Journals American Journal of Clinical N...

American Journal of Clinical Nutrition
Mariel Arvizu, Siwen Wang, Makiko Mitsunami, Lidia Mínguez-Alarcón, Audrey J Gaskins, Bernard Rosner, Janet W Rich-Edwards, Jorge E Chavarro
BACKGROUND: Prepregnancy body mass index (BMI) is a well-established risk factor of adverse pregnancy outcomes (APOs). The associations of long-term and short-term weight trajectories with APOs are less clear. OBJECTIVES: This study aimed to determine the associations of weight trajectories during females' reproductive years, before and between pregnancies, with risk of APOs. METHODS: We followed 16,241 females (25,386 singleton pregnancies) participating in a prospective cohort, the Nurses' Health Study II...
May 20, 2024: American Journal of Clinical Nutrition
Yue Chen, Xin Zheng, Chenan Liu, Tong Liu, Shiqi Lin, Hailun Xie, Heyang Zhang, Jinyu Shi, Xiaoyue Liu, Zhaoting Bu, Shubin Guo, Zhenghui Huang, Li Deng, Hanping Shi
BACKGROUND: Anthropometric indicators have been shown to be associated with the prognosis of patients with cancer. However, any single anthropometric index has limitation in predicting the prognosis. OBJECTIVES: This study aimed to observe the predictive role of 7 anthropometric indicators based on body size on the prognosis of patients with cancer. METHODS: A principal component analysis (PCA) on 7 anthropometric measurements: height, weight, BMI, hand grip strength (HGS), triceps skinfold thickness (TSF), mid-upper arm circumference (MAC), and calf circumference (CAC) was conducted...
May 18, 2024: American Journal of Clinical Nutrition
James McKendry, Caroline V Lowisz, Arraksana Nanthakumar, Meaghan MacDonald, Changhyun Lim, Brad S Currier, Stuart M Phillips
BACKGROUND: Skeletal muscle mass is determined predominantly by feeding-induced and activity-induced fluctuations in muscle protein synthesis (MPS). Older individuals display a diminished MPS response to protein ingestion, referred to as age-related anabolic resistance, which contributes to the progression of age-related muscle loss known as sarcopenia. OBJECTIVES: We aimed to determine the impact of consuming higher-quality compared with lower-quality protein supplements above the recommended dietary allowance (RDA) on integrated MPS rates...
May 16, 2024: American Journal of Clinical Nutrition
Yang Hu, Molin Wang, Walter C Willett, Meir Stampfer, Liming Liang, Frank B Hu, Eric Rimm, Lorraine Brennan, Qi Sun
BACKGROUND: Whether observational study can be employed to establish calibration equations for self-reported dietary intake using food biomarkers is unknown. OBJECTIVE: This study aims to demonstrate the feasibility of obtaining calibration equations based on food biomarkers and 7-day diet records (7DDRs) to correct measurement errors of food frequency questionnaires (FFQ) in an observational study setting. METHODS: The study population consisted of 669 male and 749 female from the Women and Men's Lifestyle Validation Study...
May 16, 2024: American Journal of Clinical Nutrition
Rikuta Hamaya, Qi Sun, Jun Li, Huan Yun, Fenglei Wang, Gary C Curhan, Tianyi Huang, JoAnn E Manson, Walter C Willett, Eric B Rimm, Clary Clish, Liming Liang, Frank B Hu, Yuan Ma
BACKGROUND: High sodium and low potassium intakes are associated with a higher risk of hypertension and cardiovascular disease (CVD), but there are limited data on the circulating metabolomics profiles of 24-hour urinary sodium and potassium excretions in free-living individuals. OBJECTIVES: To characterize metabolomics signatures of a high-sodium and low-potassium diet in a cross-sectional study. METHODS: In 1,028 healthy older adults from the Women's and Men's Lifestyle Validation Studies, we investigated the association of habitual sodium and potassium intakes measured by 2-4 24-hour urine samples with plasma metabolites (quantified using liquid chromatography-tandem mass spectrometry) and metabolomic pathways...
May 16, 2024: American Journal of Clinical Nutrition
Teresa T Fung, Sinara L Rossato, Zhangling Chen, Neha Khandpur, Fernando Rodriguez-Artalejo, Walter C Willett, Ellen A Struijk, Esther Lopez-Garcia
BACKGROUND: Ultraprocessed foods (UPFs) and poor diet quality have been associated with frailty but existing studies had relatively short follow-up time. It is also unclear whether the association of UPF was primarily due to its correlation with poorer diet quality. OBJECTIVES: We examined the association between unprocessed or minimally processed foods (UMFs) and UPF and risk of frailty and explored whether the association with UPF was mainly driven by poor diet quality...
May 14, 2024: American Journal of Clinical Nutrition
Benjamin Caballero, Irwin Rosenberg
No abstract text is available yet for this article.
May 10, 2024: American Journal of Clinical Nutrition
Yaron Avitzur, Lissette Jimenez, Inez Martincevic, Sari Acra, Glenda Courtney-Martin, Megan Gray, Kayla Hope, Aleixo Muise, Paula M Prieto Jimenez, Nancy Taylor, Jay R Thiagarajah, Martín G Martín
Congenital diarrheas and enteropathies (CODE) are a group of rare, heterogenous, monogenic disorders that lead to chronic diarrhea in infancy. Definitive treatment is rarely available, and supportive treatment is the mainstay. Nutritional management in the form of either specialized formulas, restrictive diet, or parenteral nutrition support in CODE with poor enteral tolerance, is the cornerstone of CODE treatment and long-term growth. The evidence to support the use of specific diet regimens and nutritional approaches in most CODE disorders is limited due to the rarity of those diseases and the scant published clinical experience...
May 9, 2024: American Journal of Clinical Nutrition
Shuangyuan Wang, Chunyan Hu, Hong Lin, Xiaojing Jia, Ruying Hu, Ruizhi Zheng, Mian Li, Yu Xu, Min Xu, Jie Zheng, Xinjie Zhao, Yanli Li, Lulu Chen, Tianshu Zeng, Zhen Ye, Lixin Shi, Qing Su, Yuhong Chen, Xuefeng Yu, Li Yan, Tiange Wang, Zhiyun Zhao, Guijun Qin, Qin Wan, Gang Chen, Meng Dai, Di Zhang, Bihan Qiu, Xiaoyan Zhu, Ruixin Liu, Xiao Wang, Xulei Tang, Zhengnan Gao, Feixia Shen, Xuejiang Gu, Zuojie Luo, Yingfen Qin, Li Chen, Xinguo Hou, Yanan Huo, Qiang Li, Guixia Wang, Yinfei Zhang, Chao Liu, Youmin Wang, Shengli Wu, Tao Yang, Huacong Deng, Jiajun Zhao, Yiming Mu, Guowang Xu, Shenghan Lai, Donghui Li, Guang Ning, Weiqing Wang, Yufang Bi, Jieli Lu
BACKGROUND: Long-chain free fatty acids (FFAs) are associated with risk of incident diabetes. However, a comprehensive assessment of the associations in normoglycemic populations is lacking. OBJECTIVES: Our study aimed to comprehensively investigate the prospective associations and patterns of FFA profiles with diabetes risk among normoglycemic Chinese adults. METHODS: This is a prospective nested case-control study from the China Cardiometabolic Disease and Cancer Cohort (4C) study...
May 8, 2024: American Journal of Clinical Nutrition
Monique van de Lagemaat, Charlotte A Ruys, Jacqueline Muts, Martijn J J Finken, Joost Rotteveel, Johannes B van Goudoever, Harrie N Lafeber, Chris H P van den Akker
BACKGROUND: Infants born moderate-to-late preterm (i.e., 32 0 /7 -35 6 /7 weeks' gestation) are, analogous to those born very preterm, at risk of later obesity, hypertension, and diabetes. Appropriate early life nutrition is key for ensuring optimal growth and body composition, thereby mitigating potential cardiometabolic risks. OBJECTIVE: To compare growth and body composition between infants born moderate-to-late preterm fed isocaloric but protein- and mineral-enriched postdischarge formula (PDF) or standard term formula (STF) until 6 months corrected age (CA; i...
May 6, 2024: American Journal of Clinical Nutrition
Clare Whitton, Clare E Collins, Barbara A Mullan, Megan E Rollo, Satvinder S Dhaliwal, Richard Norman, Carol J Boushey, Edward J Delp, Fengqing Zhu, Tracy A McCaffrey, Sharon I Kirkpatrick, Christina M Pollard, Janelle D Healy, Amira Hassan, Shivangi Garg, Paul Atyeo, Syed Aqif Mukhtar, Deborah A Kerr
BACKGROUND: Technology-assisted 24-hour dietary recalls (24HR) have been widely adopted in population nutrition surveillance. Evaluations of 24HR inform improvements but direct comparisons of 24HR methods for accuracy in reference to a measure of true intake are rarely undertaken in a single study population. OBJECTIVE: To compare the accuracy of energy and nutrient intake estimation of four technology-assisted dietary assessment methods relative to true intake across breakfast, lunch, and dinner...
May 4, 2024: American Journal of Clinical Nutrition
Marjolein H de Jong, Alida Melse-Boonstra, Johanna M Geleijnse, Janneke Verkaik-Kloosterman
BACKGROUND: The iron intake requirement distribution for premenopausal females is not symmetric, which invalidates the EAR (Estimated Average Requirement) cut-point approach for assessing prevalence of iron inadequacy. Therefore, Beaton's Full Probability Approach (PA) must be used. While the PA requires information on the entire iron intake requirement distribution, the European Food Safety Authority (EFSA) only provided the EAR (50th percentile), 90th, 95th (PRI) and 97.5th percentiles...
May 4, 2024: American Journal of Clinical Nutrition
Maryam Samsamikor, Dylan S Mackay, Rebecca C Mollard, Adeola M Alashi, Rotimi E Aluko
BACKGROUND: The effects of consuming hemp seed protein (HSP) as well as its hydrolysate-derived bioactive peptide (HSP+) on blood pressure (BP) has not to our knowledge been investigated in humans. OBJECTIVE: We aimed to investigate how consumption of HSP and its hydrolysate modulates 24-hr systolic and diastolic BP (24-hrSBP and 24-hrDBP) and plasma biomarkers of BP compared to casein. DESIGN: In a double-blind, randomized, cross-over design trial, 35 adults who had mild hypertension with SBP between 130 and 160 millimeters of mercury (mmHg), and DBP ≤110 mmHg were recruited...
May 4, 2024: American Journal of Clinical Nutrition
Mehmet Furkan Burak, Takara L Stanley, Elizabeth A Lawson, Sophia L Campbell, Lydia Lynch, Alyssa H Hasty, Ana I Domingos, Vishwa D Dixit, Gökhan S Hotamışlıgil, Frederick J Sheedy, Anne E Dixon, Tina E Brinkley, Joseph A Hill, Marc Y Donath, Steven K Grinspoon
The rapidly evolving field of immunometabolism explores how changes in local immune environments may affect key metabolic and cellular processes, including that of adipose tissue. Importantly, these changes may contribute to low-grade systemic inflammation. In turn, chronic low-grade inflammation affecting adipose tissue may exacerbate the outcome of metabolic diseases. Novel advances in our understanding of immunometabolic processes may critically lead to interventions to reduce disease severity and progression...
May 3, 2024: American Journal of Clinical Nutrition
Alistair Monteyne, Sam West, Francis B Stephens, Benjamin T Wall
The regulation of postprandial muscle protein synthesis (MPS) with or without physical activity has been an intensely studied area within nutrition and physiology. The leucine content of dietary protein, and the subsequent plasma leucinemia it elicits post-ingestion, are often considered the primary drivers of the postprandial MPS response. This concept, generally known as the leucine 'trigger' hypothesis, has also been adopted within more applied aspects of nutrition. Our view is that recent evidence is driving a more nuanced picture of the regulation of postprandial MPS by revealing a compelling dissociation between ingested leucine or plasma leucinemia and the magnitude of the postprandial MPS response...
May 3, 2024: American Journal of Clinical Nutrition
Lars T Fadnes, Elaheh Javadi Arjmand, Jan-Magnus Økland, Carlos Celis-Morales, Katherine M Livingstone, Rajiv Balakrishna, John C Mathers, Kjell Arne Johansson, Øystein A Haaland
BACKGROUND: Eating healthier is associated with a range of favorable health outcomes. Our previous model estimated the impact of dietary changes on life expectancy gains, but did not consider height, weight, or physical activity. OBJECTIVE: We estimate the increase in life expectancy resulting from the transition from typical national dietary patterns to longevity-optimizing dietary changes, more feasible dietary modifications, and optimized vegan dietary changes for China, France, Germany, Iran, Norway, the United Kingdom, and the United States...
April 29, 2024: American Journal of Clinical Nutrition
Lubaina Ehsan, David Coomes, Paul Kelly, Adam R Greene, S Asad Ali, Chola Mulenga, Donna M Denno, Kelley VanBuskirk, Muhammad Faraz Raghib, Mustafa Mahfuz, Sean R Moore, M Shabab Hossain, Tahmeed Ahmed, Peter B Sullivan, Christopher A Moskaluk, Sana Syed
BACKGROUND: Environmental enteric dysfunction (EED), a chronic inflammatory condition of the small intestine, is an important driver of childhood malnutrition globally. Quantifying intestinal morphology in EED allows for exploration of its association with functional and disease outcomes. OBJECTIVE: We sought to define morphometric characteristics of childhood EED and determine whether morphology features were associated with disease pathophysiology. METHODS: Morphometric measurements and histology were assessed on duodenal biopsy slides for this cross-sectional study from children with EED in Bangladesh, Pakistan, and Zambia (n=69), and those with no pathologic abnormality (NPA; n=8) or celiac disease (n=18) in North America...
April 27, 2024: American Journal of Clinical Nutrition
Ying Zhang, Xiuwei Li, Jianqiang Wang, Wei Ma, Haiyan Wang, Jinpeng Wang, Jing Xu
BACKGROUND: It is unclear whether salivary iodine concentration (SIC) can assess iodine status in females from different water iodine regions. OBJECTIVE: Through a cross-sectional study, we explored the feasibility of SIC as a biomarker to assess iodine status in females and develop optimal cut-off values. METHODS: A total of 1991 females were analyzed in this cross-sectional study from the coastal iodine-deficient areas (CIDA), inland iodine-deficient areas (IIDA), iodine-adequate areas (IAA), iodine-excess areas (IEA), and iodine extra-high areas (IEHA)...
April 25, 2024: American Journal of Clinical Nutrition
G Jake LaPorte, Skyler Chauff, Josephine Cammack, Britt Burton-Freeman, Jonathan Krakoff, Emma J Stinson, Barbara Gower, Leanne M Redman, Diana M Thomas
BACKGROUND: Response curves formed by analyte concentrations measured at sampled time points after consuming a mixed meal are increasingly being used to characterize responses to differing diets. Unfortunately, owing to a variety of reasons, analyte concentrations for some of the time points may be missing. OBJECTIVES: This study aimed to develop an algorithm to estimate the missing values at sampled time points in the analyte response curve to a mixed meal tolerance test (MMTT)...
April 25, 2024: American Journal of Clinical Nutrition
Yanbo Zhang, Yang Li, Rita Peila, Tao Wang, Xiaonan Xue, Robert C Kaplan, Andrew J Dannenberg, Qibin Qi, Thomas E Rohan
BACKGROUND: Interplay between lifestyle risk scores (LRSs) and genetic risk scores (GRSs) on obesity and related chronic diseases are underinvestigated and necessary for understanding obesity causes and developing prevention strategies. OBJECTIVES: This study aimed to investigate independent and joint associations and interactions of LRS and GRS with obesity prevalence and risks of diabetes, cardiovascular disease (CVD), and obesity-related cancer. METHODS: In this cohort study of 444,957 UK Biobank participants [age: 56...
April 25, 2024: American Journal of Clinical Nutrition
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