Journals Toxicology and Applied Pharmac...

Toxicology and Applied Pharmacology
Xin Liu, Shangfeng Zhao, Qianqian Zhao, Yiwei Chen, Shubing Jia, Rongwu Xiang, Jinghai Zhang, Jianfang Sun, Yijia Xu, Mingyi Zhao
Bone cancer pain is a difficult-to-treat pathologic condition that impairs the patient's quality of life. The effective therapy options for BCP are restricted due to the unknown pathophysiology. Transcriptome data were obtained from the Gene Expression Omnibus database and differentially expressed gene extraction was performed. DEGs integrated with pathological targets found 68 genes in the study. Butein was discovered as a possible medication for BCP after the 68 genes were submitted to the Connectivity Map 2...
May 31, 2023: Toxicology and Applied Pharmacology
Maryam Mahjoubian, Akram Sadat Naeemi, Zeinab Moradi-Shoeili, Charles R Tyler, Borhan Mansouri
This study assessed the oxidative stress impacts of Ag NPs and ZnO NPs and their mixtures in zebrafish (Danio rerio). Zebrafish were exposed to sublethal concentrations of each NP and a mixture for 28 days followed by a 28-day recovery period (without NP exposure) and measurements made on hepatic levels of antioxidant enzymes (CAT, SOD, and GPx), MDA levels, expression of the genes for the Hsp70 and Hsp90, and MT, blood biochemical parameters (total protein, globulin, albumin, AST, ALT, ALP, and LDH), and genotoxicity in erythrocytes (via measurement of micronuclei (MN) and nuclear (NA) abnormalities)...
May 30, 2023: Toxicology and Applied Pharmacology
Jiunn-Chang Lin, Tsang-Pai Liu, Yan-Bin Chen, Tun-Sung Huang, Tung-Ying Chen, Pei-Ming Yang
Cyclin-dependent kinase 9 (CDK9) inhibitors are a novel category of anticancer treatment for cancers. However, their effects on hepatocellular carcinoma (HCC) are rarely investigated. Human ribonucleotide reductase (RR, which consists of RRM1 and RRM2 subunits) catalyzes the conversion of ribonucleoside diphosphate into 2'-deoxyribonucleoside diphosphate to maintain the homeostasis of nucleotide pools, which play essential roles in DNA synthesis and DNA repair. In this study, we identified that CDK9 protein expression in adjacent non-tumor tissues predicted HCC patients' overall and progression-free survivals...
May 26, 2023: Toxicology and Applied Pharmacology
Analía Ale, Victoria S Andrade, María F Gutierrez, Carla Bacchetta, Andrea S Rossi, Pablo Santo Orihuela, Martín F Desimone, Jimena Cazenave
The imminent increase in global food demand inevitably leads to an increase in agricultural practices, with an emphasis on pesticide applications. Nanotechnology-based pesticides, or nanopesticides, have gained importance as they are more efficient and, in some cases, less toxic than their conventional counterparts. However, concerns about these novel products have arisen as evidence about their (eco)safety is controversial. This review aims to: (1) introduce the currently applied nanotechnology-based pesticides and their mechanisms of toxic action; (2) describe their fate when released into the environment, with an emphasis on aquatic environments; (3) summarize available research on ecotoxicological studies in freshwater non-target organisms through a bibliometric analysis; and (4) identify gaps in knowledge from an ecotoxicological perspective...
May 23, 2023: Toxicology and Applied Pharmacology
Arooj Rizwan, Muhammad Umar Ijaz, Ali Hamza, Haseeb Anwar
Polystyrene microplastics (PS-MPs) are the potential environmental pollutants that possess the ability to induce testicular damage. Astilbin (ASB) is a dihydroflavonol, abundantly reported in multiple plants that has various pharmacological properties. This research elucidated the mitigative potential of ASB against PS-MPs-instigated testicular toxicity. 48 adult male rats (200 ± 10 g) were distributed into 4 groups (n = 12): control, PS-MPs received (0.01 mg/kg), PS-MPs + ASB received (0...
May 20, 2023: Toxicology and Applied Pharmacology
Nursarah Syamimi Anuar, Syahirah Ain Shafie, Muhammad Aiman Faris Maznan, Noor Syaffinaz Noor Mohamad Zin, Nur Ain Sabrina Azmi, Rohaizad Abdul Raoof, Diyas Myrzakozha, Nurdiana Samsulrizal
Lauric acid, a 12‑carbon atom medium chain fatty acid (MCFA) has strong antioxidant and antidiabetic activities. However, whether lauric acid can ameliorate hyperglycaemia-induced male reproductive damage remains unclear. The study aimed to determine the optimal dose of lauric acid with glucose-lowering activity, antioxidant potential and tissue-protective effects on the testis and epididymis of streptozotocin (STZ)-induced diabetic rats. Hyperglycaemia was induced in Sprague Dawley rats by an intravenous injection of STZ at a dose of 40 mg/kg body weight (bwt)...
May 19, 2023: Toxicology and Applied Pharmacology
Ching-Hui Loh, Wei-Wen Kuo, Shinn-Zong Lin, Cheng-Yen Shih, Pi-Yu Lin, Jiro Hasegawa Situmorang, Chih-Yang Huang
Metabolic-associated fatty liver disease (MAFLD) is a global concern, often undetected until reaching an advanced stage. Palmitic acid (PA) is a type of fatty acid that increases and leads to liver apoptosis in MAFLD. However, there is currently no approved therapy or compound for MAFLD. Recently, branched fatty acid esters of hydroxy fatty acids (FAHFAs), a group of bioactive lipids, have emerged as promising agents to treat associated metabolic diseases. This study utilizes one type of FAHFA, oleic acid ester of 9-hydroxystearic acid (9-OAHSA), to treat PA-induced lipoapoptosis in an in vitro MAFLD model using rat hepatocytes and a high-fat high-cholesterol high-fructose (HFHCHFruc) diet in Syrian hamsters...
May 17, 2023: Toxicology and Applied Pharmacology
Szabolcs Dvorácskó, Tímea Körmöczi, Éva Sija, Balázs Bende, Roland Weiczner, Tibor Varga, István Ilisz, László Institóris, Éva M Kereszty, Csaba Tömböly, Róbert Berkecz
Nowadays, more and more new synthetic cannabinoids (SCs) appearing on the illicit market present challenges to analytical, forensic, and toxicology experts. For a better understanding of the physiological effect of SCs, the key issue is studying their metabolomic and psychoactive properties. In this study, our validated targeted reversed phase UHPLC-MS/MS method was used for determination of urinary concentration of 5F-MDMB-PICA, 4F-MDMB-BICA, and their primary metabolites. The liquid-liquid extraction procedure was applied for the enrichment of SCs...
May 12, 2023: Toxicology and Applied Pharmacology
Li-Xia Xu, Rui-Xing Wang, Jian-Feng Jiang, Gao-Cheng Yi, Jin-Jin Chang, Rui-Lan He, Hai-Xia Jiao, Bin Zheng, Long-Xin Gui, Jun-Jin Lin, Zhi-Hong Huang, Mo-Jun Lin, Zhi-Juan Wu
Daunorubicin (DNR-) induced cardiotoxicity seriously restricts its clinical application. Transient receptor potential cation channel subfamily C member 6 (TRPC6) is involved in multiple cardiovascular physiological and pathophysiological processes. However, the role of TRPC6 anthracycline-induced cardiotoxicity (AIC) remains unclear. Mitochondrial fragmentation greatly promotes AIC. TRPC6-mediated ERK1/2 activation has been shown to favor mitochondrial fission in dentate granule cells. The aim of the present study was to elucidate the effects of TRPC6 on daunorubicin- induced cardiotoxicity and identify the mechanisms associated with mitochondrial dynamics...
May 11, 2023: Toxicology and Applied Pharmacology
Kritika Karri, David J Waxman
The persistent environmental aryl hydrocarbon receptor agonist and hepatotoxin TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) induces hepatic lipid accumulation (steatosis), inflammation (steatohepatitis) and fibrosis. Thousands of liver-expressed, nuclear-localized lncRNAs with regulatory potential have been identified; however, their roles in TCDD-induced hepatoxicity and liver disease are unknown. We analyzed single nucleus (sn)RNA-seq data from control and subchronic (4 wk) TCDD-exposed mouse liver to determine liver cell-type specificity, zonation and differential expression profiles for thousands of IncRNAs...
May 10, 2023: Toxicology and Applied Pharmacology
Ting-Ting Huang, Ping-Ping Yan, Yan-Ni Liu, Jia Di, Qiao-Juan Shi, Yong-Xiao Cao, Lei Cao
Helicobacter pylori (H. pylori) is an obligate microaerobion and does not survive in low oxygen. Sodium sulfite (SS) reacts and consume oxygen in solutions. The present study aimed to investigate the effects of SS on H. pylori. The effects of SS on oxygen concentrations in solutions and on H. pylori in vivo and in vitro were examined, and the mechanisms involved were explored. The results showed that SS decreased the oxygen concentration in water and artificial gastric juice. In Columbia blood agar and special peptone broth, SS concentration-dependently inhibited the proliferation of H...
May 8, 2023: Toxicology and Applied Pharmacology
Lucia M Odetti, Camila F Chacón, Pablo A Siroski, Ma Fernanda Simoniello, Gisela L Poletta
The present study demonstrated the potential of glyphosate (GLY), 2,4-dichlorophenoxyacetic acid (2,4-D), imidacloprid (IMI) and chlorantraniliprole (CAP) separately and in mixtures to induce oxidative stress and DNA damage in Caiman latirostris hatchlings. Under controlled condition, an embryonic exposure to these pesticides was done at concentrations recommended for soybean crops. Treatments were: negative control, GLY, 2,4-D, IMI, CAP, mixture 1 (M1): GLY + 2,4-D, M2: IM I + CAP and M3: GLY + 2,4-D + IMI + CAP...
May 5, 2023: Toxicology and Applied Pharmacology
Eun-Jung Park, Seung-Woo Jin, Ilseob Shim, Art E Cho
Despite their importance in combating the spread of the COVID-19 pandemic, adverse effects of disinfectants on human health, especially the respiratory system, have been of continuing concern to researchers. Considering that bronchi are the main target of sprayed disinfectants, we here treated the seven major active ingredients in disinfectant products accepted by the US EPA to human bronchial epithelial cells and determined the subtoxic levels. Then, we performed microarray analysis using total RNA obtained at the subtoxic level and designed a network representing disinfectant-induced cellular response using the KEGG pathway analysis technique...
May 4, 2023: Toxicology and Applied Pharmacology
Katarzyna Regulska, Agnieszka Matera-Witkiewicz, Aleksandra Mikołajczyk, Beata J Stanisz
According to some clinical observations, the use of angiotensin-converting enzyme inhibitors (ACEI) may be associated with an increased risk of cancer. The aim of the present study was to screen for the potential carcinogenicity, mutagenicity and genotoxicity of these drugs using in silico methodology. Delapril, enalapril, imidapril, lisinopril, moexipril, perindopril, ramipril, trandolapril, spirapril were thereby analyzed. In parallel, the corresponding degradation impurities, the diketopiperazine (DKP) derivatives, were also investigated...
May 4, 2023: Toxicology and Applied Pharmacology
Z Pandelides, M C Sturgis, C Thornton, N Aluru, K L Willett
Benzo[a]pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH), is implicated in many developmental and behavioral adverse outcomes in offspring of exposed parents. The objective of this study was to investigate sex-dependent multigenerational effects of preconceptional effects of BaP exposure. Adult wild-type (5D) zebrafish were fed 708 μg BaP/g diet (measured) at a rate of 1% body weight twice/day (14 μg BaP/g fish/day) for 21 days. Fish were spawned using a crossover design, and parental (F0) behavior and reproductive indexes were measured...
May 3, 2023: Toxicology and Applied Pharmacology
Miao-Qing Zhang, Gui-Zhi Wu, Jing-Pu Zhang, Chang-Qin Hu
The most commonly reported side effect of azithromycin is gastrointestinal (GI) disorders, and the main acid degradation product is 3'-Decladinosyl azithromycin (impurity J). We aimed to compare the GI toxicity of azithromycin and impurity J on zebrafish larvae and investigate the mechanism causing the differential GI toxicity. Results of our study showed that the GI toxicity induced by impurity J was higher than that of azithromycin in zebrafish larvae, and the effects of impurity J on transcription in the digestive system of zebrafish larvae were significantly stronger than those of azithromycin...
April 24, 2023: Toxicology and Applied Pharmacology
Peiyu Lu, Li Tian, Aihua Wu, Hua Zhou, Min Yang
OBJECTIVE: Construction of a nomogram model for predicting the risk of kidney injury associated with programmed cell death protein-1 (PD-1) inhibitors. METHODS: Patients using PD-1 inhibitors from January 2018 to January 2021 in our center were retrospectively analyzed and followed up until January 2022. Kidney injury was defined as acute kidney disease and disorders (AKD). Univariate and multivariate logistic regression models were used to identify independent risk factors for PD-1 inhibitor associated kidney injury, and nomogram prediction models were further established...
April 23, 2023: Toxicology and Applied Pharmacology
Andrea C Postmus, Janine K Kruit, Roos E Eilers, Rick Havinga, Mirjam H Koster, Yoshikazu Johmura, Makoto Nakanishi, Bart van de Sluis, Johan W Jonker
Cancer survivors who received chemotherapy, such as the anthracycline doxorubicin (DOX), have an increased risk of developing complications later in life, including the development of chronic metabolic diseases. Although the etiology of this increased risk for late metabolic complications in cancer survivors is poorly understood, a causal role of therapy-induced senescent cells has been suggested. To study the role of cellular senescence in chemotherapy-induced metabolic complications, young adult female low-density lipoprotein receptor-deficient (Ldlr-/- )-p16-3MR mice, in which p16Ink4a -positive (p16Ink4a+ ) senescent cells can be genetically eliminated, were treated with four weekly injections of DOX (2...
April 23, 2023: Toxicology and Applied Pharmacology
Mercedes Rose, Alain Filiatreault, Andrew Williams, Josée Guénette, Errol M Thomson
Air pollution is associated with increased risk of metabolic diseases including type 2 diabetes, of which dysregulation of the insulin-signaling pathway is a feature. While studies suggest pollutant exposure alters insulin signaling in certain tissues, there is a lack of comparison across multiple tissues needed for a holistic assessment of metabolic effects, and underlying mechanisms remain unclear. Air pollution increases plasma levels of glucocorticoids, systemic regulators of metabolic function. The objectives of this study were to 1) determine effects of ozone on insulin-signaling genes in major metabolic tissues, and 2) elucidate the role of glucocorticoids...
April 21, 2023: Toxicology and Applied Pharmacology
Shiho Yoshida, Alexander M Kreger, Imam H Shaik, Raymond E West, Raman Venkataramanan, George K Gittes
BACKGROUND: The effectiveness of sildenafil in the management of pulmonary hypertension in congenital diaphragmatic hernia (CDH) has been reported but has not been systematically evaluated. Our studies have also demonstrated that intra-amniotic (IA) sildenafil administration improves pulmonary hypertension in CDH. METHODS: We evaluated the pharmacokinetics of sildenafil after IA administration in pregnant rabbits. Following maternal laparotomy, fetuses received IA injection of 0...
April 18, 2023: Toxicology and Applied Pharmacology
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