Journals Progress in Biophysics and Mol...

Progress in Biophysics and Molecular Biology
John S Torday, Moshe Klein, Oded Maimon
The cell-cell signaling mechanisms that are the basis for all of physiology have been used to trace evolution back to the unicellular state, and beyond, to the "First Principles of Physiology". And since our physiology derives from the Cosmos based on Symbiogenesis, it has been hypothesized that the cell behaves like a functional Mobius Strip, having no 'inside or outside' cell membrane surface - it is continuous with the Cosmos, its history being codified from Quantum Entanglement to Newtonian Mechanics, affording the cell consciousness and unconsciousness/subconsciousness as a continuum for the first time...
December 28, 2023: Progress in Biophysics and Molecular Biology
Olen R Brown, David A Hullender
Artificial Intelligence (AI), as an academic discipline, is traceable to the mid-1950s but it is currently exploding in applications with successes and concerns. AI can be defined as intelligence demonstrated by computers, with intelligence difficult to define but it must include concepts of ability to learn, reason, and generalize from a vast amount of information and, we propose, to infer meaning. The type of AI known as general AI, has strong, but unrealized potential both for assessing and also for solving major problems with the scientific theory of Darwinian evolution, including its modern variants and for origin of life studies...
December 23, 2023: Progress in Biophysics and Molecular Biology
Mark William Johnson
One of the foundational principles of recent developments in evolutionary biology has been the acknowledgement of homeostasis as an organising principle of cellular development from unicellular origins. Fundamentally, this concerns the balance between the inside of a biological entity and its environment. Given that the organ of balance is the ear, and that the evolutionary provenance of the vestibular system can be traced back to fish, music provides a rich foundation for evolutionary biological inquiry. This paper considers a specific dimensional relationship in sonic experience between noise, signal, redundancy and anticipation...
December 14, 2023: Progress in Biophysics and Molecular Biology
Dan Cohen
Family Constellations are an emerging therapeutic approach fot working with local and non-local consciousness. First developed by German psychoanalyst Bert Hellinger, and now practiced by thousands of licensed and un-licensed facilitators globally, Family Constellations are a transpersonal and systemically oriented therapeutic process. Their aim is to address a focus client's emotional, behavioral, relational, or somatic issues by uncovering and resolving transgenerational entanglements within their family system...
December 3, 2023: Progress in Biophysics and Molecular Biology
Mansi Chaturvedi, Monika Patel, Archana Tiwari, Neeraj Dwivedi, D P Mondal, Avanish Kumar Srivastava, Chetna Dhand
Since ancient times, Tuberculosis (TB) has been a severe invasive illness that has been prevalent for thousands of years and is also known as "consumption" or phthisis. TB is the most common chronic lung bacterial illness in the world, killing over 2 million people each year, caused by Mycobacterium tuberculosis (MTB). As per the reports of WHO, in spite of technology advancements, the average rate of decline in global TB infections from 2000-2018 was only 1.6% per year, and the worldwide reduction in TB deaths was only 11%...
December 3, 2023: Progress in Biophysics and Molecular Biology
Keith Baverstock
The gene can be described as the foundational concept of modern biology. As such, it has spilled over into daily discourse, yet it is acknowledged among biologists to be ill-defined. Here, following a short history of the gene, I analyse critically its role in inheritance, evolution, development, and morphogenesis. Wilhelm Johannsen's genotype-conception, formulated in 1910, has been adopted as the foundation stone of genetics, giving the gene a higher degree of prominence than is justified by the evidence...
December 2, 2023: Progress in Biophysics and Molecular Biology
Himani Amin, Sayma Zahid, Chloe Hall, Amanda K Chaplin
The proteins and protein assemblies involved in DNA repair have been the focus of a multitude of structural studies for the past few decades. Historically, the structures of these protein complexes have been resolved by X-ray crystallography. However, more recently with the advancements in cryo-electron microscopy (cryo-EM) ranging from optimising the methodology for sample preparation to the development of improved electron detectors, the focus has shifted from X-ray crystallography to cryo-EM. This methodological transition has allowed for the structural determination of larger, more complex protein assemblies involved in DNA repair pathways and has subsequently led to a deeper understanding of the mechanisms utilised by these fascinating molecular machines...
November 28, 2023: Progress in Biophysics and Molecular Biology
Runze Liu, Zhang-He Zhen, Wenjun Li, Baosheng Ge, Song Qin
Algae, which are ubiquitous in ecosystems, have evolved a variety of light-harvesting complexes to better adapt to diverse habitats. Phycobilisomes, unique to cyanobacteria, red algae, and certain cryptomonads, compensate for the lack of chlorophyll absorption, allowing algae to capture and efficiently transfer light energy in aquatic environments. With the advancement of microscopy and spectroscopy, the structure and energy transfer processes of increasingly complex phycobilisomes have been elucidated, providing us with a vivid portrait of the dynamic adaptation of their structures to the light environment in which algae thrive: 1) Surface-dwelling cyanobacteria employ short, small phycobilisomes to absorb red-orange light and reduce the damage from blue-violet light via multiple methods; 2) Large red algae inhabiting the depths of the ocean have evolved long and dense phycobilisomes containing phycoerythrin to capture the feeble blue-green light; 3) In far-red light environments such as caves, algae use special allophycocyanin cores to optimally utilize the far-red light; 4) When the environment shifts, algae can adjust the length, composition and density of their rods to better adapt; 5) By carefully designing the position of the pigments, phycobilisomes can transfer light energy to the reaction center with nearly 100% efficiency via three energy transfer processes...
November 27, 2023: Progress in Biophysics and Molecular Biology
Michael Spitzer
No abstract text is available yet for this article.
November 23, 2023: Progress in Biophysics and Molecular Biology
Salvatore Chirumbolo, Antonio Vella
No abstract text is available yet for this article.
November 13, 2023: Progress in Biophysics and Molecular Biology
Mahmoud I Khalil, Mohamad M Ali, Jasmine Holail, Marwa Houssein
One of the central regulators of cell growth, proliferation, and metabolism is the mammalian target of rapamycin, mTOR, which exists in two structurally and functionally different complexes: mTORC1 and mTORC2; unlike m TORC2, mTORC1 is activated in response to the sufficiency of nutrients and is inhibited by rapamycin. mTOR complexes have critical roles not only in protein synthesis, gene transcription regulation, proliferation, tumor metabolism, but also in the regulation of the programmed cell death mechanisms such as autophagy and apoptosis...
November 7, 2023: Progress in Biophysics and Molecular Biology
Jude Currivan
With a Nobel Prize for Physics widely viewed as only given for 'settled' science, the award then essentially accepts the validity of universal nonlocality. Other key discoveries and insights in recent years are also progressively pointing to the appearance of our Universe, its energy-matter and space-time, as not being foundational but emerging from deeper, discarnate realms of causation. as digitized and meaningful, in-formation, its manifestation pixelated at the so-named Planck scale of existence. Extending from studies of black holes to the entire Universe, a growing number of cosmologists have also developed the so-named holographic principle, to model the four-dimensional appearance of our Universe (three dimensions of space and one of time) as a holographic projection of its two- dimensional boundary...
October 20, 2023: Progress in Biophysics and Molecular Biology
Ekambaram Gayathiri, Palanisamy Prakash, Priya Kumaravel, Jayanthi Jayaprakash, Manikkavalli Gurunathan Ragunathan, Sharmila Sankar, Saravanan Pandiaraj, Natesan Thirumalaivasan, Muthu Thiruvengadam, Rajakumar Govindasamy
The convergence of biology and computational science has ushered in a revolutionary era, revolutionizing our understanding of biological systems and providing novel solutions to global problems. The field of genetic engineering has facilitated the manipulation of genetic codes, thus providing opportunities for the advancement of innovative disease therapies and environmental enhancements. The emergence of bio-molecular simulation represents a significant advancement in this particular field, as it offers the ability to gain microscopic insights into molecular-level biological processes over extended periods...
October 9, 2023: Progress in Biophysics and Molecular Biology
Xiao-Xia Chai, Jie Liu, Tong-Yao Yu, Ge Zhang, Wen-Jun Sun, Yan Zhou, Li Ren, Hui-Ling Cao, Da-Chuan Yin, Chen-Yan Zhang
The mechanical environment is important for tumorigenesis and progression. Tumor cells can sense mechanical signals by mechanosensitive receptors, and these mechanical signals can be converted to biochemical signals to regulate cell behaviors, such as cell differentiation, proliferation, migration, apoptosis, and drug resistance. Here, we summarized the effects of the mechanical microenvironment on breast cancer cell activity, and mechanotransduction mechanism from cellular microenvironment to cell membrane, and finally to the nucleus, and also relative mechanosensitive proteins, ion channels, and signaling pathways were elaborated, therefore the mechanical signal could be transduced to biochemical or molecular signal...
October 2, 2023: Progress in Biophysics and Molecular Biology
Chao Shan, YuNing Xia, Zeyu Wu, Jin Zhao
Periodontitis, the sixth most prevalent epidemic disease globally, profoundly impacts oral aesthetics and masticatory functionality. Hypoxia-inducible factor-1α (HIF-1α), an oxygen-dependent transcriptional activator, has emerged as a pivotal regulator in periodontal tissue and alveolar bone metabolism, exerts critical functions in angiogenesis, erythropoiesis, energy metabolism, and cell fate determination. Numerous essential phenotypes regulated by HIF are intricately associated with bone metabolism in periodontal tissues...
September 26, 2023: Progress in Biophysics and Molecular Biology
Xin Liu, Weipin Niu, Shuqing Zhao, Wenjuan Zhang, Zhao Ying, Jing Li
Fibrosis is a pathological process that occurs in various organs, characterized by excessive deposition of extracellular matrix (ECM), leading to structural damage and, in severe cases, organ failure. Within the fibrotic microenvironment, mechanical forces play a crucial role in shaping cell behavior and function, yet the precise molecular mechanisms underlying how cells sense and transmit these mechanical cues, as well as the physical aspects of fibrosis progression, remain less understood. Piezo1, a mechanosensitive ion channel protein, serves as a pivotal mediator, converting mechanical stimuli into electrical or chemical signals...
September 16, 2023: Progress in Biophysics and Molecular Biology
Saad Alghamdi, Krisha Khandelwal, Soumya Pandit, Arpita Roy, Subhasree Ray, Ahad Amer Alsaiari, Abdulelah Aljuaid, Mazen Almehmadi, Mamdouh Allahyani, Rohit Sharma, Jigisha Anand, Ahmad Adnan Alshareef
Chemical signal molecules are used by bacteria to interact with one another. Small hormone-like molecules known as autoinducers are produced, released, detected, and responded to during chemical communication. Quorum Sensing (QS) is the word for this procedure; it allows bacterial populations to communicate and coordinate group behavior. Several research has been conducted on using inhibitors to prevent QS and minimize the detrimental consequences. Through the enzymatic breakdown of the autoinducer component, by preventing the formation of autoinducers, or by blocking their reception by adding some compounds (inhibitors) that can mimic the autoinducers, a technique known as "quorum quenching" (QQ) disrupts microbial communication...
September 2, 2023: Progress in Biophysics and Molecular Biology
Ancha Kishore Babu, M K Mohan Maruga Raja, Mehrukh Zehravi, Badrud Duza Mohammad, Mohammed Imran Anees, Cheepurupalli Prasad, Barrawaz Aateka Yahya, Rokeya Sultana, Rohit Sharma, Jay Singh, Khalid Ali Khan, Falak A Siddiqui, Sharuk L Khan, Talha Bin Emran
Quantum dots (QDs) are a class of remarkable materials that have garnered significant attention since their initial discovery. It is noteworthy to mention that it took approximately a decade for these materials to be successfully implemented in practical applications. While QDs have demonstrated notable optical properties, it is important to note that these attributes alone have not rendered them a feasible substitute for traditional organic dyes. Furthermore, it is worth noting that the substance under investigation exhibited inherent toxicity and instability in its initial state, primarily due to the presence of a heavy metal core...
August 29, 2023: Progress in Biophysics and Molecular Biology
Nidhi Chauhan, Kirti Saxena, Rachna Rawal, Lalit Yadav, Utkarsh Jain
Surface enhanced Raman spectroscopy (SERS) allows the ultrasensitive detection of analytes present in traces or even single molecule levels by the generation of electromagnetic fields. It is a powerful vibrational spectroscopic method that is capable to detect traces of chemical and biological analytes. SERS technique is involved in the extremely sophisticated studies of molecules with high specificity and sensitivity. In the vicinity of nanomaterials decorated surfaces, SERS can monitor extremely low concentrations of analytes in a non-destructive manner with narrow line widths...
August 28, 2023: Progress in Biophysics and Molecular Biology
J Sidorova, J J Lozano
No abstract text is available yet for this article.
August 12, 2023: Progress in Biophysics and Molecular Biology
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