François de Kermenguy, Nathan Benzazon, Pauline Maury, Rémi Vauclin, Meissane M'hamdi, Vjona Cifliku, Elaine Limkin, Ibrahima Diallo, Daphné Morel, Candice Milewski, Céline Clémenson, Michele Mondini, Eric Deutsch, Charlotte Robert
Severe radiation-induced lymphopenia occurs in 40% of patients treated for primary brain tumors and is an independent risk factor of poor survival outcomes. We developed an in-silico framework that estimates the radiation doses received by lymphocytes during VMAT brain irradiation. 
Approach: We implemented a simulation consisting of two interconnected compartmental models describing the slow recirculation of lymphocytes between lymphoid organs (M_1) and the bloodstream (M_2). We used dosimetry data from 33 patients treated with chemo-radiation for glioblastoma to compare three cases of the model, corresponding to different physical and biological scenarios: H1) lymphocytes circulation only in the bloodstream i...
April 9, 2024: Physics in Medicine and Biology