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Vox Sanguinis

Maud van Zanten, W Martin Smid, Peter van den Burg
No abstract text is available yet for this article.
February 7, 2019: Vox Sanguinis
Ai Leen Ang, Wan Hui Wong, Jeslyn Tan, Heng Joo Ng, Chuen Wen Tan, Ponnudurai Kuperan, Sally Lam, Hwee Huang Tan, Sze Sze Chua
BACKGROUND/OBJECTIVES: We compared the ex vivo haemostatic capacity of RTFP24 with FFP upon thawing and >24 h post-thaw. We included thrombin generation (TG) as few studies had compared global haemostatic function, and most did not directly compare RTFP24 with FFP >24 h post-thaw. MATERIALS/METHODS: Twenty units each of RTFP24 and FFP were measured for coagulation factors and thrombin generation upon thawing (D0) and 4 days post-thaw (D4). Labile factors were also measured from D1 to D3...
February 7, 2019: Vox Sanguinis
Sarah Vossoughi, Sylvia Parker-Jones, Joseph Schwartz, Brie Stotler
BACKGROUND AND OBJECTIVES: Passive transfusion reaction reporting systems fail to capture a significant number of reactions, and no data exist on provider reporting trends. The aim of this study was to describe transfusion reaction reporting patterns by adult and paediatric providers. MATERIALS AND METHODS: This is a multihospital study on transfusion reaction reporting over a 7-year period. Reports were categorized according to transfusion location and assigned to either a transfusion reaction or nonreaction group according to Centers for Disease Control imputability guidelines...
February 7, 2019: Vox Sanguinis
Jock D Simpson, Adam Hopkins, Adilah Amil, Bryony Ross, Anoop K Enjeti
BACKGROUND AND OBJECTIVES: Transfusion-associated circulatory overload is a leading cause of transfusion-related adverse events. The frequency and risks for transfusion-associated circulatory overload in ambulatory haematology patients are not known. MATERIALS AND METHODS: A retrospective cohort analysis of ambulatory patients transfused in a tertiary haematology centre, using medical records and an electronic transfusion database, was undertaken between January and December 2014...
February 7, 2019: Vox Sanguinis
Johnson Q Tran, Marcus O Muench, John W Heitman, Rachael P Jackman
BACKGROUND AND OBJECTIVES: Alloimmunization is common following transfusion with platelet-rich plasma (PRP) and can cause complications such as platelet refractoriness or transplant rejection. It has previously been shown that pathogen reduction of PRP with riboflavin and UV light (UV+R) can protect against alloimmunization in mice and induce partial tolerance to subsequent transfusions. MATERIALS AND METHODS: Using B6 H2d congenic mice, this study evaluated the relative contributions of major histocompatibility complex (MHC) antigens and minor antigens to both the alloresponse to PRP transfusion and the partial tolerance induced by UV+R treatment...
February 7, 2019: Vox Sanguinis
Diego Raffo, Leticia Perez Tito, María Elisa Pes, Diego Fernandez Sasso
BACKGROUND AND OBJECTIVES: Umbilical cord blood is considered an alternative source of hematopoietic stem cells. Standard banking procedures use 50/55% DMSO in dextran 40 for cryopreservation and dextran-based solutions for thawing, however, due to the potential risk of crystallization of dextran, dextran 40 approved for clinical use has become limited or unavailable. This affects cryopreservation and thawing procedures. Carbohydrates, in particular sucrose, trehalose and glucose, have been shown to be effective in reducing cell damage during dehydration and have cryoprotective potential...
February 7, 2019: Vox Sanguinis
Peer Jansen, Ariane Sümnig, Max Esefeld, Klara Greffin, Lars Kaderali, Andreas Greinacher
BACKGROUND AND OBJECTIVES: Previous studies observed a transient increase in well-being in about one-third of regular donors after blood donation. In addition, personal contact with donors after donation seems to increase return rates. We were interested whether changes in well-being and/or personal contact after the first donation impact return rates of first-time donors (FTDs). MATERIALS AND METHODS: First-time donors were randomized to a questionnaire group (QG), in which questionnaires assessing the well-being had to be filled in, or a control group (CG), which was not contacted with a questionnaire...
January 29, 2019: Vox Sanguinis
Francisco A Ferreira, Bruno D Benites, Fernando F Costa, Simone Gilli, Sara T Olalla-Saad
Disturbances in the physiological regulation of erythropoietin (EPO) in patients with sickle cell disease (SCD) may contribute to worsening anaemia and increased transfusion requirements, but the use of recombinant EPO in this group of patients is controversial. The objective of this study was to evaluate the use of this drug in adult patients with SCD and its effects on haemoglobin levels and transfusion requirements. We conducted a retrospective analysis at the University of Campinas, with nineteen adults with a diagnosis of SCD (HbSS and HbS/β+ thalassaemia), who had received at least 1 year of EPO therapy between 2007 and 2014...
January 29, 2019: Vox Sanguinis
Elisabeth F Klinkenberg, Praiseldy K B Langi Sasongko, Wim L A M de Kort, Julia C M van Weert, Mirjam P Fransen, Elisabeth M J Huis In 't Veld
BACKGROUND AND OBJECTIVES: Migrant blood donors are underrepresented worldwide resulting in shortages of compatible blood products. Prior studies focused on individual barriers and motivators of potential blood donors, but no studies addressed organisational factors of the blood supply chain. This study explored the perceptions and experiences in recruitment and retention of migrant - and potentially rare-blood donors among staff members within the blood supply chain and identified obstacles and solutions in this chain...
January 9, 2019: Vox Sanguinis
Kathy Leung, Cheuk-Kwong Lee, Eric H Y Lau, Ching-Wa Lau, Joseph T Wu
BACKGROUND: Maintaining a stable, safe and sufficient blood supply is crucial to the healthcare system. Every year, seasonal influenza epidemics lead to substantial hospitalizations and pose intense pressure on blood transfusion service worldwide, especially in an ageing population of Hong Kong which often see bi-annual influenza outbreaks. However, limited quantitative studies have been performed to assess the impacts of influenza and other respiratory infections on blood supply. METHODS: We estimated the impacts of respiratory infections on donor attendance and blood inventory, considering the confounding effects of weather conditions...
January 9, 2019: Vox Sanguinis
Tiffany C Timmer, Rosa de Groot, Karin Habets, Eva-Maria Merz, Femmeke J Prinsze, Femke Atsma, Wim L A M de Kort, Katja van den Hurk
BACKGROUND AND OBJECTIVES: More insight into donor health and behaviour may contribute to more efficient and focused strategies regarding donor care and management. Donor InSight (DIS) is a Dutch cohort study of blood and plasma donors. We aimed to outline the objectives and methods of DIS, describe the cohort, and compare it to the active Dutch donor population. MATERIALS AND METHODS: In 2007-2009 (DIS-I, n = 31 338) and 2012-2013 (DIS-II, 34 826, of whom 22 132 also participated in DIS-I) questionnaire data on demographics, donation, lifestyle, family composition, health and disease were collected...
December 27, 2018: Vox Sanguinis
Thisuri Jayawardena, Veronica Hoad, Claire Styles, Clive Seed, Peter Bentley, Vanessa Clifford, Sarina Lacey, Tessa Gastrell
BACKGROUND AND OBJECTIVES: Donor syphilis testing began in the 1940s amidst widespread transfusion-transmitted syphilis (TTS). Since then, the introduction of penicillin, pre-donation screening questionnaires and improved storage conditions have contributed to reducing transmission risk. Consequently, universal testing may no longer be cost-effective. This study analysed alternative options for donor syphilis testing to determine the optimal strategy. MATERIALS AND METHODS: A model was developed using conservative parameter estimates for factors affecting TTS and 2009-2015 Australian donations to calculate risk outcomes (TTS infections, tertiary syphilis in recipients and transfusion-associated congenital syphilis) and cost-effectiveness of alternative testing strategies...
December 18, 2018: Vox Sanguinis
Junko Ichikawa, Ichiro Koshino, Makiko Komori
We prospectively studied the dose-dependent effect of transfused stored red blood cells (RBCs) on recipient RBC indices, deformability and cell density in 10 patients administered stored RBCs for blood transfusion during general surgery. There were dose-dependent decreases in mean corpuscular volume and increases in mean corpuscular haemoglobin concentration after completion of 4- and 6-unit stored RBC transfusions. The amount of dense populations increased proportionately with the amount of stored RBCs transfused...
December 18, 2018: Vox Sanguinis
Shuichi Nakamura, Kenji Nakai, Momoko Sakata, Yoshio Nagaoka, Kozue Yoshida, Uichiro Katsumata, Toshimi Chiba, Keiji Matsubayashi
Lactococcus garvieae is a well-known fish pathogen that has low virulence in humans and is rarely isolated from the blood cultures of endocarditis patients. We describe herein the first reported case of transfusion-transmitted L. garvieae sepsis caused by a contaminated platelet concentrate from a donor who consumed raw octopus before blood donation. Retrospective examination of the laboratory results of the index donor revealed that his haemoglobin levels had been steadily decreasing, which led to the detection of a latent colon cancer...
December 12, 2018: Vox Sanguinis
Yoshihiko Kominato, Kenichi Ogasawara
No abstract text is available yet for this article.
December 10, 2018: Vox Sanguinis
Ido J Bontekoe, Pieter F van der Meer, Arthur J Verhoeven, Dirk de Korte
BACKGROUND AND OBJECTIVES: Previously it has been shown that platelet (PLT) storage performance is consistent by donor. Differences involved metabolic activity, which might be caused by mitochondrial (dys)function, associated with age and age-related diseases like Type 2 diabetes (T2D). We aimed to test PLTs from young donors in comparison with PLTs from older donors with or without diagnosis for T2D. MATERIALS AND METHODS: Fifteen whole blood donors <30 year were selected, and single-donor platelet concentrates (sPC) were prepared from buffy coats (BC) and plasma...
December 10, 2018: Vox Sanguinis
Yumi Suzuki, Kazumi Isa, Kenichi Ogasawara, Yuika Kikuchi, Ryuichi Yabe, Nelson-Hirokazu Tsuno, Makoto Uchikawa, Masahiro Satake
We found an individual with weakened S antigen expression on red blood cells (RBCs) during routine blood grouping. The proband was typed S+s+ by polyclonal antibodies, but the RBCs demonstrated different reactivity with three monoclonal anti-S. The proband did not have alloanti-S. Cloning and Sanger sequencing revealed that the proband had a c.166A>T (p.Thr56Ser) mutation in exon 4 of GYPB*S. When antibody screening of 60 455 blood donors was performed using the proband RBCs, no antibodies were detected...
December 6, 2018: Vox Sanguinis
David A Leiby, Sheila F O'Brien, Silvano Wendel, Megan L Nguyen, Gilles Delage, Sushil G Devare, Anthony Hardiman, Hira L Nakhasi, Silvia Sauleda, Evan M Bloch
BACKGROUND AND OBJECTIVES: Globally, blood safety interventions have been successful in mitigating risk of the major transfusion-transmitted (TT) viruses. However, strategies that address risk from parasites are comparatively limited. TT parasites are often regional in nature, posing unique challenges; we sought to understand their impact on blood safety. MATERIALS AND METHODS: An electronic questionnaire was distributed to transfusion medicine leaders in 100 countries...
December 6, 2018: Vox Sanguinis
Nicoletta Revelli, Maria Antonietta Villa, Barbara Olivero, Susanna Bresciani, Marco Flores, Mirella Marini, Mara Nicoletta Pizzi, Daniele Prati, Paolo Rebulla
BACKGROUND AND OBJECTIVES: Strategies for overcoming alloimmune refractoriness to random donor platelets are based on the use of compatible platelets selected from large panels of HLA-typed donors or cross-matching (XM). The aim of this study was to review the effectiveness of a platelet XM programme for treating refractory haematological patients at Milan's Policlinico Hospital (PHM) 2002-2014 and Spedali Civili in Brescia (SCB) 2013-2016. MATERIALS AND METHODS: A commercially available solid-phase antibody detection system was used for platelet antibody detection and XM...
December 6, 2018: Vox Sanguinis
Sonny Michael Assennato, Shirley Owusu-Ofori, Alex Osei-Akoto, Nathalie C Lambert, Jean-Pierre Allain
BACKGROUND AND OBJECTIVES: Transfusion-acquired microchimerism (TA-Mc) has been reported in major trauma but not in young children despite relative immunodeficiency who, in sub-Saharan Africa, often suffer severe anaemia related to haemoglobinopathies or primary malaria infections. We examined the hypothesis that such massive red cell destructions might provide conditions favourable to TA-Mc, particularly when exposed to massive amounts of parasite antigens. MATERIALS AND METHODS: Twenty-seven female children <5 years transfused with male whole blood for severe anaemia (13 with acute malaria and 14 with other causes) were retrospectively identified, and a blood sample was collected >6 months post-transfusion...
December 6, 2018: Vox Sanguinis
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