journal
https://read.qxmd.com/read/37437507/identification-and-validation-of-long-noncoding-rna-ac083900-1-and-rp11-283c24-1-for-prediction-of-progression-of-osteosarcoma
#21
JOURNAL ARTICLE
Liangkun Huang, Wenyi Jin, Yucheng Bao, Xiaoshuang Zeng, Yubiao Zhang, Jianlin Zhou, Hao Peng
BACKGROUND: The role of cuproptosis, an emerging cell death pathway that makes a remarkable contribution to tumor progression, remains elusive in osteosarcoma (OS), in addition to its regulator, including long-no-coding RNAs (lncRNAs) that are also a critical factor for fueling OS. METHODS: Transcriptome and clinical data from 70 normal human bone tissue samples and 84 frozen clinical osteosarcoma samples were included in this study. Cuproptosis-associated lncRNAs (CRlncs) were identified through differential expression and co-expression analyses...
June 22, 2023: Mutation Research
https://read.qxmd.com/read/37418818/downregulated-cav-1-in-mouse-spinal-cord-may-alleviate-bone-cancer-pain-by-inhibiting-the-erk-creb-pathway
#22
JOURNAL ARTICLE
Jianyun Ge, Jie Song, Bo Sun, Xuefeng Yang, Boxiang Du, Xin Sun, Jiejie Zhang, Jianlin Ge, Hong Xie
BACKGROUND: This study aimed to assess the potential function of Caveolin-1 (CAV-1) in mice with bone cancer pain. METHOD: Using a mice bone cancer pain model we explored the contribution of CAV-1 expression to bone cancer pain on the 14th day after surgery, mice in the tumor group were randomized and treated with increasing doses of the CAV-1 inhibitor, methyl-beta-cyclodextrin. Pain was assessed by monitoring the number of spontaneous flinches (NSF) and paw withdrawal mechanical threshold (PMWT)mechanical withdrawal threshold (MWT)...
June 19, 2023: Mutation Research
https://read.qxmd.com/read/37352694/oxidative-and-dna-damage-in-obese-patients-undergoing-bariatric-surgery-a-one-year-follow-up-study
#23
JOURNAL ARTICLE
Anna Chiaramonte, Serena Testi, Caterina Pelosini, Consuelo Micheli, Aurora Falaschi, Giovanni Ceccarini, Ferruccio Santini, Roberto Scarpato
The pathogenesis of obesity and related comorbidities has long been associated with oxidative stress. The excess of adipose tissue contributes to the production of free radicals that sustain both a local and a systemic chronic inflammatory state, whereas its reduction can bring to an improvement in inflammation and oxidative stress. In our work, using the fluorescent lipid probe BODIPY® 581/591 C11 and the γH2AX foci assay, a well-known marker of DNA double strand breaks (DSB), we evaluated the extent of cell membrane oxidation and DNA damage in peripheral blood lymphocytes of normal weight (NW) controls and obese patients sampled before and after bariatric surgery...
June 16, 2023: Mutation Research
https://read.qxmd.com/read/37300987/parp-deficiency-causes-hypersensitivity-to-taxol-through-oxidative-stress-induced-dna-damage
#24
JOURNAL ARTICLE
Junko Maeda, Ben Jepson, Kohei Sadahiro, Mami Murakami, Hiroki Sakai, Kazuki Heishima, Yukihiro Akao, Takamitsu A Kato
Taxol is an antitumor drug derived from the bark of the Pacific Yew tree that inhibits microtubule disassembly, resulting in cell cycle arrest in late G2 and M phases. Additionally, Taxol increases cellular oxidative stress by generating reactive oxygen species. We hypothesized that the inhibition of specific DNA repair machinery/mechanisms would increase cellular sensitivity to the oxidative stress capacity of Taxol. Initial screening using Chinese hamster ovary (CHO) cell lines demonstrated that base excision repair deficiency, especially PARP deficiency, caused cellular Taxol hypersensitivity...
June 2, 2023: Mutation Research
https://read.qxmd.com/read/37196609/mir-30a-5p-inhibits-cell-behaviors-in-esophageal-cancer-via-modulating-cbx2
#25
JOURNAL ARTICLE
Luxing Peng, Xinjun Huang, Defeng Qing, Heming Lu, Xu Liu, JiaXin Chen, Xianfeng Long, Qiang Pang
BACKGROUND: This investigation studied the impacts of the miR-30a-5p/CBX2 axis on esophageal cancer (EC). METHODS: Research objects were ascertained using The Cancer Genome Atlas database. Followed by qRT-PCR, western blot, dual-luciferase reporter, MTT, Transwell, and wound healing approaches, we tested gene expression and varying cell behaviors RESULTS: Conspicuously miR-30 family members (miR-30a-5p, miR-30b-5p, miR-30c-5p, miR-30d-5p, miR-30e-5p) downregulation and CBX2 upregulation were discovered in EC cells...
April 28, 2023: Mutation Research
https://read.qxmd.com/read/37104996/efficient-robust-and-versatile-fluctuation-data-analysis-using-mle-mutation-rate-calculator-mlemur
#26
JOURNAL ARTICLE
Krystian Łazowski
The fluctuation assay remains an important tool for analyzing the levels of mutagenesis in microbial populations. The mutant counts originating from some average number of mutations are usually assumed to obey the Luria-Delbrück distribution. While several tools for estimating mutation rates are available, they sometimes lack accuracy or versatility under non-standard conditions. In this work, extensions to the Luria-Delbrück protocol to account for phenotypic lag and cellular death with either perfect or partial plating were developed...
April 13, 2023: Mutation Research
https://read.qxmd.com/read/36812659/xrcc8-mutation-causes-hypersensitivity-to-parp-inhibition-without-homologous-recombination-repair-deficiency
#27
JOURNAL ARTICLE
Junko Maeda, Jeremy S Haskins, Takamitsu A Kato
PARP inhibitors inflict severe toxicity to homologous recombination (HR) repair deficient cells because DNA damages induced by PARP inhibition result in lethal DNA double strand breaks in the absence of HR repair during DNA replication. PARP inhibitors are the first clinically approved drugs designed for synthetic lethality. The synthetic lethal interaction of PARP inhibitors is not limited to HR repair deficient cells. We investigated radiosensitive mutants isolated from Chinese hamster lung origin V79 cells to identify novel synthetic lethal targets in the context of PARP inhibition...
February 13, 2023: Mutation Research
https://read.qxmd.com/read/36634476/mutagenesis-induced-by-protonation-of-single-stranded-dna-is-linked-to-glycolytic-sugar-metabolism
#28
JOURNAL ARTICLE
Suzana P Gelova, Kin Chan
Mutagenesis can be thought of as random, in the sense that the occurrence of each mutational event cannot be predicted with precision in space or time. However, when sufficiently large numbers of mutations are analyzed, recurrent patterns of base changes called mutational signatures can be identified. To date, some 60 single base substitution or SBS signatures have been derived from analysis of cancer genomics data. We recently reported that the ubiquitous signature SBS5 matches the pattern of single nucleotide polymorphisms (SNPs) in humans and has analogs in many species...
January 6, 2023: Mutation Research
https://read.qxmd.com/read/37178498/lncrna-crnde-is-involved-in-the-pathogenesis-of-renal-fibrosis-by-regulating-renal-epithelial-cell-mesenchymal-epithelial-transition-via-targeting-mir-29a-3p
#29
JOURNAL ARTICLE
Min Zhao, Nan Li, Cheng Wan, Qingyan Zhang, Hengjin Wang, Chunming Jiang
Results of previous studies suggested that renal fibrosis and epithelial-mesenchymal transition (EMT) plays an important role in the process of renal fibrosis, but the underlying mechanism remains unclear. Long coding RNA (lncRNA) CRNDE has emerged as potent regulators of EMT programs, therefore, in present work, we examined the roles of LncRNA CRNDE/miR-29a-3p axis in renal fibrosis and the underlying mechanism. We found that in both renal fibrosis animal and cell models, lncRNA CRNDE was dynamically upregulated in animal models or cells by the treatment of TGF-β...
2023: Mutation Research
https://read.qxmd.com/read/36621052/association-between-dna-repair-capacity-and-body-mass-index-in-women
#30
JOURNAL ARTICLE
Ian Crespo-Orta, Carmen Ortiz, Jarline Encarnación, Erick Suárez, Jaime Matta
OBJECTIVE: Examine whether DNA repair capacity (DRC) levels are associated with body mass index (BMI) in adult women. DESIGN AND PARTICIPANTS: A nested study composed of 539 women without breast cancer (BC) from a case-control BC study in addition to 104 that were recruited later for a total of 643. MEASUREMENTS: DRC levels were measured in lymphocytes using a host-cell reactivation assay with a luciferase reporter gene damaged by UVC. This assay measures the efficiency of nucleotide excision repair (NER)...
December 31, 2022: Mutation Research
https://read.qxmd.com/read/36628843/analysis-of-tafazzin-and-deoxyribonuclease-1-like-1-transcripts-and-x-chromosome-sequencing-in-the-evaluation-of-the-effect-of-mosaicism-in-the-taz-gene-on-phenotypes-in-a-family-affected-by-barth-syndrome
#31
JOURNAL ARTICLE
Teresa Płatek, Maria Sordyl, Anna Polus, Agnieszka Olszanecka, Sławomir Kroczka, Bogdan Solnica
Barth syndrome is a rare disease affecting mitochondria structure and function in males. In our previous study, we have shown a new mutation (c.83T>A, p.Val28Glu) in the TAZ gene in two affected patients with congenital cardiomyopathy. Furthermore, women in this family had no mutations in their blood cells, whereas they only had mutations in the oral epithelial cells. The objective of the project was to evaluate the effect of intertissue mosaicisms on the Barth syndrome phenotypes, searching for another disease-related loci on chromosome X and finally to assess the consequences of the mutation...
December 29, 2022: Mutation Research
https://read.qxmd.com/read/36603370/tumor-promoting-roles-of-hmmr-in-lung-adenocarcinoma
#32
JOURNAL ARTICLE
Qihao Wang, Guomin Wu, Linhai Fu, Zhupeng Li, Yuanlin Wu, Ting Zhu, Guangmao Yu
Searching for differential genes in lung adenocarcinoma (LUAD) is vital for research. Hyaluronan mediated motility receptor (HMMR) promotes malignant progression of cancer patients. However, the molecular regulators of HMMR-mediated LUAD onset are unknown. This work aimed to study the relevance of HMMR to proliferation, migration and invasion of LUAD cells. Let-7c-5p and HMMR levels in LUAD cells and HLF-a cells were assessed, and their correlation was also detected. Their interaction was determined by dual-luciferase experiments and qRT-PCR...
December 15, 2022: Mutation Research
https://read.qxmd.com/read/36274500/microrna-501-3p-targeting-tm4sf1-facilitates-tumor-related-behaviors-of-gastric-cancer-cells-via-emt-signaling-pathway
#33
JOURNAL ARTICLE
Yunhai Wei, Lei Yin, Xiao Xie, Zhongxin Wu, Jinyu Zhang, Yuhai Gao, Jianing Tang
BACKGROUND: Increasing evidence shows that Transmembrane 4 L6 family member 1(TM4SF1) exerts a critical role in mediating the progression of various tumors. Nevertheless, the exact mechanism of TM4SF1 in gastric cancer (GC) remains unclear. METHODS: Bioinformatics analysis was utilized to analyze TM4SF1 expression in GC tissues. Also, MiRWalk and starBase databases were used to predict the upstream microRNAs which could regulate TM4SF1 expression. Gene set enrichment analysis (GSEA) for TM4SF1 was conducted to screen the potentially involved pathways...
October 13, 2022: Mutation Research
https://read.qxmd.com/read/36270229/expression-of-the-circadian-clock-gene-arntl-associated-with-dna-repair-gene-and-prognosis-of-patient-with-osteosarcoma
#34
JOURNAL ARTICLE
Daliang Kong, Yang Liu, Minglei Zhang
PURPOSE: The study objects were to explore the correlation between the biological role of clock genes and clinical indicators in patients with osteosarcoma (OS). METHODS: We acquired the clinical information and RNA sequencing data of OS samples from the TARGET database. The protein-protein interaction (PPI) network and expression correlation analysis of clock genes were performed. Then, the functional enrichment analysis of clock genes was analyzed. The survival analysis of clock genes in patients of OS was carried out by univariate cox regression, Kaplan-Meier (KM) curve and multivariate cox regression methods...
October 10, 2022: Mutation Research
https://read.qxmd.com/read/36155262/both-phosphorylation-and-phosphatase-activity-of-pten-are-required-to-prevent-replication-fork-progression-during-stress-by-inducing-heterochromatin
#35
JOURNAL ARTICLE
Sandip Misra, Sougata Ghosh Chowdhury, Ginia Ghosh, Ananda Mukherjee, Parimal Karmakar
PTEN is a tumor suppressor protein frequently altered in various cancers. PTEN-null cells have a characteristic of rapid proliferation with an unstable genome. Replication stress is one of the causes of the accumulation of genomic instability if not sensed by the cellular signaling. Though PTEN-null cells have shown to be impaired in replication progression and stalled fork recovery, the association between the catalytic function of PTEN regulated by posttranslational modulation and cellular response to replication stress has not been studied explicitly...
September 19, 2022: Mutation Research
https://read.qxmd.com/read/36116241/evaluation-of-natural-chronic-low-dose-radiation-exposure-on-telomere-length-and-transcriptional-response-of-shelterin-complex-in-individuals-residing-in-kerala-coast-india
#36
JOURNAL ARTICLE
Divyalakshmi Saini, Vinay Jain, Birajalaxmi Das
The high level natural radiation areas (HLNRA) of Kerala coast provide unique opportunity to study the biological effect of chronic low dose ionizing radiation (LDIR) on human population below 100 mSv. The radiation level in this area varies from < 1.0-45 mGy /year due to patchy distribution of monazite in the sand, which contains 232 Th (8-10%), 238 U (0.3%), and their decay products. Telomere length attrition has been correlated to DNA damage due to genotoxic agents. The objective of the present study is to evaluate the effect of natural chronic LDIR exposure on telomere length and transcriptional response of telomere specific and DNA damage repair genes in peripheral blood mononuclear cells (PBMCs) of individuals from normal level natural radiation areas (NLNRA) and HLNRA of Kerala coast, southwest India...
September 15, 2022: Mutation Research
https://read.qxmd.com/read/36108541/treatment-with-the-anti-cd20-monoclonal-antibody-rituximab-mitigates-gonadal-disruptions-in-the-collagen-induced-arthritis-in-male-dba-1-j-mouse-model
#37
JOURNAL ARTICLE
Mohammed A Al-Hamamah, Moureq R Alotaibi, Sheikh F Ahmad, Ahmed Nadeem, Mohamed S M Attia, Mushtaq A Ansari, Saleh A Bakheet, Mohammed M Alanazi, Sabry M Attia
Rheumatoid arthritis (RA), which is driven by persistent activation of the immune system, primarily affects the joints. Several reports have estimated the risk of gonadal disruptions in arthritic patients, with potential attributable risk factors such as treatments with the disease-modifying antirheumatic drugs and the influence of the disease itself. The FDA approved rituximab, a therapy for non-Hodgkin's lymphoma, for management of RA in February 2006. However, the influence of repeated treatment with rituximab on gonadal function in RA has not been reported yet...
September 9, 2022: Mutation Research
https://read.qxmd.com/read/36087462/mirna-144-5p-down-modulates-cdca3-to-regulate-proliferation-and-apoptosis-of-lung-adenocarcinoma-cells
#38
JOURNAL ARTICLE
Jing Luo, Lilong Xia, Lei Zhang, Kaixiang Zhao, Chuanchuan Li
BACKGROUND: Lung adenocarcinoma (LUAD) belongs to non-small cell lung cancer. In addition to surgical resection, chemotherapy and radiotherapy cause great side effects and low 5-year survival rates. MiRNAs are closely related to cancer development. This study aimed to analyze the molecular mechanism of miRNA-144-5p targeting CDCA3 to inhibit LUAD proliferation. METHODS: MiRNA and mRNA data were downloaded from TCGA-LUAD dataset for differential expression analysis...
September 1, 2022: Mutation Research
https://read.qxmd.com/read/36007462/royal-jelly-reduce-dna-damage-induced-by-alkylating-agent-in-mice
#39
JOURNAL ARTICLE
Adriani Paganini Damiani, Marina Lummertz Magenis, Ligia Salvan Dagostin, Ângela Caroline da Luz Beretta, Rovena Jacobsen Sarter, Luiza Martins Longaretti, Isadora de Oliveira Monteiro, Vanessa Moraes de Andrade
Royal jelly (RJ) is a creamy white-yellow liquid that is secreted by the mandibular and hypopharyngeal glands of bees to nourish the larvae. RJ has gained increasing interest in recent years owing to its antioxidant potential. However, little is known about adequate RJ dosing and its effects on genetic material. Thus, the aim of this study was to evaluate the in vivo effects of RJ on genotoxicity and mutagenicity induced by the alkylating agent methyl methanesulfonate (MMS). In this study, 3-month-old Swiss albino male mice (N = 66) were divided into 11 groups for experimentation...
August 20, 2022: Mutation Research
https://read.qxmd.com/read/36027647/biased-distribution-of-action-at-a-distance-mutations-by-8-oxo-7-8-dihydroguanine
#40
JOURNAL ARTICLE
Ruriko Fukushima, Tetsuya Suzuki, Yasuo Komatsu, Hiroyuki Kamiya
8-Oxo-7,8-dihydroguanine (8-hydroxyguanine, G°) is a major oxidized base that is considered to play pivotal roles in the pathogenesis of various diseases, including cancer. G° induces G:C → T:A transversions at the damage site and untargeted (action-at-a-distance) mutations of G bases at 5'-GpA sequences. In this study, we examined the distribution of the action-at-a-distance mutations and the effects of the replication origin position relative to G° on the untargeted mutagenesis. The G° base was introduced into two shuttle plasmids, each with the SV40 replication origin at a different position with respect to the supF gene...
August 18, 2022: Mutation Research
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