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Journals Progress in Biophysics and Mol...

Progress in Biophysics and Molecular Biology

https://read.qxmd.com/read/38036101/cold-snapshots-of-dna-repair-cryo-em-structures-of-dna-pkcs-and-nhej-machinery
#21
REVIEW
Himani Amin, Sayma Zahid, Chloe Hall, Amanda K Chaplin
The proteins and protein assemblies involved in DNA repair have been the focus of a multitude of structural studies for the past few decades. Historically, the structures of these protein complexes have been resolved by X-ray crystallography. However, more recently with the advancements in cryo-electron microscopy (cryo-EM) ranging from optimising the methodology for sample preparation to the development of improved electron detectors, the focus has shifted from X-ray crystallography to cryo-EM. This methodological transition has allowed for the structural determination of larger, more complex protein assemblies involved in DNA repair pathways and has subsequently led to a deeper understanding of the mechanisms utilised by these fascinating molecular machines...
November 28, 2023: Progress in Biophysics and Molecular Biology
https://read.qxmd.com/read/38030044/how-can-phycobilisome-the-unique-light-harvesting-system-in-certain-algae-working-highly-efficiently-the-connection-in-between-structures-and-functions
#22
REVIEW
Runze Liu, Zhang-He Zhen, Wenjun Li, Baosheng Ge, Song Qin
Algae, which are ubiquitous in ecosystems, have evolved a variety of light-harvesting complexes to better adapt to diverse habitats. Phycobilisomes, unique to cyanobacteria, red algae, and certain cryptomonads, compensate for the lack of chlorophyll absorption, allowing algae to capture and efficiently transfer light energy in aquatic environments. With the advancement of microscopy and spectroscopy, the structure and energy transfer processes of increasingly complex phycobilisomes have been elucidated, providing us with a vivid portrait of the dynamic adaptation of their structures to the light environment in which algae thrive: 1) Surface-dwelling cyanobacteria employ short, small phycobilisomes to absorb red-orange light and reduce the damage from blue-violet light via multiple methods; 2) Large red algae inhabiting the depths of the ocean have evolved long and dense phycobilisomes containing phycoerythrin to capture the feeble blue-green light; 3) In far-red light environments such as caves, algae use special allophycocyanin cores to optimally utilize the far-red light; 4) When the environment shifts, algae can adjust the length, composition and density of their rods to better adapt; 5) By carefully designing the position of the pigments, phycobilisomes can transfer light energy to the reaction center with nearly 100% efficiency via three energy transfer processes...
November 27, 2023: Progress in Biophysics and Molecular Biology
https://read.qxmd.com/read/38006982/cells-and-sounds
#23
JOURNAL ARTICLE
Michael Spitzer
No abstract text is available yet for this article.
November 23, 2023: Progress in Biophysics and Molecular Biology
https://read.qxmd.com/read/37967622/shannon-s-informational-dissipation-as-the-major-engine-leading-to-living-dynamic-and-the-origin-of-self
#24
LETTER
Salvatore Chirumbolo, Antonio Vella
No abstract text is available yet for this article.
November 13, 2023: Progress in Biophysics and Molecular Biology
https://read.qxmd.com/read/37944568/growth-or-death-control-of-cell-destiny-by-mtor-and-autophagy-pathways
#25
REVIEW
Mahmoud I Khalil, Mohamad M Ali, Jasmine Holail, Marwa Houssein
One of the central regulators of cell growth, proliferation, and metabolism is the mammalian target of rapamycin, mTOR, which exists in two structurally and functionally different complexes: mTORC1 and mTORC2; unlike m TORC2, mTORC1 is activated in response to the sufficiency of nutrients and is inhibited by rapamycin. mTOR complexes have critical roles not only in protein synthesis, gene transcription regulation, proliferation, tumor metabolism, but also in the regulation of the programmed cell death mechanisms such as autophagy and apoptosis...
November 7, 2023: Progress in Biophysics and Molecular Biology
https://read.qxmd.com/read/37866471/how-an-emergent-cosmology-of-a-nonlocally-unified-meaningfully-in-formed-and-holographically-manifested-universe-can-underpin-and-frame-the-biological-embodiment-of-quantum-entanglement
#26
JOURNAL ARTICLE
Jude Currivan
With a Nobel Prize for Physics widely viewed as only given for 'settled' science, the award then essentially accepts the validity of universal nonlocality. Other key discoveries and insights in recent years are also progressively pointing to the appearance of our Universe, its energy-matter and space-time, as not being foundational but emerging from deeper, discarnate realms of causation. as digitized and meaningful, in-formation, its manifestation pixelated at the so-named Planck scale of existence. Extending from studies of black holes to the entire Universe, a growing number of cosmologists have also developed the so-named holographic principle, to model the four-dimensional appearance of our Universe (three dimensions of space and one of time) as a holographic projection of its two- dimensional boundary...
October 20, 2023: Progress in Biophysics and Molecular Biology
https://read.qxmd.com/read/37821048/computational-approaches-for-modeling-and-structural-design-of-biological-systems-a-comprehensive-review
#27
REVIEW
Ekambaram Gayathiri, Palanisamy Prakash, Priya Kumaravel, Jayanthi Jayaprakash, Manikkavalli Gurunathan Ragunathan, Sharmila Sankar, Saravanan Pandiaraj, Natesan Thirumalaivasan, Muthu Thiruvengadam, Rajakumar Govindasamy
The convergence of biology and computational science has ushered in a revolutionary era, revolutionizing our understanding of biological systems and providing novel solutions to global problems. The field of genetic engineering has facilitated the manipulation of genetic codes, thus providing opportunities for the advancement of innovative disease therapies and environmental enhancements. The emergence of bio-molecular simulation represents a significant advancement in this particular field, as it offers the ability to gain microscopic insights into molecular-level biological processes over extended periods...
October 9, 2023: Progress in Biophysics and Molecular Biology
https://read.qxmd.com/read/37793504/recent-progress-of-mechanosensitive-mechanism-on-breast-cancer
#28
REVIEW
Xiao-Xia Chai, Jie Liu, Tong-Yao Yu, Ge Zhang, Wen-Jun Sun, Yan Zhou, Li Ren, Hui-Ling Cao, Da-Chuan Yin, Chen-Yan Zhang
The mechanical environment is important for tumorigenesis and progression. Tumor cells can sense mechanical signals by mechanosensitive receptors, and these mechanical signals can be converted to biochemical signals to regulate cell behaviors, such as cell differentiation, proliferation, migration, apoptosis, and drug resistance. Here, we summarized the effects of the mechanical microenvironment on breast cancer cell activity, and mechanotransduction mechanism from cellular microenvironment to cell membrane, and finally to the nucleus, and also relative mechanosensitive proteins, ion channels, and signaling pathways were elaborated, therefore the mechanical signal could be transduced to biochemical or molecular signal...
October 2, 2023: Progress in Biophysics and Molecular Biology
https://read.qxmd.com/read/37769974/hif-1%C3%AE-and-periodontitis-novel-insights-linking-host-environment-interplay-to-periodontal-phenotypes
#29
REVIEW
Chao Shan, YuNing Xia, Zeyu Wu, Jin Zhao
Periodontitis, the sixth most prevalent epidemic disease globally, profoundly impacts oral aesthetics and masticatory functionality. Hypoxia-inducible factor-1α (HIF-1α), an oxygen-dependent transcriptional activator, has emerged as a pivotal regulator in periodontal tissue and alveolar bone metabolism, exerts critical functions in angiogenesis, erythropoiesis, energy metabolism, and cell fate determination. Numerous essential phenotypes regulated by HIF are intricately associated with bone metabolism in periodontal tissues...
September 26, 2023: Progress in Biophysics and Molecular Biology
https://read.qxmd.com/read/37722629/piezo1%C3%AF-the-potential-new-therapeutic-target-for-fibrotic-diseases
#30
REVIEW
Xin Liu, Weipin Niu, Shuqing Zhao, Wenjuan Zhang, Zhao Ying, Jing Li
Fibrosis is a pathological process that occurs in various organs, characterized by excessive deposition of extracellular matrix (ECM), leading to structural damage and, in severe cases, organ failure. Within the fibrotic microenvironment, mechanical forces play a crucial role in shaping cell behavior and function, yet the precise molecular mechanisms underlying how cells sense and transmit these mechanical cues, as well as the physical aspects of fibrosis progression, remain less understood. Piezo1, a mechanosensitive ion channel protein, serves as a pivotal mediator, converting mechanical stimuli into electrical or chemical signals...
September 16, 2023: Progress in Biophysics and Molecular Biology
https://read.qxmd.com/read/37666284/application-of-nanomaterials-as-potential-quorum-quenchers-for-disease-recent-advances-and-challenges
#31
JOURNAL ARTICLE
Saad Alghamdi, Krisha Khandelwal, Soumya Pandit, Arpita Roy, Subhasree Ray, Ahad Amer Alsaiari, Abdulelah Aljuaid, Mazen Almehmadi, Mamdouh Allahyani, Rohit Sharma, Jigisha Anand, Ahmad Adnan Alshareef
Chemical signal molecules are used by bacteria to interact with one another. Small hormone-like molecules known as autoinducers are produced, released, detected, and responded to during chemical communication. Quorum Sensing (QS) is the word for this procedure; it allows bacterial populations to communicate and coordinate group behavior. Several research has been conducted on using inhibitors to prevent QS and minimize the detrimental consequences. Through the enzymatic breakdown of the autoinducer component, by preventing the formation of autoinducers, or by blocking their reception by adding some compounds (inhibitors) that can mimic the autoinducers, a technique known as "quorum quenching" (QQ) disrupts microbial communication...
September 2, 2023: Progress in Biophysics and Molecular Biology
https://read.qxmd.com/read/37652186/an-overview-of-polymer-surface-coated-synthetic-quantum-dots-as-therapeutics-and-sensors-applications
#32
REVIEW
Ancha Kishore Babu, M K Mohan Maruga Raja, Mehrukh Zehravi, Badrud Duza Mohammad, Mohammed Imran Anees, Cheepurupalli Prasad, Barrawaz Aateka Yahya, Rokeya Sultana, Rohit Sharma, Jay Singh, Khalid Ali Khan, Falak A Siddiqui, Sharuk L Khan, Talha Bin Emran
Quantum dots (QDs) are a class of remarkable materials that have garnered significant attention since their initial discovery. It is noteworthy to mention that it took approximately a decade for these materials to be successfully implemented in practical applications. While QDs have demonstrated notable optical properties, it is important to note that these attributes alone have not rendered them a feasible substitute for traditional organic dyes. Furthermore, it is worth noting that the substance under investigation exhibited inherent toxicity and instability in its initial state, primarily due to the presence of a heavy metal core...
August 29, 2023: Progress in Biophysics and Molecular Biology
https://read.qxmd.com/read/37648087/advances-in-surface-enhanced-raman-spectroscopy-based-sensors-for-detection-of-various-biomarkers
#33
REVIEW
Nidhi Chauhan, Kirti Saxena, Rachna Rawal, Lalit Yadav, Utkarsh Jain
Surface enhanced Raman spectroscopy (SERS) allows the ultrasensitive detection of analytes present in traces or even single molecule levels by the generation of electromagnetic fields. It is a powerful vibrational spectroscopic method that is capable to detect traces of chemical and biological analytes. SERS technique is involved in the extremely sophisticated studies of molecules with high specificity and sensitivity. In the vicinity of nanomaterials decorated surfaces, SERS can monitor extremely low concentrations of analytes in a non-destructive manner with narrow line widths...
August 28, 2023: Progress in Biophysics and Molecular Biology
https://read.qxmd.com/read/37579795/commentary-on-a-systematic-review-on-machine-learning-and-deep-learning-techniques-in-cancer-survival-prediction-validation-of-survival-methods
#34
LETTER
J Sidorova, J J Lozano
No abstract text is available yet for this article.
August 12, 2023: Progress in Biophysics and Molecular Biology
https://read.qxmd.com/read/37499766/a-systematic-review-on-intracranial-aneurysm-and-hemorrhage-detection-using-machine-learning-and-deep-learning-techniques
#35
REVIEW
S Nafees Ahmed, P Prakasam
The risk of discovering an intracranial aneurysm during the initial screening and follow-up screening are reported as around 11%, and 7% respectively (Zuurbie et al., 2023) to these mass effects, unruptured aneurysms frequently generate symptoms, however, the real hazard occurs when an aneurysm ruptures and results in a cerebral hemorrhage known as a subarachnoid hemorrhage. The objective is to study the multiple kinds of hemorrhage and aneurysm detection problems and develop machine and deep learning models to recognise them...
July 25, 2023: Progress in Biophysics and Molecular Biology
https://read.qxmd.com/read/37369293/method-versatility-in-rna-extraction-free-pcr-detection-of-sars-cov-2-in-saliva-samples
#36
JOURNAL ARTICLE
Orchid M Allicock, Devyn Yolda-Carr, Rebecca Earnest, Mallery I Breban, Noel Vega, Isabel M Ott, Chaney Kalinich, Tara Alpert, Anne L Wyllie
Early in the pandemic, a simple, open-source, RNA extraction-free RT-qPCR protocol for SARS-CoV-2 detection in saliva was developed and made widely available. This simplified approach (SalivaDirect) requires only sample treatment with proteinase K prior to PCR testing. However, feedback from clinical laboratories highlighted a need for a flexible workflow that can be seamlessly integrated into their current health and safety requirements for the receiving and handling of potentially infectious samples. To address these varying needs, we explored additional pre-PCR workflows...
June 25, 2023: Progress in Biophysics and Molecular Biology
https://read.qxmd.com/read/37343790/biological-evolution-requires-an-emergent-self-organizing-principle
#37
REVIEW
Olen R Brown, David A Hullender
In this perspective review, we assess fundamental flaws in Darwinian evolution, including its modern versions. Fixed mutations 'explain' microevolution but not macroevolution including speciation events and the origination of all the major body plans of the Cambrian explosion. Complex, multifactorial change is required for speciation events and inevitably requires self-organization beyond what is accomplished by known mechanisms. The assembly of ribosomes and ATP synthase are specific examples. We propose their origin is a model for what is unexplained in biological evolution...
June 19, 2023: Progress in Biophysics and Molecular Biology
https://read.qxmd.com/read/37307955/a-review-exploring-the-metabolic-and-structural-characterisation-of-beta-pleated-amyloid-fibril-in-human-tissue-using-raman-spectrometry-and-saxs
#38
REVIEW
N S Mohd Nor Ihsan, S F Abdul Sani, L M Looi, P L Cheah, S F Chiew, Dharini Pathmanathan, D A Bradley
Amyloidosis is a deleterious condition caused by abnormal amyloid fibril build-up in living tissues. To date, 42 proteins that are linked to amyloid fibrils have been discovered. Amyloid fibril structure variation can affect the severity, progression rate, or clinical symptoms of amyloidosis. Since amyloid fibril build-up is the primary pathological basis for various neurodegenerative illnesses, characterization of these deadly proteins, particularly utilising optical techniques have been a focus. Spectroscopy techniques provide significant non-invasive platforms for the investigation of the structure and conformation of amyloid fibrils, offering a wide spectrum of analyses ranging from nanometric to micrometric size scales...
June 10, 2023: Progress in Biophysics and Molecular Biology
https://read.qxmd.com/read/37302516/cross-talk-between-non-ionizing-electromagnetic-fields-and-metastasis-emt-and-hybrid-e-m-may-explain-the-anticancer-role-of-emfs
#39
REVIEW
Romina Mehdizadeh, Alireza Madjid Ansari, Flora Forouzesh, Reyhane Ghadirian, Fatemeh Shahriari, Seyed Peyman Shariatpanahi, Mohammad Amin Javidi
Recent studies have shown that non-ionizing electromagnetic fields (NIEMFs) in a specific frequency, intensity, and exposure time can have anti-cancer effects on various cancer cells; however, the underlying precise mechanism of action is not transparent. Most cancer deaths are due to metastasis. This important phenomenon plays an inevitable role in different steps of cancer including progression and development. It has different stages including invasion, intravasation, migration, extravasation, and homing...
June 9, 2023: Progress in Biophysics and Molecular Biology
https://read.qxmd.com/read/37268025/a-revised-central-dogma-for-the-21st-century-all-biology-is-cognitive-information-processing
#40
JOURNAL ARTICLE
William B Miller, František Baluška, Arthur S Reber
Crick's Central Dogma has been a foundational aspect of 20th century biology, describing an implicit relationship governing the flow of information in biological systems in biomolecular terms. Accumulating scientific discoveries support the need for a revised Central Dogma to buttress evolutionary biology's still-fledgling migration from a Neodarwinian canon. A reformulated Central Dogma to meet contemporary biology is proposed: all biology is cognitive information processing. Central to this contention is the recognition that life is the self-referential state, instantiated within the cellular form...
May 31, 2023: Progress in Biophysics and Molecular Biology
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