecting amines. Zebrafish possess over one hundred of these receptors, but the responses of olfactory sensory neurons to amines have not been known so far...
February 13, 2024: Cell and Tissue Research
https://read.qxmd.com/read/38326636/electron-microscopic-analysis-of-the-influence-of-ipsc-derived-motor-neurons-on-bioengineered-human-skeletal-muscle-tissues
#35
JOURNAL ARTICLE
Christine T Nguyen, Carolina Chávez-Madero, Erik Jacques, Brennen Musgrave, Ting Yin, Kejzi Saraci, Penney M Gilbert, Bryan A Stewart
3D bioengineered skeletal muscle macrotissues are increasingly important for studies of cell biology and development of therapeutics. Tissues derived from immortalized cells obtained from patient samples, or from pluripotent stem cells, can be co-cultured with motor-neurons to create models of human neuromuscular junctions in culture. In this study, we present foundational work on 3D cultured muscle ultrastructure, with and without motor neurons, which is enabled by the development of a new co-culture platform...
February 8, 2024: Cell and Tissue Research
https://read.qxmd.com/read/38311679/dynamic-changes-in-endoplasmic-reticulum-morphology-and-its-contact-with-the-plasma-membrane-in-motor-neurons-in-response-to-nerve-injury
#36
JOURNAL ARTICLE
Mahmoud Elgendy, Hiromi Tamada, Takaya Taira, Yuma Iio, Akinobu Kawamura, Ayusa Kunogi, Yuka Mizutani, Hiroshi Kiyama
The endoplasmic reticulum (ER) extends throughout a cell and plays a critical role in maintaining cellular homeostasis. Changes in ER shape could provide a clue to explore the mechanisms that underlie the fate determination of neurons after axon injury because the ER drastically changes its morphology under neuronal stress to maintain cellular homeostasis and recover from damage. Because of their tiny structures and richness in the soma, the detailed morphology of the ER and its dynamics have not been well analysed...
February 5, 2024: Cell and Tissue Research
https://read.qxmd.com/read/38305882/structure-of-putative-epidermal-sensory-receptors-in-an-acoel-flatworm-praesagittifera-naikaiensis
#37
JOURNAL ARTICLE
Tosuke Sakagami, Kaho Watanabe, Mayuko Hamada, Tatsuya Sakamoto, Toshimitsu Hatabu, Motonori Ando
Acoel flatworms possess epidermal sensory-receptor cells on their body surfaces and exhibit behavioral repertoires such as geotaxis and phototaxis. Acoel epidermal sensory receptors should be mechanical and/or chemical receptors; however, the mechanisms of their sensory reception have not been elucidated. We examined the three-dimensional relationship between epidermal sensory receptors and their innervation in an acoel flatworm, Praesagittifera naikaiensis. The distribution of the sensory receptors was different between the ventral and dorsal sides of worms...
February 2, 2024: Cell and Tissue Research
https://read.qxmd.com/read/38112806/wharton-s-jelly-mesenchymal-stem-cells-transplantation-for-critical-limb-ischemia-in-patients-with-type-2-diabetes-mellitus-a-preliminary-report-of-phase-i-clinical-trial
#38
JOURNAL ARTICLE
Mohammad Taghi Ashoobi, Hossein Hemmati, Hamid Reza Aghayan, Zeinab Zarei-Behjani, Samaneh Keshavarz, Hamideh Babaloo, Saman Maroufizadeh, Saeed Yousefi, Mohaya Farzin, Elham Vojoudi
Peripheral artery disease (PAD) affects more than 230 million people worldwide, with approximately 11% of patients presenting with advanced-stage PAD or critical limb ischemia (CLI). To avoid or delay amputation, particularly in no-option CLI patients with infeasible or ineffective revascularization, new treatment strategies such as regenerative therapies should be developed. Mesenchymal stem cells (MSCs) are the most popular cell source in regenerative therapies. They possess significant characteristics such as angiogenic, anti-inflammatory, and immunomodulatory activities, which encourage their application in different diseases...
February 2024: Cell and Tissue Research
https://read.qxmd.com/read/38291253/suppression-of-malat1-promotes-human-synovial-mesenchymal-stem-cells-enhance-chondrogenic-differentiation-and-prevent-osteoarthritis-of-the-knee-in-a-rat-model-via-regulating-mir-212-5p-myd88-axis
#39
JOURNAL ARTICLE
Zhengyu Gao, Cuicui Guo, Shuai Xiang, Haining Zhang, Yingzhen Wang, Hao Xu
Osteoarthritis (OA) is one of the most common diseases of the skeleton. Long non-coding RNAs (lncRNAs) are emerging as key players in OA pathogenesis. This work sets out to determine the function of lncRNA MALAT1 in OA and the mechanisms by which it does so. Mesenchymal stem cells isolated from the human synovial membrane are called hSMSCs. The hSMSCs' surface markers were studied using flow cytometry. To determine whether or not hSMSC might differentiate, researchers used a number of different culture settings and labeling techniques...
January 31, 2024: Cell and Tissue Research
https://read.qxmd.com/read/38267760/acknowledgement-to-reviewers
#40
JOURNAL ARTICLE
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January 25, 2024: Cell and Tissue Research
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