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Tohoku Journal of Experimental Medicine

Takahiko Shibahara
Bisphosphonates (BPs) have been used as antiresorptive agents to treat patients with osteoporosis or metastatic bone cancer, each of which is characterized by bone loss due to the increased bone resorption. However, BPs could cause osteonecrosis of the jaw (ONJ), known as bisphosphonate-related osteonecrosis of the jaw (BRONJ). ONJ is associated with severe pain and deteriorated quality of life. ONJ is also caused by administration of denosumab, a monoclonal antibody against receptor activator of NFκB ligand (RANKL), that functions as a powerful antiresorptive agent...
2019: Tohoku Journal of Experimental Medicine
Haruka Sato, Koichiro Sugimura, Masanobu Miura, Ryo Konno, Katsuya Kozu, Nobuhiro Yaoita, Toru Shimizu, Saori Yamamoto, Tatsuo Aoki, Shunsuke Tatebe, Kimio Satoh, Hiroaki Shimokawa
Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary hypertension (PH). The prognosis of PVOD patients remains poor, since no effective medical therapy is yet available. Imatinib is a tyrosine kinase inhibitor specific for platelet-derived growth factor receptor and is expected as a treatment option for pulmonary arterial hypertension (PAH). Recently, it has been reported that imatinib improved functional capacity of a patient with PVOD. We here report a patient with suspected PVOD who has been successfully treated with imatinib and is alive for 6 years after diagnosis...
2019: Tohoku Journal of Experimental Medicine
Mahy Egiz, Toshinori Usui, Masumi Ishibashi, Xuewei Zhang, Shogo Shigeta, Masafumi Toyoshima, Kazuyuki Kitatani, Nobuo Yaegashi
The La-related proteins (LARPs) are a family of RNA binding proteins that control the degradation and stabilization of RNAs. As emerging research reveals the biology of each LARP, it is evident that LARPs are dysregulated in some types of cancer. Upregulation of cell motility potentiates the metastatic potential of ovarian cancer cells; however, the roles of LARPs in cell motility remain unknown. In the present study, we investigated the roles of LARPs in the progression of ovarian cancer using SKOV3 human ovarian cancer cells and a public database that integrates microarray-based gene expression data and clinical data...
2019: Tohoku Journal of Experimental Medicine
Yosuke Chiba, Takashi Kido, Masahiro Tahara, Keishi Oda, Shingo Noguchi, Toshinori Kawanami, Mitsuru Yokoyama, Kazuhiro Yatera
Hard metal lung disease (HMLD) is a pneumoconiosis caused by occupational exposure to hard metals such as tungsten carbide and cobalt, but the treatment strategies for HMLD have not been well established. A 68-year-old Japanese man with occupational history as a grinder of hard metals for 18 years referred to our hospital because of dry cough and dyspnea. A chest computed tomography (CT) on admission revealed centrilobular micronodules, ground-glass opacities, and reticular opacities in the peripheral zone of both lungs...
2019: Tohoku Journal of Experimental Medicine
Tadashi Ishii, Tetsuya Akaishi, Michiaki Abe, Shin Takayama, Ken Koseki, Takashi Kamei, Toru Nakano
Esophageal achalasia is a disease characterized by the impaired esophageal peristalsis and non-relaxation of the lower esophageal sphincter muscle with unknown causes. Clinical manifestation of the disease is nonspecific (e.g., weight loss, vomiting, and persistent cough); namely, early diagnosis of the disease is often difficult. Delayed diagnosis of the disease is known to impair the patients' quality of life. Identifying the diagnostic factors that could cause diagnostic delay is needed. In this study, we collected data from 38 patients with achalasia and searched for diagnostic factors associated with delayed diagnosis (i...
2019: Tohoku Journal of Experimental Medicine
Yasushi Chiba, Chiyoko N Inoue
Cyclosporine A is known to be effective in some genetic podocyte injury. However, the efficacy of cyclosporine A depends on the degree of histopathological findings, and the relationship between long-term use and renal prognosis remains unknown. Frasier syndrome is a rare genetic disorder caused by intronic mutations in WT1, and is characterized by progressive glomerulopathy, a 46,XY disorder of sex development, and an increased risk of gonadoblastoma. We report here a 16-year-old phenotypically female patient with Frasier syndrome...
January 2019: Tohoku Journal of Experimental Medicine
Yusuke Watanabe, Shizukiyo Ishikawa, Hiroyuki Nagata, Masayuki Kojima
Japan is an aging society, and the incidence of diseases related to aging, such as pneumonia, heart failure, vertebral compression fracture (VCF), is increasing. Prolonged hospital stays are becoming a serious social problem, leading to elevated medical expenses. Thus, shortening the period of hospitalization is important. This study aimed to reveal determinants associated with prolonged hospital stays for patients with VCF. Our institution is the primary hospital in a rural area in the Kanto region of Japan...
January 2019: Tohoku Journal of Experimental Medicine
Michio Murakami, Yoshitake Takebayashi, Masaharu Tsubokura
Psychological distress has become a serious health risk after the Fukushima nuclear accident. Although, following the lifting of evacuation orders, the affected people have started returning home, their current status of psychological distress has not been reported yet. Here, we report the levels of psychological distress in both returnees and evacuees by using a K6 indicator. In January 2018, questionnaires were randomly distributed among 2,000 people, aged 20 to 79 years old, who were registered on the Basic Resident Register in the evacuation order areas of nine municipalities where residents have now started returning home...
2019: Tohoku Journal of Experimental Medicine
Ke Dong, Li Ye, Yun Leng, Shu Liang, Liao Feng, Hong Yang, Ling Su, Yiping Li, Saira Baloch, Fangting He, Dan Yuan, Xiaofang Pei
Antiretroviral therapy (ART) has been introduced recently and has significantly impacted morbidity and mortality, but can also engender drug resistance. To identify the prevalence of HIV-1 drug resistance (HIVDR) among patients with antiretroviral therapy failure in Sichuan during the period from 2010 to 2016, we carried out a longitudinal study in Sichuan, a province with the highest HIV/AIDS prevalence in China. The data and blood samples were collected from HIV/AIDS patients who received ART for more than half a year...
January 2019: Tohoku Journal of Experimental Medicine
Motohiko Suzuki, Makoto Yokota, Tamami Matsumoto, Meiho Nakayama, Masaya Takemura, Yoshihiro Kanemitsu, Akio Niimi, Yoshihisa Nakamura, Shingo Murakami
Patients with laryngopharyngeal reflux (LPR) were reported to suffer from hypogeusia that affects quality of life. Proton pump inhibitor (PPI) is a useful drug in the treatment of LPR, but its effect on hypogeusia is not known. We therefore assessed the effects of PPI or a histamine H2 receptor antagonist (H2 blocker) on hypogeusia among patients with LPR. Both PPI and H2 blocker could inhibit acid reflux. LPR was diagnosed with reflux finding score and reflux symptom index. The visual analogue scale (VAS) of taste disturbance symptoms and the gustatory tests were assessed before and 8 weeks after treatment with esomeprazole, a PPI (20 patients, aged 50...
January 2019: Tohoku Journal of Experimental Medicine
Hayder Al-Momen, Majed Kadhim Muhammed, Ali Abdulhussein Alshaheen
During a daily neonatology practice, seizures are a continuous challenge as a common neurological disease with a wide range of underlying etiologies, and considerable risks of morbidity and mortality. This study aimed to clarify the rate, etiological factors and outcomes of neonatal seizures, and a possible foresight of neonatal death in Iraq. A prospective cohort study was conducted in neonates with seizures admitted to 3 major neonatology centers in Baghdad, Iraq, from 1st of December 2017 till the end of May 2018...
December 2018: Tohoku Journal of Experimental Medicine
Kazuhiro Takahashi
No abstract text is available yet for this article.
December 2018: Tohoku Journal of Experimental Medicine
Makoto Harada, Tohru Ichikawa, Mamoru Kobayashi
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a systemic vasculitis resulting in severe organ injuries. ANCA is a disease-labeled antibody of AAV, and myeloperoxidase (MPO) and proteinase 3 are the main targeted antigens of ANCA. Takotsubo syndrome, a transient cardiac dysfunction caused by emotional or physical stress, is characterized by ST-segment elevation and negative T waves in electrocardiogram, transient left ventricular asynergy, and absence of obstructive coronary disease...
December 2018: Tohoku Journal of Experimental Medicine
Ryusuke Ouchi, Tasuku Kawano, Hitomi Yoshida, Masato Ishii, Tomomitsu Miyasaka, Yuichi Ohkawara, Motoaki Takayanagi, Tomoko Takahashi, Isao Ohno
Epidemiologic studies indicate that exposure to psychosocial stress in early childhood is a risk factor of adult-onset asthma, but the mechanisms of this relationship are poorly understood. Therefore, we examined whether early-life stress increases susceptibility to adult-onset asthma by inhibiting the development of respiratory tolerance. Neonatal BALB/c female mice were aerosolized with ovalbumin (OVA) to induce immune tolerance prior to immune sensitization with an intraperitoneal injection of OVA and the adjuvant aluminum hydroxide...
November 2018: Tohoku Journal of Experimental Medicine
Youlim Kim, Yeon Joo Lee, Young-Jae Cho, Ho Il Yoon, Jae Ho Lee, Choon-Taek Lee, Jong Sun Park
Chronic fibrosing interstitial lung disease (ILD)s are characterized by chronic progressive fibrosis of lung which include idiopathic pulmonary fibrosis (IPF), nonspecific interstitial pneumonia (NSIP), and connective tissue disease-associated interstitial lung disease (CTD-ILD). IPF is an irreversible fibrotic lung disease which results in respiratory failure. Although NSIP and CTD-ILD can be improved or stable by treatment with corticosteroid or immunosuppressant, some of them progress to fibrotic lung diseases...
November 2018: Tohoku Journal of Experimental Medicine
Chitaru Tokutake, Akiko Haga, Kesami Sakaguchi, Atsuko Samejima, Miki Yoneyama, Yoshiharu Yokokawa, Masayoshi Ohira, Motoki Ichikawa, Makoto Kanai
Co-sleeping and breastfeeding in the side-lying position have recently been pointed out as risk factors for suffocation in sleeping infants; however, there is no actual report on an "incident." "Incident" is defined as a tense or sobering experience without a consequential fatal suffocation accident. It is important to understand infant suffocation incidents to prevent accidents during co-sleeping and breastfeeding in the side-lying position. We investigated factors and frequency of infant suffocation incidents associated with co-sleeping and breastfeeding in the side-lying position using a self-administered questionnaire survey of 895 mothers during their infant's 1-, 4-, or 10-month health checkups...
October 2018: Tohoku Journal of Experimental Medicine
María Cristina Negrete-Garcia, Sandra Lizbeth Ramírez-Rodriguez, Claudia Rangel-Escareño, Said Muñoz-Montero, Javier Kelly-García, María Eugenia Vázquez-Manríquez, Patricio Santillán, Martha Montaño Ramírez, Gustavo Ramírez-Martínez, Alejandra Ramírez-Venegas, Blanca Ortiz-Quintero
Cancer-associated fibroblasts (CAFs) are the main component of the tumor stroma and promote tumor progression through several mechanisms. Recent evidence indicates that small noncoding RNAs, microRNAs (miRNAs), play key roles in CAF tumor-promoting properties; however, the role of miRNAs in lung cancer-associated fibroblasts remains poorly defined. We characterized the differential miRNA expression profile of fibroblasts isolated from matched tumor front (F-CAFs), inner tumor (In-CAFs), and normal adjacent (NFs) tissues from four lung adenocarcinoma patients (ADs) using microarray analysis...
October 2018: Tohoku Journal of Experimental Medicine
Jun Suzuki, Yoriko Harazaki, Shinkichi Morita, Yoshiko Kaga, Kazuhiro Nomura, Mitsuru Sugawara, Yukio Katori
Myeloid sarcoma (MS) is an uncommon extramedullary malignant tumor, and often represents a subgroup of acute myeloid leukemia (AML). MS of paranasal sinus origin is extremely rare. We report an uncommon case of sinonasal MS associated with AML, who was successfully treated with hematopoietic stem-cell transplantation. A 39-year-old male was admitted with complaints of left nasal obstruction and proptosis. Computed tomography and magnetic resonance imaging identified a left ethmoidal mass involving the maxillary sinus, the orbit, and the skull base...
October 2018: Tohoku Journal of Experimental Medicine
Shigeto Koizumi, Satoru Motoyama, Noboru Watanabe, Tamotsu Matsuhashi, Katsunori Iijima
With the decreasing global trend in the Helicobacter pylori infection rate, compositional changes in the gastric cancer subsites have occurred worldwide. However, the compositional changes in Asian countries, including Japan, remain to be clarified. The aim of this study is to investigate the latest chronological changes in the gastric cancer subsite using a hospital-based registration system in Akita prefecture in Japan. From 2007-2015, subsites of gastric cancers were coded according to the International Classification of Diseases for Oncology (ICD-03)...
October 2018: Tohoku Journal of Experimental Medicine
Mami Ishikuro, Taku Obara, Tamae Osanai, Chizuru Yamanaka, Yuki Sato, Satoshi Mizuno, Masako Miyashita, Masahiro Kikuya, Kasumi Sakurai, Atsushi Hozawa, Hiroaki Tomita, Yasuyuki Taki, Fuji Nagami, Hirohito Metoki, Shinichi Kuriyama
Involvement of family members, especially grandparents, in genome epidemiological research is important to investigate both genetic and environmental factors of common diseases. The aim of the present study was to establish strategies to obtain enough number of family recruitment, especially focusing on grandparents, for the Tohoku Medical Megabank Birth and Three-Generation Cohort Study. Our main strategies are summarized below. 1) We standardized informed consent process with reference materials to help people understand the consent form, 2) we created an invitation letter to contact family members, and 3) we recruited family members in several settings...
October 2018: Tohoku Journal of Experimental Medicine
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