Leonardo Angeli, Constantino Pereira Caetano, Nicolas Franco, Steven Abrams, Pietro Coletti, Inneke Van Nieuwenhuyse, Sorin Pop, Niel Hens
Age-related heterogeneity in a host population, whether due to how individuals mix and contact each other, the nature of host-pathogen interactions defining epidemiological parameters, or demographics, is crucial in studying infectious disease dynamics. Compartmental models represent a popular approach to address the problem, dividing the population of interest into a discrete and finite number of states depending on, for example, individuals' age and stage of infection. We study the corresponding linearised system whose operator, in the context of a discrete-time model, equates to a square matrix known as the next generation matrix...
January 11, 2024: Journal of Theoretical Biology