N V Mitiushkina, M M Kholmatov, A R Venina, V I Tiurin, G A Yanus, T N Sokolova, O S Yatsuk, O A Zaitseva, A O Ivantsov, E Sh Kuligina, A V Togo, E N Imyanitov
In contrast to other countries with predominantly white populations, Russian smoking-related lung cancers (LC) are mainly squamous cell carcinomas and approximately half lung adenocarcinomas (AdCa) are not related to tobacco consumption. Given that smoking significantly influences the probability of presence of actionable mutations in LC, one would expect that Russian lung AdCa patients would differ from other white populations in distribution of EGFR, ALK, KRAS and BRAF mutations. Herein, 2,336 consecutive lung AdCa cases, including 1,203 patients with known smoking status, were subjected to sequential testing for the above mutations...
November 15, 2018: Neoplasma