Larissa Alexsandra da Silva Neto Trajano, Priscyanne Barreto Siqueira, Mariana Moreno de Sousa Rodrigues, Bruno Ricardo Barreto Pires, Adenilson de Souza da Fonseca, Andre Luiz Mencalha
Mitochondrial dysfunction is one of the leading causes of disease development. Dysfunctional mitochondria limit energy production, increase reactive oxygen species generation, and trigger apoptotic signals. Photobiomodulation is a noninvasive, nonthermal technique involving the application of monochromatic light with low energy density, inducing non-thermal photochemical effects at the cellular level, and it has been used due to its therapeutic potential. This review focuses on the mitochondrial dynamic's role in various diseases, evaluating the possible therapeutic role of low-power lasers (LPL) and light-emitting diodes (LED)...
May 22, 2024: Photochemistry and Photobiology
Yolanda Gilaberte, Jaime Piquero-Casals, Sergio Schalka, Giovanni Leone, Anthony Brown, Carles Trullàs, Eric Jourdan, Henry W Lim, Jean Krutmann, Thierry Passeron
The skin microbiome undergoes constant exposure to solar radiation (SR), with its effects on health well-documented. However, understanding SR's influence on host-associated skin commensals remains nascent. This review surveys existing knowledge on SR's impact on the skin microbiome and proposes innovative sun protection methods that safeguard both skin integrity and microbiome balance. A team of skin photodamage specialists conducted a comprehensive review of 122 articles sourced from PubMed and Research Gateway...
May 20, 2024: Photochemistry and Photobiology
Manisha Sharma, Devanshu Sajwan, Ashrumochan Gouda, Anitya Sharma, Venkata Krishnan
Rapid industrial advancement over the last few decades has led to an alarming increase in pollution levels in the ecosystem. Among the primary pollutants, harmful organic dyes and pharmaceutical drugs are directly released by industries into the water bodies which serves as a major cause of environmental deterioration. This warns of a severe need to find some sustainable strategies to overcome these increasing levels of water pollution and eliminate the pollutants before being exposed to the environment. Photocatalysis is a well-established strategy in the field of pollutant degradation and various metal oxides have been proven to exhibit excellent physicochemical properties which makes them a potential candidate for environmental remediation...
May 16, 2024: Photochemistry and Photobiology
Garima Bhutani, Pratima Verma, Sasthi Paul, Shaina Dhamija, Kausik Chattopadhyay, Arijit K De
Large Stokes shift red fluorescent proteins (LSS-RFPs) are genetically encoded and exhibit a significant difference of a few hundreds of nanometers between their excitation and emission peak maxima (i.e., the Stokes shift). These LSS-RFPs (absorbing blue light and emitting red light) feature a unique photocycle responsible for their significant Stokes shift. The photocycle associated with this LSS characteristic in certain RFPs is quite perplexing, hinting at the complex nature of excited-state photophysics...
May 16, 2024: Photochemistry and Photobiology
Monika, Santhosh Kumar Madugula, Kiran Kondabagil, Ambarish Kunwar
Ultraviolet-C (UVC) irradiation is being used as an effective approach for the disinfection of pathogenic viruses present in air, surfaces, and water. Recently, far-UVC radiation (222 nm) emitted by KrCl* (krypton-chloride) excimer lamps have been recommended for disinfecting high-risk public spaces to reduce the presence and transmission of infectious viruses owing to limited human health exposure risks as compared to germicidal UVC (254 nm). In this study, the UVC inactivation performances of individual filtered KrCl* excimer lamp (222 nm) and germicidal UVC lamp (254 nm) were determined against four viruses, bacteriophages MS2, Phi6, M13, and T4, having different genome compositions (ssRNA, dsRNA, ssDNA and dsDNA, respectively) and shapes (i...
May 12, 2024: Photochemistry and Photobiology
Sudip Timilsina, Mohammad Ahsan Saad, Ryan T Lang, Tayyaba Hasan, Bryan Q Spring
Tumor-targeted, activatable photoimmunotherapy (taPIT) has been shown to selectively destroy tumor in a metastatic mouse model. However, the photoimmunoconjugate (PIC) used for taPIT includes a small fraction of non-covalently associated (free) benzoporphyrin derivative (BPD), which leads to non-specific killing in vitro. Here, we report a new treatment protocol for patient-derived primary tumor cell cultures ultrasensitive to BPD photodynamic therapy (BPD-PDT). Based on free BPD efflux dynamics, the updated in vitro taPIT protocol precludes non-specific BPD-PDT by silencing the effect of free BPD...
May 10, 2024: Photochemistry and Photobiology
David Welch, Raabia Hashmi, Camryn Petersen, Steven Erde, David J Brenner, Edward Nardell
Far-UVC radiation between 200 and 230 nm is a promising technology for reducing airborne disease transmission. Previous work with far-UVC lamps has demonstrated the efficacy of far-UVC radiation to inactivate bacteria and viruses while presenting minimal human health hazards. While far-UVC intentionally exposes the occupied space, effectively disinfecting air between occupants, installations must still ensure that occupant eye and skin exposure is within the recommended daily limits. This study examines far-UVC-sensitive films for measuring the dose received by occupants within two real-world far-UVC installations...
May 3, 2024: Photochemistry and Photobiology
Xiuping Lin, Chang-Sheng Shao, Shereen M Elsherbiny, Qing Huang
Astaxanthin (AST) is a xanthophyll carotenoid with strong oxidation resistance, which can effectively scavenge various free radicals and protect organisms from oxidative damage. AST is also known to have prominent anti-aging effects, but the underlying mechanism of AST in anti-radiation aging is largely unknown. In this work, we applied ultraviolet (UV) irradiation to accelerate the aging of Caenorhabditis elegans (C. elegans) and treated the nematodes with AST to explore whether and how AST could attenuate the radiation-induced aging effect...
May 2, 2024: Photochemistry and Photobiology
Srijan Chatterjee, Samadhan H Deshmukh, Tubai Chowdhury, Sayan Bagchi
Diols, characterized by the presence of two hydroxyl groups, form extended hydrogen-bonded networks. Increasing hydrocarbon chain length is known to elevate the viscosity of diols. Given the established influence of viscosity on solvent dynamics, it becomes imperative to comprehend the impact of viscosity on the fluctuation dynamics within diols and establish connections with hydrogen bond formation and breaking dynamics. In this study, we employ two-dimensional infrared spectroscopy to investigate the viscosity dependence of the structural evolution dynamics in three diols with varying chain lengths...
May 1, 2024: Photochemistry and Photobiology
Neha Jalan, Tiasha Das, Sumit Sarkar, Partha Pratim Ghosh, Sumi Ganguly, Aparna Dutta, Madhumita Mukhopadhyay, Soumyabrata Goswami, Debosreeta Bose
The present article attempts to interpret the modulation of photophysical properties of isophthalic acid (IPA) through its amino [5-amino isophthalic acid (5-amino IPA)] and azido [5-azido isophthalic acid (5-azido IPA)] substituted derivatives which are chemically potent organic ligands. The ground state structure-reactivity correlation of 5-amino IPA and 5-azido IPA has been deciphered through computational studies. The computed energetics show significant interaction feasibility of the substituted ligand systems with the biomimetic systems which is further validated experimentally...
April 30, 2024: Photochemistry and Photobiology
Subhajit Bandyopadhyay
This perspective article features the recent work published in this journal on functionalized azobenzene photoswitches, studied by Venkataramani and coworkers [Grewal, S. et al (2024) Photochem. Photobiol., 1-16]. Azobenzene-based photochromic molecules undergo reversible trans-to-cis isomerization under exposure to light. The reverse cis-to-trans isomerization also takes place under thermal conditions in the dark. The study explores how different functional groups at various positions affect the responses of these compounds to light, their thermal stabilities, the isomeric ratios in the photostationary states, and their supramolecular behavior...
April 25, 2024: Photochemistry and Photobiology
Yunge Ma, Yingyan Li, Yike Yao, Tao Huang, Chong Lan, Liyan Li
The aim of the present research is to investigate anti-UVB radiation activity of total flavonoids from Ilex latifolia Thunb. (namely large-leaved Kuding tea) on human keratinocyte cell line (HaCaT cells) based on network pharmacology and molecular docking technique. Network pharmacology was used to screen target genes of active ingredients from Ilex latifolia Thunb. associated with UVB irradiation. The possible signaling pathways were analyzed by KEGG enrichment and verified by cellular experiments. Molecular docking was used to assess the affinity between the active ingredients and the core targets...
April 21, 2024: Photochemistry and Photobiology
Xiao Wang, Yifan Sun, Changlin Luan, Shiqiao Yang, Kailei Wang, Xiaoran Zhang, Rui Hao, Wei Zhang
Excessive exposure to blue light can cause retinal damage. Hydrogen-rich saline (HRS), one of the hydrogen therapies, has been demonstrated to be effective in eye photodamage, but the effect on the expression of melanopsin in intrinsically photosensitive retinal ganglion cells (ipRGCs) is unknown. In this study, we used a rat model of light-induced retinal injury to observe the expression of melanopsin after HRS treatment and to determine the effect of HRS on retinal ganglion cell protection. Adult SD rats were exposed to blue light (48 h) and treated with HRS for 0, 3, 7, and 14 days...
April 18, 2024: Photochemistry and Photobiology
Ali Parvin, Gisou Erabi, Mohammad Reza Saboohi Tasooji, Sonia Sadeghpour, Hassan Mellatyar, Sahar Rezaei Arablouydareh, Leila Navapour, Mortaza Taheri-Anganeh, Hojat Ghasemnejad-Berenji
The prevalence of male infertility has become a significant clinical concern worldwide, with a noticeable upward trend in recent times. The rates of fertilization and subsequent development of embryos are dependent on many parameters associated with the quality and viability of sperm. Photobiomodulation (PBM) is a promising approach with a great potential for translational applications in the treatment of spermatozoa exhibiting low quality and motility. In this study, a comprehensive analysis of the existing literature, specifically examining the mechanisms of action of PBM has been presented...
April 16, 2024: Photochemistry and Photobiology
Pranav Volety, Carl A Shirley, Gagan Chhabra, Nihal Ahmad
Metastatic melanoma is an aggressive skin cancer with high mortality and recurrence rates. Despite the clinical success of recent immunotherapy approaches, prevailing resistance rates necessitate the continued development of novel therapeutic options. Photoimmunotherapy (PIT) is emerging as a promising immunotherapy strategy that uses photodynamic therapy (PDT) to unleash systemic immune responses against tumor sites while maintaining the superior tumor-specificity and minimally invasive nature of traditional PDT...
April 16, 2024: Photochemistry and Photobiology
Rong Zhang, Zhuannian Liu, Taoli Chen
Developing cost-effective and efficient photo-Fenton catalysts is crucial for advancing photo-Fenton technology. MoS2 is a representative transition metal disulfide with attractive photoresponsiveness, making it ideal for preparing composite photo-Fenton catalysts. In this study, natural molybdenite was innovatively utilized as a source of MoS2 (OM) to synthesize a low-cost and efficient Fe@MoS2 (OMF) composite photo-Fenton catalyst by comminution and adsorption, which was then applied to the remediation of antibiotic-contaminated water...
April 16, 2024: Photochemistry and Photobiology
Yao Du, Yating Zhang, Shitao Liu, Xiwang Zhang, Tao Wang
The field of biofabrication imposes stringent requirements on the polymerization activity and biosafety of photopolymeric hydrogel systems. In this investigation, we designed and synthesized four hemicyanine dyes with a D-π-A structure specifically tailored for biofabrication purposes. These novel dyes, incorporating carbazole (CZ), triphenylamine (TPA), anthracene (AN), and benzodithiophene (BDT) as electron donors, along with heterocyclic salt (IN) as electron acceptors, were prepared using a straightforward synthesis method...
April 16, 2024: Photochemistry and Photobiology
Rekha, Shaheen Fatma, Sonam Sharma, Ramasamy Vijaya Anand
In this manuscript, we demonstrate a visible-light driven dimerization of para-quinone methides using eosin Y catalyst via a reductive homocoupling process. This mild and operationally simple methodology was found to be compatible with a variety of differently substituted para-quinone methides and a broad range of tetra-arylethane derivatives were obtained in moderate to good yields (47%-87%).
April 10, 2024: Photochemistry and Photobiology
Yurii B Tsaplev, Aleksei V Trofimov
The results reported herein demonstrate for the first time that typical reducing agents in an alkaline medium initiate chemiluminescence of luminol in the presence of hemin, and the efficiency of their action is comparable to that of hydrogen peroxide and exceeds it in the case of the superoxide anion. The pertinent implications of these findings refer to new possibilities for developing chemiluminescence assays and biosensors and to precautions for determining hydrogen peroxide using luminol and hemin in samples of unknown composition, most prominently, of biological origin...
April 9, 2024: Photochemistry and Photobiology
João Vitor de Oliveira Silva, Jean Eduardo Meneguello, Maíra Dante Formagio, Camila Fabiano de Freitas, Luis Carlos Malacarne, Rogério Marchiosi, Patrícia de Souza Bonfim de Mendonça, Paula Aline Zanetti Campanerut-Sá, Jane Martha Graton Mikcha
Staphylococcus aureus is a global challenge to the clinical field and food industry. Therefore, the development of antimicrobial photodynamic therapy (aPDT) has become one of the valuable methods to control this pathogen. The antibacterial activity of photoinactivation by erythrosine (Ery) against S. aureus has been reported, but its modes of action are unclear. This study aimed to employ a proteomic approach to analyze modes of action of Ery-aPDT against S. aureus. We determined the antibacterial effect by Ery-aPDT assays, quantified reactive oxygen species (ROS) and injury to the cell membrane, and determined protein expression using a proteomic approach combined with bioinformatic tools...
April 9, 2024: Photochemistry and Photobiology
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