Zifeng Yang, Siyao Zhang, Xiang Liu, Rui Shu, Wei Shi, Weiyi Qu, Dianyu Liu, Zhiwei Cai, Ye Wang, Xu Cheng, Yemao Liu, Xiao-Jing Zhang, Lan Bai, Hongliang Li, Zhi-Gang She
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease without specific Food and Drug Administration-approved drugs. Recent advances suggest that chromatin remodeling and epigenetic alteration contribute to the development of NAFLD. The functions of the corresponding molecular modulator in NAFLD, however, are still elusive. KDM1A, commonly known as lysine-specific histone demethylase 1, has been reported to increase glucose uptake in hepatocellular carcinoma. In addition, a recent study suggests that inhibition of KDM1A reduces lipid accumulation in primary brown adipocytes...
January 29, 2024: Journal of Lipid Research