journal
https://read.qxmd.com/read/38991706/some-issues-to-consider-with-the-use-of-serum-indices
#1
EDITORIAL
Janice Lee Veronica Reeve, David Housley, Patrick J Twomey
No abstract text is available yet for this article.
July 11, 2024: Journal of Clinical Pathology
https://read.qxmd.com/read/38991705/haemolysis-index-conundrum-in-a-covid-19-patient
#2
JOURNAL ARTICLE
Chong Qin Michael Zhao, Jordan Steinberg, Dennise Otero Espinal, Oana Vele
In this study, we report a preanalytical challenge noted in our laboratory on plasma samples from a critically ill COVID-19 patient treated with hydroxychloroquine. This is significant because, in critically ill COVID-19 patients on hydroxychloroquine, plasma samples can have a high measured haemolysis index in the absence of haemolysis, with the impact on reporting the results for potassium and other analytes.
July 11, 2024: Journal of Clinical Pathology
https://read.qxmd.com/read/38981664/the-road-ahead-a-brief-guide-to-navigating-the-2022-who-classification-of-endocrine-and-neuroendocrine-tumours
#3
REVIEW
Carl Christofer Juhlin
The most recent WHO classification of endocrine and neuroendocrine tumours has brought about significant changes in the diagnosis and grading of these lesions. For instance, pathologists now have the ability to stratify subsets of thyroid and adrenal neoplasms using various histological features and composite risk assessment models. Moreover, novel recommendations on how to approach endocrine neoplasia involve additional immunohistochemical analyses, and the recognition and implementation of these key markers is essential for modernising diagnostic capabilities...
July 9, 2024: Journal of Clinical Pathology
https://read.qxmd.com/read/38981663/-f8-variants-and-their-genotype-phenotype-correlations-in-thai-patients-with-haemophilia-a-a-nationwide-multicentre-study
#4
JOURNAL ARTICLE
Chayanit Trirut, Darintr Sosothikul, Rungnapa Ittiwut, Chupong Ittiwut, Sureeporn Pongsewalak, Natsaruth Songthawee, Rungrote Natesirinilkul, Pallapa Banjerdlak, Pokpong Na Songkhla, Patcharee Komvilaisak, Chatphatai Moonla, Kanya Suphapeetiporn
AIMS: Analysis of the F8 gene helps predict the risk of developing factor VIII (FVIII) inhibitors and the depth of phenotype in haemophilia A (HA) patients. Since data in Southeast Asian countries remain scarce, we aim to study F8 variation correlated with HA phenotypes in Thailand. METHODS: Thai patients with HA were enrolled from seven haemophilia treatment centres during 2022-2023. Using peripheral blood DNA, inverse shifting-polymerase chain reaction (IS-PCR) for F8 -intron 22 inversion (Inv22) and F8 -intron 1 inversion (Inv1) was performed...
July 9, 2024: Journal of Clinical Pathology
https://read.qxmd.com/read/38914446/implementation-of-an-iso-15189-accredited-next-generation-sequencing-service-for-cell-free-total-nucleic-acid-cftna-analysis-to-facilitate-driver-mutation-reporting-in-blood-the-experience-of-a-clinical-diagnostic-laboratory
#5
JOURNAL ARTICLE
Reiltin Werner, Ruth Crosbie, Mairead Dorney, Amy Connolly, Dearbhaile Collins, Collette K Hand, Louise Burke
AIMS: Next generation sequencing (NGS) on tumour tissue is integral to the delivery of personalised medicine and targeted therapy. NGS on liquid biopsy, a much less invasive technology, is an emerging clinical tool that has rapidly expanded clinical utility. Gene mutations in cell-free total nucleic acids (cfTNA) circulating in the blood are representative of whole tumour biology and can reveal different mutations from different tumour sites, thus addressing tumour heterogeneity challenges...
June 24, 2024: Journal of Clinical Pathology
https://read.qxmd.com/read/38886044/molecular-profiling-of-visible-polypoid-and-invisible-conventional-intestinal-type-low-grade-dysplasia-in-patients-with-idiopathic-inflammatory-bowel-disease
#6
JOURNAL ARTICLE
Alexander Christakis, Jonathan Nowak, Matthew J Hamilton, John R Goldblum, Paige Parrack, Neal I Lindeman, Robert Odze, Deepa T Patil
AIMS: Little is known about the molecular features of visible polyps with low-grade intestinal-type dysplasia in patients with inflammatory bowel disease (IBD). To better understand their origins and biological potential, we sought to genomically profile these lesions and compare them with invisible low-grade dysplasia and sporadic adenomas from non-IBD patients. METHODS: 22 polyps within areas of colitis, 13 polyps outside areas of colitis, 10 foci of invisible dysplasia from patients with IBD and 6 sporadic tubular adenomas from non-IBD patients were analysed using the OncoPanel assay...
June 17, 2024: Journal of Clinical Pathology
https://read.qxmd.com/read/38886043/clinicopathological-significance-and-prognostic-analysis-of-p21-and-egfr-in-colorectal-cancer-a-retrospective-analysis-on-12-319-cases-in-china
#7
JOURNAL ARTICLE
Yang Fei, Mengke Ma, Lu Gan, Midie Xu, Yu Yang, Dan Huang, Weiqi Sheng
AIMS: Colorectal cancer (CRC) is the third most common malignancy worldwide. Accurate pathological diagnosis and predictive abilities for treatment response and prognosis are crucial for patients with CRC. This study aims to analyse the expressions of p21 and EGFR in CRC and their relationships with clinicopathological characteristics and prognosis to enhance diagnostic and prognostic evaluations. METHODS: This study conducted a retrospective analysis of p21 and EGFR expressions in 12 319 Chinese patients with CRC using immunohistochemistry...
June 17, 2024: Journal of Clinical Pathology
https://read.qxmd.com/read/38876777/the-highs-and-lows-of-grading-intraductal-carcinoma-of-the-prostate
#8
LETTER
Jodie Ai Ling McDonald, Jonathan O'Brien, Brian Kelly, Declan Murphy, Nathan Lawrentschuk, Renu Eapen, Catherine Mitchell
No abstract text is available yet for this article.
June 14, 2024: Journal of Clinical Pathology
https://read.qxmd.com/read/38876776/macro-microscopic-evaluation-of-pathology-specimens-with-large-format-histology-for-the-benefit-of-our-service-users-and-patients
#9
LETTER
Alessia Cimadamore, Liang Cheng, Antonio Lopez-Beltran, Carmine Franzese, Eamonn T Rogers, Rodolfo Montironi
No abstract text is available yet for this article.
June 14, 2024: Journal of Clinical Pathology
https://read.qxmd.com/read/38876775/medium-term-storage-of-frozen-residual-antenatal-sera-in-gel-separator-tube-is-suitable-for-subsequent-serological-investigation-of-intrauterine-infection
#10
JOURNAL ARTICLE
Weiling Ng, Ter Yong Tan, Xin Yu Venessa Chow, Siew Hoon Lim, Wei Yee Wan
AIM: We assessed the feasibility of storing sera in primary gel separator tube over medium-term for retrospective serological tests to facilitate investigation of intra-uterine infection. METHOD: 120 residual serum samples, consisting of 30 positive samples each for rubella, cytomegalovirus, parvovirus B19 and varicella zoster IgG were aliquoted into secondary propylene tubes and stored together with the original primary tubes at -20°C for 1 year. The serum was subsequently retested to compare results from both storage methods...
June 14, 2024: Journal of Clinical Pathology
https://read.qxmd.com/read/38876774/authors-reply-megablocks-are-nice-but-not-really-necessary
#11
LETTER
Murali Varma, John Dormer
No abstract text is available yet for this article.
June 14, 2024: Journal of Clinical Pathology
https://read.qxmd.com/read/38862215/comparing-the-diagnostic-efficacy-of-optical-coherence-tomography-and-frozen-section-for-margin-assessment-in-breast-conserving-surgery-a-meta-analysis
#12
JOURNAL ARTICLE
Shishun Fan, Huirui Zhang, Zhenyu Meng, Ang Li, Yuqing Luo, Yueping Liu
AIMS: This meta-analysis assessed the relative diagnostic accuracy of optical coherence tomography (OCT) versus frozen section (FS) in evaluating surgical margins during breast-conserving procedures. METHODS: PubMed and Embase were searched for relevant studies published up to October 2023. The inclusion criteria encompassed studies evaluating the diagnostic accuracy of OCT or FS in patients undergoing breast-conserving surgery. Sensitivity and specificity were analysed using the DerSimonian and Laird method and subsequently transformed through the Freeman-Tukey double inverse sine method...
June 11, 2024: Journal of Clinical Pathology
https://read.qxmd.com/read/38849197/s100-protein-is-commonly-expressed-in-neuroendocrine-tumours-of-major-and-minor-ampulla
#13
LETTER
Alessandro Vanoli, Frediano Inzani, Paola Parente, Luca Albarello, Matteo Fassan, Federica Grillo, Alessia Messina, Angela Carlino, Silvia Uccella, Paola Spaggiari, Stefano La Rosa, Guido Rindi
No abstract text is available yet for this article.
June 7, 2024: Journal of Clinical Pathology
https://read.qxmd.com/read/38849196/assessing-venous-invasion-in-stage-ii-colon-cancer-optimal-elastin-stains-and-survival-analysis
#14
JOURNAL ARTICLE
Soo Hyun Lee, Omer Yilmaz, Nandan Padmanabha, Vikram Deshpande, Osman Yilmaz
AIMS: Venous invasion (VI) in colorectal carcinoma influences treatment strategies, especially in early stages. Despite elastin staining effectiveness in detecting VI, guidelines for its routine application, including the optimal number of slides for staining, are limited. METHODS: Elastin staining was performed for VI assessment in patients with colorectal adenocarcinoma. Patients were categorised into two groups: single elastin stain group (SEG, n=248) and multiple elastin stain group (MEG, n=204)...
June 7, 2024: Journal of Clinical Pathology
https://read.qxmd.com/read/38839087/ingested-foreign-bodies-mimicking-inflammatory-bowel-disease
#15
LETTER
Chenxu Shi, Shariq Raza, Andrew Tieniber, Pak Chau, Franz Fogt
No abstract text is available yet for this article.
June 5, 2024: Journal of Clinical Pathology
https://read.qxmd.com/read/38839089/invasion-risk-of-cutaneous-squamous-cell-carcinoma-in-situ-by-histological-subtype-a-retrospective-cohort-study
#16
JOURNAL ARTICLE
Danielle K Stamer, Joshua Goldsmith, Laura E Dodge, Steven R Tahan
AIMS: Cutaneous squamous cell carcinoma in situ (SCCis) can be classified histopathologically into four subtypes: full-thickness (FT), hypertrophic actinic keratosis (HAK), Bowenoid, and acantholytic types. 3%-5% of SCCis lesions progress to invasive squamous cell carcinoma (iSCC), however progression risk by subtype has not been assessed. Aim one of this study is to quantitatively assess the risk of iSCC associated with each histological subtype of SCCis. Aim two is to evaluate if the histological grade of iSCC differs among subtypes of the associated SCCis...
June 4, 2024: Journal of Clinical Pathology
https://read.qxmd.com/read/38839088/-alk-rearranged-mesenchymal-neoplasms-a-clinicopathological-and-molecular-study-of-eight-additional-cases-of-an-emerging-group-of-tyrosine-kinase-fusion-mesenchymal-tumours
#17
JOURNAL ARTICLE
Ming Zhao, Jing Song, Xiaona Yin, Jiayun Xu, Xiaodong Teng, Jian Wang
AIMS: Mesenchymal neoplasms characterised by ALK fusions mainly include inflammatory myofibroblastic tumour (IMT) and epithelioid fibrous histiocytoma (EFH). Most recently, ALK -rearranged mesenchymal tumours that are not IMT or EFH have been reported. Our aim is to further characterise eight such neoplasms, with a detailed clinicopathological, immunohistochemical and molecular analysis. METHODS: Clinicopathological features were assessed and partner agnostic targeted RNA-sequencing on clinically validated platforms was performed...
June 4, 2024: Journal of Clinical Pathology
https://read.qxmd.com/read/38821855/attitudes-of-uk-pathologists-and-judicial-officers-towards-medicolegal-view-and-grant-examinations-a-cross-sectional-mixed-methods-study
#18
JOURNAL ARTICLE
Jacob Foster, David Sadler, Sam Taylor
AIMS: Despite the 1988 'Dundee Initiative', which maximised the use of view and grant examinations to reduce the invasive forensic autopsy rate in Tayside, the view and grant itself remains controversial. This is the first study to measure attitudes towards view and grants, applying the Theory of Planned Behaviour to investigate what attitudes are held, the reasons behind them and their association with deciding the scope of postmortem examinations. METHODS: A mixed-methods cross-sectional study examined 62 UK pathologists, coroners and procurators fiscal using an online questionnaire...
May 31, 2024: Journal of Clinical Pathology
https://read.qxmd.com/read/38821854/relationship-between-parathyroid-adenoma-size-weight-and-histological-subtypes-with-perioperative-serum-levels
#19
JOURNAL ARTICLE
Fred Chuang, Shu Kay Ng, Roger Khan, Alfred King-Yin Lam
AIMS: This study aims to identify associations between parathyroid adenoma (PTA) characteristics (histology, weight and size) with the change in parathyroid hormone (PTH) and calcium levels. METHODS: A historical cohort study was conducted on adult patients with solitary PTA removed in the Gold Coast Health Precinct, Australia, between 2017 and 2022. RESULTS: PTA weight is correlated with the change in day 1 PTH level (r=0.26, p=0.036), the change in day 1 corrected calcium level (r=0...
May 31, 2024: Journal of Clinical Pathology
https://read.qxmd.com/read/38777570/prevalence-and-clinical-outcomes-of-germline-variants-among-patients-with-myeloid-neoplasms
#20
JOURNAL ARTICLE
Sunisa Kongkiatkamon, Pimjai Niparuck, Thanawat Rattanathammethee, Sirorat Kobbuaklee, Amornchai Suksusut, Kitsada Wudhikarn, Chupong Ittiwut, Wanna Chetruengchai, Suporn Chuncharunee, Udomsak Bunworasate, Kanya Suphapeetiporn, Ponlapat Rojnuckarin, Chantana Polprasert
AIMS: Myeloid neoplasms (MNs) with germline predisposition have been recognised as a distinct entity. Emerging evidence suggests that sporadic myelodysplastic syndromes may also harbour undetected germline predispositions. We investigated germline alterations in a cohort of 122 adult Thai MNs. METHODS: MN patients were recruited and tested for germline variants using deep targeted next-generation sequencing. The germline variant was filtered using American College of Medical Genetics classifications and then evaluated for the association with clinical characteristics and outcomes...
May 22, 2024: Journal of Clinical Pathology
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