Ryan P Silk, Hanagh R Winter, Ouria Dkhissi-Benyahya, Carmella Evans-Molina, Alan W Stitt, Vijay K Tiwari, David A Simpson, Eleni Beli
Retinal function changes dramatically from day to night, yet clinical diagnosis, treatments, and experimental sampling occur during the day. To begin to address this gap in our understanding of disease pathobiology, this study investigates whether diabetes affects the retina's daily rhythm of gene expression. Diabetic, Ins2Akita/J mice, and non-diabetic littermates were kept under a 12 h:12 h light/dark cycle until 4 months of age. mRNA sequencing was conducted in retinas collected every 4 h throughout the 24 hr light/dark cycle...
November 30, 2023: Vision Research