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April 18, 2024: Urologia Internationalis
Jakob Michaelis, Ruth Himmelsbach, Patrick Metzger, Silke Lassmann, Melanie Börries, Martin Werner, Cornelius Miething, Rouven Höfflin, Anna L Illert, Justus Duyster, Heiko Becker, August Sigle, Christian Gratzke, Markus Grabbert
PURPOSE: Personalized medicine poses great opportunities and challenges. While therapeutic landscape markedly expands, descriptions about status, clinical implementation and real-world benefits of precision oncology and molecular tumor boards (MTB) remain sparse, particularly in the field of genitourinary (GU) cancer. Hence, this study characterized urological MTB cases to better understand the potential role of MTB in uro-oncology. METHODS: We analyzed patients with complete data sets being reviewed at an MTB from January 2019 to October 2022, focusing on results of molecular analysis and treatment recommendations...
April 16, 2024: Urologia Internationalis
Maximilian Reinhard Müller, Eva-Maria Prey, Philipp Julian Spachmann, Christopher Goßler, Maximilian Burger, Marco Julius Schnabel
Purpose To assess the feasibility of sparing routine antibiotic prophylaxis in patients without preoperative urinary tract infection (UTI) undergoing a ureterorenoscopy (URS) for stone removal. Patients and Methods A retrospective, monocentric study was conducted to evaluate the outcome of a modified perioperative antibiotic management strategy according to the principles of antibiotic stewardship (ABS). Patients with preoperative unremarkable urine culture received no antibiotic prophylaxis for ureterorenoscopic stone removal (NoPAP)...
April 16, 2024: Urologia Internationalis
Tomohiro Kameda, Yoshimasa Kondo, Yasuko Fukataki, Shiro Hinotsu, Tetsuya Fujimura, Tatsuya Takayama
INTRODUCTION: To examine whether disinfection of Bacillus Calmette-Guerin -containing urine with etaprocohol® (Ethanol 76.9-81.4 vol % and isopropanol as an additive) is safer than disinfection with sodium hypochlorite. METHOD: In prospective research, safety, and efficacy was analyzed in five patients in the etaprocohol® disinfection group and five patients in the sodium hypochlorite disinfection group. The primary endpoint was the temperature change after disinfection and the secondary endpoint was the unpleasantness of the odor caused by disinfection...
April 12, 2024: Urologia Internationalis
Phirawat Phromprathum, Sittiporn Srinualnad, Sunai Leewansangtong, Tawatchai Taweemonkongsap, Kittipong Phinthusophon, Siros Jitpraphai, Patkawat Ramart, Varat Woranisarakul, Chalairat Suk-Ouichai, Thawatchai Mankongsrisuk, Thitipat Hansomwong, Kantima Jongjitaree, Ekkarin Chotikawanich
INTRODUCTION: Disposable (single-use) flexible ureteroscopes are alternatives to reusable ureteroscopes. With their superior surgical efficacy and safety in the presence of upper urinary calculi, disposable ureteroscopes aim to overcome the main limitations of conventional reusable ureteroscopes. However, studies on the performance of the most recently developed models of single-use flexible ureteroscopes are scarce. This study aimed to compare the in vitro performance of several recently introduced, single-use, flexible ureteroscopes...
April 10, 2024: Urologia Internationalis
Matthias May, Katharina Körner-Riffard, Lisa Kollitsch, Maximilian Burger, Sabine D Brookman-May, Michael Rauchenwald, Martin Marszalek, Klaus Eredics
INTRODUCTION: This study assessed the potential of Large Language Models (LLMs) as educational tools by evaluating their accuracy in answering questions across urological subtopics. METHODS: Three LLMs (ChatGPT-3.5, ChatGPT-4, and Bing AI) were examined in two testing rounds, separated by 48-hours, using 100 Multiple-Choice Questions (MCQs) from the 2022 European Board of Urology (EBU) In-Service Assessment (ISA), covering five different subtopics. The correct answer was defined as "formal accuracy" (FA) representing the designated single best answer (SBA) among four options...
March 30, 2024: Urologia Internationalis
Hao Yang, Weiyang Wei, Qi Wang, Linfeng Li, Qisheng Lin, Hongxing Huang, Yaqiang Huang
Objective The aim of this study was to explore the safety and feasibility of single-port nephroscopy combined with a needle electrode technique to unroof single dorsal simple renal cysts (SRCs). Methods This was a retrospective analysis of the clinical data for 18 patients with single dorsal SRCs treated with single-port nephroscopy and a needle electrode technique at Zhongshan City People's Hospital from August 2021 to August 2022. The basic information included the cyst condition, surgical methods and recurrence rate, and follow-up was conducted with CT imaging...
March 27, 2024: Urologia Internationalis
Jinhyung Jeon, Jae Heon Kim, Jee Soo Ha, Won Jae Yang, Kang Su Cho, Do Kyung Kim
INTRODUCTION: To determine effects of adjuvant chemotherapy (AC) on survival outcomes compared to surgery alone without AC for upper tract urothelial carcinoma (UTUC) patients with variant histology (VH). METHODS: We conducted a systematic review and meta-analysis of studies investigating AC for UTUC in Medline, Embase, the Cochrane library up to January 2023. Population, intervention, comparator, and outcome were UTUC patients with VH, radical nephroureterectomy with AC, radical nephroureterectomy only, and oncological survival, respectively...
March 26, 2024: Urologia Internationalis
Chen Sun, Zhengrong Duan
INTRODUCTION: Our study aimed to assess the independent and joint effects of leisure-time physical activity and sedentary behavior with urinary incontinence (UI). METHODS: Data were obtained from the National Health and Nutrition Examination Survey 2011-2016. The primary endpoint was the risk of different subtypes of UI, including stress UI, urgency UI, and mixed UI. The primary exposures were leisure-time physical activity and sedentary behavior. Sedentary behavior was assessed by screen time...
March 21, 2024: Urologia Internationalis
Mancheng Xia, Chang Meng, Peng Zhang, Xiaohui Tan, Yuke Chen, Jian Fan, Zhihua Li, Bing Wang, Hongjian Zhu, Kunlin Yang, Liqun Zhou, Ninghan Feng, Kai Zhang, Xuesong Li
INTRODUCTION: To present the surgical technique and clinical outcomes of modified ileal conduit for pelvic lipomatosis (PL). METHODS: From 2020 to 2022, we prospectively enrolled 9 patients with PL undergoing modified ileal conduit. The patient characteristics, perioperative variables, and follow-up outcomes as well as the description of surgical technique were reported. RESULTS: All 9 patients successfully completed the operation. Two patients had perioperative complications of Clavien-Dindo grade I...
March 21, 2024: Urologia Internationalis
Huanglin Duan, Zanxuan Deng, Junrong Zou, Guoxi Zhang, Xiaofeng Zou, Tianpeng Xie
Background:The current treatment of non-muscle-invasive bladder cancer is suboptimal. However, in recent years, hyperthermia intravesical chemotherapy has emerged as a more effective alternative to conventional bladder perfusion. This novel treatment approach appears to have a similar therapeutic effect as BCG perfusion. Objective: This study aims to evaluate the safety and effectiveness of hyperthermia intravesical chemotherapy compared to conventional bladder perfusion chemotherapy for non-muscle-invasive bladder cancer...
March 20, 2024: Urologia Internationalis
Volkan Özen, Ayça Sultan Şahin, Elif Aybike Ayyildiz, Mehmet Eren Açık, Tayfun Eyileten, Nurten Özen
INTRODUCTION: Caudal block (CB) and erector spina plane block (ESPB) has been shown to provide effective postoperative analgesia following circumcision. Our aim was to compare the analgesic efficacy of sacral ESPB and CB, as well as the time to first analgesic requirement and postoperative complications. METHODS: Patients aged 1-7 years in the ASA I-II group, who were scheduled for circumcision were included in the study. Blocks were performed under general anesthesia before the operation...
March 16, 2024: Urologia Internationalis
Alper Simsek, Sinan Celen, Mesut Berkan Duran, Kursat Kucuker, Ahmet Baki Yagci, Nilay Sen Turk, Dogangun Yuksel, Tahir Turan
INTRODUCTION: Prostate cancer (PCa) is a common and leading course of cancer-related death in men. Although there are studies on multiparametric magnetic resonance imaging (MpMRI) with good diagnostic results in detecting clinically significant prostate cancer, new methods have been investigated due to the low positive predictive values. In this context, Prostate Specific Membrane Antigen Positron Emission Tomography (PSMA PET) emerges as an alternative imaging method to MpMRI. This study aims to compare 68Ga PSMA I&T-PET/CT and MpMRI in determining tumor location...
March 13, 2024: Urologia Internationalis
Séverine Banek, Mike Wenzel, Benedikt Lauer, Quynh Chi Le, Benedikt Hoeh, Florestan Koll, Cristina Cano Garcia, Clara Humke, Jens Köllermann, Felix K H Chun, Marina Kosiba, Luis A Kluth
PURPOSE: Despite the prospective randomized controlled JAVELIN Bladder 100 trial, no real-world evidence exists regarding tumor characteristics, adverse events (AE) and survival of avelumab maintenance (AVM) treated patients with partial/complete response or stable disease after previous platinum-based chemotherapy for advanced/metastatic urothelial carcinoma (mUC). METHODS: We relied on our institutional database to identify mUC patients who received AVM between 01/2021-12/2023...
March 6, 2024: Urologia Internationalis
Lichen Jin, Zongxin Chen, Yizhang Sun, Zhen Tian, Xincheng Yi, Yuhua Huang
The incidence of urinary tract stones is increasing worldwide, with a notably high recurrence rate. Among upper urinary tract stones, a significant proportion comprises uric acid stones. This study aims to rapid and reliable identification of uric acid stones in the upper urethra by gathering comprehensive biochemical profiles, urinalysis, and CT scan data from 276 patients diagnosed with kidney and ureteral stones. Leveraging machine learning techniques, the goal is to establish multiple predictive models that can accurately identify uric acid stones...
March 2, 2024: Urologia Internationalis
Siping Hu, Xingyu Xiong, Shi Qiu, Jiakun Li, Hang Xu, Xianghong Zhou, Sheng Wang, Qiang Wei, Lu Yang
INTRODUCTION: Previous studies showed exercise have efficacies for androgen deprivation therapy (ADT) adverse effects. To compare the efficacies of different exercises on ADT adverse effects, we conducted the network meta-analysis (NMA). METHODS: Literature retrieval was performed in PubMed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL). 19 studies (1184 participants) were included. All analyses were performed in R 4.1.2 or RevMan 5.4.1. RESULTS: NMA results showed that compared with the control group, both aerobic + resistance training (ART) (MD = 5...
March 2, 2024: Urologia Internationalis
Emre Şam, Muhittin Atar, Enes Alemdar, Abdullah Turan, İbrahim Karabulut
Spontaneous migration of the intrauterine device (IUD) into the bladder is a rare complication. We detected migrated IUDs in two female patients, aged 37 and 56 years, who had undergone surgery at our clinic due to bladder stones. In the first case, endoscopic cystolithotripsy was performed, and the IUD was removed without complications. In the second case, the IUD could not be removed endoscopically since it had fractionally invaded the bladder wall, and the IUD was removed without complications by performing an open cystolithotomy...
February 20, 2024: Urologia Internationalis
Xunguo Yang, Han Lin, Zhenhua Gao, Xingqi Wang, Ling Li, Daoming Tian, Yubin Wen, Jihong Shen
INTRODUCTION: Extramammary Paget's Disease of the scrotum and penis is a relatively rare cutaneous malignant tumor. At present, its pathogenesis, clinical and pathological characteristics are not very clear. There is controversial regarding surgical margin width to decrease the high recurrence rate. This paper aims to report the case and review the literature of Extramammary Paget's Disease of scrotum and penis. CASE PRESENTATION: We presented the case of a 74-year-old male patient with the patchy erythema and pruritus in the perineum who was admitted to our department...
February 17, 2024: Urologia Internationalis
Levent Ozcan, Emre Can Polat, Caner Baran, Ahmet Boylu, Mustafa Erkoc, Alper Otunctemur
INTRODUCTION: The main challenge to the optimal use of neoadjuvant chemotherapy (NAC) is the difficulty in selecting patients who may or may not benefit from NAC. Our aim in this study is to investigate whether the Systemic Inflammation Index (SII) predicts response to chemotherapy in patients who receive NAC prior to cystectomy. METHODS: We retrospectively analysed the data of patients who underwent NAC followed by cystectomy at our institution between January 2010 and September 2015 and whose 5-year follow-up was completed...
February 17, 2024: Urologia Internationalis
Stefanie Ziewers, Nikita Druva Fischer, Jan Hendrik Börner, Lilly Kaufmann, Alexander Tamm, Yang Yang, Florian Jungmann, Robert Dotzauer, Peter Sparwasser, Thomas Hoefner, Igor Tsaur, Axel Haferkamp, Rene Mager
INTRODUCTION: To investigate prevalence and impact of incidental renal masses (IRM) accompanying increasing computed tomography (CT) work-up for symptomatic aortic valve stenosis (sAVS) of the elderly with regard to the relevance of urological consultation for overall survival (OS). METHODS: A retrospective analysis of pre-transcatheter aortic-valve implantations (TAVI) CT scans of patients with sAVS (N=1253) harboring IRM was performed for 2014-2019. According to the clinical management, groups 1 (urologic consultation) and 2 (findings ignored) were formed and analyzed in terms of OS...
February 14, 2024: Urologia Internationalis
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