journal
https://read.qxmd.com/read/37498075/effects-of-different-sized-silver-nanoparticles-on-morphological-and-functional-alterations-in-lung-cancer-and-non-cancer-lung-cells
#1
JOURNAL ARTICLE
Kristina Jakic, Michal Selc, Radka Macova, Antonia Kurillova, Libor Kvitek, Ales Panacek, Andrea Babelova
Silver nanoparticles (AgNPs) exhibit unique physicochemical properties, making these nanomaterials attractive for various medical applications. Among them, AgNPs have shown great potential in the treatment of cancer by inducing apoptosis in cancer cells, inhibiting tumor growth, and enhancing the efficacy of conventional cancer treatments such as chemotherapy and radiation therapy. Despite the promising therapeutical advantage of AgNPs, there are several challenges that need to be addressed. One of the most important is AgNPs' toxicity, which in case of treatment might be extended to non-cancerous cells and tissues...
June 2023: Neoplasma
https://read.qxmd.com/read/37498074/functional-consequences-of-altered-glycosylation-of-tumor-associated-hypoxia-biomarker-carbonic-anhydrase-ix
#2
JOURNAL ARTICLE
Magdalena Baratova, Lucia Skvarkova, Maria Bartosova, Lenka Jelenska, Miriam Zatovicova, Barbora Puzderova, Ivana Kajanova, Lucia Csaderova, Silvia Pastorekova, Eliska Svastova
Glycosylation is a posttranslational modification of proteins affecting numerous cellular functions. A growing amount of evidence confirms that aberrant glycosylation is involved in pathophysiological processes, including tumor development and progression. Carbonic anhydrase IX (CAIX) is a transmembrane protein whose expression is strongly induced in hypoxic tumors, which makes it an attractive target for anti-tumor therapy. CAIX facilitates the maintenance of intracellular pH homeostasis through its catalytic activity, which is linked with extracellular pH acidification promoting a more aggressive phenotype of tumor cells...
June 2023: Neoplasma
https://read.qxmd.com/read/37498073/topical-application-of-local-anesthetics-to-melanoma-increases-the-efficacy-of-anti-pd-1-therapy
#3
JOURNAL ARTICLE
Miroslav Tibensky, Filip Blasko, Peter Vargovic, Jana Jakubikova, Dana Cholujova, Jana Jakubechova, Boris Mravec
Experimental and clinical data have shown that the nervous system can significantly stimulate the initiation and progression of melanoma. In support of this, approaches that reduce the transmission of signals from peripheral nerves to effector tissues reduce the recurrence of melanoma. Therefore, we investigated the effect of topical application of the local anesthetic Pliaglis (7% lidocaine and 7% tetracaine) on the growth of melanoma induced by intradermal application of B16F0 cells in mice without treatment and in mice treated with the anti-PD-1 antibody...
June 2023: Neoplasma
https://read.qxmd.com/read/37498072/chemotherapy-versus-chemoradiotherapy-in-borderline-resectable-and-locally-advanced-pancreatic-adenocarcinoma
#4
JOURNAL ARTICLE
Soňa Argalácsová, Michal Vočka, Luboš Petruželka, Miroslav Ryska, Pavel Záruba, Zdeněk Krška, Vladimír Frýba, Jan Ulrych, Vladimír Černý, Tomáš Tůma, David Hoskovec
The role of radiotherapy in borderline resectable (BRPC) and locally advanced pancreatic carcinoma (LAPC) remains controversial. In our study, we retrospectively evaluated 48 patients with BRPC (14; 29.2%) and LAPC (34; 70. 8%) who underwent 6-8 cycles of induction mFOLFIRINOX chemotherapy alone (23; 47.9%) or 4-6 cycles of mFOLFIRINOX followed by hypofractionated radiotherapy (up to the total dose of 39.9 Gy in 15 fractions) (25; 52.1%). Survival parameters were evaluated using the Gehan-Breslow-Wilcoxon Test and compared by using the long-rank test...
June 2023: Neoplasma
https://read.qxmd.com/read/37498071/what-is-the-best-time-for-postoperative-radiation-therapy-in-pn1-prostate-cancer
#5
JOURNAL ARTICLE
Francesco Alessandro Mistretta, Stefano Luzzago, Giulia Marvaso, Giulia Corrao, Ilaria Sabatini, Matteo Fontana, Federico Mastroleo, Mattia Zaffaroni, Maria Giulia Vincini, Ettore Di Trapani, Gabriele Cozzi, Roberto Bianchi, Matteo Ferro, Ottavio de Cobelli, Barbara Alicja Jereczek-Fossa, Gennaro Musi
We retrospectively compared long-term biochemical recurrence rates (BCR) in pN1 PCa patients that underwent adjuvant radiotherapy (aRT) vs. no aRT/early salvage (esRT) after robot-assisted radical prostatectomy and extended pelvic lymphadenectomy. All PCa pN1 M0 patients treated at a single high-volume center between 2010 and 2020 were analyzed. Patients with <10 LNs yield, or >10 positive LNs, or persistently detectable PSA after RARP were excluded. Kaplan-Meier (KM) plots depicted BCR rates. Multivariable Cox regression models (MCRMs) focused on predictors of BCR...
June 2023: Neoplasma
https://read.qxmd.com/read/37498070/tumor-targeted-suicide-gene-directed-enzyme-prodrug-therapy-mediated-by-extracellular-vesicles
#6
JOURNAL ARTICLE
Jana Jakubechova, Ursula Altanerova, Cestmir Altaner
In this article, we describe the gene-directed enzyme prodrug therapy, also known as the "Trojan Horse" therapy mediated by exosomes - small extracellular vesicles (sEVs) secreted from mesenchymal stem/stromal cells (MSCs) and cancer cells. MSC-EVs possess strong migrating tropism toward tumor sites. EVs derived from tumor cells mimic the parental cells in an invasive metastatic growth trait and the capability to reprogram the recipient cells. The behavior of these EVs when modified with the suicide gene predestinates them to be a drug with guided intracellular action...
June 2023: Neoplasma
https://read.qxmd.com/read/37498069/lncrna-slc7a11-as1-promotes-the-progression-of-hepatocellular-carcinoma-by-mediating-klf9-ubiquitination
#7
JOURNAL ARTICLE
Fan-Lin Zeng, Jie Lin, Xing Xie, Yuan-Kang Xie, Jian-Hong Zhang, Daofeng Xu, Xiao He, Feng En Liu, Bin-Hui Xie
Hepatocellular carcinoma (HCC) is a malignant tumor, which seriously threatens the life of patients. LncRNA SLC7A11-AS1 was reported to be abnormally expressed in HCC. Here, the functions and relative molecular regulatory mechanism of SLC7A11-AS1 in HCC were investigated. Nude mice and HCC cells were used as the experimental subjects. Knockdown or overexpression of exogenous genes was conducted in HCC cells. RT-qPCR, IHC, and western blot were employed to evaluate the abundance of genes and proteins. The malignant behaviors were evaluated using CCK-8, clone formation, wound-healing, and Transwell...
June 2023: Neoplasma
https://read.qxmd.com/read/37498068/trim31-promotes-the-progression-of-oral-squamous-cell-carcinoma-through-upregulating-akt-phosphorylation-and-subsequent-cellular-glycolysis
#8
JOURNAL ARTICLE
Sheng-Qi Sang, Yi-Jie Zhao, Meng Wang, Xiao-Qi Zhong, Zhi-Cheng Yang, Meng-Meng Lu
The regulation of protein kinase B (AKT) phosphorylation by Tripartite motif-containing protein 31 (TRIM31) is implicated as an essential mechanism in the progression of many malignant tumors. Nevertheless, the function of the TRIM31/AKT pathway in oral squamous cell carcinoma (OSCC) remains elusive. Here, immunohistochemistry analysis of human OSCC tissue microarrays indicated significantly higher levels of TRIM31 and phosphorylated AKT (p-AKT) in OSCC tumors than in adjacent tissue samples. Also, we detected a positive association between TRIM31 expression and clinical OSCC development...
June 2023: Neoplasma
https://read.qxmd.com/read/37498067/prognostic-implications-of-the-egfr-polymorphism-rs763317-and-clinical-variables-among-young-chinese-lung-cancer-population
#9
JOURNAL ARTICLE
Zheng-Xing Li, Fan Wang, Zhen-Yu Sun, Chang Xu, Zi-Xiu Zou, Zong-Xu Zhao, Hai-Jian Wang, Shi-Cheng Guo, Li Jin, Qiang Li, Jiu-Cun Wang, Fan Xia, Xiao-Qiang Yue, Junjie Wu
The 5-year survival rate for patients with lung cancer, the world's second most frequent malignant tumor, is less than 20%, and its prognosis cannot be clearly predicted. Our aim was to analyze the epidermal growth factor receptor (EGFR) rs763317 (G>A) single nucleotide polymorphism and its association with prognosis in Chinese Han lung cancer patients. 839 patients with primary lung cancer were recruited, and genomic DNA was extracted and genotyped by SNPscan. Kaplan-Meier technique and multivariate Cox proportional hazards model were used to analyze the association between prognosis and EGFR polymorphism rs763317...
June 2023: Neoplasma
https://read.qxmd.com/read/37498066/function-drug-resistance-and-prognostic-effect-of-akr1c2-in-human-cancer
#10
JOURNAL ARTICLE
Zhao Wang, Yue Feng, Jiayu Song, Di Sun, Yun-Yan Zhang
Aldo-keto reductases (ARKs), a group of reductases that rely on nicotinamide adenine dinucleotide (NADH) and nicotinamide adenine dinucleotide phosphate (NADPH) to catalyze carbonyl, are widely found in various organisms, which play an important role in the physiological and pathological processes of human. Aldo-keto reductase family 1 member C2 (AKR1C2) as a member of the human ARKs family, can regulate steroid hormones and is abnormally expressed in many cancers. According to whether the tumor can be affected by hormones, we divide malignancies into hormone-dependent and hormone-independent types...
June 2023: Neoplasma
https://read.qxmd.com/read/37498065/immunohistochemical-p16-expression-in-the-prognosis-of-patients-with-sinonasal-squamous-cell-carcinoma
#11
JOURNAL ARTICLE
Li Wang, Hua-Tao Quan, Jie Wang, Tian-Ci Tang, Yi Li, Xin-Mao Song
In sinonasal squamous cell carcinoma (SNSCC), the prognostic relevance of p16INK4a (p16) expression has been reported rarely. This study aims to examine the immunohistochemical expression of p16 and investigate the possibility of p16 as a prognostic factor for SNSCC. The medical records of 173 individuals with SNSCC between 2010 and 2022 were retrospectively reviewed. The researchers examined patients' demographics, p16 status, staging, tumor histological subtypes, treatment details, recurrence, metastasis, and survival outcomes...
June 2023: Neoplasma
https://read.qxmd.com/read/37498064/a-new-pathway-for-the-transformation-of-aml-in-mds-apa-mechanism-regulated-by-nudt21-and-runx1
#12
JOURNAL ARTICLE
Shuo Li, Fanggang Ren, Xiao-Li Liu, Hong-Yu Zhang, Zhi-Fang Xu, Daniel Muteb Muyey, Zhuanzhen Zheng, Yan-Hong Tan, Xiu-Hua Chen, Hong-Wei Wang
We have identified that NUDT21 plays a vital role in MDS transformations, while the transcription factor RUNX1 is essential for normal hematopoiesis, which is a high expression in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS), and we aim to explore the linkage between the two genes and new pathways for MDS transformation to AML. Prediction of RUNX1 expression levels and its relationship with NUDT21 in AML and MDS patients was performed using bioinformatics techniques and validated in patients...
June 2023: Neoplasma
https://read.qxmd.com/read/37498063/nop2-mediated-m5c-methylation-of-xpd-is-associated-with-hepatocellular-carcinoma-progression
#13
JOURNAL ARTICLE
Guo-Fang Sun, Hao Ding
Hepatocellular carcinoma (HCC) is a common malignant tumor with high mortality. Our previous study has confirmed that XPD acts as an anti-oncogene and is downregulated in HCC. The mechanism of XPD downregulation in HCC is unclear. In this work, we obtained the datasets related to HCC patients from GSE76427, LIRI-JP, and TCGA-LIHC cohorts. Among 15 m5C regulators (NSUN2, NSUN3, NSUN4, NSUN5, NSUN6, NSUN7, DNMT1, TRDMT1, DNMT3A, DNMT3B and NOP2, TET1, TET2, and TET3, ALYREF), 14 m5C regulators were upregulated in tumor tissues of HCC patients, except for TET2...
June 2023: Neoplasma
https://read.qxmd.com/read/37498062/predictors-of-outcomes-of-docetaxel-treatment-in-de-novo-metastatic-hormone-sensitive-prostate-cancer-a-single-center-cohort-study
#14
JOURNAL ARTICLE
Tomislav Omrčen, Davor Eterović, Tea Jozić, Eduard Vrdoljak
Six cycles of docetaxel in addition to androgen deprivation therapy (ADT) are currently one of the treatment options for patients with de novo metastatic hormone-sensitive prostate cancer (mHSPC). Since the outcomes in patients with high-volume (HV) disease remain modest, we aimed to identify patients for more intensified treatment. We report a cohort of 73 consecutive patients with de novo mHSPC treated with early docetaxel at the Department of Oncology and Radiotherapy, University Hospital of Split, Croatia, from October 2015 until March 2020...
June 2023: Neoplasma
https://read.qxmd.com/read/37498061/circular-rna_0000326-accelerates-breast-cancer-development-via-modulation-of-the-mir-9-3p-yap1-axis
#15
JOURNAL ARTICLE
Xiao-Ling Xue, Shuai Zhao, Meng-Chang Xu, Ying Li, Wen-Fei Liu, Hong-Zhen Qin
Circular RNA (circ)_0000326 has been reported in bladder cancer and cervical cancer and is concerned to be involved with the development of cancerous cells. Whereas, there have been no reports concentrating on the influences of circ_0000326 in breast cancer (BC). Therefore, the latent modulatory mechanisms of circ_0000326 in BC are researched. circ_0000326 expression in BC tissues and correlative cells was evaluated via RT-qPCR, and the relevance between circ_0000326 expression and overall survival and the clinicopathological feature was also investigated...
June 2023: Neoplasma
https://read.qxmd.com/read/37226933/the-inhibition-of-aurora-a-kinase-regulates-phospholipid-remodeling-by-upregulating-lpcat1-in-glioblastoma
#16
JOURNAL ARTICLE
Ya-Zhou Miao, Jing Wang, Shu-Yu Hao, Yu-Xuan Deng, Zhe Zhang, Ze-Ping Jin, Da-Yuan Liu, Shao-Dong Zhang, Hong Wan, Nan Ji, Jie Feng
Metabolic reprogramming is a common feature of glioblastoma (GBM) progression and metastasis. Altered lipid metabolism is one of the most prominent metabolic alterations in cancer. Understanding the links between phospholipid remodeling and GBM tumorigenesis may help develop new anticancer strategies and improve treatments to overcome drug resistance. We used metabolomic and transcriptomic analyses to systematically investigate metabolic and molecular changes in low-grade glioma (LGG) and GBM. We then re-established the reprogrammed metabolic flux and membrane lipid composition in GBM based on metabolomic and transcriptomic analyses...
April 2023: Neoplasma
https://read.qxmd.com/read/37226932/nucks1-promotes-the-progression-of-colorectal-cancer-via-activating-pi3k-akt-mtor-signaling-pathway
#17
JOURNAL ARTICLE
Liao-Liao Zhu, Jing-Jie Shi, Yong-Dong Guo, Cheng Yang, Rong-Lin Wang, Shan-Shan Li, Dong-Xue Gan, Pei-Xiang Ma, Jun-Qiang Li, Hai-Chuan Su
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (NUCKS1) is highly expressed in a variety of malignant tumors and functions as an oncogene; however, its role in colorectal cancer (CRC) remains unclear. We aimed to explore the function and regulatory mechanisms of NUCKS1 and potential therapeutic agents targeting NUCKS1 in CRC. We knocked down and overexpressed NUCKS1 in CRC cells and explored its effects in vitro and in vivo. Flow cytometry, CCK-8, Western blotting, colony formation, immunohistochemistry, in vivo tumorigenic, and transmission electron microscopy analyses were performed to determine the effects of NUCKS1 on CRC cell function...
April 2023: Neoplasma
https://read.qxmd.com/read/37226931/urinary-shedding-of-common-dna-viruses-and-their-possible-association-with-bladder-cancer-a-qpcr-based-study
#18
JOURNAL ARTICLE
Jan Hrbáček, Vítězslav Hanáček, Dominika Kadlečková, Adéla Cirbusová, Pavel Čermák, Ruth Tachezy, Roman Zachoval, Martina Saláková
After a decade of human urinary microbiota research, little is known about the composition of the urinary virome and its association with health and disease. This study aimed to investigate the presence of 10 common DNA viruses in human urine and their putative association with bladder cancer (BC). Catheterized urine samples were collected from patients undergoing endoscopic urological procedures under anesthesia. After DNA extraction from the samples, viral DNA sequences were detected using real-time PCR. Viruria rates were compared between BC patients and controls...
April 2023: Neoplasma
https://read.qxmd.com/read/37005955/transcriptional-adaptor-3-influences-the-proliferative-and-invasive-phenotypes-of-non-small-cell-lung-cancer-cells-via-regulating-emt
#19
JOURNAL ARTICLE
Li-Qin Xu, Shu-Wen Zhang, Rui Zhang, Jing-Jing Chen, Zai-Xin Yuan, Jian Feng, Jian-An Huang
Transcriptional adaptor 3 (TADA3/ADA3) is a conserved transcriptional co-activator and is dysregulated in many aggressive tumors. However, the role of TADA3 in non-small cell lung cancer (NSCLC) remains unknown. It was previously demonstrated that TADA3 expression correlates with poor prognosis in patients with NSCLC. In the present study, the expression and function of TADA3 were investigated in cells in vitro and in vivo. TADA3 expression was evaluated in clinical specimens and cell lines using reverse transcription-quantitative PCR and western blot analysis...
April 2023: Neoplasma
https://read.qxmd.com/read/37005956/cellular-immunotherapy-combined-with-platinum-based-chemotherapy-prolongs-survival-for-non-small-cell-lung-cancer-patients
#20
JOURNAL ARTICLE
Lei Qian, Xiao Ding, Fang-Qi Li, Hui-Min Tian, Xiao Chen, Fu-Jun Han, Hong-Yi Wang, Wen-Qian Li, Chao Niu, Jian-Ting Xu, Zhao-Zhi Li, Hua He, Jiu-Wei Cui
Platinum-based chemotherapy is the primary treatment option for advanced non-small cell lung cancer (NSCLC) patients without a driver gene mutation, but its efficacy is still modest. Through a potential synergistic effect, autologous cellular immunotherapy (CIT) composed of cytokine-induced killer (CIK, natural killer (NK), and T cells) might enhance it. NK cells exhibited in vitro cytotoxicity toward lung cancer cells (A549 cells) following platinum therapy. Using flow cytometry, the expression of MICA, MICB, DR4, DR5, CD112, and CD155 on lung cancer cells was assessed...
March 30, 2023: Neoplasma
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