Cihan Erol, Emre Yekedüz, Deniz Tural, Serdar Karakaya, Nihan Şentürk Öztaş, Gökhan Uçar, Saadettin Kılıçkap, İsmail Ertürk, Özlem Nuray Sever, Çağatay Arslan, Ahmet Küçükarda, Orçun Can, Özlem Balvan, Satı Coşkun Yazgan, Mustafa Özgüroğlu, Berna Öksüzoğlu, Mehmet Ali Nahit Şendur, Yüksel Ürün
INTRODUCTION: We aimed to evaluate clinical features, prognostic factors, and treatment preferences in patients with non-clear cell renal cell carcinoma (nccRCC). METHODS: Patients with metastatic nccRCC were selected from the Turkish Oncology Group Kidney Cancer Consortium (TKCC) database. Clinical features, prognostic factors, and overall survival (OS) outcomes were investigated. RESULTS: A total of 118 patients diagnosed with nccRCC were included in this study...
March 30, 2023: Urologia Internationalis
Sae Morishige, Takehiro Ohyama, Nobuko Fujita, Megumi Kameda, Yuuki Yonekura, Fumiyasu Endo, Seiki Abe
INTRODUCTION: Holmium laser enucleation of the prostate (HoLEP) is considered a size-independent gold standard for benign prostatic hyperplasia (BPH), and there is no upper limit of prostate weight that can be treated. Tissue retrieval can be time-consuming in cases of significant prostatic enlargement, which may lead to intraoperative hypothermia. As there are few studies on perioperative hypothermia in HoLEP, we conducted a retrospective study of patients who underwent HoLEP at our hospital...
March 30, 2023: Urologia Internationalis
Nathan Wirtzfeld, Frédéric Leduc, Roland Vaesen
Giant hydronephrosis (GH), characterized by the presence of more than 1 L of fluid in the renal collecting system, is a rare urological condition, particularly in adults. Obstruction of the pyeloureteral junction is the most common cause of GH. We report the case of a 51-year-old man who presented with dyspnea, edema of the lower limbs, and major abdominal distension. The patient was diagnosed with obstruction of the pyeloureteral junction, causing a left giant hydronephrotic kidney. After renal drainage of 27 L of urine, a laparoscopic nephrectomy was performed...
March 30, 2023: Urologia Internationalis
Bumjin Lim, Sangwook Lee, Taehun Kim, Junhyeok Ock, Cheryn Song, Namkug Kim, Yoon Soo Kyung
Partial nephrectomy (PN) is a common surgery for small renal masses. The goal is to remove the mass completely while preserving renal function. A precise incision is, therefore, important. However, no specific method for surgical incision in PN exists, although there are several guides for bony structures using three-dimensional (3D) printing methods. Therefore, we tested the 3D printing method to create a surgical guide for PN. We describe the workflow to make the guide, which comprises computed tomography data acquisition and segmentation, incision line creation, surgical guide design, and its use during surgery...
March 30, 2023: Urologia Internationalis
Yang Wang, Xiaoke Chen, Kun Liu, Ruijuan Liu, Liangliang Li, Chaoshan Yin, Peixing Song
INTRODUCTION: Previous studies have revealed that Gleason score upgrading (GSU) was closely related to an increased biochemical recurrence rate and adverse oncologic outcomes in patients with prostate cancer (PC). Therefore, we performed a meta-analysis to determine the predictive factors for GSU following radical prostatectomy (RP). METHODS: We performed an extensive literature search using PubMed, Embase, and Cochrane in September 2022. In order to calculate the pooled odds ratio (OR), standardized mean difference (SMD), and 95% confidence intervals, a fixed effect or a DerSimonian and Laird random effect was applied...
March 29, 2023: Urologia Internationalis
Yang Fu, Kun Liu, Xi Jiang, Lun Zhao, Tianwei Wang
INTRODUCTION: Circular RNAs (circRNAs) are related to the pathogenesis and progression of bladder cancer (BC). This research aimed to investigate the role and mechanism of hsa_circ_0008035 (circ_0008035) in BC progression. METHODS: Circ_0008035, microRNA (miR)-1,184, and Ras-related protein 2B (RAP2B) levels were examined in BC via quantitative real-time polymerase chain reaction and Western blotting. Cell Counting Kit-8, colony formation, 5-ethynyl-2'-deoxyuridine staining, flow cytometry, caspase-3 assay kit, transwell, and tube formation assays were conducted to estimate the effects of circ_0008035 on the malignant phenotypes of BC tumors...
March 23, 2023: Urologia Internationalis
Lingling Zhang, Hongye Xu, Yikun Feng, Xiaoqing Wang, Guoqiang Du, Rongde Wu, Wei Liu
INTRODUCTION: This study aimed to analyze the changes in differential renal function (DRF) after laparoscopic pyeloplasty in children with high-grade hydronephrosis and factors influencing DRF improvement. METHODS: We reviewed the clinical data of unilateral ureteropelvic junction obstruction (UPJO) patients with SFU grade IV who underwent laparoscopic pyeloplasty between February 2018 and October 2020. The patients were divided into two groups: DRF improvement ≥5% (group 1) and DRF improvement <5% (group 2)...
March 23, 2023: Urologia Internationalis
Ibrahim Can Aykanat, Melih Balci, Muhammed Fevzi Kilinckaya, Serkan Akdemir, Cagdas Senel, Ozer Guzel, Yilmaz Aslan, Turan Turhan, Murat Arslan, Cagri Guneri, Altug Tuncel
INTRODUCTION: The aim of the study was to investigate the effect of the diameter of the ureteral access sheath (UAS) used during RIRS on kidney injury based on acute kidney injury (AKI) biomarkers. METHODS: This prospectively randomized controlled study included a total of 125 patients divided into three groups: group 1 (n = 52) in which a 12/14 Fr UAS was used, group 2 (n = 52) in which a 9.5/11.5 Fr UAS was used, and group 3 (n = 21) that was designed as the control group with no urogenital disease history...
March 21, 2023: Urologia Internationalis
Juntao Zhuang, Qikai Wu, Xiao Yang, Lingkai Cai, Kai Li, Hongjin Hua, Meiling Bao, Ruixi Yu, Peikun Liu, Pengchao Li, Qiang Cao, Qiang Lu
Angiomyolipoma (AML) complicated with tumour thrombus extending to the confluence of inferior vena cava (IVC) with right atrium is rarely observed. We report a female AML patient admitted to our centre on January 21, 2020, with complication of tumour thrombus extending to the confluence of IVC with right atrium and had no sign of difficult breathing. She underwent whole-abdominal enhanced CT for abdominal pain and was diagnosed with a possible renal AML with tumour thrombus. Open radical nephrectomy and thrombectomy of vena cava were performed...
March 8, 2023: Urologia Internationalis
Mehmet Yilmaz, Cäcilia Elisabeth Maria Heuring, Dominik Schoeb, Rodrigo Suarez-Ibarrola, Christian Gratzke, Simon Hein, Arkadiusz Miernik
INTRODUCTION: Holmium laser enucleation of the prostate (HoLEP) has become popular worldwide for the surgical treatment of benign prostate hyperplasia. Holmium laser is considered an ideal transurethral thermomechanical device for enucleating the prostate. Although there is evidence on Ho:YAG laser-related heat generation, the studies mainly investigated ex vivo temperature generation during holmium laser lithotripsy. In this in vivo study, we aimed to assess for the first time the real-time heat generated during HoLEP...
March 1, 2023: Urologia Internationalis
Chao Cheng, Yucheng Ma, Jun Wen, Liyuan Xiang, Xi Jin
INTRODUCTION: Urolithiasis is one of the most common diseases in the world, and at present, ureteroscopy (URS) is the first choice for its treatment. Although the effect is good, there is a risk of insertion failure of ureteroscope. Tamsulosin, as an α-receptor blocker, has the function of relaxing ureteral muscles, and can help stones to be discharged from ureteral orifice. In this study, we aimed to determine the effect of preoperative tamsulosin on ureteral navigation, operation, and safety...
February 22, 2023: Urologia Internationalis
Britta Grüne, Karl-Friedrich Kowalewski, Christel Weiß, Manuel Neuberger, Malin Nientiedt, Maren Juliane Wenk, Friedrich Otto Hartung, Maximilian Christian Kriegmair, Frank Waldbillig
INTRODUCTION: First external validation of the Bladder Complexity Score (BCS) for predicting complex transurethral resection of bladder tumours (TURBT). METHODS: For BCS calculation, TURBTs performed at our institution between January 2018 and December 2019 were reviewed for the presence of preoperative characteristics listed in the Bladder Complexity Checklist (BCC). Receiver operating characteristics (ROC) analysis was used for BCS validation. To establish a modified BCS (mBCS) with maximum area under the curve (AUC), multivariable logistic regression (MLR) analysis was performed with all BCC-characteristics for different definitions of complex TURBT...
February 22, 2023: Urologia Internationalis
Giorgio Mazzon, Francesco Claps, Federico Germinale, Davide Brusa, Simon Choong, Adara Caruso, Marco Pirozzi, Alessandro Antonelli, Maria Angela Cerruto, Antonio Celia
INTRODUCTION: The aim of the study was to provide data related to endoscopic combined intra-renal surgery learning curve using minimally invasive techniques with vacuum-assisted devices. Minimal data exist on the learning curve for these techniques. METHODS: We conducted a prospective study monitoring the training of a mentored surgeon learning ECIRS with vacuum assistance. We use varied parameters for improvements. After collection of peri-operative data, tendency lines and CUSUM analysis were used to investigate the learning curves...
February 21, 2023: Urologia Internationalis
Deniz Bolat, Sumer Baltaci, Murat Akgul, Emre Karabay, Volkan Izol, Guven Aslan, Saadettin Eskicorapci, Hayrettin Sahin, Levent Turkeri
INTRODUCTION: In this study, we aimed to explore using the predictive role of systemic immune inflammation index (SII) for responses of intravesical Bacillus Calmette-Guérin (BCG) therapy in patients with intermediate- and high-risk non-muscle-invasive bladder cancer (NMIBC). METHODS: From 9 centers, we reviewed the data of patients treated for intermediate- and high-risk NMIBC between 2011 and 2021. All patients enrolled in the study presented with T1 and/or high-grade tumors on initial TURB had undergone re-TURB within 4-6 weeks after initial TURB and had received at least a 6-week course of intravesical BCG induction...
February 21, 2023: Urologia Internationalis
Atanas Ivanov, Petar Antonov, Eleonora Hristova-Atanasova, Petar Uchikov
INTRODUCTION: Benign prostatic hyperplasia (BPH) is a histological diagnosis characterized by an increase in the number of epithelial and stromal cells in the transitional zone of the prostate gland. The clinical manifestation of BPH is associated with the appearance of so-called lower urinary tract symptoms (LUTS) which can also be a consequence of other conditions not related to the prostate. Covid-19, also known as severe acute respiratory syndrome coronavirus 2 was discovered as a disease in late 2019 in the city of Wuhan, China...
February 20, 2023: Urologia Internationalis
Bo Xiao, Xue Zeng, Gang Zhang, Chaoyue Ji, Song Jin, Wenjie Bai, Yuzhe Tang, Bixiao Wang, Jianxing Li
INTRODUCTION: The aim of the study was to assess the safety and efficacy of ultrasound (US)-guided percutaneous nephrolithotomy (PCNL) for complex renal stones when performed in a modified supine position. METHODS: We retrospectively reviewed the charts of patients who underwent PCNL for complex renal stones at our institution between August 2018 and December 2021. During this time, 188 consecutive patients underwent US-guided PCNL in the prone position (P group, n = 129) or in the flank-free modified supine position (S group, n = 59)...
February 8, 2023: Urologia Internationalis
David Hernández-Hernández, Miguel Angel Navarro-Galmés, Bárbara Padilla-Fernández, Stephany Hess-Medler, David Manuel Castro-Díaz
INTRODUCTION: Post-prostatectomy urinary incontinence (PPUI) has an enormous impact in quality of life (QoL). Transobturator-rethrourethral sling (AdVanceTMXP sling) is a well-established treatment option although there is paucity of data on long-term outcomes. Our objective was to assess the long-term functional outcomes and QoL in a cohort of men undergoing AdVanceTMXP sling surgery. METHODS: Retrospective observational study of men undergoing AdVanceTMXP sling in a tertiary referral institution from August 2013 to July 2020...
February 8, 2023: Urologia Internationalis
Yukari Bando, Junya Furukawa, Takuto Hara, Yasuyoshi Okamura, Tomoaki Terakawa, Yuzo Nakano, Masato Fujisawa
Combination therapies of an immune checkpoint inhibitor and a molecular targeted agent are widely accepted as an appropriate initial systemic therapy for metastatic renal cell carcinoma (RCC), but there is little published evidence regarding the efficacy of this approach in patients with end-stage renal disease (ESRD). Here, we report three patients who were undergoing hemodialysis for ESRD whose metastatic RCC was successfully treated using avelumab plus axitinib. The patients were a 67-year-old man with swollen lymph nodes, a 65-year-old man with pleural dissemination, and a 71-year-old man with lung nodules and an infra-diaphragmatic nodule...
February 2, 2023: Urologia Internationalis
Egesta Lopci, Massimo Lazzeri, Piergiuseppe Colombo, Paolo Casale, Nicolo M Buffi, Alberto Saita, Roberto Peschechera, Rodolfo Hurle, Katia Marzo, Lorenzo Leonardi, Emanuela Morenghi, Luca Balzarini, Luca Disconzi, Giorgio Guazzoni, Arturo Chiti, Giovanni Lughezzani
BACKGROUND: This prospective single-arm study is designed to compare in parallel 68Ga-PSMA PET/TRUS (transrectal or transperineal) fusion biopsy ("experimental test") with multiparametric MRI (mpMRI)/TRUS fusion prostate biopsy ("standard test") in men with a high suspicion of prostate cancer (PCa) after at least one negative biopsy. The primary objective was to evaluate the diagnostic performance of 68Ga-PSMA PET/TRUS fusion prostate biopsy in comparison to mpMRI/TRUS fusion prostate biopsy analyzed in parallel...
February 1, 2023: Urologia Internationalis
Ran Katz, Muhamad Sabih Abu Ahmed, Ali Safadi, Shmuel Roizman, Amnon Zisman, Maharan Kabha, Yoram Dekel, Jack Baniel, Shachar Aharony
INTRODUCTION: The Butterfly Prostatic Retraction device is a novel transurethral implant designed to dilate the prostatic urethra and treat lower urinary tract symptoms. We assessed its safety, efficacy and impact on urinary flow, ejaculation, and quality of life. MATERIALS AND METHODS: We included 64 men, treated for benign prostate hyperplasia for at least 1 year. All patients had Qmax≤ 13 mL/s and IPSS >12. Insertion of the device was performed via cystoscopy...
January 31, 2023: Urologia Internationalis
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