Adrian C Bateman, Adam L Booth, Raul S Gonzalez, Neil A Shepherd
The range of lesions with a serrated appearance within the large intestine has expanded and become more complex over the last 30 years. The majority of these were previously known as metaplastic polyps but are today called hyperplastic polyps (HPs). HPs show two main growth patterns: microvesicular and goblet cell-rich. The former type shows morphological and molecular similarities (eg, BRAF mutations) to the more recently described sessile serrated lesion (SSL). In this review, we debate whether these lesions represent a biological spectrum or separate entities...
March 16, 2023: Journal of Clinical Pathology
Yunling Li, Guannan Wang, Enjie Liu, Dandan Zhang, Yanping Zhang, Xiangyu Jian, Wugan Zhao, Wencai Li
AIMS: To investigate the clinicopathological features, immunophenotypes and differential diagnosis of CD5-positive splenic marginal zone lymphoma (SMZL). METHODS: We retrospectively analysed 16 CD5-positive cases of SMZL. Assess their clinicopathological features and survival outcomes to evaluate their similarities and differences with a control group of 25 CD5-negative cases of SMZL. RESULTS: Compared with CD5-negative patients, CD5-positive SMZL tends to be more prone to B symptoms, peripheral lymphadenopathy and extranodal infiltration, high Ann Arbor stage, high International Prognostic Index scores, high serum lactic dehydrogenase and high rates of bone marrow involvement...
March 15, 2023: Journal of Clinical Pathology
Aswathy Ashok Menon, Vikram Deshpande, David Suster
The mouse double minute 2 ( MDM2 ) gene is located on the long arm of chromosome 12 and is the primary negative regulator of p53. The MDM2 gene encodes an E3 ubiquitin-protein ligase that mediates the ubiquitination of p53, leading to its degradation. MDM2 enhances tumour formation by inactivating the p53 tumour suppressor protein. The MDM2 gene also has many p53-independent functions. Alterations of MDM2 may occur through various mechanisms and contribute to the pathogenesis of many human tumours and some non-neoplastic diseases...
March 10, 2023: Journal of Clinical Pathology
Helen Ashwin, Luke Milross, Julie Wilson, Joaquim Majo, Jimmy Tsz Hang Lee, Grant Calder, Bethany Hunter, Sally James, Dimitris Lagos, Nathalie Signoret, Andrew Filby, Omer Ali Bayraktar, Andrew J Fisher, Paul M Kaye
Diffuse alveolar damage (DAD) is the histological expression of acute respiratory distress syndrome and characterises lung pathology due to infection with SARS-CoV-2, and other respiratory pathogens of clinical significance. DAD reflects a time-dependent immunopathological process, progressing from an early/exudative stage through to an organising/fibrotic stage, yet within an individual these different stages of DAD may coexist. Understanding the progression of DAD is central to the development of new therapeutics to limit progressive lung damage...
March 9, 2023: Journal of Clinical Pathology
Qiu-Ju Miao, Jie Zang, Xue-Bao Shao, Jian-Fang Sun, Yan-Ping Chen, Hao Chen
AIMS: Preferentially expressed antigen in melanoma (PRAME) recently is a reliable immunohistochemistry (IHC) marker for distinguishing melanoma from other lesions. However, there are few articles focused on PRAME use in acral malignant melanoma, the most common type in Asians. This study investigated PRAME IHC expression in a large series of acral malignant melanoma in situ to add to the body of clinical knowledge. METHODS: PRAME IHC was performed in unequivocal cases of primary acral lentiginous melanoma in situ (ALMIS), subungual melanoma in situ (SMIS) and acral recurrent nevi as the control...
March 7, 2023: Journal of Clinical Pathology
Xiao-Jie Chen, Yu-Ting Bai, Ji-Rong Xie, Gang Zhou
AIMS: To explore the accumulation of lipid droplets (LDs) and its relationship with lipid metabolism, and epithelial-mesenchymal transition (EMT) in the carcinogenesis processes in the oral cavity. METHODS: LDs were stained by oil red O. Forty-eight oral squamous cell carcinomas (OSCC), 78 oral potentially malignant disorders (OPMDs) and 25 normal tissue sections were included to explore the LDs surface protein caveolin-2 and perilipin-3, lipid metabolism-related molecule FABP5 and EMT biomarker E-cadherin expression by immunohistochemical staining...
February 28, 2023: Journal of Clinical Pathology
Sayna Samaee, Sepideh Samaee, Diana Mihalca, Laura Fitzgerald, Adeel Ahmed, John Hall, Dimitris A Tsitsikas
Fat embolism syndrome is a rare but underdiagnosed complication of sickle cell disease associated with high morbidity and mortality. It affects predominantly patients with a previously mild course of their illness and those of non-SS genotypes while there is possibly an association with infection with human parvovirus B19 (HPV B19). Here, we present the mortality rates and autopsy findings of all reported cases to date. A systematic review has revealed 99 published cases in the world literature with a mortality rate of 46%...
February 27, 2023: Journal of Clinical Pathology
Gordon D O Lowe, Katie Harris, Wolfgang Koenig, Yoav Ben-Shlomo, Barbara Thorand, Annette Peters, Christa Meisinger, Armin Imhof, Hugh Tunstall-Pedoe, Sanne A E Peters, Mark Woodward
AIMS: Associations of plasma viscosity and plasma Ig levels (a determinant of viscosity) with incident coronary heart disease (CHD) events; and with CHD, cardiovascular disease (CVD: CHD and stroke) and all-cause mortalities. METHODS: Meta-analysis of plasma viscosity levels from the MONitoring of trends and determinants of CArdiovascular (MONICA)/Cooperative Health Research in the Region of Augsburg, MONICA Glasgow and Speedwell Studies; and five other published studies...
February 24, 2023: Journal of Clinical Pathology
Jan Balko, Martin Stanek, Lenka Krskova, Josef Zamecnik
AIMS: This retrospective non-randomised study aims to identify new and rare fusion partners with USP6 in the setting of nodular fasciitis. It has been proven, that nodular fasciitis can harbour different variants of USP6 fusions, which can be used in routine diagnostics and even determine the biological behaviour of the process. METHODS: A total of 19 cases of nodular fasciitis examined between 2011 and 2022 at Motol University Hospital in Prague were included into this study...
February 24, 2023: Journal of Clinical Pathology
Roberto Verna
This review summarises the long period in which man has approached nature to understand its powers, and has tried to control it through physical and chemical, and also magical, practices. From the attempt to manage nature to the development of primordial drugs and medical practices and later to achieve modern biomedical science, laboratory practices always played a pivotal role. Over the years and centuries, the laboratory has acquired more and more importance in the improvement of health.In addition to the well-known importance of laboratory medicine in the early diagnosis and appropriateness, the discoveries of the last 50 years have also given the Laboratory a decisive role in regenerative and personalised medicine...
February 24, 2023: Journal of Clinical Pathology
Azfar Neyaz, Steffen Rickelt, Omer H Yilmaz, Paige H Parrack, Chenyue Lu, Osman Yilmaz, Elizabeth Y Wu, Won-Tak Choi, Manish Gala, David T Ting, Robert D Odze, Deepa T Patil, Vikram Deshpande
AIMS: The lack of accepted scoring criteria has precluded the use of p53 in routine practice. We evaluate the utility of automated quantitative p53 analysis in risk stratifying Barrett's oesophagus (BE) patients using non-dysplastic BE (NDBE) biopsies in a multicentric cohort of BE progressor (P) and non-progressor (NP) patients. METHODS: NDBE biopsies prior to the diagnosis of advanced neoplasia from 75 BE-P, and index and last surveillance biopsies from 148 BE-NP were stained for p53, and scored digitally as 1+, 2+ and 3+...
February 23, 2023: Journal of Clinical Pathology
Newton Acs Wong
Resections of ischaemic bowel are one of the most common pathology specimens yet are often viewed as unappealing and diagnostically unrewarding. This article serves to dispel both misconceptions. It also provides guidance on how clinical information, macroscopic handling and microscopic assessment-and especially the interlinking of all three-can maximise the diagnostic yield of these specimens. This diagnostic process requires recognition of the wide range of causes of intestinal ischaemia, including several more recently described entities...
February 22, 2023: Journal of Clinical Pathology
Greta Bindi, Andrew Smith, Glenda Oliveira, Albino Eccher, Simona Vatrano, Federico Alberici, Giorgio Cazzaniga, Stefania Galimberti, Giulia Capitoli, Fulvio Magni, Fabio Pagni, Vincenzo L'Imperio
AIMS: Identification and characterisation of monoclonal gammopathies of renal significance (MGRS) is critical for therapeutic purposes. Amyloidosis represents one of the most common forms of MGRS, and renal biopsy remains the gold standard for their classification, although mass spectrometry has shown greater sensitivity in this area. METHODS: In the present study, a new in situ proteomic technique, matrix-assisted laser desorption/ionisation mass spectrometry imaging (MALDI-MSI), is investigated as an alternative to conventional laser capture microdissection MS for the characterisation of amyloids...
February 22, 2023: Journal of Clinical Pathology
Murali Varma, Brett Delahunt, Liang Cheng, Runjan Chetty, Eva Compérat, Vikram Deshpande, Lars Egevad, Theodorus H van der Kwast, Antonio Lopez-Beltran, W Glenn McCluggage
No abstract text is available yet for this article.
February 22, 2023: Journal of Clinical Pathology
Ayat Gamal Lashen, Michael S Toss, Suzan Fathy Ghannam, Shorouk Makhlouf, Andrew Green, Nigel P Mongan, Emad Rakha
Ki67 expression is one of the most important and cost-effective surrogate markers to assess for tumour cell proliferation in breast cancer (BC). The Ki67 labelling index has prognostic and predictive value in patients with early-stage BC, particularly in the hormone receptor-positive, HER2 (human epidermal growth factor receptor 2) - negative (luminal) tumours. However, many challenges exist in using Ki67 in routine clinical practice and it is still not universally used in the clinical setting. Addressing these challenges can potentially improve the clinical utility of Ki67 in BC...
February 22, 2023: Journal of Clinical Pathology
Katarina Mirjačić Martinović, Ana Vuletić, Nevena Tišma Miletić, Suzana Matković, Dušica Gavrilović, Aleksandra Ninković, Vladimir Jurišić, Nada Babović
AIMS: Despite efficacy of anti-PD-1 blockade in treatment of metastatic melanoma (MM), many patients achieve rapid disease progression (DP). Therefore, the aim of this study is to better define biomarkers for DP by analysing levels of circulating cytokines TGF-β, IFN-γ, IL-6, IL-8 and IL-10 in MM patients prior to anti-PD-1 therapy. METHODS: Cytokine levels were evaluated before therapy with pembrolizumab in peripheral blood of BRAF wild-type (wt) MM patients by ELISA method...
February 8, 2023: Journal of Clinical Pathology
Carina Mellemgaard, Ib Jarle Christensen, Giedrius Salkus, Pia Wirenfeldt Staun, Niels Korsgaard, Kim Hein Lindahl, Mathilde Skaarup Larsen, Siri Klausen, Johanne Lade-Keller
AIMS: Even though extensive melanoma sentinel node (SN) pathology protocols increase metastasis detection, there is a need for balancing high detection rates with reasonable workload. A newly tested Danish protocol recommended examining nodes at six levels 150 µm apart (six-level model) and using SOX10 and Melan-A immunohistochemistry (IHC). We explored if a protocol examining 3 levels 300 µm apart (three-level model) combined with IHC would compromise metastasis detection. The study aim was to optimise the protocol to reduce workload without compromising detection rate...
February 3, 2023: Journal of Clinical Pathology
Aidan Ryan, Erum Rasheed, Patrick J Twomey
No abstract text is available yet for this article.
January 31, 2023: Journal of Clinical Pathology
Matthew Phillip Humphries, Victoria Bingham, Fatima Abdullah Sidi, Stephanie Craig, Beatrize Lara, Hesham El-Daly, Nicole O'Doherty, Perry Maxwell, Claire Lewis, Stephen McQuaid, James Lyness, Jacqueline James, David R J Snead, Manuel Salto-Tellez
Interrogation of immune response in autopsy material from patients with SARS-CoV-2 is potentially significant. We aim to describe a validated protocol for the exploration of the molecular physiopathology of SARS-CoV-2 pulmonary disease using multiplex immunofluorescence (mIF).The application of validated assays for the detection of SARS-CoV-2 in tissues, originally developed in our laboratory in the context of oncology, was used to map the topography and complexity of the adaptive immune response at protein and mRNA levels...
January 30, 2023: Journal of Clinical Pathology
Shaoling Li, Likun Hou, Yan Huang, Wei Wu, Chunyan Wu, Liping Zhang
AIMS: To investigate the clinicopathological features, molecular characteristics and diagnostic criteria of primary salivary duct carcinoma of the lung (LSDC). METHODS: We analysed the clinicopathological and molecular features of five cases of LSDC retrieved from the archives of Shanghai Pulmonary Hospital from 2020 to 2022, and reviewed the relevant literature. RESULTS: All patients were men, with an average age of 66 years (age range: 49-79 years), and all lesions were central masses with a mean maximum diameter of 42...
January 25, 2023: Journal of Clinical Pathology
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