journal
https://read.qxmd.com/read/39019038/from-periphery-to-center-stage-50-years-of-advancements-in-innate-immunity
#1
Susan Carpenter, Luke A J O'Neill
No abstract text is available yet for this article.
July 16, 2024: Cell
https://read.qxmd.com/read/39013470/allogeneic-cd19-targeted-car-t-therapy-in-patients-with-severe-myositis-and-systemic-sclerosis
#2
JOURNAL ARTICLE
Xiaobing Wang, Xin Wu, Binghe Tan, Liang Zhu, Yi Zhang, Li Lin, Yi Xiao, An Sun, Xinyi Wan, Shiyuan Liu, Yanfang Liu, Na Ta, Hang Zhang, Jialin Song, Ting Li, Ling Zhou, Jian Yin, Lingying Ye, Hongjuan Lu, Jinwei Hong, Hui Cheng, Ping Wang, Weiqing Li, Jianfeng Chen, Jin Zhang, Jing Luo, Miaozhen Huang, Lehang Guo, Xiaoming Pan, Yi Jin, Wenjing Ye, Lie Dai, Jian Zhu, Lingyun Sun, Biao Zheng, Dali Li, Yanran He, Mingyao Liu, Huaxiang Wu, Bing Du, Huji Xu
Allogeneic chimeric antigen receptor (CAR)-T cells hold great promise for expanding the accessibility of CAR-T therapy, whereas the risks of allograft rejection have hampered its application. Here, we genetically engineered healthy-donor-derived, CD19-targeting CAR-T cells using CRISPR-Cas9 to address the issue of immune rejection and treated one patient with refractory immune-mediated necrotizing myopathy and two patients with diffuse cutaneous systemic sclerosis with these cells. This study was registered at ClinicalTrials...
July 9, 2024: Cell
https://read.qxmd.com/read/39013471/integrated-cryoem-structure-of-a-spumaretrovirus-reveals-cross-kingdom-evolutionary-relationships-and-the-molecular-basis-for-assembly-and-virus-entry
#3
JOURNAL ARTICLE
Thomas Calcraft, Nicole Stanke-Scheffler, Andrea Nans, Dirk Lindemann, Ian A Taylor, Peter B Rosenthal
Foamy viruses (FVs) are an ancient lineage of retroviruses, with an evolutionary history spanning over 450 million years. Vector systems based on Prototype Foamy Virus (PFV) are promising candidates for gene and oncolytic therapies. Structural studies of PFV contribute to the understanding of the mechanisms of FV replication, cell entry and infection, and retroviral evolution. Here we combine cryoEM and cryoET to determine high-resolution in situ structures of the PFV icosahedral capsid (CA) and envelope glycoprotein (Env), including its type III transmembrane anchor and membrane-proximal external region (MPER), and show how they are organized in an integrated structure of assembled PFV particles...
July 6, 2024: Cell
https://read.qxmd.com/read/38971151/neoadjuvant-parpi-or-chemotherapy-in-ovarian-cancer-informs-targeting-effector-treg-cells-for-homologous-recombination-deficient-tumors
#4
JOURNAL ARTICLE
Yikai Luo, Yu Xia, Dan Liu, Xiong Li, Huayi Li, Jiahao Liu, Dongchen Zhou, Yu Dong, Xin Li, Yiyu Qian, Cheng Xu, Kangjia Tao, Guannan Li, Wen Pan, Qing Zhong, Xingzhe Liu, Sen Xu, Zhi Wang, Ronghua Liu, Wei Zhang, Wanying Shan, Tian Fang, Siyuan Wang, Zikun Peng, Ping Jin, Ning Jin, Shennan Shi, Yuxin Chen, Mengjie Wang, Xiaofei Jiao, Mengshi Luo, Wenjian Gong, Ya Wang, Yue Yao, Yi Zhao, Xinlin Huang, Xuwo Ji, Zhaoren He, Guangnian Zhao, Rong Liu, Mingfu Wu, Gang Chen, Li Hong, Ding Ma, Yong Fang, Han Liang, Qinglei Gao
Homologous recombination deficiency (HRD) is prevalent in cancer, sensitizing tumor cells to poly (ADP-ribose) polymerase (PARP) inhibition. However, the impact of HRD and related therapies on the tumor microenvironment (TME) remains elusive. Our study generates single-cell gene expression and T cell receptor profiles, along with validatory multimodal datasets from >100 high-grade serous ovarian cancer (HGSOC) samples, primarily from a phase II clinical trial (NCT04507841). Neoadjuvant monotherapy with the PARP inhibitor (PARPi) niraparib achieves impressive 62...
July 5, 2024: Cell
https://read.qxmd.com/read/38996527/assembly-and-activation-of-ebv-latent-membrane-protein-1
#5
JOURNAL ARTICLE
Jiafeng Huang, Xiaolin Zhang, Xiaohua Nie, Xuyuan Zhang, Yong Wang, Linlong Huang, Xiaohan Geng, Dong Li, Liguo Zhang, Guangxia Gao, Pu Gao
Latent membrane protein 1 (LMP1) is the primary oncoprotein of Epstein-Barr virus (EBV) and plays versatile roles in the EBV life cycle and pathogenesis. Despite decades of extensive research, the molecular basis for LMP1 folding, assembly, and activation remains unclear. Here, we report cryo-electron microscopy structures of LMP1 in two unexpected assemblies: a symmetric homodimer and a higher-order filamentous oligomer. LMP1 adopts a non-canonical and unpredicted fold that supports the formation of a stable homodimer through tight and antiparallel intermolecular packing...
July 4, 2024: Cell
https://read.qxmd.com/read/38986619/tulips-decorate-the-three-dimensional-genome-of-pfa-ependymoma
#6
JOURNAL ARTICLE
Michael J Johnston, John J Y Lee, Bo Hu, Ana Nikolic, Elham Hasheminasabgorji, Audrey Baguette, Seungil Paik, Haifen Chen, Sachin Kumar, Carol C L Chen, Selin Jessa, Polina Balin, Vernon Fong, Melissa Zwaig, Kulandaimanuvel Antony Michealraj, Xun Chen, Yanlin Zhang, Srinidhi Varadharajan, Pierre Billon, Nikoleta Juretic, Craig Daniels, Amulya Nageswara Rao, Caterina Giannini, Eric M Thompson, Miklos Garami, Peter Hauser, Timea Pocza, Young Shin Ra, Byung-Kyu Cho, Seung-Ki Kim, Kyu-Chang Wang, Ji Yeoun Lee, Wieslawa Grajkowska, Marta Perek-Polnik, Sameer Agnihotri, Stephen Mack, Benjamin Ellezam, Alex Weil, Jeremy Rich, Guillaume Bourque, Jennifer A Chan, V Wee Yong, Mathieu Lupien, Jiannis Ragoussis, Claudia Kleinman, Jacek Majewski, Mathieu Blanchette, Nada Jabado, Michael D Taylor, Marco Gallo
Posterior fossa group A (PFA) ependymoma is a lethal brain cancer diagnosed in infants and young children. The lack of driver events in the PFA linear genome led us to search its 3D genome for characteristic features. Here, we reconstructed 3D genomes from diverse childhood tumor types and uncovered a global topology in PFA that is highly reminiscent of stem and progenitor cells in a variety of human tissues. A remarkable feature exclusively present in PFA are type B ultra long-range interactions in PFAs (TULIPs), regions separated by great distances along the linear genome that interact with each other in the 3D nuclear space with surprising strength...
July 4, 2024: Cell
https://read.qxmd.com/read/38996528/molecular-and-cellular-mechanisms-of-teneurin-signaling-in-synaptic-partner-matching
#7
JOURNAL ARTICLE
Chuanyun Xu, Zhuoran Li, Cheng Lyu, Yixin Hu, Colleen N McLaughlin, Kenneth Kin Lam Wong, Qijing Xie, David J Luginbuhl, Hongjie Li, Namrata D Udeshi, Tanya Svinkina, D R Mani, Shuo Han, Tongchao Li, Yang Li, Ricardo Guajardo, Alice Y Ting, Steven A Carr, Jiefu Li, Liqun Luo
In developing brains, axons exhibit remarkable precision in selecting synaptic partners among many non-partner cells. Evolutionarily conserved teneurins are transmembrane proteins that instruct synaptic partner matching. However, how intracellular signaling pathways execute teneurins' functions is unclear. Here, we use in situ proximity labeling to obtain the intracellular interactome of a teneurin (Ten-m) in the Drosophila brain. Genetic interaction studies using quantitative partner matching assays in both olfactory receptor neurons (ORNs) and projection neurons (PNs) reveal a common pathway: Ten-m binds to and negatively regulates a RhoGAP, thus activating the Rac1 small GTPases to promote synaptic partner matching...
July 3, 2024: Cell
https://read.qxmd.com/read/38981480/intestinal-blastocystis-is-linked-to-healthier-diets-and-more-favorable-cardiometabolic-outcomes-in-56-989-individuals-from-32-countries
#8
JOURNAL ARTICLE
Elisa Piperni, Long H Nguyen, Paolo Manghi, Hanseul Kim, Edoardo Pasolli, Sergio Andreu-Sánchez, Alberto Arrè, Kate M Bermingham, Aitor Blanco-Míguez, Serena Manara, Mireia Valles-Colomer, Elco Bakker, Fabio Busonero, Richard Davies, Edoardo Fiorillo, Francesca Giordano, George Hadjigeorgiou, Emily R Leeming, Monia Lobina, Marco Masala, Andrea Maschio, Lauren J McIver, Mauro Pala, Maristella Pitzalis, Jonathan Wolf, Jingyuan Fu, Alexandra Zhernakova, Simone M Cacciò, Francesco Cucca, Sarah E Berry, Danilo Ercolini, Andrew T Chan, Curtis Huttenhower, Tim D Spector, Nicola Segata, Francesco Asnicar
Diet impacts human health, influencing body adiposity and the risk of developing cardiometabolic diseases. The gut microbiome is a key player in the diet-health axis, but while its bacterial fraction is widely studied, the role of micro-eukaryotes, including Blastocystis, is underexplored. We performed a global-scale analysis on 56,989 metagenomes and showed that human Blastocystis exhibits distinct prevalence patterns linked to geography, lifestyle, and dietary habits. Blastocystis presence defined a specific bacterial signature and was positively associated with more favorable cardiometabolic profiles and negatively with obesity (p < 1e-16) and disorders linked to altered gut ecology (p < 1e-8)...
July 2, 2024: Cell
https://read.qxmd.com/read/38981481/all-rna-mediated-targeted-gene-integration-in-mammalian-cells-with-rationally-engineered-r2-retrotransposons
#9
JOURNAL ARTICLE
Yangcan Chen, Shengqiu Luo, Yanping Hu, Bangwei Mao, Xinge Wang, Zongbao Lu, Qingtong Shan, Jin Zhang, Siqi Wang, Guihai Feng, Chenxin Wang, Chen Liang, Na Tang, Rui Niu, Jiaqiang Wang, Jiabao Han, Ning Yang, Haoyi Wang, Qi Zhou, Wei Li
All-RNA-mediated targeted gene integration methods, rendering reduced immunogenicity, effective deliverability with non-viral vehicles, and a low risk of random mutagenesis, are urgently needed for next-generation gene addition technologies. Naturally occurring R2 retrotransposons hold promise in this context due to their site-specific integration profile. Here, we systematically analyzed the biodiversity of R2 elements and screened several R2 orthologs capable of full-length gene insertion in mammalian cells...
July 1, 2024: Cell
https://read.qxmd.com/read/38964327/the-life-saving-benefit-of-dexamethasone-in-severe-covid-19-is-linked-to-a-reversal-of-monocyte-dysregulation
#10
JOURNAL ARTICLE
Rainer Knoll, Elisa T Helbig, Kilian Dahm, Olufemi Bolaji, Frederik Hamm, Oliver Dietrich, Martina van Uelft, Sophie Müller, Lorenzo Bonaguro, Jonas Schulte-Schrepping, Lev Petrov, Benjamin Krämer, Michael Kraut, Paula Stubbemann, Charlotte Thibeault, Sophia Brumhard, Heidi Theis, Gudrun Hack, Elena De Domenico, Jacob Nattermann, Matthias Becker, Marc D Beyer, David Hillus, Philipp Georg, Constantin Loers, Janina Tiedemann, Pinkus Tober-Lau, Lena Lippert, Belén Millet Pascual-Leone, Frank Tacke, Gernot Rohde, Norbert Suttorp, Martin Witzenrath, Antoine-Emmanuel Saliba, Thomas Ulas, Julia K Polansky, Birgit Sawitzki, Leif E Sander, Joachim L Schultze, Anna C Aschenbrenner, Florian Kurth
Dexamethasone is a life-saving treatment for severe COVID-19, yet its mechanism of action is unknown, and many patients deteriorate or die despite timely treatment initiation. Here, we identify dexamethasone treatment-induced cellular and molecular changes associated with improved survival in COVID-19 patients. We observed a reversal of transcriptional hallmark signatures in monocytes associated with severe COVID-19 and the induction of a monocyte substate characterized by the expression of glucocorticoid-response genes...
July 1, 2024: Cell
https://read.qxmd.com/read/39013469/the-wdr11-complex-is-a-receptor-for-acidic-cluster-containing-cargo-proteins
#11
JOURNAL ARTICLE
Huaqing Deng, Guowen Jia, Ping Li, Yingying Tang, Lin Zhao, Qin Yang, Jia Zhao, Jinrui Wang, Yingfeng Tu, Xin Yong, Sitao Zhang, Xianming Mo, Daniel D Billadeau, Zhaoming Su, Da Jia
Vesicle trafficking is a fundamental process that allows for the sorting and transport of specific proteins (i.e., "cargoes") to different compartments of eukaryotic cells. Cargo recognition primarily occurs through coats and the associated proteins at the donor membrane. However, it remains unclear whether cargoes can also be selected at other stages of vesicle trafficking to further enhance the fidelity of the process. The WDR11-FAM91A1 complex functions downstream of the clathrin-associated AP-1 complex to facilitate protein transport from endosomes to the TGN...
June 28, 2024: Cell
https://read.qxmd.com/read/38981482/a-non-canonical-role-for-a-small-nucleolar-rna-in-ribosome-biogenesis-and-senescence
#12
JOURNAL ARTICLE
Yujing Cheng, Siwen Wang, He Zhang, Jong-Sun Lee, Chunyang Ni, Jason Guo, Eric Chen, Shenming Wang, Asha Acharya, Tsung-Cheng Chang, Michael Buszczak, Hao Zhu, Joshua T Mendell
Cellular senescence is an irreversible state of cell-cycle arrest induced by various stresses, including aberrant oncogene activation, telomere shortening, and DNA damage. Through a genome-wide screen, we discovered a conserved small nucleolar RNA (snoRNA), SNORA13, that is required for multiple forms of senescence in human cells and mice. Although SNORA13 guides the pseudouridylation of a conserved nucleotide in the ribosomal decoding center, loss of this snoRNA minimally impacts translation. Instead, we found that SNORA13 negatively regulates ribosome biogenesis...
June 28, 2024: Cell
https://read.qxmd.com/read/38968937/progestogen-driven-b7-h4-contributes-to-onco-fetal-immune-tolerance
#13
JOURNAL ARTICLE
Jiali Yu, Yijian Yan, Shasha Li, Ying Xu, Abhijit Parolia, Syed Rizvi, Weichao Wang, Yiwen Zhai, Rongxin Xiao, Xiong Li, Peng Liao, Jiajia Zhou, Karolina Okla, Heng Lin, Xun Lin, Sara Grove, Shuang Wei, Linda Vatan, Jiantao Hu, Justyna Szumilo, Jan Kotarski, Zachary T Freeman, Stephanie Skala, Max Wicha, Kathleen R Cho, Arul M Chinnaiyan, Samantha Schon, Fei Wen, Ilona Kryczek, Shaomeng Wang, Lieping Chen, Weiping Zou
Immune tolerance mechanisms are shared in cancer and pregnancy. Through cross-analyzing single-cell RNA-sequencing data from multiple human cancer types and the maternal-fetal interface, we found B7-H4 (VTCN1) is an onco-fetal immune tolerance checkpoint. We showed that genetic deficiency of B7-H4 resulted in immune activation and fetal resorption in allogeneic pregnancy models. Analogously, B7-H4 contributed to MPA/DMBA-induced breast cancer progression, accompanied by CD8+ T cell exhaustion. Female hormone screening revealed that progesterone stimulated B7-H4 expression in placental and breast cancer cells...
June 28, 2024: Cell
https://read.qxmd.com/read/38959890/loss-of-transient-receptor-potential-channel-5-causes-obesity-and-postpartum-depression
#14
JOURNAL ARTICLE
Yongxiang Li, Tessa M Cacciottolo, Na Yin, Yang He, Hesong Liu, Hailan Liu, Yuxue Yang, Elana Henning, Julia M Keogh, Katherine Lawler, Edson Mendes de Oliveira, Eugene J Gardner, Katherine A Kentistou, Panayiotis Laouris, Rebecca Bounds, Ken K Ong, John R B Perry, Inês Barroso, Longlong Tu, Jonathan C Bean, Meng Yu, Kristine M Conde, Mengjie Wang, Olivia Ginnard, Xing Fang, Lydia Tong, Junying Han, Tia Darwich, Kevin W Williams, Yongjie Yang, Chunmei Wang, Shelagh Joss, Helen V Firth, Yong Xu, I Sadaf Farooqi
Hypothalamic neural circuits regulate instinctive behaviors such as food seeking, the fight/flight response, socialization, and maternal care. Here, we identified microdeletions on chromosome Xq23 disrupting the brain-expressed transient receptor potential (TRP) channel 5 (TRPC5). This family of channels detects sensory stimuli and converts them into electrical signals interpretable by the brain. Male TRPC5 deletion carriers exhibited food seeking, obesity, anxiety, and autism, which were recapitulated in knockin male mice harboring a human loss-of-function TRPC5 mutation...
June 28, 2024: Cell
https://read.qxmd.com/read/38971152/early-rhombic-lip-protogenin-ve-stem-cells-in-a-human-specific-neurovascular-niche-initiate-and-maintain-group-3-medulloblastoma
#15
JOURNAL ARTICLE
Abhirami Visvanathan, Olivier Saulnier, Chuan Chen, Parthiv Haldipur, Wilda Orisme, Alberto Delaidelli, Seungmin Shin, Jake Millman, Andrew Bryant, Namal Abeysundara, Xujia Wu, Liam D Hendrikse, Vikas Patil, Zahedeh Bashardanesh, Joseph Golser, Bryn G Livingston, Takuma Nakashima, Yusuke Funakoshi, Winnie Ong, Alexandra Rasnitsyn, Kimberly A Aldinger, Cory M Richman, Randy Van Ommeren, John J Y Lee, Michelle Ly, Maria C Vladoiu, Kaitlin Kharas, Polina Balin, Anders W Erickson, Vernon Fong, Jiao Zhang, Raúl A Suárez, Hao Wang, Ning Huang, Jonelle G Pallota, Tajana Douglas, Joonas Haapasalo, Ferechte Razavi, Evelina Silvestri, Olga Sirbu, Samantha Worme, Michelle M Kameda-Smith, Xiaochong Wu, Craig Daniels, Antony K MichaelRaj, Aparna Badhuri, Daniel Schramek, Hiromichi Suzuki, Livia Garzia, Nabil Ahmed, Claudia L Kleinman, Lincoln D Stein, Peter Dirks, Christopher Dunham, Nada Jabado, Jeremy N Rich, Wei Li, Poul H Sorensen, Robert J Wechsler-Reya, William A Weiss, Kathleen J Millen, David W Ellison, Dimiter S Dimitrov, Michael D Taylor
We identify a population of Protogenin-positive (PRTG+ve ) MYChigh NESTINlow stem cells in the four-week-old human embryonic hindbrain that subsequently localizes to the ventricular zone of the rhombic lip (RLVZ ). Oncogenic transformation of early Prtg+ve rhombic lip stem cells initiates group 3 medulloblastoma (Gr3-MB)-like tumors. PRTG+ve stem cells grow adjacent to a human-specific interposed vascular plexus in the RLVZ , a phenotype that is recapitulated in Gr3-MB but not in other types of medulloblastoma...
June 26, 2024: Cell
https://read.qxmd.com/read/38964328/human-coronavirus-hku1-recognition-of-the-tmprss2-host-receptor
#16
JOURNAL ARTICLE
Matthew McCallum, Young-Jun Park, Cameron Stewart, Kaitlin R Sprouse, Amin Addetia, Jack Brown, M Alejandra Tortorici, Cecily Gibson, Emily Wong, Margareta Ieven, Amalio Telenti, David Veesler
The human coronavirus HKU1 spike (S) glycoprotein engages host cell surface sialoglycans and transmembrane protease serine 2 (TMPRSS2) to initiate infection. The molecular basis of HKU1 binding to TMPRSS2 and determinants of host receptor tropism remain elusive. We designed an active human TMPRSS2 construct enabling high-yield recombinant production in human cells of this key therapeutic target. We determined a cryo-electron microscopy structure of the HKU1 RBD bound to human TMPRSS2, providing a blueprint of the interactions supporting viral entry and explaining the specificity for TMPRSS2 among orthologous proteases...
June 26, 2024: Cell
https://read.qxmd.com/read/38959891/the-germline-coordinates-mitokine-signaling
#17
JOURNAL ARTICLE
Koning Shen, Jenni Durieux, Cesar G Mena, Brant M Webster, C Kimberly Tsui, Hanlin Zhang, Larry Joe, Kristen M Berendzen, Andrew Dillin
The ability of mitochondria to coordinate stress responses across tissues is critical for health. In C. elegans, neurons experiencing mitochondrial stress elicit an inter-tissue signaling pathway through the release of mitokine signals, such as serotonin or the Wnt ligand EGL-20, which activate the mitochondrial unfolded protein response (UPRMT ) in the periphery to promote organismal health and lifespan. We find that germline mitochondria play a surprising role in neuron-to-periphery UPRMT signaling. Specifically, we find that germline mitochondria signal downstream of neuronal mitokines, Wnt and serotonin, and upstream of lipid metabolic pathways in the periphery to regulate UPRMT activation...
June 26, 2024: Cell
https://read.qxmd.com/read/38942013/stress-dependent-condensate-formation-regulated-by-the-ubiquitin-related-modifier-urm1
#18
JOURNAL ARTICLE
Lucas V Cairo, Xiaoyu Hong, Martin B D Müller, Patricia Yuste-Checa, Chandhuru Jagadeesan, Andreas Bracher, Sae-Hun Park, Manajit Hayer-Hartl, F Ulrich Hartl
The ability of proteins and RNA to coalesce into phase-separated assemblies, such as the nucleolus and stress granules, is a basic principle in organizing membraneless cellular compartments. While the constituents of biomolecular condensates are generally well documented, the mechanisms underlying their formation under stress are only partially understood. Here, we show in yeast that covalent modification with the ubiquitin-like modifier Urm1 promotes the phase separation of a wide range of proteins. We find that the drop in cellular pH induced by stress triggers Urm1 self-association and its interaction with both target proteins and the Urm1-conjugating enzyme Uba4...
June 26, 2024: Cell
https://read.qxmd.com/read/38942015/the-extracellular-matrix-integrates-mitochondrial-homeostasis
#19
JOURNAL ARTICLE
Hanlin Zhang, C Kimberly Tsui, Gilberto Garcia, Larry K Joe, Haolun Wu, Ayane Maruichi, Wudi Fan, Sentibel Pandovski, Peter H Yoon, Brant M Webster, Jenni Durieux, Phillip A Frankino, Ryo Higuchi-Sanabria, Andrew Dillin
Cellular homeostasis is intricately influenced by stimuli from the microenvironment, including signaling molecules, metabolites, and pathogens. Functioning as a signaling hub within the cell, mitochondria integrate information from various intracellular compartments to regulate cellular signaling and metabolism. Multiple studies have shown that mitochondria may respond to various extracellular signaling events. However, it is less clear how changes in the extracellular matrix (ECM) can impact mitochondrial homeostasis to regulate animal physiology...
June 24, 2024: Cell
https://read.qxmd.com/read/38942014/microglial-derived-c1q-integrates-into-neuronal-ribonucleoprotein-complexes-and-impacts-protein-homeostasis-in-the-aging-brain
#20
JOURNAL ARTICLE
Nicole Scott-Hewitt, Matthew Mahoney, Youtong Huang, Nils Korte, T Yvanka de Soysa, Daniel K Wilton, Emily Knorr, Kevin Mastro, Allison Chang, Allison Zhang, David Melville, Monica Schenone, Christina Hartigan, Beth Stevens
Neuroimmune interactions mediate intercellular communication and underlie critical brain functions. Microglia, CNS-resident macrophages, modulate the brain through direct physical interactions and the secretion of molecules. One such secreted factor, the complement protein C1q, contributes to complement-mediated synapse elimination in both developmental and disease models, yet brain C1q protein levels increase significantly throughout aging. Here, we report that C1q interacts with neuronal ribonucleoprotein (RNP) complexes in an age-dependent manner...
June 24, 2024: Cell
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