Xiao-Xia Chai, Jie Liu, Tong-Yao Yu, Ge Zhang, Wen-Jun Sun, Yan Zhou, Li Ren, Hui-Ling Cao, Da-Chuan Yin, Chen-Yan Zhang
The mechanical environment is important for tumorigenesis and progression. Tumor cells can sense mechanical signals by mechanosensitive receptors, and these mechanical signals can be converted to biochemical signals to regulate cell behaviors, such as cell differentiation, proliferation, migration, apoptosis, and drug resistance. Here, we summarized the effects of the mechanical microenvironment on breast cancer cell activity, and mechanotransduction mechanism from cellular microenvironment to cell membrane, and finally to the nucleus, and also relative mechanosensitive proteins, ion channels, and signaling pathways were elaborated, therefore the mechanical signal could be transduced to biochemical or molecular signal...
October 2, 2023: Progress in Biophysics and Molecular Biology