Corey Grozier, Megan Keen, Katherine Collins, Jessica Tolzman, Ryan Fajardo, Jill M Slade, Christopher Kuenze, Matthew S Harkey
OBJECTIVE: The aim of the work described here was to evaluate quadriceps muscle ultrasound metrics and common demographic variables to create a conversion equation that validly predicts magnetic resonance imaging (MRI) percent intramuscular fat after anterior cruciate ligament reconstruction (ACLR). METHODS: We recruited 15 participants between the ages of 18 and 35 y who were 1-5 y post-ACLR. For the MRI assessment, we used an iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL) sequence to assess the mid-thigh...
September 27, 2023: Ultrasound in Medicine & Biology
Feiyuan Yu, Wolfgang S Müller, Gösta Ehnholm, Yoshio Okada, Jen-Wei Lin
OBJECTIVE: Focused ultrasound (FUS) can modulate neuronal activity by depolarization or hyperpolarization. Although FUS-evoked depolarization has been studied extensively, the mechanisms underlying FUS-evoked hyperpolarization (FUSH) have received little attention. In the study described here, we developed a procedure using FUS to selectively hyperpolarize motor axons in crayfish. As a previous study had reported that these axons express mechano- and thermosensitive two-pore domain potassium (K2P) channels, we tested the hypothesis that K2P channels underlie FUSH...
September 26, 2023: Ultrasound in Medicine & Biology
Jiyoung Yoon, Eunjung Lee, Hye Sun Lee, Sangwoo Cho, JinWoo Son, Hyuk Kwon, Jung Hyun Yoon, Vivian Youngjean Park, Minah Lee, Miribi Rho, Daham Kim, Jin Young Kwak
OBJECTIVE: The aims of the work described here were to evaluate the learnability of thyroid nodule assessment on ultrasonography (US) using a big data set of US images and to evaluate the diagnostic utilities of artificial intelligence computer-aided diagnosis (AI-CAD) used by readers with varying experience to differentiate benign and malignant thyroid nodules. METHODS: Six college freshmen independently studied the "learning set" composed of images of 13,560 thyroid nodules, and their diagnostic performance was evaluated after their daily learning sessions using the "test set" composed of images of 282 thyroid nodules...
September 26, 2023: Ultrasound in Medicine & Biology
Jinghui Fang, Qiongxia Deng, Jingwen Zhang, Yuqin Ma, Chunchun Jin, Jianghao Lu, Yanli Hao, Yuanyuan Ma, Weizong Liu, Zhengyi Li, Guowen Liu, Yongpan Mo, Yu Xiao, Chang Zheng, Yajie Yang, Tingting Wu, Chao Zhao, Xin Zhou, Peng Zhou
OBJECTIVE: Accurately predicting nipple-areola complex (NAC) involvement in breast cancer is essential for identifying eligible patients for a nipple-sparing mastectomy. This study was aimed at developing a pre-operative nomogram for NAC involvement in breast cancer using conventional ultrasound (US) and contrast-enhanced ultrasound (CEUS). METHODS: All patients with primary breast cancer confirmed by pre-operative biopsy underwent US and CEUS examinations. Post-operative pathology was used as the gold standard in assessing NAC involvement...
September 24, 2023: Ultrasound in Medicine & Biology
Yiqiong Zhang, Jundong Yao, Fangyi Liu, Zhigang Cheng, Erpeng Qi, Zhiyu Han, Jie Yu, Jianping Dou, Ping Liang, Shuilian Tan, Xuejuan Dong, Xin Li, Ya Sun, Shuo Wang, Zhen Wang, Xiaoling Yu
OBJECTIVE: The purpose of the study was to develop and validate a radiomics model by using contrast-enhanced ultrasound (CEUS) data for pre-operative differential diagnosis of pancreatic cystic neoplasms (PCNs), especially pancreatic serous cystadenoma (SCA). METHODS: Patients with pathologically confirmed PCNs who underwent CEUS examination at Chinese PLA hospital from May 2015 to August 2022 were retrospectively collected. Radiomic features were extracted from the regions of interest, which were obtained based on CEUS images...
September 23, 2023: Ultrasound in Medicine & Biology
Ozhan M Turan, Jeffery S Babischkin, Graham W Aberdeen, Shifa Turan, Gerald J Pepe, Eugene D Albrecht
OBJECTIVE: During early human pregnancy, placental trophoblasts remodel spiral arteries into distensible low-resistance vessels to promote placental perfusion. We have established a model of impaired spiral artery remodeling (SAR) by elevating estradiol levels in the first trimester of baboon pregnancy. In the present study, B-flow/spatiotemporal image correlation (STIC) M-mode ultrasonography, a non-Doppler technology for sharp rendering of vessel dimensions, was used to determine whether spiral artery distensibility was altered in SAR-suppressed baboons...
September 23, 2023: Ultrasound in Medicine & Biology
Rafey A Feroze, Jonathan Kopechek, Jianhui Zhu, Xucai Chen, Flordeliza S Villanueva
OBJECTIVE: Cardiac fibrosis contributes to adverse ventricular remodeling and is associated with loss of miR-29b. Overexpression of miR-29b via plasmid or intravenous injection of microRNA mimic has blunted fibrosis, but these are inefficient and non-targeted delivery strategies. In this study, we tested the hypothesis that delivery of microRNA-29b (miR-29b) using ultrasound-targeted microbubble cavitation (UTMC) of miR-29b-loaded microbubbles would attenuate cardiac fibrosis and preserve left ventricular (LV) function...
September 23, 2023: Ultrasound in Medicine & Biology
Ming-Wei Wang, Wei-Ning Lee, Chih-Chien Hung, Jung-Hsien Hsieh, Yueh-Hsia Chen, Tiffany Ting-Fang Shih, Jyh-Horng Wang, Nai-Hao Yin, Hsing-Kuo Wang
OBJECTIVE: Restricted tendon gliding is commonly observed in patients after finger flexor tendon (FFT) repair. The study described here was aimed at quantifying the amount of FFT gliding to evaluate the recovery of post-operative tendons using a 2-D radiofrequency (RF)-based ultrasound speckle tracking algorithm (UST). METHODS: Ex vivo uniaxial tensile testing of porcine flexor tendons and in vivo isometric testing of human FFT were implemented to verify the efficacy of UST beforehand...
September 21, 2023: Ultrasound in Medicine & Biology
Weiyan Jiang, Yulin Yan, Simin Cheng, Shanshan Wan, Linying Huang, Hongmei Zheng, Miao Tian, Jian Zhu, Yumiao Pan, Jia Li, Li Huang, Lianlian Wu, Yuelan Gao, Jiewen Mao, Yuyu Cong, Yujin Wang, Qian Deng, Xiaoshuo Shi, Zixian Yang, Siqi Liu, Biqing Zheng, Yanning Yang
OBJECTIVE: The goal of the work described here was to develop and assess a deep learning-based model that could automatically segment anterior chamber angle (ACA) tissues; classify iris curvature (I-Curv), iris root insertion (IRI), and angle closure (AC); automatically locate scleral spur; and measure ACA parameters in ultrasound biomicroscopy (UBM) images. METHODS: A total of 11,006 UBM images were obtained from 1538 patients with primary angle-closure glaucoma who were admitted to the Eye Center of Renmin Hospital of Wuhan University (Wuhan, China) to develop an imaging database...
September 18, 2023: Ultrasound in Medicine & Biology
Connor Edsall, Austin Fergusson, Richey M Davis, Craig H Meyer, Steven P Allen, Eli Vlaisavljevich
OBJECTIVE: A coupling bath of circulating, chilled, degassed water is essential to safe and precise acoustic transmittance during transcranial magnetic resonance-guided focused ultrasound (tMRgFUS) procedures, but the circulating water impairs the critical real-time magnetic resonance imaging (MRI). An iron-based coupling medium (IBCM) using iron oxide nanoparticles previously developed by our group increased the relaxivity of the coupling bath such that it appears to be invisible on MRI compared with degassed water...
September 18, 2023: Ultrasound in Medicine & Biology
Junlin Zhong, Licong Huang, Manting Su, Manli Wu, Xin Lin, Xing Shui, Ye Jiang, Xinling Zhang
OBJECTIVE: The aim of the work described here was to evaluate the feasibility of superb microvascular imaging (SMI) and vascular endothelial growth factor receptor 2 (VEGFR2)-targeted microbubble (MBVEGFR2 )-based ultrasound molecular imaging (USMI) for visualizing microvessels in cervical cancer. METHODS: Hela cells were used to establish subcutaneous cervical cancer models. SMI and MBVEGFR2 -based USMI were performed, and the results were compared with intratumoral microvessel density (MVD) in four groups based on tumor diameter (<3 mm, 3-5 mm, 5-7 mm and ≥7 mm)...
September 18, 2023: Ultrasound in Medicine & Biology
Chao Hou, Xin-Yao Liu, Yue Du, Ling-Gang Cheng, Lu-Ping Liu, Fang Nie, Wei Zhang, Wen He
Imaging modalities provide information on plaque morphology and vulnerability; however, they are operator dependent and miss a great deal of microscopic information. Recently, many radiomics models for carotid plaque that identify unstable plaques and predict cardiovascular outcomes have been proposed. This systematic review was aimed at assessing whether radiomics is a reliable and reproducible method for the clinical prediction of carotid plaque. A systematic search was conducted to identify studies published in PubMed and Cochrane library from January 1, 2001, to September 30, 2022...
September 15, 2023: Ultrasound in Medicine & Biology
Pratik A Ambekar, Yak-Nam Wang, Tatiana Khokhlova, Matthew Bruce, Daniel F Leotta, Stephanie Totten, Adam D Maxwell, Keith Chan, W Conrad Liles, E Patchen Dellinger, Wayne Monsky, Adeyinka A Adedipe, Thomas J Matula
OBJECTIVE: Bacterial loads can be effectively reduced using cavitation-mediated focused ultrasound, or histotripsy. In this study, gram-negative bacteria (Escherichia coli) in suspension were used as model bacteria to evaluate the effectiveness of two regimens of histotripsy treatments: cavitation histotripsy (CH) and boiling histotripsy (BH). METHODS: Ten-milliliter volumes of Escherichia coli were treated at different negative focal pressure amplitudes and over time periods up to 40 min...
September 15, 2023: Ultrasound in Medicine & Biology
Cecille Labuda, Blake C Lawler, Brent K Hoffmeister, Shona C Harbert, Ann M Viano, Phyu Sin M Myat
OBJECTIVE: The ultrasonic properties of scalp may be relevant to a variety of applications including transcranial ultrasound. However, there is no information about the ultrasonic properties of scalp available in the literature. While ultrasonic studies of skin from other anatomic regions have been previously reported, scalp tissue is generally thicker with a higher density of hair follicles, blood vessels and sebaceous glands. Thus, it is unknown if the ultrasonic properties of scalp are similar to skin from other regions...
September 14, 2023: Ultrasound in Medicine & Biology
Ting Zhou, Chen Xu Zhou, Quan Bing Zhang, Feng Wang, Yun Zhou
OBJECTIVE: The aim of the work described here was to investigate the efficacy and potential mechanisms of low-intensity pulsed ultrasound (LIPUS) for the treatment of arthrogenic contracture induced by immobilization in rabbits. METHODS: The left knee joint of rabbits was immobilized for 6 wk to establish the model of extending knee joint contracture. The rabbits were divided into a control group (C), a group immobilized for 6 wk (IM-6w), a group remobilized for 1 wk (RM-1w), a group subjected to LIPUS intervention for 1 wk (LIPUS-1w), a group remobilized for 2 wk (RM-2w) and a group subjected to LIPUS intervention for 2 wk (LIPUS-2w)...
September 14, 2023: Ultrasound in Medicine & Biology
Rudolf W M Keunen, Sayonara M Daal, Geert Jan Romers, Gerard J F Hoohenkerk, Paulien M van Kampen, Willem J L Suyker
OBJECTIVE: The aim of the work described here was to assess the diagnostic accuracy of a new algorithm (SGA-a) for time-domain analysis of transcranial Doppler audio signals to discriminate presumed solid and gaseous microembolic signals and artifacts (SGAs). METHODS: SGA-a was validated by human experts in an artifact cohort of 20 patients subjected to a 1-h transcranial Doppler exam before cardiac surgery (cohort 1). Emboli were validated in a cohort of 10 patients after aortic valve replacement in a 4-h monitoring period (cohort 2)...
September 12, 2023: Ultrasound in Medicine & Biology
Luxi Wei, Geraldi Wahyulaksana, Maaike Te Lintel Hekkert, Robert Beurskens, Enrico Boni, Alessandro Ramalli, Emile Noothout, Dirk J Duncker, Piero Tortoli, Antonius F W van der Steen, Nico de Jong, Martin Verweij, Hendrik J Vos
OBJECTIVE: The aim of this study was to assess the feasibility and imaging options of contrast-enhanced volumetric ultrasound kidney vasculature imaging in a porcine model using a prototype sparse spiral array. METHODS: Transcutaneous freehand in vivo imaging of two healthy porcine kidneys was performed according to three protocols with different microbubble concentrations and transmission sequences. Combining high-frame-rate transmission sequences with our previously described spatial coherence beamformer, we determined the ability to produce detailed volumetric images of the vasculature...
September 11, 2023: Ultrasound in Medicine & Biology
Yusen Zhang, Chenyang Zhao, Heng Lv, Licong Dong, Lu Xie, Yun Tian, Wangjie Wu, Haiyu Luo, Qi Yang, Li Liu, Desheng Sun, Haiqin Xie
OBJECTIVE: Ultrasonography (US) is the primary imaging method for soft tissue tumors (STTs), the diagnostic performance of which still requires improvement. To achieve an accurate evaluation of STTs, we built the diagnostic nomogram for STTs using the clinical and US features of patients with STTs. METHODS: A total of 613 patients with 195 malignant and 418 benign STTs were retrospectively recruited. We used a blend of clinical and ultrasonic features, as well as exclusively US features, to develop two distinct diagnostic models for STTs: the clinical-US model and the US-only model, respectively...
September 11, 2023: Ultrasound in Medicine & Biology
Zi-Ling You, Zhi-Lin Ding, Qin-Yun Ruan, Li-Yun Fu
OBJECTIVE: The aim of the work described here was to evaluate strain and morphological change of the left ventricle in Sprague Dawley (SD) rats at different exercise intensities by 2-D speckle tracking imaging (STI). METHODS: Seventy-two 8-wk-old SD rats were divided into four groups on the basis of exercise intensity: sedentary (SED), low-intensity running, medium-intensity running (MIR) and high-intensity running (HIR). Each group was further sub-divided into three groups of different exercise lengths: 1, 4 and 8 wk...
September 7, 2023: Ultrasound in Medicine & Biology
Chen Chu Ying, Cai Shan Wang, Ya Kun Ren, Chang Wei Ding, Ying Chun Zhang, Jian Wu, Min Yang, Ying Zhang, Pan Mao, Yu Jing Sheng, Xiao Fang Chen, Cheng Jie Mao, Chun Feng Liu
OBJECTIVE: The correlation between substantia nigra (SN) hyperechogenicity on transcranial sonography (TCS) and serum iron metabolism parameters in patients with the postural instability gait difficulty (PIGD) subtype of Parkinson's disease (PD) was investigated so as to explore the pathological mechanism of SN hyperechogenicity. METHODS: The study enrolled 95 PIGD patients recruited by the Parkinson's Disease Specialty in the Second Affiliated Hospital of Soochow University during June 2019-2021...
September 2, 2023: Ultrasound in Medicine & Biology
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