journal
https://read.qxmd.com/read/38515338/risk-of-thoracic-soft-tissue-sarcoma-after-breast-cancer-radiotherapy-a-population-based-cohort-study-in-osaka-japan
#1
JOURNAL ARTICLE
Toshiki Ikawa, Yoshihiro Kuwabara, Kayo Nakata, Naoyuki Kanayama, Masahiro Morimoto, Isao Miyashiro, Koji Konishi
Postoperative radiotherapy for breast cancer reportedly increases the risk of thoracic soft tissue sarcomas, particularly angiosarcomas; however, the risk in the Japanese population remains unknown. Therefore, this study aimed to investigate the incidence of thoracic soft tissue sarcoma among patients with breast cancer in Japan and determine its association with radiotherapy. This retrospective cohort study used data from the population-based cancer registry of the Osaka Prefecture. The inclusion criteria were female sex, age 20-84 years, diagnosis of breast cancer between 1990 and 2010, no supraclavicular lymph node or distant metastasis, underwent surgery and survived for at least 1 year...
March 21, 2024: Journal of Radiation Research
https://read.qxmd.com/read/38499489/probability-of-normal-tissue-complications-for-hematologic-and-gastrointestinal-toxicity-in-postoperative-whole-pelvic-radiotherapy-for-gynecologic-malignancies-using-intensity-modulated-proton-therapy-with-robust-optimization
#2
JOURNAL ARTICLE
Takaaki Yoshimura, Ryota Yamada, Rumiko Kinoshita, Taeko Matsuura, Takahiro Kanehira, Hiroshi Tamura, Kentaro Nishioka, Koichi Yasuda, Hiroshi Taguchi, Norio Katoh, Keiji Kobashi, Takayuki Hashimoto, Hidefumi Aoyama
This retrospective treatment-planning study was conducted to determine whether intensity-modulated proton therapy with robust optimization (ro-IMPT) reduces the risk of acute hematologic toxicity (H-T) and acute and late gastrointestinal toxicity (GI-T) in postoperative whole pelvic radiotherapy for gynecologic malignancies when compared with three-dimensional conformal radiation therapy (3D-CRT), intensity-modulated X-ray (IMXT) and single-field optimization proton beam (SFO-PBT) therapies. All plans were created for 13 gynecologic-malignancy patients...
March 17, 2024: Journal of Radiation Research
https://read.qxmd.com/read/38461549/inhibition-of-intracellular-atp-synthesis-impairs-the-recruitment-of-homologous-recombination-factors-after-ionizing-radiation
#3
JOURNAL ARTICLE
Ryota Hayashi, Hikaru Okumura, Mayu Isono, Motohiro Yamauchi, Daiki Unami, Rahmartani Tania Lusi, Masamichi Yamamoto, Yu Kato, Yuki Uchihara, Atsushi Shibata
Ionizing radiation (IR)-induced double-strand breaks (DSBs) are primarily repaired by non-homologous end joining or homologous recombination (HR) in human cells. DSB repair requires adenosine-5'-triphosphate (ATP) for protein kinase activities in the multiple steps of DSB repair, such as DNA ligation, chromatin remodeling, and DNA damage signaling via protein kinase and ATPase activities. To investigate whether low ATP culture conditions affect the recruitment of repair proteins at DSB sites, IR-induced foci were examined in the presence of ATP synthesis inhibitors...
March 8, 2024: Journal of Radiation Research
https://read.qxmd.com/read/38461548/modeling-of-a-tissue-expander-with-a-radiofrequency-identification-port-in-postmastectomy-radiation-therapy-planning
#4
JOURNAL ARTICLE
Fumiyasu Matsubayashi, Taro Takahashi, Hikaru Miyauchi, Yasushi Ito, Arisa Harada, Yasuo Yoshioka
The purpose of this study was to evaluate the dose attenuation of Motiva Flora® (Flora, Establishment Labs, Alajuela, Costa Rica) tissue expander with a radiofrequency identification port locator and to develop a model for accurate postmastectomy radiation therapy planning. Dose attenuation was measured using an EBT3 film (Ashland, Bridgewater, NJ), and the optimal material and density assignment for the radiofrequency identification coil for dose calculation were investigated using the AcurosXB algorithm on the Eclipse (Varian Medical Systems, Palo Alto, CA) treatment planning system...
March 8, 2024: Journal of Radiation Research
https://read.qxmd.com/read/38415344/albumin-bilirubin-score-is-a-useful-predictor-of-worsening-liver-reserve-after-stereotactic-body-radiation-therapy-in-elderly-japanese-patients-with-hepatocellular-carcinoma
#5
JOURNAL ARTICLE
Yuki Yoshino, Gen Suzuki, Hiroya Shiomi, Takuya Kimoto, Sho Seri, Hideya Yamazaki, Kei Yamada
The prognosis of patients with hepatocellular carcinoma (HCC) is closely related to their liver reserves. The Child-Pugh (CP) score has traditionally been used to evaluate this reserve, with CP Grade B (CP score ≥ 7) associated with a higher risk of radiation-induced liver disease after stereotactic body radiation therapy (SBRT). However, the CP score has limitations, as it does not accurately assess liver reserve capacity. The albumin-bilirubin (ALBI) score has been introduced as a meticulous indicator of liver reserve for the treatment of HCC...
February 26, 2024: Journal of Radiation Research
https://read.qxmd.com/read/38331401/effect-of-bolus-materials-on-dose-deposition-in-deep-tissues-during-electron-beam-radiotherapy
#6
JOURNAL ARTICLE
Dong Kong, Jia Wu, Xudong Kong, Jianfeng Huang, Yutian Zhao, Bo Yang, Qing Zhao, Ke Gu
Several materials are utilized in the production of bolus, which is essential for superficial tumor radiotherapy. This research aimed to compare the variations in dose deposition in deep tissues during electron beam radiotherapy when employing different bolus materials. Specifically, the study developed general superficial tumor models (S-T models) and postoperative breast cancer models (P-B models). Each model comprised a bolus made of water, polylactic acid (PLA), polystyrene, silica-gel or glycerol. Geant4 was employed to simulate the transportation of electron beams within the studied models, enabling the acquisition of dose distributions along the central axis of the field...
February 8, 2024: Journal of Radiation Research
https://read.qxmd.com/read/38330507/mhy1485-potentiates-immunogenic-cell-death-induction-and-anti-cancer-immunity-following-irradiation
#7
JOURNAL ARTICLE
Lue Sun, Kumi Morikawa, Yu Sogo, Yuki Sugiura
Recent in vitro experiments showed that combined treatment with MHY1485, a low-molecular-weight compound, and X-ray irradiation significantly increased apoptosis and senescence in tumor cells, which was associated with oxidative stress, endoplasmic reticulum (ER) stress and p21 stabilization, compared to radiation treatment alone. However, evidence for MHY1485 treatment-mediated suppression of tumor growth in animals is still lacking. Furthermore, it has been shown that ER stress enhances immunogenic cell death (ICD) in tumor cells, as it can exert a favorable influence on the anti-cancer immune system...
February 8, 2024: Journal of Radiation Research
https://read.qxmd.com/read/38321606/the-japanese-nationwide-cohort-data-of-proton-beam-therapy-for-liver-oligometastasis-in-breast-cancer-patients
#8
JOURNAL ARTICLE
Hisashi Yamaguchi, Nobuyoshi Fukumitsu, Haruko Numajiri, Hiroyuki Ogino, Tomoaki Okimoto, Takashi Ogino, Motohisa Suzuki, Shigeyuki Murayama
A nationwide multicenter cohort study on particle therapy was launched by the Japanese Society for Radiation Oncology in Japan in May 2016. We analyzed the outcome of proton beam therapy (PBT) for liver oligometastasis in breast cancers. Cases in which PBT was performed at all Japanese proton therapy facilities between May 2016 and February 2019 were enrolled. The patients were selected based on the following criteria: the primary cancer was controlled, liver recurrence without extrahepatic tumors and no more than three liver lesions...
February 6, 2024: Journal of Radiation Research
https://read.qxmd.com/read/38321603/evaluating-thyroid-cancer-risks-for-nuclear-workers-related-to-the-fukushima-daiichi-nuclear-power-plant-accident-based-on-lnt-theory-is-problematic
#9
JOURNAL ARTICLE
Bobby R Scott
No abstract text is available yet for this article.
February 6, 2024: Journal of Radiation Research
https://read.qxmd.com/read/38265112/an-analysis-of-muscle-growth-after-proton-beam-therapy-for-pediatric-cancer
#10
JOURNAL ARTICLE
Hazuki Nitta, Masashi Mizumoto, Yinuo Li, Yoshiko Oshiro, Hiroko Fukushima, Ryoko Suzuki, Sho Hosaka, Takashi Saito, Haruko Numajiri, Chie Kawano, Satoshi Kamizawa, Kazushi Maruo, Hideyuki Sakurai
Retardation of growth and development is a well-known late effect after radiotherapy for pediatric patients. The goal of the study was to examine the effect of proton beam therapy (PBT) on the growth of muscles included in the irradiated area. The subjects were 17 pediatric patients (age ≤ 5 years) who received PBT with a treatment field including a muscle on only one side out of a pair of symmetrical bilateral muscles and had imaging evaluations for at least 1 year after PBT...
January 23, 2024: Journal of Radiation Research
https://read.qxmd.com/read/38264835/application-of-a-derivative-of-human-defensin-5-to-treat-ionizing-radiation-induced-enterogenic-infection
#11
JOURNAL ARTICLE
Gaomei Zhao, Yingjuan He, Yin Chen, Yiyi Jiang, Chenwenya Li, Tainong Xiong, Songling Han, Yongwu He, Jining Gao, Yongping Su, Junping Wang, Cheng Wang
Enterogenic infection is a common complication for patients with radiation injury and requires efficient therapeutics in the clinic. Herein, we evaluated the promising drug candidate T7E21RHD5, which is a peptide derived from intestinal Paneth cell-secreted human defensin 5. Oral administration of this peptide alleviated the diarrhea symptoms of mice that received total abdominal irradiation (TAI, γ-ray, 12 Gy) and improved survival. Pathologic analysis revealed that T7E21RHD5 elicited an obvious mitigation of ionizing radiation (IR)-induced epithelial damage and ameliorated the reduction in the levels of claudin, zonula occluden 1 and occludin, three tight junction proteins in the ileum...
January 23, 2024: Journal of Radiation Research
https://read.qxmd.com/read/38264828/cone-beam-computed-tomography-guided-online-adaptive-radiotherapy-for-pharyngeal-cancer-with-whole-neck-irradiation-dose-volume-histogram-analysis-between-adapted-and-scheduled-plans
#12
JOURNAL ARTICLE
Takuya Uehara, Yasumasa Nishimura, Kazuki Ishikawa, Masahiro Inada, Kenji Matsumoto, Hiroshi Doi, Hajime Monzen, Yukinori Matsuo
The present study aimed to evaluate whether an adapted plan with Ethos™ could be used for pharyngeal cancer. Ten patients with pharyngeal cancer who underwent chemoradiotherapy with available daily cone-beam computed tomography (CBCT) data were included. Simulated treatments were generated on the Ethos™ treatment emulator using CBCTs every four to five fractions for two plans: adapted and scheduled. The simulated treatments were divided into three groups: early (first-second week), middle (third-fourth week), and late (fifth-seventh week) periods...
January 23, 2024: Journal of Radiation Research
https://read.qxmd.com/read/38247158/anti-radiation-effect-of-mrn-100-a-hydro-ferrate-fluid-in-vivo
#13
JOURNAL ARTICLE
Mamdooh Ghoneum, Nariman K Badr El-Din, Mai Alaa El-Dein
Ionizing radiation (IR) severely harms many organs, especially the hematopoietic tissue, mandating the development of protective nutraceuticals. MRN-100, a hydro-ferrate fluid, has been shown to protect γ-radiated fish against hematopoietic tissue damage and lethality. The current study aimed to examine MRN-100's protective effect against irradiated mice and explore the mechanisms underlying its effect. Mice received a single acute, sub-lethal, 5 Gy, whole body dose of X-ray IR. MRN-100 treatment was administered daily for 2-weeks pre-irradiation until 1-week post-irradiation...
January 21, 2024: Journal of Radiation Research
https://read.qxmd.com/read/38171574/enhanced-induction-of-abnormal-telomere-fish-signals-in-response-to-oxidative-dna-damage
#14
JOURNAL ARTICLE
Yoshimi Sakamoto, Kazunori Shiraishi, Seiji Kodama
Telomere dysfunction induces chromosomal instability, which is a driving force in the development of cancers. To examine X-irradiation's effect on telomere integrity, we investigated X-ray-induced abnormalities in telomere signals detected by fluorescence in situ hybridization (telomere FISH) in mouse embryo fibroblast cells. The abnormalities were categorized as either extra telomere signals (ETSs) or loss of telomere signals (LTSs). The results indicated that low doses (0.3-0.5 Gy) of X-rays significantly induced ETS but not LTS and that ETS induction was saturated at doses above 0...
January 3, 2024: Journal of Radiation Research
https://read.qxmd.com/read/37996086/a-multivariable-normal-tissue-complication-probability-model-for-predicting-radiation-induced-hypothyroidism-in-nasopharyngeal-carcinoma-patients-in-the-modern-radiotherapy-era
#15
JOURNAL ARTICLE
Siriporn Wongwattananard, Anussara Prayongrat, Natchalee Srimaneekarn, Anthony Hayter, Jiratchaya Sophonphan, Seksan Kiatsupaibul, Puvarith Veerabulyarith, Yothin Rakvongthai, Napat Ritlumlert, Sarin Kitpanit, Danita Kannarunimit, Chawalit Lertbutsayanukul, Chakkapong Chakkabat
Radiation-induced hypothyroidism (RHT) is a common long-term complication for nasopharyngeal carcinoma (NPC) survivors. A model using clinical and dosimetric factors for predicting risk of RHT could suggest a proper dose-volume parameters for the treatment planning in an individual level. We aim to develop a multivariable normal tissue complication probability (NTCP) model for RHT in NPC patients after intensity-modulated radiotherapy or volumetric modulated arc therapy. The model was developed using retrospective clinical data and dose-volume data of the thyroid and pituitary gland based on a standard backward stepwise multivariable logistic regression analysis and was then internally validated using 10-fold cross-validation...
January 19, 2024: Journal of Radiation Research
https://read.qxmd.com/read/38155365/preventive-and-therapeutic-effects-of-low-dose-whole-body-irradiation-on-collagen-induced-rheumatoid-arthritis-in-mice
#16
JOURNAL ARTICLE
Ji Young Kim, Yeong Ro Lee, Young Ae Lee, Chin-Hee Song, So Hyun Han, Seong Jun Cho, Seon Young Nam
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by progressive joint inflammation, resulting in cartilage destruction and bone erosion. It was reported that low-dose radiation modulates immune disease. Here, we investigated whether low-dose whole-body irradiation has preventive and therapeutic effects in collagen-induced RA (CIA) mouse models. Fractionated low-dose irradiation (0.05 Gy/fraction, total doses of 0.1, 0.5 or 0.8 Gy) was administered either concurrently with CIA induction by Type II collagen immunization (preventive) or after CIA development (therapeutic)...
December 28, 2023: Journal of Radiation Research
https://read.qxmd.com/read/38151954/mechanistic-insights-into-the-survival-curve-of-hela-cells-with-a-short-shoulder-and-their-s-phase-specific-sensitivity%C3%A2
#17
JOURNAL ARTICLE
Kenshi Komatsu, Hiroshi Tauchi
HeLa cells are a cell line with two unique cellular features: a short-shouldered survival curve and two peaks of radioresistance during the cell cycle phase, while their underlying mechanisms remain unclear. We herein proposed that these radiobiological features are due to a common mechanism by which radiation suppresses homologous recombination repair (HRR) in a dose-dependent manner. This radio-suppression of HRR is mediated by an intra-S checkpoint and reduces survivals of cells in S phase, especially early S phase, resulting in both short shoulder and radioresistance with two peaks in the cell cycle...
December 26, 2023: Journal of Radiation Research
https://read.qxmd.com/read/38151953/radiological-imaging-protection-a-study-on-imaging-dose-used-while-planning-computed-tomography-for-external-radiotherapy-in-japan
#18
JOURNAL ARTICLE
Satoshi Kito, Yuhi Suda, Satoshi Tanabe, Takeshi Takizawa, Tomomasa Nagahata, Naoki Tohyama, Hiroyuki Okamoto, Takumi Kodama, Yukio Fujita, Hisayuki Miyashita, Kazuya Shinoda, Masahiko Kurooka, Hidetoshi Shimizu, Takeshi Ohno, Masataka Sakamoto
Previous studies have primarily focused on quality of imaging in radiotherapy planning computed tomography (RTCT), with few investigations on imaging doses. To our knowledge, this is the first study aimed to investigate the imaging dose in RTCT to determine baseline data for establishing national diagnostic reference levels (DRLs) in Japanese institutions. A survey questionnaire was sent to domestic RT institutions between 10 October and 16 December 2021. The questionnaire items were volume computed tomography dose index (CTDIvol), dose-length product (DLP), and acquisition parameters, including use of auto exposure image control (AEC) or image-improving reconstruction option (IIRO) for brain stereotactic irradiation (brain STI), head and neck (HN) intensity-modulated radiotherapy (IMRT), lung stereotactic body radiotherapy (lung SBRT), breast-conserving radiotherapy (breast RT), and prostate IMRT protocols...
December 26, 2023: Journal of Radiation Research
https://read.qxmd.com/read/38151923/patterns-of-care-for-brachytherapy-in-japan
#19
JOURNAL ARTICLE
Hitoshi Ikushima, Noriko Ii, Shin-Ei Noda, Koji Masui, Naoya Murakami, Ken Yoshida, Miho Watanabe, Shinnji Kawamura, Toru Kojima, Yoshihito Nomoto, Takafumi Toita, Tatsuya Ohno, Hideyuki Sakurai, Hiroshi Onishi
This study aimed to assess the current state of brachytherapy (BT) resources, practices and resident education in Japan. A nationwide survey was undertaken encompassing 177 establishments facilitating BT in 2022. Questionnaires were disseminated to each BT center, and feedback through online channels or postal correspondence was obtained. The questionnaire response rate was 90% (159/177), and every prefecture had a response in at least one center. The number of centers in each prefecture ranged from 0.6 to 3...
December 26, 2023: Journal of Radiation Research
https://read.qxmd.com/read/38151920/the-potential-overdose-of-heart-and-left-anterior-descending-coronary-artery-region-during-intensity-modulated-radiation-therapy-in-patients-with-esophageal-cancer
#20
JOURNAL ARTICLE
Kenji Makita, Yasushi Hamamoto, Hiromitsu Kanzaki, Kei Nagasaki
This study aimed to investigate the changes in dose distribution in the heart and left anterior descending coronary artery region (LADR) during intensity-modulated radiation therapy (IMRT) in patients with esophageal cancer (EC) treated at our institution. The heart and LADR were delineated on the initial and off-cord boost planning computed tomography (CT) images. Cardiac volume reduction (CVR) was defined as the reduction in cardiac volume between the initial CT and off-cord boost CT at the dose of 36 Gy irradiated...
December 26, 2023: Journal of Radiation Research
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