Kelly M Winter, Rachel G Webb, Eugenia Mazur, Sue Ismay, Dimitra Marinakis, Denese C Marks
BACKGROUND AND OBJECTIVES: In Australia, the vast distances between blood collection centres and processing facilities make it challenging to align supply with demand. Increasing the time to freezing for clinical plasma beyond 6 h would alleviate supply issues. This study aimed to determine the quality of clinical apheresis plasma frozen within 12 h of collection. MATERIALS AND METHODS: Apheresis plasma (n = 20) collected at donor centres was immediately transported to a blood processing facility, stored at 26°C and sampled aseptically at 6, 8 and 12 h post collection...
September 18, 2023: Vox Sanguinis
Shuhong Xie, Yan Cao, Xixi Shen, Chuan Tian, Mingyuan Wang
BACKGROUND AND OBJECTIVES: Currently, blood allocation is solely done by scanning barcode labels for each bag of blood, with low efficiency. However, the rapid allocation of emergency blood is required owing to the rapid increase in blood consumption during unconventional emergencies. This study aimed to design and apply radiofrequency identification (RFID) technology for the rapid allocation of blood in batches with advantages in time, efficiency and accuracy. MATERIALS AND METHODS: A blood emergency allocation system based on RFID technology was designed using a multi-label anti-collision algorithm and tested with automatic information check, a comparative study of scanning speed and accuracy, data analysis and other methods...
September 18, 2023: Vox Sanguinis
Syria Laperche, Claire Sauvage, Pierre Gallian, Saadia Jbilou, Elodie Pouchol, Jean Yves Py, Lila Chabli, Pascale Richard, Pascal Morel, Florence Lot, Pierre Tiberghien
BACKGROUND AND OBJECTIVES: Data from 21 years (2000-2020) of haemovigilance were used to assess human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV) incidence rates in repeat blood donors and the occurrence of transfusion-transmitted (TT) viral infections. MATERIALS AND METHODS: Blood donors who converted for HIV, HCV or HBV markers within serial three-year analysis periods were included. Epidemiological and virological data were retrieved from the national epidemiological donor database and were supplemented with information on blood components and the infection status of recipients of the previous negative donation (D...
September 11, 2023: Vox Sanguinis
Dilaram Acharya, Amaury Gaussen, Thomas G Poder, Gilles Lambert, Christian Renaud, Karlitaj Nawej, Antoine Lewin
BACKGROUND AND OBJECTIVES: Septic transfusion reactions (STRs) occur as a result of bacterial contamination of blood or blood products, resulting in sepsis. This scoping review aimed to identify, explore and map the available literature on the STR criteria triggering the investigation of STR. MATERIALS AND METHODS: Four electronic databases (MEDLINE, Web of Science, Science Direct, Embase) were searched to retrieve scientific literature reporting such criteria, published from 1 January 2000 to 5 May 2022...
September 11, 2023: Vox Sanguinis
Shaoheng Chen, Yan Zang, Lili Wang, Jun Zheng, Huimin Deng, Meiting Li, Yaohua Li, Baohua Qian, Yuanshan Lu
BACKGROUND AND OBJECTIVES: Rail logistics transmission systems (RLTSs) are commonly used for the transportation of blood samples, pathological specimens and other medical materials in many hospitals, as they are rapid, secure, cost-effective and intelligent. However, few studies have evaluated blood component transportation from blood banks to the patient care areas of hospitals using RLTS. In this study, we evaluate the RLTS used for the transportation of blood components within a medical centre...
September 6, 2023: Vox Sanguinis
Antoine Lewin, Marc Germain, Christian Renaud, Nancy Robitaille, Catherine Latour
BACKGROUND AND OBJECTIVES: Systematically measuring pre-donation haemoglobin (Hb) levels might be overly cautious for apheresis plasma donation, since plasmapheresis entails a small loss of red blood cells. We explored the association between the frequency of apheresis plasma donation and capillary blood Hb levels. MATERIALS AND METHODS: This retrospective cohort study included donors who gave apheresis plasma at least twice between 24 October 2020 and 23 October 2022 in Québec, Canada...
September 6, 2023: Vox Sanguinis
Shuoyan Ning, Akash Gupta, Khalid Batarfi, Yang Liu, Kayla J Lucier, Rebecca Barty, Nancy M Heddle
BACKGROUND AND OBJECTIVES: Debate exists surrounding the optimal duration of red blood cell (RBC) storage. A hypothesis emerging from previous research suggests that exposure to fresh blood may be harmful to patients undergoing cardiac surgery. This study uses a large transfusion medicine database to explore the association between in-hospital mortality and red cell storage duration. MATERIALS AND METHODS: This is an exploratory retrospective cohort study of all adult patients at Hamilton, Canada, over a 14-year period that received at least one allogeneic red cell transfusion during their hospitalization for cardiac surgery requiring bypass...
September 6, 2023: Vox Sanguinis
Klaus Rieneck, Grethe Risum Krog, Frederik Banch Clausen, Christoffer Egeberg Hother, Morten Hanefeld Dziegiel
BACKGROUND AND OBJECTIVES: For 5 years, routine genotyping has been performed for selected blood groups of blood donors in the Copenhagen Capital Region, Denmark. The result is summarized in the following. MATERIALS AND METHODS: Genotyping was carried out by an external service provider using the competitive allele specific PCR (KASP) technology. The genotypes were returned to the blood bank and translated into phenotypes by a proprietary IT application. RESULTS: In total, 65 alleles from 16 blood group systems (ABO, MNS, Rh, Lutheran, Kell, Duffy, Kidd, Diego, Yt, Dombrock, Colton, Landsteiner-Wiener, Cromer, Knops, Vel, secretor status) and the HPA1, HPA5 and HPA15 antigens were interrogated...
September 6, 2023: Vox Sanguinis
Asashi Tanaka, Hiroshi Fujita, Kota Ohashi, Akihito Tsujikawa, Kanami Uchiyama, Tatsuya Ito, Koichiro Kawashima, Reiko Kodama, Takashi Mine, Makoto Okuda, Teruo Endoh, Youko Fukuyoshi, Junichi Kitazawa, Eisaburo Sueoka, Kazuhiro Nagai, Akaru Ishida, Koji Matsuzaki, Yoko Kato, Kazuo Takanashi, Koki Takahashi
BACKGROUND AND OBJECTIVES: Japan's ageing society has increased the need for home healthcare, including home transfusions. We hence aimed to elucidate the purpose and utilization of home transfusions in Japan, which has not been clarified to date. MATERIALS AND METHODS: Clinics throughout Japan that provide home care and have experience in performing blood transfusions were surveyed. The study period was February to December 2019, and information of patients receiving home red blood cell transfusions, including patient background, pre-transfusion laboratory data and the purpose of the transfusions, was collected...
September 6, 2023: Vox Sanguinis
Marieke Vinkenoog, Jarkko Toivonen, Matthijs van Leeuwen, Mart P Janssen, Mikko Arvas
BACKGROUND AND OBJECTIVES: On-site haemoglobin deferral for blood donors is sometimes necessary for donor health but demotivating for donors and inefficient for the blood bank. Deferral rates could be reduced by accurately predicting donors' haemoglobin status before they visit the blood bank. Although such predictive models have been published, there is ample room for improvement in predictive performance. We aim to assess the added value of ferritin levels or genetic markers as predictor variables in haemoglobin deferral prediction models...
August 30, 2023: Vox Sanguinis
Veronica C Hoad, Johanna Castrén, Rut Norda, Joanne Pink
Many blood establishments are expanding plasmapheresis collection capacity to achieve increasing plasma for fractionation volume targets, driven by immunoglobulin product demand. Some adverse events occur in both apheresis and whole blood collection, such as venepuncture-related trauma and vasovagal reactions. Others are specifically related to the apheresis procedure, such as citrate reactions, haemolysis, infiltration and air embolism. Whilst plasmapheresis procedures are generally well tolerated, theoretical longer term donor health considerations, such as the effects on donor plasma protein levels, bone mineral density, iron deficiency and malignancy also require consideration...
August 29, 2023: Vox Sanguinis
Esa Turkulainen, Jarkko Ihalainen, Mikko Arvas
BACKGROUND AND OBJECTIVES: Ferritin is commonly measured to evaluate iron stores in the body. Some countries have added or considered adding ferritin lower bounds to donor eligibility criteria. Ferritin is also elevated by inflammation. The main goal of this study is to estimate how different ferritin cut-offs would affect the proportion of donors with a C-reactive protein (CRP) level over 3 mg/L, which is the decision limit of the highest chronic cardiovascular risk. MATERIALS AND METHODS: To simulate recruitment of new blood donors, we selected participants from two Finnish general population cohorts, namely FINRISK 1997 (n = 5369) and Health 2000 (n = 3278), that would likely fulfil the selection criteria of blood donation...
August 25, 2023: Vox Sanguinis
Behnaz Bayat, Jonas Lowack, Marie Audrain, Laure Croisille, Brian Curtis, Rebecca Dangerfield, Behnaz Esmaeili, Claudia Grabowski, Margaret Keller, Hyungsuk Kim, Hartmut Kroll, Marjeta Macek Kvanka, Janette Kwok, Elyse Moritz, Oytip Nathalang, Derrick Nelson, Kaspar René Nielsen, Gail Pahn, Anthony Poles, Leendert Porcelijn, Ulrich J Sachs, Marlies Schönbacher, Günther F Körmöczi, Pawinee Kupatawintu, Daisuke Takahashi, Malgorzata Uhrynowska, Brigitte Flesch, Yoke-Lin Fung
BACKGROUND AND OBJECTIVES: Human neutrophil antigens (HNAs) are categorized into five systems: HNA-1 to HNA-5. Given the importance of neutrophils in immunity, we sought to create awareness of the role of HNA diagnostic services in managing immune neutropenia and transfusion-related acute lung injury. To provide health communities all around the world with access to these services, we conducted a survey to create a directory of these HNA diagnostic services. MATERIALS AND METHODS: An Excel table-based survey was created to capture information on the laboratory's location and was emailed to 55 individuals with known or possible HNA investigation activity...
August 22, 2023: Vox Sanguinis
Khalid Batarfi, Yang Liu, Joanne Nixon, Kathryn E Webert, Melanie St John, Meera Karunakaran, Nour Alhomsi, Jane J Park, Nancy M Heddle
BACKGROUND AND OBJECTIVES: Haemolysis can occur following intravenous immunoglobulin (IVIG) infusion. Haemovigilance data were analysed using a novel approach for including two control groups with no haemolysis to IVIG. Objectives included a summary of all reactions to IVIG, rate estimates and analysis of haemolytic reactions including risk factors. MATERIALS AND METHODS: Canadian haemovigilance data from Ontario (2013-2021), IVIG distribution and transfusion data from the blood supplier, and data from a large local transfusion registry were used...
August 17, 2023: Vox Sanguinis
Catherine Latour, Amaury Gaussen, Julie Beaudoin, Gabriel André Leiva-Torres, Samuel Rochette, Nancy Robitaille
BACKGROUND AND OBJECTIVES: ABO antigens are among the most immunogenic, but the haemolytic risks of ABO incompatibilities involving a donor with a weak ABO phenotype are little documented. MATERIALS AND METHODS: This retrospective case series assessed the incidence of acute haemolytic transfusion reaction (AHTR) among ABO-incompatible recipients of A3 blood in Québec (Canada). Transfusion safety officers reported laboratory AHTR indicators measured ≤24 h pre- and post-transfusion...
August 17, 2023: Vox Sanguinis
Hang Lei, Hui Zhang, Liujun Guo, Dong Xiang, Xuefeng Wang, Xi Liu, Xiaohong Cai
BACKGROUND AND OBJECTIVES: ABO antigens are produced from H antigen by the activity of glycosyltransferase enzyme encoded by the ABO gene. Variants in the ABO gene can produce a weak ABO phenotype. In this study, we identify a novel ABO*BW allele and investigate the underlying mechanism leading to the Bweak phenotype. MATERIALS AND METHODS: The ABO phenotype and genotype of the sample were determined using serological and direct DNA sequencing methods. We assessed the impact of the novel variant by three-dimensional modelling to predict protein stability changes (ΔΔG), and carried out an in vitro expression assay...
August 11, 2023: Vox Sanguinis
Veronica C Hoad, Clive R Seed, Philip Kiely, Claire E Styles, Hamish McManus, Matthew Law, John Kaldor, Iain B Gosbell
BACKGROUND AND OBJECTIVES: Until 25 July 2022, people who spent more than 6 months in the United Kingdom during the variant Creutzfeldt-Jakob disease (vCJD) risk period 1980-1996 (UK donors) were deferred from blood donation in Australia. Regulatory approval to remove the deferral was underpinned by published mathematical modelling predicting negligible vCJD transmission risk increase with a gain of 58,000 donations. MATERIALS AND METHODS: The donor questionnaire retained the UK deferral screening question until a version update effective 12 February 2023, which enabled identification of the newly eligible cohort of UK donors...
August 11, 2023: Vox Sanguinis
Jessica E Schucht, Brian G Harbrecht, Logan M Bond, William B Risinger, Paul J Matheson, Jason W Smith
BACKGROUND AND OBJECTIVES: Intestinal ischaemia-reperfusion injury following resuscitated haemorrhagic shock (HS) leads to endothelial and microcirculatory dysfunction and intestinal barrier breakdown. Although vascular smooth muscle machinery remains intact, microvascular vasoconstriction occurs secondary to endothelial cell dysfunction, resulting in further ischaemia and organ injury. Resuscitation with fresh frozen plasma (FFP) improves blood flow, stabilizes the endothelial glycocalyx and alleviates organ injury...
August 10, 2023: Vox Sanguinis
Rocio Trueba-Gómez, Fany Rosenfeld-Mann, Hector A Baptista-González, María L Domínguez-López, Higinio Estrada-Juárez
BACKGROUND AND OBJECTIVES: Computational biology analyses the theoretical tertiary structure of proteins and identifies the 'topological' differences between RhD and RhCE. Our aim was to identify the theoretical structural differences between the four isoforms of RhCE and RhD using computational biological tools. MATERIALS AND METHODS: Physicochemical profile was determined by hydrophobicity and electrostatic potential analysis. Secondary and tertiary structures were generated using computational biology tools...
August 9, 2023: Vox Sanguinis
Carine Prisco Arnoni, Nayara Morais Silva, Flavia Sant'Anna Silva, Rafael Martins Parreira, Tatiane Vendrame, Marcos Paulo Miola, Janaína Muniz, Afonso Cortez, Marilia Valvasori, Evanilde Pereira de Araujo, Leandro Dalmazzo, Alyne Freitas, Flavia Latini, Lilian Castilho
BACKGROUND AND OBJECTIVES: Gerbich (GE) blood group system carries high-frequency antigens and the absence of them leads to rare phenotypes: GE:-2,3,4, GE:-2,-3,4 and GE:-2,-3,-4. Their serological differentiation is limited and misclassification of Gerbich phenotypes may occur, but this can be avoided by molecular characterization. This study aimed to characterize the molecular background responsible for rare Gerbich phenotypes in Brazilian population. MATERIALS AND METHODS: We selected eight samples from patients with anti-Ge, six from their relatives and nine samples with normal expression of Gerbich antigens...
August 8, 2023: Vox Sanguinis
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