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Yonsei Medical Journal

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https://read.qxmd.com/read/30666847/the-author-reply-mitochondrial-ophthalmoplegia-is-not-only-due-to-mtdna-deletions
#1
LETTER
Young Mock Lee
No abstract text is available yet for this article.
February 2019: Yonsei Medical Journal
https://read.qxmd.com/read/30666846/mitochondrial-ophthalmoplegia-is-not-only-due-to-mtdna-deletions
#2
LETTER
Josef Finsterer
No abstract text is available yet for this article.
February 2019: Yonsei Medical Journal
https://read.qxmd.com/read/30666845/the-risk-of-malignancy-in-korean-patients-with-rheumatoid-arthritis
#3
Hwajeong Lee
PURPOSE: To investigate the overall cancer risk and risk for specific cancers in rheumatoid arthritis (RA) patients in Korea by comparing cancer incidence between RA patients and the general population. MATERIALS AND METHODS: Individuals diagnosed with RA between 1996 and 2009 who underwent treatment at the Daegu Catholic University Medical Center were retrospectively examined. 1885 patients with RA were included in the analyses. Occurrence of cancer and death during follow up was ascertained by linking medical records to the Korean Central Cancer Registry and national death certificates...
February 2019: Yonsei Medical Journal
https://read.qxmd.com/read/30666844/bacterial-and-viral-identification-rate-in-acute-exacerbation-of-chronic-obstructive-pulmonary-disease-in-korea
#4
Juwhan Choi, Jee Youn Oh, Young Seok Lee, Gyu Young Hur, Sung Yong Lee, Jae Jeong Shim, Kyung Ho Kang, Kyung Hoon Min
PURPOSE: The most common cause of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is respiratory infection. Most studies of bacterial or viral cause in AECOPD have been conducted in Western countries. We investigated bacterial and viral identification rates in AECOPD in Korea. MATERIALS AND METHODS: We reviewed and analyzed medical records of 736 cases of AECOPD at the Korea University Guro Hospital. We analyzed bacterial and viral identification rates and classified infections according to epidemiological factors, such as Global Initiative for Chronic Obstructive Lung Disease stage, mortality, and seasonal variation...
February 2019: Yonsei Medical Journal
https://read.qxmd.com/read/30666843/analysis-of-individual-case-safety-reports-of-severe-cutaneous-adverse-reactions-in-korea
#5
Min Gyu Kang, Kyung Hee Sohn, Dong Yoon Kang, Han Ki Park, Min Suk Yang, Ju Yeun Lee, Hye Ryun Kang
PURPOSE: Despite morbidities and fatalities, nationwide epidemiologic data for severe cutaneous adverse reactions (SCARs), including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS), are not widely available. We aimed to investigate SCAR epidemiology over the last two decades in Korea. MATERIALS AND METHODS: We analyzed individual case safety reports (ICSRs) of SCARs in the Korea Adverse Event Reporting System from 1988 to 2013...
February 2019: Yonsei Medical Journal
https://read.qxmd.com/read/30666842/signal-detection-for-cardiovascular-adverse-events-of-dpp-4-inhibitors-using-the-korea-adverse-event-reporting-system-database-2008-2016
#6
Hyemin Yi, Ji Ho Lee, Ju Young Shin
PURPOSE: Cardiovascular adverse events (AEs) after use of dipeptidyl peptidase-4 (DPP4) inhibitors have been reported and suspected since the launch of DPP-4 inhibitors in 2006. However, few studies have investigated the association between cardiovascular AEs and DPP-4 inhibitors. The objective of this study is to detect the signals of cardiovascular AEs after use of DPP-4 inhibitors by analyzing the Korea Institute of Drug Safety & Risk Management-Korea Adverse Event Reporting System Database (KIDS-KD)...
February 2019: Yonsei Medical Journal
https://read.qxmd.com/read/30666841/machine-learning-for-the-prediction-of-new-onset-diabetes-mellitus-during-5-year-follow-up-in-non-diabetic-patients-with-cardiovascular-risks
#7
Byoung Geol Choi, Seung Woon Rha, Suhng Wook Kim, Jun Hyuk Kang, Ji Young Park, Yung Kyun Noh
PURPOSE: Many studies have proposed predictive models for type 2 diabetes mellitus (T2DM). However, these predictive models have several limitations, such as user convenience and reproducibility. The purpose of this study was to develop a T2DM predictive model using electronic medical records (EMRs) and machine learning and to compare the performance of this model with traditional statistical methods. MATERIALS AND METHODS: In this study, a total of available 8454 patients who had no history of diabetes and were treated at the cardiovascular center of Korea University Guro Hospital were enrolled...
February 2019: Yonsei Medical Journal
https://read.qxmd.com/read/30666840/silencing-the-pik3ca-gene-enhances-the-sensitivity-of-childhood-leukemia-cells-to-chemotherapy-drugs-by-suppressing-the-phosphorylation-of-akt
#8
Xiuling Liang, Xianfang Xin, Dongmei Qi, Chengyan Fu, Mingde Ding
PURPOSE: This study aimed to investigate the effects of PIK3CA on the sensitivity of acute B lymphocytic leukemia cells (Nalm-6 cells) to chemotherapy drugs. MATERIALS AND METHODS: Children's normal B lymphocytes and Nalm-6 cells were cultured. Nalm-6 cells were transfected with PIK3CA siRNA (siPIK3CA group) or its negative control (PIK3CA-Control group). Normal Nalm-6 cells were named Mock group. Nalm-6 cells transfected by PIK3CA siRNA were treated with Akt inhibitor (siPIK3CA+Akti-1/2 group)...
February 2019: Yonsei Medical Journal
https://read.qxmd.com/read/30666839/prognostic-value-of-lymphovascular-invasion-in-node-negative-upper-urinary-tract-urothelial-carcinoma-patients-undergoing-radical-nephroureterectomy
#9
Wen Liu, Zhonghan Zhou, Dahai Dong, Lijiang Sun, Guiming Zhang
PURPOSE: This study aimed to evaluate the prognostic impact of lymphovascular invasion (LVI) in patients treated with radical nephroureterectomy (RNU) for upper urinary tract urothelial carcinoma (UTUC). MATERIALS AND METHODS: We collected data from 180 patients who were treated with RNU from 2005 to 2013 at our institution. The Kaplan-Meier method with log-rank test and Cox proportional hazards regression models were used for univariate and multivariate analyses...
February 2019: Yonsei Medical Journal
https://read.qxmd.com/read/30666838/microrna-206-reduces-osteosarcoma-cell-malignancy-in-vitro-by-targeting-the-pax3-met-axis
#10
Fang Biao Zhan, Xian Wei Zhang, Shi Long Feng, Jun Cheng, You Zhang, Bo Li, Li Zhong Xie, Qian Rong Deng
PURPOSE: This study was undertaken to explore how miR-206 represses osteosarcoma (OS) development. MATERIALS AND METHODS: Expression levels of miR-206, PAX3, and MET mRNA were explored in paired OS and adjacent tissue specimens. A patient-derived OS cell line was established. miR-206 overexpression and knockdown were achieved by lentiviral transduction. PAX3 and MET overexpression were achieved by plasmid transfection. Treatment with hepatocyte growth factor (HGF) was utilized to activate c-Met receptor...
February 2019: Yonsei Medical Journal
https://read.qxmd.com/read/30666837/image-analysis-of-her2-immunohistochemical-staining-of-surgical-breast-cancer-specimens
#11
Kwangil Yim, Hong Sik Park, Dong Min Kim, Youn Soo Lee, Ahwon Lee
PURPOSE: Trastuzumab is an effective treatment for human epidermal growth factor receptor 2 (HER2)-amplified breast cancers. We sought to develop a simple protocol for HER2 image analysis of breast cancer specimens. MATERIALS AND METHODS: In a preliminary test, we found that at least 1000 tumor cells need to be examined in the most strongly stained areas. Next, we evaluated the clinical usefulness of this established protocol of image analysis in 555 breast cancer patients...
February 2019: Yonsei Medical Journal
https://read.qxmd.com/read/30666836/mir-182-5p-knockdown-targeting-pten-inhibits-cell-proliferation-and-invasion-of-breast-cancer-cells
#12
Yue Sheng Zhao, Wei Chao Yang, Hong Wei Xin, Ji Xia Han, Su Gang Ma
PURPOSE: Breast cancer (BC) is one of the most common malignant tumors, affecting a significant number of women worldwide. MicroRNAs (miRNAs) have been reported to play important roles in tumorigenesis. The aim of this study was to determine the roles of miR-182-5p in BC progression. MATERIALS AND METHODS: The expressions of miR-182-5p and phosphatase and tensin homolog deleted on chromosome 10 (PTEN) were measured in BC tissues and cells by quantitative real-time polymerase chain reaction or Western blot...
February 2019: Yonsei Medical Journal
https://read.qxmd.com/read/30666835/the-7th-8th-american-joint-committee-on-cancer-and-the-modified-union-for-international-cancer-control-staging-system-for-hepatocellular-carcinoma
#13
In Gyu Kim, Xu Guang Hu, Hee Jung Wang, Bong Wan Kim, Sung Yeon Hong, Xue Yin Shen
PURPOSE: Although many staging systems have been proposed for hepatocellular carcinoma (HCC), there is no globally accepted system due to the extreme heterogeneity of the disease. We aimed to compare the results of the 7th/8th American Joint Committee on Cancer (AJCC) and the modified Union for International Cancer Control (mUICC) staging systems in patients with HCC. MATERIALS AND METHODS: We collected data from 792 patients who underwent hepatic resection at our center...
February 2019: Yonsei Medical Journal
https://read.qxmd.com/read/30666834/single-patient-classifier-assay-microsatellite-instability-and-epstein-barr-virus-status-predict-clinical-outcomes-in-stage-ii-iii-gastric-cancer-results-from-classic-trial
#14
Chul Kyu Roh, Yoon Young Choi, Seohee Choi, Won Jun Seo, Minah Cho, Eunji Jang, Taeil Son, Hyoung Il Kim, Hyeseon Kim, Woo Jin Hyung, Yong Min Huh, Sung Hoon Noh, Jae Ho Cheong
PURPOSE: Clinical implications of single patient classifier (SPC) and microsatellite instability (MSI) in stage II/III gastric cancer have been reported. We investigated SPC and the status of MSI and Epstein-Barr virus (EBV) as combinatory biomarkers to predict the prognosis and responsiveness of adjuvant chemotherapy for stage II/III gastric cancer. MATERIALS AND METHODS: Tumor specimens and clinical information were collected from patients enrolled in CLASSIC trial, a randomized controlled study of capecitabine plus oxaliplatin-based adjuvant chemotherapy...
February 2019: Yonsei Medical Journal
https://read.qxmd.com/read/30666833/tumor-necrosis-factor-and-regulatory-t-cells
#15
REVIEW
Min Kyung Jung, Jeong Seok Lee, Jeong Eun Kwak, Eui Cheol Shin
CD4⁺CD25⁺FoxP3⁺ regulatory T (Treg) cells play major roles in the maintenance of immune homeostasis. In this review, we comprehensively describe the relationship between tumor necrosis factor (TNF) and Treg cells, focusing on the effects of TNF on Treg cells and on TNF-producing Treg cells. Contradictory results have been reported for the effect of TNF on the suppressive activity of Treg cells. In patients with rheumatoid arthritis, TNF has been shown to reduce the suppressive activity of Treg cells. Meanwhile, however, TNF has also been reported to maintain the suppressive activity of Treg cells via a TNFR2-mediated mechanism...
February 2019: Yonsei Medical Journal
https://read.qxmd.com/read/30666832/desensitization-for-allergic-reactions-to-chemotherapy
#16
REVIEW
David In Chull Hong
Drug desensitization is procedure by which patients can be tolerized to medications that have previously induced hypersensitivity reactions. Initially used in treating hypersensitivity reactions to antibiotics, desensitization is now frequently used in the setting of allergy to chemotherapy drugs and biologics, thus widening the clinical applicability of this procedure which has been proven to be quite safe and effective in improving clinical outcomes, mainly by allowing patients to remain on preferred first-line therapy...
February 2019: Yonsei Medical Journal
https://read.qxmd.com/read/30554500/retraction-paper-comparison-of-effect-of-treatment-with-etidronate-and-alendronate-on-lumbar-bone-mineral-density-in-elderly-women-with-osteoporosis-by-iwamoto-j-et-al-yonsei-med-j-2005-46-6-750-758
#17
https://read.qxmd.com/read/30554499/retraction-paper-differential-effect-of-vitamin-k-and-vitamin-d-supplementation-on-bone-mass-in-young-rats-fed-normal-or-low-calcium-diet-by-iwamoto-j-et-al-yonsei-med-j-2004-45-2-314-324
#18
(no author information available yet)
This corrects the article on p. 314 in vol. 45, PMID: 15119005.
January 2019: Yonsei Medical Journal
https://read.qxmd.com/read/30554498/retraction-paper-combined-treatment-with-vitamin-k%C3%A2-and-bisphosphonate-in-postmenopausal-women-with-osteoporosis-by-iwamoto-j-et-al-yonsei-med-j-2003-44-5-751-756
#19
(no author information available yet)
This corrects the article on p. 751 in vol. 44, PMID: 14584089.
January 2019: Yonsei Medical Journal
https://read.qxmd.com/read/30554497/lennox-gastaut-syndrome-in-mitochondrial-disease
#20
Soonie Lee, Min Seong Baek, Young Mock Lee
PURPOSE: Previous studies have shown that neurologic symptoms are dominant in patients with mitochondrial diseases, and most of these patients have seizure-related disorders. The epileptic classification of these patients as Lennox-Gastaut syndrome (LGS) is as high as 25%. This study aimed to investigate the clinical manifestations, diagnoses, treatments, and epilepsy in LGS, which is associated with mitochondrial disease. MATERIALS AND METHODS: A retrospective study was conducted on 372 patients who were diagnosed with mitochondrial disease between 2006 and 2016...
January 2019: Yonsei Medical Journal
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