American Journal of Clinical Nutrition

BACKGROUND: Previous studies showed that a reduced plasma concentration of the amino acid glycine (Gly) is associated with intra-abdominal obesity, but the mechanism remains unclear. The study aimed to investigate whether lower Gly concentrations in older adults are independently associated with (visceral) adiposity, age, sex, presence of chronic disease, and glucose intolerance, and whether they are caused by a reduced whole-body production (WBP) and/or increased Gly disposal capacity...

BACKGROUND: Evidence regarding the relationships of serum 25-hydroxyvitamin D (25[OH]D) with cardiovascular diseases (CVD) and mortality among patients with chronic kidney disease (CKD) is limited and inconsistent. OBJECTIVE: This study aimed to investigate the associations between serum 25(OH)D and CVD incidence and mortality among patients with CKD. METHODS: This prospective study included 21,507 participants with CKD and free of CVD in the UK Biobank...

BACKGROUND: Prospective observational data revealed lower cardiovascular disease (CVD) incidence with modelled replacement of saturated fatty acids (SFA) from total meat by total dairy, but it is unknown what the associations are of replacing SFA from types of meat by types of dairy with CVD incidence. OBJECTIVE: To investigate the associations of replacing SFA from total, red, processed and poultry meat by SFA from total dairy, milk, cheese, and yogurt with the incidence of CVD...

BACKGROUND: With the growing popularity of plant-based meat analogues (PBMAs), an examination of their effects on health is warranted in an Asian population. OBJECTIVE: This research investigated the impact of consuming an omnivorous animal-based meat diet (ABMD) compared to a PBMAs diet (PBMD) on cardiometabolic health among adults with elevated risk of diabetes in Singapore. METHODS: In an 8-week parallel design randomized controlled trial, participants (n=89) were instructed to substitute habitual protein-rich foods with fixed quantities of either PBMAs (n=44) or their corresponding animal-based meats (n=45; 2...

BACKGROUND: Hypomagnesemia is commonly observed in individuals with diabetes, but how diabetes medications alter magnesium (Mg) status remains unclear. OBJECTIVE: We aimed to 1) examine the association between diabetes medication and hypomagnesemia and 2) evaluate whether serum Mg mediates the association between diabetes medication and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) in a prospective cohort. METHODS: Adults from the Boston Puerto Rican Health Study were included (n=1106)...

BACKGROUND: The partially hydrogenated oil (PHO) prohibition came into effect in Canada in September 2018 to reduce the intakes of total trans fatty acids (t-TFA) and industrially produced TFA (i-TFA). OBJECTIVE: We aimed to estimate the red blood cell (RBC) proportions of t-TFA (primary objective) and total 18:1 TFA (secondary objective) of adults in Canada before the PHO prohibition and to identify the population subgroups at risk of higher TFA intakes. DESIGN: We pooled data from 4,025 adult participants of the cross-sectional Canadian Health Measures Survey cycles 3 and 4 (2012-2015)...

BACKGROUND: Existing gestational weight gain (GWG) charts vary considerably in their choice of exclusion/inclusion criteria, and it is unclear to what extent these criteria create differences in the charts' percentile values. We aimed to establish the impact of including/excluding pregnancies with adverse neonatal outcomes when constructing GWG charts. METHODS: This is an individual participant data analysis from 31 studies from low- and middle-income countries...

No abstract text is available yet for this article.

BACKGROUND: The substitution of monounsaturated acids (MUFAs) for saturated fatty acids (SFAs) is recommended for cardiovascular disease prevention but its impact on lipoprotein metabolism in subjects with dyslipidemia associated with insulin resistance (IR) remains largely unknown. OBJECTIVE: This study aimed to evaluate the impact of substituting MUFAs for SFAs on the in vivo kinetics of apolipoprotein (apo)B-containing lipoproteins and on the plasma lipidomic profile in adults with IR-induced dyslipidemia...

No abstract text is available yet for this article.

BACKGROUND: Predicting energy requirements for older adults is compromised by the underpinning data being extrapolated from younger adults. OBJECTIVES: To generate and validate new total energy expenditure (TEE) predictive equations specifically for older adults using readily available measures (age, weight, height) and to generate and test new physical activity level (PAL) values derived from 1) reference method of indirect calorimetry and 2) predictive equations in adults aged ≥65 y...

BACKGROUND: Metabolite abundance is a dynamic trait that varies in response to environmental stimuli and phenotypic traits, such as food consumption and body mass index (BMI). OBJECTIVES: Here we use the Netherlands Epidemiology of Obesity (NEO) study to identify observational and causal associations between BMI and metabolite response to a liquid meal. METHODS: A liquid meal challenge was performed and Nightingale Health metabolite profiles were collected in 5744 NEO participants...

BACKGROUND: Extracellular vesicles (EVs) are proposed to play a role in the development of cardiovascular diseases (CVDs) and are considered emerging markers of CVDs. N-3 polyunsaturated fatty acids (PUFAs) are abundant in oily fish and fish oil and are reported to reduce CVD risk, but there has been little research to date examining the effects of n-3 PUFAs on the generation and function of EVs. OBJECTIVE: The objective of the study was to investigate the effects of fish oil supplementation on the number, generation and function of EVs in subjects with moderate risk of CVDs...

BACKGROUND: Higher 25-hydroxyvitamin D (25(OH)D) in serum has a positive association with pulmonary function. Investigating genome-wide interactions with 25(OH)D may reveal new biological insights into pulmonary function. OBJECTIVE: We aimed to identify novel genetic variants associated with pulmonary function by accounting for 25(OH)D interaction. METHODS: We included 211,264 participants from the observational UK Biobank study with pulmonary function tests (PFTs), genome-wide genotypes, and 25(OH)D levels from four ancestral backgrounds-European, African, East Asian, and South Asian...

BACKGROUND: Epidemiological evidence suggests that a potential association between dietary protein intake and cardiovascular disease (CVD) may depend on the protein source, that is, plant- or animal-derived, but past research was limited and inconclusive. OBJECTIVES: To evaluate the association of dietary plant- or animal-derived protein consumption with risk of CVD, and its components ischemic heart disease (IHD) and stroke. METHODS: This analysis in the European Prospective Investigation into Cancer and Nutrition (EPIC)-CVD case-cohort study included 16,244 incident CVD cases (10,784 IHD and 6423 stroke cases) and 15,141 subcohort members from 7 European countries...

BACKGROUND: Early life nutrition is crucial for the development of the gut microbiota that, in turn, plays an essential role in the maturation of the immune system and the prevention of infections. OBJECTIVES: The aim of this study was to investigate whether feeding synbiotic infant and follow-on formulas during the first year of life reduces the incidence rate (IR) of infectious diarrhea compared to standard formulas. Secondary endpoints included the IR of other infectious diseases as well as fecal milieu parameters...

BACKGROUND: Higher cost of healthy foods may explain unhealthy dietary patterns in lower income households. Unfortunately, combining food selection and nutrient intake data to price and expenditure is challenging. Food retailer's customer loyalty card data, linked to nutrient composition database, is a novel method for simultaneous exploration of food purchases, price, and nutrition. OBJECTIVES: We studied the associations between Perceived Income Adequacy (PIA) as a grouping variable with price (per kg or MJ) and the volume of purchases (% of expenditure or energy) simultaneously as outcome variables for 17 most purchased food groups...

BACKGROUND: Variability in BMI trajectories is associated with body composition and cardiometabolic markers in early childhood, but it is unknown how these associations track to later childhood. OBJECTIVES: We aimed to assess associations of BMI trajectories from 0-5 years with body composition and cardiometabolic markers at 10 years. METHODS: In the Ethiopian iABC birth cohort, we previously identified 4 distinct BMI trajectories from 0-5 years: stable low BMI (19...

The Dietary Guidelines for Americans (DGA) provides science-based advice on dietary intake to promote health, reduce the risk of chronic disease, and meet nutrient needs. It is jointly published by the U.S. Departments of Health and Human Services (HHS) and Agriculture (USDA) every five years. As chronic diseases continue to rise to pervasive levels, helping the U.S. population follow the DGA is especially important for improving the health of our nation. The DGA is developed using a rigorous and transparent scientific process, and with the involvement of an independent, external committee of leading scientists...

BACKGROUND: Heat treatments of dairy, including pasteurization and ultra-high temperature (UHT) processing, alter milk macromolecular structures, and ultimately affect digestion. In vitro, animal, and human studies show faster nutrient release or circulating appearance after consuming UHT milk (UHT-M) compared to pasteurized milk (PAST-M), with a faster gastric emptying (GE) rate proposed as a possible mechanism. OBJECTIVES: To investigate the impact of milk heat treatment on GE as a mechanism of faster nutrient appearance in blood...