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Journals Scandinavian Journal of Clinic...

Scandinavian Journal of Clinical and Laboratory Investigation

https://read.qxmd.com/read/38420711/reproducibility-and-stability-of-the-immature-platelet-fraction-using-sysmex-xn-10
#1
JOURNAL ARTICLE
Usman Ali, Gavin Knight, Mridula Chopra, Dimitris A Tsitsikas
BACKGROUND: The Immature Platelet Fraction (IPF) is an indicator of thrombopoiesis which is a useful parameter in thrombocytopenia. It demonstrates compensatory mechanisms in production of platelets, but currently not implemented in routine clinical practice. The aim of this study was to establish the reproducibility and stability of IPF, for both percentage (%-IPF) and absolute (A-IPF) measurements. Material/methods: A total of 71 samples, of which 45 for reproducibility and 26 for stability analysis, were assayed for full blood count using the Sysmex XN-10 analyser at room temperature (RT:19-25 °C)...
February 29, 2024: Scandinavian Journal of Clinical and Laboratory Investigation
https://read.qxmd.com/read/38414267/secondary-polycythemia-in-acutely-ill-covid-19-patients-is-associated-with-higher-mortality-but-not-markedly-higher-thrombotic-risk
#2
JOURNAL ARTICLE
Marko Lucijanic, Ivan Krecak, Ena Soric, Anica Sabljic, Tamara Vasilj, David Cicic, Anamarija Vrkljan Vuk, Zvonimir Kremer, Ivo Dilber, Anton Glasnovic, Ozren Jaksic, Rajko Kusec
Secondary polycythemia is commonly observed among patients with chronic pulmonary diseases. However, its significance in the context of Coronavirus disease 2019 (COVID-19) is unknown. We retrospectively evaluated a total of 5872 hospitalized COVID-19 patients with mostly severe and critical symptoms, and without prior or subsequently diagnosed myeloproliferative neoplasm. Patients were stratified based on admission hemoglobin into four subgroups: anemia (hemoglobin <120 g/L for females and 130 g/L for males), normal hemoglobin, mild (hemoglobin 160-165 g/L for females and 165-185 g/L for males) and severe polycythemia (hemoglobin >165 g/L for females and >185 g/L for males)...
February 27, 2024: Scandinavian Journal of Clinical and Laboratory Investigation
https://read.qxmd.com/read/38402583/plasma-metabolomics-for-diagnostic-biomarkers-on-ectopic-pregnancy
#3
JOURNAL ARTICLE
Ozan Kaplan, Sezin Ertürk Aksakal, Bilge Başak Fidan, Yaprak Engin-Üstün, Mustafa Çelebier
Metabolomics is a relatively novel omics tool to provide potential biomarkers for early diagnosis of the diseases and to insight the pathophysiology not having discussed ever before. In the present study, an ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) was employed to the plasma samples of Group T1: Patients with ectopic pregnancy diagnosed using ultrasound, and followed-up with beta-hCG level ( n  = 40), Group T2: Patients with ectopic pregnancy diagnosed using ultrasound, underwent surgical treatment and confirmed using histopathology ( n  = 40), Group P: Healthy pregnant women ( n  = 40) in the first prenatal visit of pregnancy, Group C: Healthy volunteers ( n  = 40) scheduling a routine gynecological examination...
February 25, 2024: Scandinavian Journal of Clinical and Laboratory Investigation
https://read.qxmd.com/read/38385221/correction
#4
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
February 22, 2024: Scandinavian Journal of Clinical and Laboratory Investigation
https://read.qxmd.com/read/38381053/measurement-of-plasma-total-calcium-before-plasma-free-ionized-calcium-a-possibility-with-affordable-pitfalls
#5
JOURNAL ARTICLE
Tobias Skou Kjøller, Bent S Lind, Peter Schwarz, Henrik L Jørgensen
Free ionized calcium (fCa) is considered the gold standard for assessing calcium status in patients, but it is relatively expensive and is associated with several preanalytical and analytical error sources. We investigated the feasibility of using a reflex test that involves first measuring total calcium (tCa) and if out of reference range, then measure fCa, with expectation of reducing the number of fCa measurements. We used data from 1815 unique patients with concurrent measurement of fCa, tCa and albumin adjusted calcium (aCa)...
February 21, 2024: Scandinavian Journal of Clinical and Laboratory Investigation
https://read.qxmd.com/read/38376201/reliability-of-a-point-of-care-testing-blood-gas-analyzer-for-measurement-of-lactate-levels-in-cerebrospinal-fluid
#6
JOURNAL ARTICLE
Alberto Fernández Reina, María Dolores López Abellán, Samir Attaibi Hadri, Ángela Puche Candel, María Isabel Díaz López, Eva Pérez Fernández, Manuel Tomás Orgaz Morales, Luis García de Guadiana-Romualdo
Analysis of cerebrospinal fluid (CSF), including lactate, is key for diagnosis of acute meningitis. Since blood gas analyzers (BGA) enable rapid and safe blood-lactate measurements, we evaluated the reliability of RAPIDPoint 500 BGA to provide a fast and accurate measure of CSF lactate. In this study, CSF lactate levels were measured by a reference assay and on RAPIDPoint 500 BGA. Comparability was evaluated through difference analysis, using Bland Altman test, and linear regression analysis, using the Passing Bablok test...
February 20, 2024: Scandinavian Journal of Clinical and Laboratory Investigation
https://read.qxmd.com/read/38362664/abbott-d-dimer-assay-analytical-performance-and-diagnostic-accuracy-in-management-of-venous-thromboembolism
#7
JOURNAL ARTICLE
Ivana Lapić, Anamarija Bogić, Ivana Stojan, Dunja Rogić
This study aimed to assess analytical characteristics and diagnostic accuracy in management of venous thromboembolism (VTE) in the Emergency Department (ED) of the Abbott D-dimer assay applied on the Alinity c clinical chemistry analyzer (Abbott Laboratories, Chicago, IL) compared to the INNOVANCE D-dimer assay (Siemens Healthineers, Marburg, Germany). Precision was determined at three concentration levels following the CLSI EP15-A3 protocol. Method comparison and diagnostic accuracy were assessed using samples obtained from 85 patients who were referred for diagnostic imaging and D-dimer testing due to clinically suspected VTE...
February 16, 2024: Scandinavian Journal of Clinical and Laboratory Investigation
https://read.qxmd.com/read/38329472/ige-kappa-multiple-myeloma-with-kappa-free-light-chain-a-case-report
#8
JOURNAL ARTICLE
Yuyi Hu, Wenqi Shao, Baishen Pan, Beili Wang, Wei Guo
No abstract text is available yet for this article.
February 8, 2024: Scandinavian Journal of Clinical and Laboratory Investigation
https://read.qxmd.com/read/38319290/plasma-legumain-in-familial-hypercholesterolemia-associations-with-statin-use-and-cardiovascular-risk-markers
#9
JOURNAL ARTICLE
Ida Gregersen, Ingunn Narverud, Jacob Juel Christensen, Anders Hovland, Linn K L Øyri, Thor Ueland, Kjetil Retterstøl, Martin P Bogsrud, Pål Aukrust, Bente Halvorsen, Kirsten B Holven
Legumain is known to be regulated in atherosclerotic disease and may have both pro- and anti-atherogenic properties. The study aimed to explore legumain in individuals with familial hypercholesterolemia (FH), a population with increased cardiovascular risk. Plasma legumain was measured in 251 subjects with mostly genetically verified FH, of which 166 were adults (≥18 years) and 85 were children and young adults (<18 years) and compared to 96 normolipidemic healthy controls. Plasma legumain was significantly increased in the total FH population compared to controls (median 4...
February 6, 2024: Scandinavian Journal of Clinical and Laboratory Investigation
https://read.qxmd.com/read/38319177/pre-analytical-diagnostic-differences-despite-high-adherence-to-guidelines-for-gestational-diabetes-mellitus
#10
JOURNAL ARTICLE
Cathrine Scavenius, Eva Rabing Brix Petersen, Dorte Møller Jensen, Lene Ringholm, Jakoba Sevdal Danielsen, Elisabeth Reinhardt Mathiesen, David McIntyre, Peter Damm, Martin Overgaard, Tine Dalsgaard Clausen
Regional variations in the prevalence of gestational diabetes mellitus (GDM) have been found across Denmark. The objectives of this exploratory survey were to evaluate adherence to the national guideline for screening and diagnosing GDM and to identify variations in pre-analytical or analytical factors, which could potentially contribute to variations in GDM prevalence across regions. In a national interview-based survey, obstetric departments and laboratories throughout Denmark handling GDM screening or diagnostic testing were invited to participate...
February 6, 2024: Scandinavian Journal of Clinical and Laboratory Investigation
https://read.qxmd.com/read/38300114/a-case-of-platelet-%C3%AE-granule-defect-identified-by-decreased-cd63-expression-and-decreased-serotonin-release-measured-by-flow-cytometry-and-liquid-chromatography-tandem-mass-spectrometry
#11
JOURNAL ARTICLE
Peter H Nissen, Torben Stamm Mikkelsen, Carsten Schriver Højskov, Johanne Andersen Højbjerg
No abstract text is available yet for this article.
February 1, 2024: Scandinavian Journal of Clinical and Laboratory Investigation
https://read.qxmd.com/read/38265854/kinetics-of-insulin-and-c-peptide-and-estimation-of-prehepatic-insulin-secretion-rates-after-intravenous-glucose-stimulation-using-arterial-versus-venous-blood-sampling-in-healthy-males
#12
JOURNAL ARTICLE
Emil Brink Wriedt, Urd Kielgast, Maria S Svane, Søren Møller, Sten Madsbad
An intravenous glucose-infusion of 0.3 g glucose per Kg body weight was administered over 1 min in nine healthy males with simultaneous blood sampling from the hepatic vein, femoral artery and a peripheral vein. Insulin secretion rates (ISR) were determined by the Eaton method and the ISEC method using C-peptide concentrations from arterial and peripheral venous blood. First phase (0-10 min), second phase (10-60 min), and total insulin secretion (0-60 min) were calculated as the incremental areas (iAUC) above baseline...
January 24, 2024: Scandinavian Journal of Clinical and Laboratory Investigation
https://read.qxmd.com/read/38265850/duplicate-measures-of-hemoglobin-mass-within-an-hour-feasibility-reliability-and-comparison-of-three-devices-in-supine-position
#13
JOURNAL ARTICLE
Andreas Breenfeldt Andersen, Thomas Christian Bonne, Nikolai Baastrup Nordsborg, Henrik Holm-Sørensen, Jacob Bejder
Duplicate measure of hemoglobin mass by carbon monoxide (CO)-rebreathing is a logistical challenge as recommendations prompt several hours between measures to minimize CO-accumulation. This study investigated the feasibility and reliability of performing duplicate CO-rebreathing procedures immediately following one another. Additionally, it was evaluated whether the obtained hemoglobin mass from three different CO-rebreathing devices is comparable. Fifty-five healthy participants (22 males, 23 females) performed 222 duplicate CO-rebreathing procedures in total...
January 24, 2024: Scandinavian Journal of Clinical and Laboratory Investigation
https://read.qxmd.com/read/38240284/analysis-of-hba1c-using-microfluidic-card-capitainer-qdbs-card-as-a-pre-step-before-determination-of-the-hba1c-value-with-an-immunological-method
#14
JOURNAL ARTICLE
Niclas Rollborn, Anders Larsson, Kim Kultima
The objective of the study was to evaluate Capitainer's quantitative dried blood spots (qDBS) card for Hemoglobin A1c (HbA1c) testing. qDBS cards can be used for at-home sampling for HbA1c determination in a Swedish laboratory setting. A total of 153 routine requested HbA1c samples were used in this evaluation of microfluidic cards (qDBS). The HbA1c was extracted from the disc and HbA1c was determined at cobas 6000 instruments with immunological technology. The results were compared with results from traditional venous HbA1c testing...
January 19, 2024: Scandinavian Journal of Clinical and Laboratory Investigation
https://read.qxmd.com/read/38226930/dysmagnesemia-as-a-predictor-of-developing-diabetic-levels-of-hemoglobin%C3%A2-a1c
#15
JOURNAL ARTICLE
Solav Aziz Ali, Anna Elise Engell, Bent Struer Lind, Henrik Løvendahl Jørgensen
The aim of this study was to assess the possible association between P-Mg and subsequent high levels of HbA1c. The study involves data from primary health care patients and data from patients treated in hospitals located in the capital region of Denmark. P-Mg and HbA1c levels were analyzed from 121,575 patients in the period 2010-2022. Patients were categorized in a diabetic and non-diabetic group. Out of 121,575 patients, 8,532 were categorized as diabetic. A reverse J-shaped association between P-Mg and HbA1c levels ≥ 48 mmol/mol was observed with nadir at P-Mg of 0...
January 16, 2024: Scandinavian Journal of Clinical and Laboratory Investigation
https://read.qxmd.com/read/38219224/reference-standard-analysis-of-multiple-new-and-old-plasma-clearance-models-and-renal-clearance-with-special-attention-to-measurement-of-reduced-glomerular-filtration-rate
#16
JOURNAL ARTICLE
Carl A Wesolowski
Nine models were evaluated as candidate glomerular filtration rate (GFR) reference standards in three datasets using [51 Cr(EDTA)]- or [169 Yb(DTPA)]2- anions in 98 studies. Noncompartmental methods formed an upper limit for estimating mass excreted and voluntary urine collection formed a lower limit. For current models and methods, reduced GFR in adults resulted in inflated clearance estimates. Two different logarithmic models with exponential tails were created and may have underestimated reduced clearance...
January 14, 2024: Scandinavian Journal of Clinical and Laboratory Investigation
https://read.qxmd.com/read/38193733/validation-of-the-hem-col-capillary-blood-collection-system-for-routine-laboratory-analyses
#17
JOURNAL ARTICLE
Steef Kurstjens, Marjon J den Besten, Dorien A M van Dartel, Marloes C C van Gend, Lizzy Meerts, Rein M J Hoedemakers
At home collection of capillary blood using Hem-Col tubes (Labonovum) could offer a solution to patients with chronic conditions, who require frequent laboratory analyses. The collection tubes contain a conservation buffer to stabilize analytes for up to 5 days. In this validation study it was investigated whether analytes are measured accurately in Hem-Col tubes 5 days after collection. Forty-six healthy volunteers donated blood via venepuncture as well as capillary blood by finger prick using Hem-Col tubes...
January 9, 2024: Scandinavian Journal of Clinical and Laboratory Investigation
https://read.qxmd.com/read/38165140/correction
#18
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
January 2, 2024: Scandinavian Journal of Clinical and Laboratory Investigation
https://read.qxmd.com/read/38156824/serum-inter%C3%AE-trypsin-inhibitor-heavy-chain-h4-may-be-an-anti-inflammatory-marker-reflecting-disease-risk-activity-and-treatment-outcome-of-ankylosing-spondylitis
#19
JOURNAL ARTICLE
Zhumin Sun, Yang Zhang, Haiyan Zhou, Jingyun Li, Yue Zhou, Liyun Wang
Interα-trypsin inhibitor heavy chain H4 (ITIH4) modulates inflammation and immunity, which take part in the pathogenesis of ankylosing spondylitis (AS). The current research intended to discover the clinical value of serum ITIH4 quantification for AS management. Serum ITIH4 among 80 AS patients before current treatment initiation (baseline) at weeks (W) 4, 8 and 12 after treatment was detected by ELISA. Serum ITIH4 from 20 disease controls (DCs) and 20 healthy controls (HCs) was detected. ITIH4 expression was lower in AS patients than in DCs ( p  = 0...
December 29, 2023: Scandinavian Journal of Clinical and Laboratory Investigation
https://read.qxmd.com/read/38145316/vitamin-b12-insufficiency-and-deficiency-a-review-of-nondisease-risk-factors
#20
REVIEW
Omar Abuyaman, Ali Abdelfattah, Faten Shehadeh-Tout, Ahmad A Deeb, Ma'mon M Hatmal
Vitamin B12 deficiency and insufficiency can lead to both hematological and neurological impairments. This review examines nondisease causes and risk factors associated with dietary availability, such as eating habits, food processing, cooking techniques, and bioavailability, as well as increased physiological needs and iatrogenic factors linked to medication use or surgical procedures. As a result of these nondisease influences, groups at higher risk include vegans, vegetarians, older adults, individuals with limited diets, breastfed and preterm infants, and those who primarily consume foods prepared or cooked in ways that reduce vitamin B12 content, as well as individuals on certain medications or who have undergone specific surgeries...
December 25, 2023: Scandinavian Journal of Clinical and Laboratory Investigation
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