Xiao-Jing Liu, Xiao-Jing Yu, Yu-Kun Su, Jin-An Qiao, Yao-Jun Sun, Xiao-Jie Bai, Nana Zhang, Hui-Yu Yang, Li-Xi Yin, Yu-Ming Kang, Zhi-Ming Yang
Proinflammatory cytokines, reactive oxygen species and imbalance of neurotransmitters are involved in the pathophysiology of angiotensin II-induced hypertension. The hypothalamic paraventricular nucleus (PVN) plays a vital role in hypertension. Evidences show that microglia are activated and release proinflammatory cytokines in angiocardiopathy. We hypothesized that angiotensin II induces PVN microglial activation, and the activated PVN microglia release proinflammatory cytokines and cause oxidative stress through nuclear factor-kappa B (NF-κB) pathway, which contributes to sympathetic overactivity and hypertension...
January 27, 2023: Tohoku Journal of Experimental Medicine