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South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde

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https://read.qxmd.com/read/30606306/major-depressive-disorder-in-patients-with-diabetes-mellitus-in-pietermaritzburg-south-africa
#1
J M Jansen van Vuuren, S Pillay
BACKGROUND: Diabetes mellitus (DM) and major depressive disorder (MDD) constitute a major burden of disease. A study found that type 2 DM (DM2) is associated with a two-fold increase in risk of developing MDD worldwide - except in Africa. The present study challenges this statement. OBJECTIVES: To determine the prevalence of MDD in a cohort of patients with DM and its effect on glycaemic control. METHODS: A cross-sectional study was performed at a diabetes clinic at Edendale Hospital, Pietermaritzburg, South Africa (1 March - 31 May 2017)...
December 13, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://read.qxmd.com/read/30606305/histopathological-diagnoses-on-pleural-biopsy-specimens-over-a-15-year-period-at-chris-hani-baragwanath-academic-hospital-johannesburg-south-africa-a-retrospective-review
#2
J R Edgar, M L Wong, M Hale, C N Menezes
BACKGROUND: Pleural effusions are a common reason for presentation to healthcare facilities. Blind closed pleural biopsy can be a useful tool to diagnose their cause, especially in resource-limited settings. OBJECTIVES: To determine the aetiology, frequency and change in profile of histopathological diagnoses made at Chris Hani Baragwanath Academic Hospital (CHBAH), Johannesburg, South Africa, over the period 1 January 2001 - 31 December 2015. METHODS: Pleural biopsies performed at CHBAH and analysed by histopathologists from the National Health Laboratory Service at the hospital over the study period were retrospectively reviewed by accessing reports from two databases (DISA and TrakCare)...
December 13, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://read.qxmd.com/read/30606304/south-african-women-s-perspectives-on-self-sampling-for-cervical-cancer-screening-a-mixed-methods-study
#3
R Saidu, J Moodley, A Tergas, M Momberg, R Boa, T Wright, S Campbell, C Svanholm-Barrie, D Persing, L Kuhn, L Denny
BACKGROUND: Self-sampling as a method of screening for cervical cancer and its precursors is an attractive option for low-resource settings. However, to allow successful integration of self-sampling into national screening programmes, it is necessary to understand women's perceptions and beliefs surrounding this method of sampling the cervix. OBJECTIVES: To explore women's attitudes to self-collection of samples for cervical screening in a low-resource setting in South Africa (SA)...
December 13, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://read.qxmd.com/read/30606303/transitions-between-lifetime-alcohol-use-regular-use-and-remission-results-from-the-2004-south-african-stress-and-health-survey
#4
N Harker Burnhams, C Bharat, D R Williams, D J Stein, B Myers
BACKGROUND: Hazardous alcohol consumption presents a serious threat to the health and wellbeing of all people and is linked to chronic and acute health problems. OBJECTIVES: To: (i) estimate the prevalence of alcohol use disorders and remission from alcohol abuse and dependence in the South African (SA) population; and (ii) determine whether age of onset, education, sex and level of cohort alcohol use are associated with commencement of use, regularity of use, and transitions to and remission from more harmful levels of use...
December 13, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://read.qxmd.com/read/30606302/cost-of-intensive-care-services-at-a-central-hospital-in-south-africa
#5
S Mahomed, O H Mahomed
BACKGROUND: Intensive care services are one of the largest cost drivers in a hospital. Increasing life expectancy and comorbidities have resulted in an increased need for intensive care beds. OBJECTIVES: To conduct a cost analysis of intensive care services at a central hospital in the public sector in South Africa (SA). METHODS: A retrospective cost analysis for the 2015/16 financial year was conducted across two intensive care units (ICUs), a trauma ICU (10 beds) and a combined ICU for neurosurgery, medicine and surgery (18 beds)...
December 13, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://read.qxmd.com/read/30606301/treatment-outcomes-in-perinatally-infected-hiv-positive-adolescents-and-young-adults-after-%C3%A2-10-years-on-antiretroviral-therapy
#6
K Anderson, R Muloiwa, M-A Davies
BACKGROUND: The burden of paediatric HIV in South Africa has shifted to older children and adolescents. Nevertheless, information on long-term treatment outcomes of perinatally HIV-infected (PHIV) children is limited. OBJECTIVES: To examine long-term immunological and virological outcomes of children who were in care for at least 10 years after starting antiretroviral therapy (ART). METHODS: We performed a retrospective cohort study of 127 PHIV children who initiated ART at a Cape Town clinic between 2002 and 2005 and were followed up for ≥10 years from the ART initiation date...
December 13, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://read.qxmd.com/read/30606300/overnight-oximetry-as-a-screening-tool-for-moderate-to-severe-obstructive-sleep-apnoea-in-south-african-children
#7
M Zampoli, N Abousetta, A Vanker
BACKGROUND: Obstructive sleep apnoea (OSA) is common in children yet often overlooked, as symptom-based screening is unreliable. Polysomnography is regarded as the gold standard for the diagnosis of OSA, but is not widely available in South Africa (SA). Overnight oximetry is a validated screening tool for OSA. OBJECTIVES: To describe the impact and utility of overnight oximetry at a tertiary children's hospital in SA. METHODS: A retrospective descriptive study was conducted of patients screened for OSA by overnight oximetry at a paediatric referral hospital from December 2012 to December 2014...
December 13, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://read.qxmd.com/read/30606299/cell-and-gene-therapies-at-the-forefront-of-innovative-medical-care-implications-for-south-africa
#8
M S Pepper, M Alessandrini, A Pope, W Van Staden, R J Green
The fields of cell and gene therapy are moving rapidly towards providing innovative cures for incurable diseases. A current and highly topical example is immunotherapies involving T-cells that express chimeric antigen receptors (CAR T-cells), which have shown promise in the treatment of leukaemia and lymphoma. These new medicines are indicative of the changes we can anticipate in the practice of medicine in the near future. Despite their promise, they pose challenges for introduction into the healthcare sector in South Africa (SA), including: (i) that they are technologically demanding and their manufacture is resource intensive; (ii) that the regulatory system is underdeveloped and likely to be challenged by ethical, legal and social requirements that accompany these new therapies; and (iii) that costs are likely to be prohibitive, at least initially, and before economies of scale take effect...
December 13, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://read.qxmd.com/read/30606298/cystic-fibrosis-what-s-new-in-south-africa-in-2019
#9
M Zampoli On Behalf Of The Msac
Cystic fibrosis (CF) is one of the most common autosomal recessive disorders worldwide. The incidence of CF depends on the prevalence of CFTR (cystic fibrosis transmembrane conductance regulator) gene mutations in the population, which is determined by genetic diversity and ethnicity. Over 2 000 CFTR mutation variants, divided into six distinct functional classes, are now identified, but not all cause CF disease. Advancements in the molecular diagnosis of CF and recognition of a wider spectrum of CF severity have led to recent revision of CF diagnostic nomenclature and criteria...
December 13, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://read.qxmd.com/read/30606297/human-papillomavirus-vaccination-acceptance-and-hesitancy-in-south-africa-research-and-policy-agenda
#10
N J Ngcobo, R J Burnett, S Cooper, C S Wiysonge
Cervical cancer is responsible for one-quarter of a million deaths per year worldwide. In South Africa (SA), cervical cancer is the leading cause of cancer deaths among women aged 15 - 44 years. Human papillomavirus (HPV) vaccines provide a safe and highly effective means to reduce the burden of cervical cancer. The World Health Organization initiated a plan for the elimination of cervical cancer; the programme's success relies on the introduction and high uptake of HPV vaccines globally. SA introduced a school-based HPV vaccination programme in 2014, but uptake is not as high as expected...
December 13, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://read.qxmd.com/read/30606296/empathy-an-essential-tool-in-any-doctor-s-skillset
#11
E Archer, R Turner
No abstract text is available yet for this article.
December 13, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://read.qxmd.com/read/30606295/genomic-characterisation-of-klebsiella-michiganensis-co-producing-oxa-181-and-ndm-1-carbapenemases-isolated-from-a-cancer-patient-in-umgungundlovu-district-kwazulu-natal-province-south-africa
#12
R C Founou, L L Founou, M Allam, A Ismail, S Y Essack
No abstract text is available yet for this article.
December 13, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://read.qxmd.com/read/30606294/requesting-a-patient-to-document-her-decision-for-refusal-of-hospital-treatment-promotes-beneficence
#13
N C Ngene, C O Onyia, J Moodley
No abstract text is available yet for this article.
December 13, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://read.qxmd.com/read/30606293/establishing-a-multidisciplinary-aids-associated-kaposi-s-sarcoma-clinic-patient-characteristics-management-and-outcomes
#14
H Burger, Z Ismail, J J Taljaard
BACKGROUND: Kaposi's sarcoma (KS) typically occurs in the setting of immunodeficiency and specifically in the presence of HIV infection, when it is called AIDS-associated KS (AIDS-KS). In spite of impressive gains in the South African (SA) antiretroviral therapy (ART) roll-out programme since 2004, AIDS-KS still causes significant morbidity and mortality, and the treatment of advanced disease can be challenging owing to the centralisation of oncology services and the high incidence of concurrent infections...
November 26, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://read.qxmd.com/read/30606292/empyema-in-children-hospitalised-at-chris-hani-baragwanath-academic-hospital-johannesburg-south-africa-a-retrospective-study
#15
A Ghoor, T Mabaso, K Mopeli, A Izu, S A Madhi, S G Lala, C Verwey, Z Dangor
BACKGROUND: There is a paucity of information on empyema in children from low- and middle-income countries since the introduction of the pneumococcal conjugate vaccine. OBJECTIVES: To describe the aetiology and management of empyema in a setting of high HIV and tuberculosis (TB) prevalence. METHODS: A retrospective descriptive study was undertaken between January 2012 and December 2016 in children aged <14 years at a large secondary-tertiary referral hospital in Soweto, South Africa...
November 26, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://read.qxmd.com/read/30606291/another-piece-to-the-epidemiological-puzzle-of-traumatic-spinal-cord-injury-in-cape-town-south-africa-a-population-based-study
#16
J Phillips, J Braaf, C Joseph
BACKGROUND: The epidemiology of traumatic spinal cord injury (TSCI) is poorly understood in developing countries. In South Africa (SA) specifically, two healthcare systems (private v. government funded) exist, and it is therefore important to assess patient characteristics in order to plan appropriately. OBJECTIVES: To determine epidemiological characteristics of TSCI in the private healthcare system in Cape Town, SA, and compare findings with previously published data from the government sector...
November 26, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://read.qxmd.com/read/30606290/an-evaluation-of-warfarin-use-at-an-urban-district-level-hospital-in-kwazulu-natal-province-south-africa
#17
D J Laäs, M Naidoo
BACKGROUND: Warfarin is a commonly prescribed drug that needs to be monitored regularly. OBJECTIVES: To evaluate the quality of care of patients on warfarin and to determine the cost-effectiveness of this drug in a South African district hospital setting. METHODS: Quality of care was assessed through a structured patient interview, and cost-effectiveness of warfarin was determined by retrospective review of all costs over a 6-month period...
November 26, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://read.qxmd.com/read/30606289/a-retrospective-review-of-fatal-electrocution-cases-at-tygerberg-forensic-pathology-services-cape-town-south-africa-over-the-5-year-period-1-january-2008-31-december-2012
#18
S Von Caues, C I Herbst, S A Wadee
BACKGROUND: Electrocution as a cause of death has been discussed extensively in the international literature. However, research on this topic in South Africa (SA) is scarce. OBJECTIVES: To address the need for further research in this field and emphasise the necessity for preventive measures by determining the demographic and pathological profile of fatal electrocution cases seen in the Tygerberg Forensic Pathology Services, Western Cape Province, SA. METHODS: The study was a retrospective and descriptive case series of all the cases of death secondary to electrocution referred to the study facility from 1 January 2008 to 31 December 2012...
November 26, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://read.qxmd.com/read/30606288/a-contextualisation-approach-to-health-promotion-guideline-development-in-south-africa
#19
N Siegfried, B Draper, G Draper, M Porter, C Bonaconsa, J Hunter, L Moeng-Mahlangu, S Asmall
BACKGROUND: Risk factors for chronic illness contribute significantly to the disease burden in South Africa. The National Department of Health (NDoH) commissioned the development of a toolkit of health promotion guidelines for use by healthcare professionals working in the primary care setting to address this burden. OBJECTIVES: To (i) demonstrate the contextualisation approach to evidence-based health promotion recommendations; and (ii) present the development process of a contextually sensitive and illustrated fit-for-purpose product...
November 26, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://read.qxmd.com/read/30606287/comparison-of-xpert-gbs-v-culture-for-rapid-detection-of-group-b-streptococcus-in-pregnant-women-sensitivity-specificity-and-predictive-values
#20
M Said, Y Dangor, N Mbelle, A Sihlabela, M Lekalakala, F Ismail
BACKGROUND: Group B streptococcus (GBS) is a leading cause of invasive disease, particularly in newborns. Seventy-five percent of neonates will be colonised by mothers carrying the organism. Confirmation of maternal colonisation with GBS is essential for prompt treatment and prevention of neonatal sepsis. The current gold standard of culture for isolation of GBS has a disadvantage of long turnaround time (24 - 72 hours). Rapid assays are required to determine maternal carriage of GBS...
November 26, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
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