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Kobe Journal of Medical Sciences

Sachiyo Fukushima, Kazumichi Fujioka, Mariko Ashina, Shohei Ohyama, Toshihiko Ikuta, Kosuke Nishida, Harunori Miyauchi, Yuichi Okata, Yuko Bitoh, Kenji Tanimura, Masashi Deguchi, Hideto Yamada, Kazumoto Iijima
Fetal intestinal volvulus is a rare condition, and fetal diagnosis of this disease is still challenging, especially in primary cases not accompanied by other comorbidities, such as intestinal malformations. Herein, we report a case of fetal primary small bowel volvulus associated with acute gastric dilatation detected by ultrasonography. We speculate that the mechanism of acute gastric dilatation in our case was peristatic malfunction of the whole intestine caused by a strangulated ileus resulting from fetal intestinal volvulus...
January 11, 2019: Kobe Journal of Medical Sciences
Mehmet Demir, Emre Atay, Bülent Güneri, Halil Yilmaz, Muhammed Furkan Arpaci, Hatice Susar Güler, Özge Al, Tolga Ertekin, Mehtap Nisari, Erdoğan Unur
OBJECTIVES: Coxal bone paticipates in the formation of the pelvic skeleton. Anatomy knowledge on coxafemoral joint as well as careful history taking and physical examination are crucial in evaluation and management of disorders involving hip joint. The aims of the present study were to perform morphometric measurements of the human coxal bones, calculation of their articular surface areas and report the range of these parameters regarding Turkish adult population. METHODS: Seventy-two dry human adult coxal bones (39 left and 33 right) from the Anatomy Departments of Erciyes University, Inonu University and Kahramanmaras Sutcu Imam University were measured using a caliper sensitive to 0...
December 10, 2018: Kobe Journal of Medical Sciences
Takafumi Otsuka, Makoto Ooi, Kazutoshi Tobimatsu, Chika Wakahara, Daisuke Watanabe, Soichiro Adachi, Eiichiro Yasutomi, Haruka Yamairi, Yuna Ku, Masaru Yoshida, Namiko Hoshi, Yuzo Kodama
BACKGROUND/AIMS: While some studies have shown that IFX and TAC exhibit similar efficacy against UC in the short-term, it is unclear which drug produces better long-term outcomes. In this study, we compared the long-term efficacy of IFX and TAC in patients with moderate to severe UC. METHODS: This retrospective study was conducted from 2009 to 2017. It included patients with no history of IFX or TAC treatment. We analyzed the clinical response and remission rates at 12 and 52 weeks, and colectomy-free and relapse-free survival were evaluated until the end of the study...
December 4, 2018: Kobe Journal of Medical Sciences
Nanako Miwa, Tatsuya Nagano, Hisashi Ohnishi, Teruaki Nishiuma, Kazuhiro Takenaka, Tomohiko Shirotani, Takeo Nakajima, Ryota Dokuni, Yoshitaka Kawa, Kazuyuki Kobayashi, Yasuhiro Funada, Yoshikazu Kotani, Yoshihiro Nishimura
Cough-variant asthma is one of the most common reasons for chronic cough. It is important to treat appropriately cough-variant asthma because 30% to 40% of cough-variant asthma becomes a typical asthma. However, little is known about the treatment of cough-variant asthma except for inhaled corticosteroid (ICS). The aim of this study was to validate the additive efficacy of a leukotriene receptor antagonist (LTRA) on cough score and respiratory function in patients with cough-variant asthma being treated with ICS...
December 4, 2018: Kobe Journal of Medical Sciences
Chie Kondo, Satoshi Takada
BACKGROUND: The mothers of twins often suffer from sleeplessness. However, little is known about the relation of sleep behaviors between these mothers and their infants. The change of this relation with age has not been reported. The aims of this study are firstly to clarify the sleep behaviors of twin infants and their mothers by using actigraphy (four measurement periods at approximately 4- to 6-week intervals) and secondary to evaluate the relations of sleep behaviors between twin infants and their mothers...
December 4, 2018: Kobe Journal of Medical Sciences
Maria Dara Novi Handayani, Ahmad Hamim Sadewa, Arta Farmawati, Wasilah Rochmah
Decline in muscle mass due to aging is a growing public health problem as it contributes to a decreased capacity for independent living among elderly people. A clear understanding of genetic factors is important, as it is known that angiotensin-converting enzyme insertion/deletion (ACE I/D) polymorphism affects muscle mass, although the findings are frequently heterogeneous. This study was conducted to determine the association between ACE I/D polymorphism and muscle mass in elderly people. A total of 130 elderly people were recruited from nursing homes in Jakarta...
November 12, 2018: Kobe Journal of Medical Sciences
Atsuyuki Inui, Tsukasa Kuroda, Takashi Kurosawa, Takeshi Kokubu, Yutaka Mifune, Hanako Nishimoto, Ryosuke Kuroda
Comminuted olecranon fracture requires surgical intervention. Plate fixation has been performed on the majority of cases. We reviewed the cases of comminuted olecranon fracture in young and middle age treated by plate osteosynthesis and analyzed the functional outcome, complications and ratio and timing of hardware removal. Fifteen cases of comminuted olecranon fractures treated by plate fixation were reviewed. Bone union was achieved in all cases, the average range of motion at the final follow up was -11° in extension, 133° in flexion, 89° in pronation and 88° in supination...
November 12, 2018: Kobe Journal of Medical Sciences
Andreas Haryono, Dwi Aris Agung Nugrahaningsih, Dwi Cahyani Ratna Sari, Muhammad Mansyur Romi, Nur Arfian
BACKGROUND: Hyperuricemia contributed to endothelial dysfunction, activation of the RAS system, increased oxidative stress and maladaptive immune system response. M1 and M2 macrophages were known to contribute to the onset of renal fibrosis. This study aimed to look at the effect of lowering serum uric acid levels on renal injury in mice. METHODS: This study used 25 male mice, 3 months old, that divided into 5 groups. We injected uric acid intraperitoneally, 125mg/kg/day for 7 days (UA7) and 14 days (UA14), to induce hyperuricemia and then gave allopurinol 50mg/kg/day for 7 days to lower serum uric acid levels (UA7AL7 and UA14AL7)...
October 29, 2018: Kobe Journal of Medical Sciences
Ery Hermawati, Nur Arfian, Mustofa, Ginus Partadiredja
A number of studies have investigated the effects of ischemic injury on functional and cellular characteristics of hippocampus. There is only a limited study on vascular remodeling of it. The present study aimed at examining vascular remodeling in hippocampus and spatial memory disturbances after transient brain ischemia. Male Wistar rats were randomly divided into four groups, i.e. sham operated (SHAM), transient brain ischemia with 1 day reperfusion (IR1), 3 day reperfusion (IR3), and 10 days reperfusion (IR10) groups...
October 15, 2018: Kobe Journal of Medical Sciences
Acharaporn Duangjai, Nitra Nuengchamnong, Nungruthai Suphrom, Kanittaporn Trisat, Nanteetip Limpeanchob, Surasak Saokaew
This study was to assess the impact of different colors of coffee fruit (green, yellow and red) on adipogenesis and/or lipolysis using 3T3-L1 adipocytes. Characterization of chemical constituents in different colors of coffee fruit extracts was determined by ESI-Q-TOF-MS. The cytotoxicity of the extracts in 3T3-L1 preadipocytes were evaluated by MTT assay. Oil-red O staining and amount of glycerol released in 3T3-L1 adipocytes were measured for lipid accumulation and lipolysis activity. All coffee fruit extracts displayed similar chromatographic profiles by chlorogenic acid > caffeoylquinic acid > caffeic acid...
October 15, 2018: Kobe Journal of Medical Sciences
Gulshan Fahmi El Bayani, Nurasi Lidya E Marpaung, Dedy Arnold Sastrajaya Simorangkir, Imelda Rosalyn Sianipar, Nurhadi Ibrahim, Neng Tine Kartinah, Indra Gusti Mansur, Jan S Purba, Ermita I Ibrahim Ilyas
Overtraining leads to an increase in IL-1β systemically due to muscle microtrauma, which affects the hippocampus, an important structure in spatial memory consolidation. The administration of Hibiscus sabdariffa Linn is expected to decrease IL-1β and increase IL-1ra, thereby potentially preventing impairments in spatial memory consolidation. This research was an experimental study using 20 male Wistar rats. The overtraining of Wistar rats altered the ratio of IL-1β/IL-1ra in the plasma and hippocampus. Moreover, this overtraining impaired spatial memory consolidation...
October 15, 2018: Kobe Journal of Medical Sciences
Harry Nugroho Eko Surniyantoro, Ahmad Hanim Sadewa, Pramudji Hastuti
Ala55Val and 45 basepair (bp) insertion/deletion (I/D) of UCP2 gene polymorphisms cause a decrease in resting energy expenditure, decreasing fatty acid oxidation and influencing mRNA transcription and stability, thereby increasing the risk of obesity. The purpose of this study was to determine the role of Ala55Val and 45 bp I/D polymorphisms of the UCP2 gene as a risk factor for obesity. This study consisted of 200 Indonesian subjects of Javanese ethnicity consisting of 100 obese and 100 non-obese participants...
October 15, 2018: Kobe Journal of Medical Sciences
Natsuko Tahara, Toshiro Shinke, Hiromasa Otake, Ryo Nishio, Akihide Konishi, Ken-Ichi Hirata
We previously reported that the cytochrome P450 (CYP) 2C19 reduced-function polymorphism was associated with decreased responsiveness to clopidogrel and intra-stent thrombus formation, as well as subsequent ischemic events after drug-eluting stent (DES) implantation. However, the relationship between the polymorphism and bleeding events remains unclear. Among 1427 consecutive patients who underwent DES implantation at Kobe University Hospital, 247 patients (341 lesions) were enrolled for this prospective observational study...
September 18, 2018: Kobe Journal of Medical Sciences
Emi Suzuki, Tomokazu Matsuda, Takeshi Kawamoto, Hiroaki Takahashi, Yusuke Mieda, Yuki Matsuura, Tomoko Takai, Ayumi Kanno, Maki Koyanagi-Kimura, Shun-Ichiro Asahara, Hiroshi Inoue, Wataru Ogawa, Yoshiaki Kido
Endoplasmic reticulum (ER) stress leads to peripheral insulin resistance and the progression of pancreatic beta cell failure in type 2 diabetes. Although ER stress plays an important role in the pathogenesis of diabetes, it is indispensable for cellular activity. Therefore, when assessing the pathological significance of ER stress, it is important to monitor and quantify ER stress levels. Here, we have established a novel system to monitor ER stress levels quickly and sensitively, and using this method, we have clarified the effect of differences in glucose concentration and various fatty acids on the ER of pancreatic β cells...
September 11, 2018: Kobe Journal of Medical Sciences
Saki Sato, Yojiro Ojima, Masatoshi Kanda, Tomohiko Kizaki, Noriyuki Ohara
Endometrial stromal sarcoma (ESS) is a rare malignant tumor of the uterus. We report an uncommon case of ESS composed of both low-grade ESS and high-grade ESS arising from an endometrial polyp. On the findings of magnetic resonance imaging and contrast computed tomography, a patient was suspected of having uterine malignant tumor. She underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy. Macroscopically, the tumor was a polypoid lesion in the uterine cavity. The tumor was an endometrial polyp with ESS components...
September 11, 2018: Kobe Journal of Medical Sciences
Yui Enomoto, Akira Kimoto, Hiroaki Suzuki, Shin Nishiumi, Masaru Yoshida, Takahide Komori
AIM: This study aimed to explore novel metabolite biomarker candidates for screening oral squamous cell carcinoma (OSCC). PATIENTS & METHODS: We collected plasma samples from 48 patients with OSCC and 29 with an oral disease and conducted a plasma metabolomics analysis of patients with OSCC using gas chromatography mass spectrometry. Then, we used the cross-validation procedure to ensure the accuracy of biomarker candidates. RESULTS: We selected four biomarker candidates against OSCC...
September 11, 2018: Kobe Journal of Medical Sciences
Saeko Tsujimae, Katsuhiko Yoshii, Keiji Yamana, Kazumichi Fujioka, Kazumoto Iijima, Ichiro Morioka
BACKGROUND: Hyperbilirubinemia in term newborns needing phototherapy within 48 hours after birth, early-onset hyperbilirubinemia, has not been evaluated in recent Japanese healthy birth centers. In this study, we sought to determine the cause of early-onset hyperbilirubinemia in a Japanese healthy birth center and to evaluate the 1992 Kobe University phototherapy treatment criterion requiring total serum bilirubin (TSB) and unbound bilirubin (UB). METHODS: In this retrospective observational study, we collected data on newborns diagnosed with early-onset hyperbilirubinemia between 2009 and 2016 at the Chibune General Hospital...
September 11, 2018: Kobe Journal of Medical Sciences
Tetsuya Fukuda, Hitoshi Matsuda, Hiroshi Tanaka, Yoshihiro Sanda, Yoshiaki Morita, Yoshimasa Seike
PURPOSE: The purpose of this study was to evaluate the efficacy of simultaneous IMA (s-IMA) embolization during the endovascular abdominal aortic aneurysm repair (EVAR). MATERIALS AND METHOD: From July 2007 to January 2011, 189 patients in the no embolization (NE) group underwent EVAR without the indication for s-IMA embolization. Since February 2011 to April 2014, 143 patients have undergone EVAR. Among these patients, 26 patients underwent s-IMA embolism under a predefined indication and constituted the simultaneous embolization (SE) group...
July 3, 2018: Kobe Journal of Medical Sciences
Mari Kitao, Noriko Setou, Akio Yamamoto, Satoshi Takada
PURPOSE: This study aimed (1) to examine the current status of psychological distress experienced by neonatal intensive care unit (NICU) nurses in supporting bereaved families, (2) to identify the factors associated with psychological distress, and (3) to understand the professional characteristics of nurses experiencing high psychological distress by comparing the study results with those of pediatricians. METHODS: We sent questionnaires to 64 NICUs. The psychological distress of nurses was classified into two groups based on the frequency of psychological distress experienced and analyzed using the χ2 test and Fisher's exact test...
June 6, 2018: Kobe Journal of Medical Sciences
Bambang Udji Djoko Rianto, Didit Yudhanto, Camelia Herdini
Gasoline contains toxic substances such as benzene, toluene, ethylbenzene, xylene (BTEX) that negatively influence gas/fuel station workers' health via continuous inhalation, causing loss of cilia and epithelial cell necrosis of the nasal mucosa. The aim of this study is to determine the correlation between length of work with nasal mucociliary transport time (NMCTT) of the gas/fuel station workers This study used a cross sectional design. The data were obtained from anamnesis, physical and NMCTT examinations of gas station workers in Yogyakarta, during November 2013...
May 28, 2018: Kobe Journal of Medical Sciences
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