journal
https://read.qxmd.com/read/38889553/prevalence-demographic-characteristics-and-clinical-features-of-suicide-risk-in-first-episode-drug-na%C3%A3-ve-schizophrenia-patients-with-comorbid-severe-anxiety
#1
JOURNAL ARTICLE
Mengjie Ding, Xiaoe Lang, Junhan Wang, Fangfang Shangguan, Xiang-Yang Zhang
BACKGROUND: Both anxiety symptoms and suicide risk are common in schizophrenia. However, previous findings about the association between anxiety and suicide risk in schizophrenia were controversial. This study is the first to examine the prevalence of suicide risk and related demographic, clinical features in a large sample of first episode drug-naïve (FEDN) schizophrenia patients with comorbid severe anxiety. METHODS: In total, 316 patients with FEDN schizophrenia were enrolled in this study...
June 14, 2024: Journal of Psychiatric Research
https://read.qxmd.com/read/38889554/active-suicidal-ideation-associated-with-dysfunction-in-default-mode-network-using-resting-state-eeg-and-functional-mri-findings-from-the-t-rad-study
#2
JOURNAL ARTICLE
Cherise R Chin Fatt, Elizabeth D Ballard, Abu T Minhajuddin, Russell Toll, Taryn L Mayes, Jane A Foster, Madhukar H Trivedi
Suicide in youth and young adults is a serious public health problem. However, the biological mechanisms of suicidal ideation (SI) remain poorly understood. The primary goal of these analyses was to identify the connectome profile of suicidal ideation using resting state electroencephalography (EEG). We evaluated the neurocircuitry of SI in a sample of youths and young adults (aged 10-26 years, n = 111) with current or past diagnoses of either a depressive disorder or bipolar disorder who were enrolled in the Texas Resilience Against Depression Study (T-RAD)...
June 11, 2024: Journal of Psychiatric Research
https://read.qxmd.com/read/38889552/disrupted-dynamic-brain-functional-connectivity-in-male-cocaine-use-disorder-hyperconnectivity-strongly-connected-state-tendency-and-links-to-impulsivity-and-borderline-traits
#3
JOURNAL ARTICLE
Zhaoyang Cong, Lin Yang, Ziyang Zhao, Guowei Zheng, Cong Bao, Pengfei Zhang, Jun Wang, Weihao Zheng, Zhijun Yao, Bin Hu
Cocaine use is a major public health problem with serious negative consequences at both the individual and societal levels. Cocaine use disorder (CUD) is associated with cognitive and emotional impairments, often manifesting as alterations in brain functional connectivity (FC). This study employed resting-state functional magnetic resonance imaging (rs-fMRI) to examine dynamic FC in 38 male participants with CUD and 31 matched healthy controls. Using group spatial independent component analysis (group ICA) combined with sliding window approach, we identified two recurring distinct connectivity states: the strongly-connected state (state 1) and weakly-connected state (state 2)...
June 11, 2024: Journal of Psychiatric Research
https://read.qxmd.com/read/38878649/health-correlates-of-experiential-and-behavioral-avoidance-among-trauma-exposed-veterans
#4
JOURNAL ARTICLE
Elizabeth K C Schwartz, Alexandra N Palmisano, Ismene L Petrakis, Robert H Pietrzak, Mehmet Sofuoglu
INTRODUCTION: Avoidance is a well-documented risk factor for poor mental and physical health outcomes. However, limited research has explored this relationship specifically among trauma-exposed veterans, a population known to be particularly prone to avoidance behavior. Conceptually, avoidance is often divided into two distinct but overlapping constructs - experiential avoidance (resisting distressing internal states) and behavioral avoidance (avoiding or changing experiences that elicit distress)...
June 11, 2024: Journal of Psychiatric Research
https://read.qxmd.com/read/38878648/efficacy-and-safety-of-chinese-patent-medicines-combined-with-antidepressants-for-treatment-of-depression-in-adults-a-multiple-treatment-meta-analysis
#5
REVIEW
Lidan Yi, Jing Chen, Sini Li, Wei Cui, Jianhe Li, Liubao Peng, Ciyan Peng
BACKGROUND: Combinations of Chinese patent medicines (CPM) with antidepressants (including selective serotonin reuptake inhibitors (SSRI), selective serotonin-norepinephrine reuptake inhibitors (SNRI), tricyclic antidepressants (TCA), and noradrenergic and specific serotonergic antidepressants (NaSSA)) are frequently utilized for treating depression in adults. However, the efficacy and safety of these combination treatments remain to be established. METHODS: Systematic search was conducted in seven electronic databases, regulatory websites and international registers of trials from 1994 to 2023 that included adult patients with depressive disorders who received CPM combined with antidepressants...
June 11, 2024: Journal of Psychiatric Research
https://read.qxmd.com/read/38865865/the-relationship-of-peripheral-blood-cell-inflammatory-biomarkers-and-psychological-stress-in-unmedicated-major-depressive-disorder
#6
JOURNAL ARTICLE
Yigang Liu, Cuicui Li, Honghong Ren, Ke Han, Ximing Wang, Shuqi Zang, Guoqing Zhao
BACKGROUND: Recent research has explored the linkage between major depressive disorder (MDD) and inflammation, especially via altered peripheral blood immune markers. However, the relationship between several novel leukocyte-derived ratios (LDR) and psychological stress in MDD remains uncertain. This study aimed to explore the relationship between LDR, clinical characteristics, recent life events, and childhood maltreatment in MDD patients. METHODS: A cross-sectional case-control study was conducted involving 59 healthy controls (HC) and 50 unmedicated MDD patients...
June 9, 2024: Journal of Psychiatric Research
https://read.qxmd.com/read/38897055/prefrontal-brain-activity-and-self-injurious-behavior-in-adolescents-with-major-depressive-disorder-a-functional-near-infrared-spectroscopy-fnirs-study
#7
JOURNAL ARTICLE
Yunshu Zhang, Bing Li, Lili Zhang, Aobo Cheng, Shuaiyu Long, Jie Wang, Min Wen, Keqing Li, Chaomeng Liu
In clinical practice, accurately identifying self-injurious behavior among adolescents with major depressive disorder (MDD) is crucial for individualized treatment. This study aimed to examine the differences in prefrontal cortex activation using the functional near-infrared spectroscopy (fNIRS) during the verbal fluency task (VFT) assessment of adolescents with MDD and self-harm (SH) compared with those without SH. A total of 60 eligible patients were included for final analysis, with the SH group containing 36 participants, and the Non-SH group containing 24 participants...
June 7, 2024: Journal of Psychiatric Research
https://read.qxmd.com/read/38875773/probing-the-neurocardiac-circuit-in-trauma-and-posttraumatic-stress
#8
JOURNAL ARTICLE
Antonia V Seligowski, Nathaniel G Harnett, Robyn A Ellis, Lana R Grasser, Mubeena Hanif, Charis Wiltshire, Timothy D Ely, Lauren A M Lebois, Sanne J H van Rooij, Stacey L House, Francesca L Beaudoin, Xinming An, Thomas C Neylan, Gari D Clifford, Sarah D Linnstaedt, Laura T Germine, Kenneth A Bollen, Scott L Rauch, John P Haran, Alan B Storrow, Christopher Lewandowski, Paul I Musey, Phyllis L Hendry, Sophia Sheikh, Christopher W Jones, Brittany E Punches, Robert A Swor, Lauren A Hudak, Jose L Pascual, Mark J Seamon, Erica Harris, Claire Pearson, David A Peak, Roland C Merchant, Robert M Domeier, Niels K Rathlev, Brian J O'Neil, Paulina Sergot, Leon D Sanchez, Steven E Bruce, Steven E Harte, Karestan C Koenen, Ronald C Kessler, Samuel A McLean, Kerry J Ressler, Jennifer S Stevens, Tanja Jovanovic
The neurocardiac circuit is integral to physiological regulation of threat and trauma-related responses. However, few direct investigations of brain-behavior associations with replicable physiological markers of PTSD have been conducted. The current study probed the neurocardiac circuit by examining associations among its core regions in the brain (e.g., insula, hypothalamus) and the periphery (heart rate [HR], high frequency heart rate variability [HF-HRV], and blood pressure [BP]). We sought to characterize these associations and to determine whether there were differences by PTSD status...
June 7, 2024: Journal of Psychiatric Research
https://read.qxmd.com/read/38870782/influence-of-antipsychotic-drugs-on-microrna-expression-in-schizophrenia-patients-a-systematic-review
#9
REVIEW
Gabriela Xavier, Jessica Mauer, Vanessa K Ota, Marcos L Santoro, Sintia I Belangero
Schizophrenia (SCZ) is a severe psychiatric disorder with unclear pathophysiology. Moreover, there is no specific biological marker to help clinicians to define a diagnosis, and medication is decided according to the psychiatrist's experience. In this scenario, microRNAs (miRNAs), which are small noncoding RNA molecules that regulate several genes, emerge as potential peripheral biomarkers to help not only the evaluation of the disease state but also the treatment response. Here, we systematically reviewed indexed literature and evaluated follow-up studies investigating the changes in miRNA expression due to antipsychotic treatment...
June 7, 2024: Journal of Psychiatric Research
https://read.qxmd.com/read/38865864/anterior-capsulotomy-combined-with-subthalamic-nucleus-deep-brain-stimulation-for-tardive-dystonia
#10
JOURNAL ARTICLE
Fang Wang, Peng Huang, Suzhen Lin, Lulin Dai, Zhengyu Lin, Yixin Pan, Chencheng Zhang, Bomin Sun, Yiwen Wu, Dianyou Li
BACKGROUND: Deep brain stimulation (DBS) has been reported as a therapy option for the motor dysfunction of severe tardive dystonia (TD). The major psychiatric diseases, however, are contraindications to DBS treatment in TD patients. METHODS: Six severe, medically refractory TD patients undergoing bilateral anterior capsulotomy combined with bilateral subthalamic nucleus (STN)-DBS treatment were studied retrospectively at two time points: pre-operation, and 1-3 years post-operation...
June 7, 2024: Journal of Psychiatric Research
https://read.qxmd.com/read/38875774/effects-of-inpatient-residential-and-day-patient-treatment-on-obsessive-compulsive-symptoms-in-persons-with-obsessive-compulsive-disorder-a-systematic-review-and-meta-analysis
#11
REVIEW
Eva M Zisler, Adrian Meule, Dominique Endres, Rebecca Schennach, Lena Jelinek, Ulrich Voderholzer
INTRODUCTION: Patients with severe or treatment-refractory obsessive-compulsive disorder (OCD) often need an extensive treatment which cannot be provided by outpatient care. Therefore, we aimed to estimate the effects and their moderators of inpatient, residential, or day-patient treatment on obsessive-compulsive symptoms in patients with OCD. METHODS: PubMed, PsycINFO, and Web of Science were systematically screened according to the PRISMA guidelines. Studies were selected if they were conducted in an inpatient, residential, or day-patient treatment setting, were using a number of pre-defined instruments for assessing OCD symptom severity, and had a sample size of at least 20 patients...
June 6, 2024: Journal of Psychiatric Research
https://read.qxmd.com/read/38857554/dietary-sulforaphane-glucosinolate-mitigates-depression-like-behaviors-in-mice-with-hepatic-ischemia-reperfusion-injury-a-role-of-the-gut-liver-brain-axis
#12
JOURNAL ARTICLE
Yong Yang, Akifumi Eguchi, Chisato Mori, Kenji Hashimoto
Nutrition has been increasingly recognized for its use in mental health. Depression is commonly observed in patients with chronic liver disease (CLD). Building on our recent findings of depression-like behaviors in mice with hepatic ischemia/reperfusion (HI/R) injury, mediated by the gut-liver-brain axis, this study explored the potential influence of dietary sulforaphane glucosinolate (SGS) on these behaviors. Behavioral assessments for depression-like behaviors were conducted 7 days post either sham or HI/R injury surgery...
June 5, 2024: Journal of Psychiatric Research
https://read.qxmd.com/read/38852542/nmt2-alleviates-depression-like-behavior-in-a-rat-model-of-chronic-unpredictable-stress-an-integrated-proteomic-and-phosphoproteomic-analysis
#13
JOURNAL ARTICLE
Ye Sun, Danmei Zhao, Qiuyan Song, Ting Cong, Liya Li, Haibo Wu, Zhaoyang Xiao
Proteomics has been widely used to investigate multiple diseases. Combining the analyses of proteomics with phosphoproteomics can be used to further explain the pathological mechanisms of depression. In this study, depression-like behavior was induced in a rat model of chronic unpredictable mild stress (CUMS). We subsequently conducted the sucrose preference test, open field experiment, and forced swimming test to assess depressive-like behavior. Proteomic and phosphoproteomic sequencing of the hippocampal tissues from depressive-like behavior and normal rats were analyzed to identify differentially expressed proteins (DEPs) and differentially phosphorylated proteins (DPPs)...
June 5, 2024: Journal of Psychiatric Research
https://read.qxmd.com/read/38852541/acute-effects-of-aerobic-exercise-on-corticomotor-plasticity-in-individuals-with-and-without-depression
#14
JOURNAL ARTICLE
Ryan E Ross, Michael E Saladin, Mark S George, Chris M Gregory
BACKGROUND: Although complex in nature, the pathophysiology of depression involves reduced or impaired neuroplastic capabilities. Restoring or enhancing neuroplasticity may serve as a treatment target for developing therapies for depression. Aerobic exercise (AEx) has antidepressant benefits and may enhance neuroplasticity in depression although the latter has yet to be substantiated. Therefore, we sought to examine the acute effect of AEx on neuroplasticity in depression. METHODS: Sixteen individuals with (DEP; 13 female; age = 28...
June 5, 2024: Journal of Psychiatric Research
https://read.qxmd.com/read/38850582/decreased-serum-vegf-and-nrg1%C3%AE-1-levels-in-male-patients-with-chronic-schizophrenia-vegf-correlation-with-clinical-symptoms-and-cognitive-deficits
#15
JOURNAL ARTICLE
Peng Chen, Wanming Chen, Li Xu, Lingshu Luan, Ruijie Peng, Xiaobin Zhang, Haidong Yang
BACKGROUND: Vascular endothelial growth factor (VEGF) and neuregulin1 (NRG1) are multifunctional trophic factors reported to be dysregulated in schizophrenia. However, the relationships between serum concentrations and schizophrenia symptoms have differed markedly across studies, possibly because schizophrenia is a highly heterogenous disorder. The aim of this study was to investigate the associations of serum VEGF and NRG1 with clinical symptoms and cognitive deficits specifically in male patients with chronic schizophrenia...
June 5, 2024: Journal of Psychiatric Research
https://read.qxmd.com/read/38878647/the-mediating-effect-of-positive-expectations-in-the-relationship-between-social-support-and-post-traumatic-stress-disorder-symptoms-among-parents-of-children-with-acute-lymphoblastic-leukemia
#16
JOURNAL ARTICLE
Shuo Feng, Lu Zhang, Jia Lin, Ruo-Wen Sun, Ru-Nan Wang, Hang-Fei Qu, Bo-Xuan Fang, Jia-Na Wang, Pin Yao
PURPOSE: Parents of children with cancer are exposed to risks of developing post-traumatic stress disorder (PTSD) symptoms, but few studies have explored PTSD symptoms of Chinese parents of children with acute lymphoblastic leukemia (ALL). Our study aimed to examine the association between social support and PTSD symptoms and to examine the mediating effect of positive expectations in this relationship among parents of children with ALL. METHODS: A cross-sectional study was conducted of consecutive parents of children with ALL in the Shengjing Hospital of China Medical University...
June 1, 2024: Journal of Psychiatric Research
https://read.qxmd.com/read/38850583/comparison-of-death-anxiety-symptoms-between-generalized-anxiety-disorder-and-somatization-disorder-in-geriatric-patients-attending-a-psychiatric-outpatient-clinic-for-the-first-time
#17
JOURNAL ARTICLE
Ugur Cikrikcili, Haluk Altıntaş
Somatic complaints are among the important complaints frequently seen in Generalized Anxiety Disorder (GAD) and Somatic Symptom Disorder (SSD). Death anxiety has also increased significantly with the Covid-19 pandemic, especially in the elderly population. In this study, we compared the difference of the death anxiety level among patients with GAD, SSD and healthy controls. This cross-sectional study which was carried out in Artvin State Hospital's Psychiatric Outpatient Clinic included 59 participants (GAD = 21, SSD = 18, HC = 20)...
June 1, 2024: Journal of Psychiatric Research
https://read.qxmd.com/read/38850581/protocols-and-practices-in-psilocybin-assisted-psychotherapy-for-depression-a-systematic-review
#18
REVIEW
Noah Chisamore, Danica Johnson, Margery J Q Chen, Hilary Offman, David Chen-Li, Erica S Kaczmarek, Zoe Doyle, Roger S McIntyre, Joshua D Rosenblat
BACKGROUND: Psilocybin-assisted psychotherapy (PAP) is a promising treatment option for depression, with randomized controlled trials (RCTs) providing preliminary support for its safety and efficacy. However, there is a lack of consistency across existing treatment protocols and psychotherapeutic approaches. The objective of this review is to summarize and compare current psychotherapy methods of PAP in treating depression and distress in life-threatening illnesses. We sought to comprehensively summarize published psychotherapy protocols from clinical trials to provide insights for future practices...
May 31, 2024: Journal of Psychiatric Research
https://read.qxmd.com/read/38857555/obstructive-respiratory-disease-in-u-s-veterans-prevalence-characteristics-and-health-burden
#19
JOURNAL ARTICLE
Patricia M Bamonti, Ian Fischer, Jennifer Moye, Hermine Poghosyan, Robert H Pietrzak
OBJECTIVE: To examine the psychiatric and physical health burden of obstructive respiratory disease in a nationally representative sample of U.S. Veterans. METHODS: Secondary data analyses were conducted using data from the 2019-2020 National Health and Resilience in Veterans Study, which surveyed a nationally representative sample of U.S. Veterans. Participants self-reported health professional-diagnosed obstructive respiratory disease (i.e., asthma, chronic bronchitis or chronic obstructive pulmonary disease)...
May 30, 2024: Journal of Psychiatric Research
https://read.qxmd.com/read/38850584/is-factor-analysis-useful-for-revising-diagnostic-criteria-for-ptsd-a-systematic-review-of-five-issues-ten-years-after-dsm-5
#20
REVIEW
Michael S Scheeringa
BACKGROUND: Based on factor analysis research, DSM-5 revised the diagnostic criteria for posttraumatic stress disorder (PTSD) by increasing symptom clusters from three to four. AIMS: To question whether that is an appropriate use of factor analysis. METHODS: Reviewed the literature on five issues of factor analysis relevant to diagnostic criteria: (1) discovery of factors identical to symptom clusters, (2) consensus about the number of factors in best-fitting models, (3) configural variance between subpopulations to explain inconsistent model results, (4) methods to externally validate factors after discovery, and (5) treatment response of symptom clusters to externally validate factors...
May 30, 2024: Journal of Psychiatric Research
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