Ryuta Nakae, Yasuo Murai, Yasuhiro Takayama, Kaoru Namatame, Yoshiyuki Matsumoto, Takahiro Kanaya, Yu Fujiki, Hidetaka Onda, Go Suzuki, Junya Kaneko, Takashi Araki, Yasutaka Naoe, Hidetaka Sato, Kyoko Unemoto, Akio Morita, Hiroyuki Yokota, Shoji Yokobori
Coagulopathy, a common complication of traumatic brain injury (TBI), is characterized by a hypercoagulable state developing immediately after injury, with hyperfibrinolysis and bleeding tendency peaking 3 h after injury, followed by fibrinolysis shutdown. Reflecting this timeframe, the coagulation factor fibrinogen is first consumed and then degraded after TBI, its concentration rapidly decreasing by 3 h post-TBI. The fibrinolytic marker D-dimer reaches its maximum concentration at the same time. Hyperfibrinolysis in the acute phase of TBI is associated with poor prognosis via hematoma expansion...
December 15, 2022: Neurologia Medico-chirurgica